Bioactive Lipid Metabolites in Age-Related Comorbidities: From Mechanisms to Therapeutics
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 20 February 2026 | Viewed by 103
Special Issue Editor
Special Issue Information
Dear Colleagues,
As global life expectancy increases, age-related comorbidities such as osteoporosis, sarcopenia, osteoarthritis, neurodegeneration, cardiovascular disease, and metabolic syndrome are becoming major public health concerns. Although the mechanisms driving these disorders are complex, accumulating evidence highlights altered lipid metabolism as a critical factor in aging and its associated complications. Dysregulation of lipid pathways such as fatty acid oxidation, sphingolipid and phospholipid signaling, cholesterol balance, and bioactive lipid mediators can lead to the buildup of toxic intermediates or the depletion of essential lipid species, thereby impairing cellular and tissue homeostasis.
Age-associated lipid imbalances contribute not only to organ dysfunction but also to fundamental cellular processes, including stem cell exhaustion, immune dysregulation, mitochondrial impairment, and chronic low-grade inflammation (“inflammaging”). Perturbations in lipid signaling, particularly those involving bioactive lipids, are increasingly recognized as key drivers of oxidative stress, cellular senescence, and systemic metabolic dysfunction, which collectively accelerate degenerative changes. At the same time, advances in lipidomics and systems biology are uncovering novel bioactive lipid-derived biomarkers that hold promise for early diagnosis, prognosis, and therapeutic monitoring in age-related diseases.
This Special Issue seeks to bring together cutting-edge research and comprehensive reviews that bridge molecular insights with clinical applications in the field of lipid metabolism and aging. By integrating mechanistic, translational, and therapeutic perspectives, we aim to identify innovative strategies for promoting healthy aging and delaying the onset of age-related complications.
Potential topics include, but are not limited to, the following:
- Dysregulated lipid metabolism and bioactive lipid signaling in musculoskeletal aging (sarcopenia, osteoporosis, osteoarthritis);
- Bioactive lipid-driven mechanisms of neurodegeneration and cognitive decline;
- Lipid signaling in immune dysfunction, chronic inflammation, and “inflammaging”;
- Crosstalk between lipid metabolism, oxidative stress, mitochondrial dysfunction, and premature senescence;
- Role of bioactive lipids and extracellular vesicles in intercellular communication during aging;
- Lipidomic and bioactive lipid-based biomarkers for early detection and risk assessment of age-related diseases;
- Gut microbiota-derived lipids and their impact on aging and longevity;
- Novel therapeutic strategies targeting lipid metabolism pathways to improve healthspan and lifespan.
Dr. Sadanand Fulzele
Guest Editor
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Keywords
- lipid metabolites
- aging
- sarcopenia
- osteoporosis
- osteoarthritis
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