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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Phytochemicals: Mechanisms and Applications in Cancer Prevention and Therapy

edited by

Mateusz Kciuk

and

Damian Kołat

submission deadline 20 Jan 2026 | Viewed by 244 | Submission Open

Keywords: phytochemicals; cancer prevention; cancer therapy; molecular mechanisms; signal transduction pathways; anti-oxidant activity; cell death; gene regulation; therapeutic targets

(This special issue belongs to the Section Biochemistry)

Synthesis and Application of Organic Antibacterial Agents

edited by

Barbara Dmochowska

submission deadline 20 Jan 2026 | Viewed by 241 | Submission Open

Keywords: organic antibacterial compounds; synthesis; natural organic compounds; biological activity; active compounds; biological applications

(This special issue belongs to the Section Biochemistry)

Advances in Plant Cell Dynamics

edited by

Andrei Smertenko

submission deadline 20 Jan 2026 | Viewed by 236 | Submission Open

Keywords: organelles; cellular polarity; cytoskeleton; vesicle trafficking; cell wall synthesis; signalling; differentiation

(This special issue belongs to the Section Molecular Plant Sciences)

Single-Atom Catalysts for Small Molecule Transformation

edited by Aijuan Han

submission deadline 20 Jan 2026 | Viewed by 235 | Submission Open

Keywords: single-atom catalyst; small molecule transformation; rational design; applications

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

DNA and RNA Nanostructures for the Assembly of Functional Molecules

edited by

Di Liu

and

Kalevi Kairemo

submission deadline 20 Jan 2026 | Viewed by 228 | Submission Open

Keywords: DNA nanotechnology; RNA nanotechnology; biomolecular engineering; biomimetics

(This special issue belongs to the Section Molecular Nanoscience)

New Insight into Bacteriophage and Their Potential Applications

edited by Wilfried Moreira

submission deadline 20 Jan 2026 | Viewed by 221 | Submission Open

Keywords: bacteriophage; phage biology; phage-host interactions; antimicrobial resistance

(This special issue belongs to the Section Molecular Microbiology)

Progress in Adipokines Research in Cardiovascular Health and Diseases

edited by

Morris Karmazyn

submission deadline 20 Jan 2026 | Viewed by 221 | Submission Open

Keywords: adipokine receptors and cell signalling; adipokines and heart failure and hypertrophy; adipokines and myocardial ischemia; adipokines and hypertension; adipokines and thrombosis/atherosclerosis; adipokines and vascular/endothelial function; structure; and integrity; adipokines and cardiovascular inflammation; adipokines; adiposity; and cardiovascular disease in obesity

(This special issue belongs to the Section Molecular Biology)

Innovations in Organic Framework Materials: Expanding the Horizons of COFs, MOFs, and HOFs for Advanced Applications

edited by Bhausaheb Dhokale

submission deadline 20 Jan 2026 | Viewed by 213 | Submission Open

Keywords: COF; MOF; HOF; synthesis; molecular applications; porous materials; molecular engineering; membranes; theoretical studies; energy

(This special issue belongs to the Section Materials Science)

New Optical, Electrical, and Thermal Materials: Recent Advances and Challenges

edited by Luyi Zou

submission deadline 20 Jan 2026 | Viewed by 209 | Submission Open

Keywords: optical materials; electrical materials; thermal materials; molecular structure; molecular composition; structural performance

(This special issue belongs to the Section Materials Science)

Diabetes and Its Complications: From Molecular Mechanisms to Novel Therapeutic Approaches—2nd Edition

edited by

Andrea Paola Rojas Gil

submission deadline 20 Jan 2026 | Viewed by 208 | Submission Open

Keywords: diabetes; diabetes complications; environmental factors; endocrine disruptors; nutrition; sleep; therapy; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Liver Transplantation: Pathogenesis, Therapeutic Strategies and Future Challenges

edited by

Francesco Tandoi

submission deadline 20 Jan 2026 | Viewed by 206 | Submission Open

Keywords: MASLD; transplant oncology; machine perfusion; extended-criteria donors; donors after cardiac death

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Latest Molecular and Psycho-Physiological Insights on “Brain Fatigue”

edited by

Takehiko Fujino

and

Masanori Honsho

submission deadline 20 Jan 2026 | Viewed by 198 | Submission Open

Keywords: epigenetics; neurotransmitter including dopamine; mitochondria dysfunction; neuroinflammation; lipidomics including plasmalogen; proteomics including neuropeptide; neural network; cognition abilities; decline in attention; judgement capacity; depressive state

(This special issue belongs to the Section Molecular Neurobiology)

The Impact of Cancer–Immune Cell Crosstalk on Diagnosis, Prognosis and Treatment

edited by Fabricio Figueiro

submission deadline 20 Jan 2026 | Viewed by 195 | Submission Open

Keywords: protumoral immunity; anticancer immunity; crosstalk; tumor microenvironment; purinergic signaling; immune checkpoints; immunometabolism; extracellular vesicles; RNA communication

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Autophagy, 2nd Edition

edited by

Maria Ines Vaccaro

submission deadline 20 Jan 2026 | Viewed by 192 | Submission Open

Keywords: ATG molecules; transcriptional and post translational modification; selective pathways; secretory pathways; complexes diseases; degenerative processes; inflammatory diseases; tumorigenesis; metabolism; proteostasis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into Chronic Inflammatory Demyelinating Polyneuropathy and Neuroimmunological Diseases

edited by

Fumitaka Shimizu

submission deadline 20 Jan 2026 | Viewed by 187 | Submission Open

Keywords: chronic inflammatory demyelinating polyneuropathy (CIDP); multiple sclerosis (MS); neuromyelitis optica spectrum disorder (NMOSD); myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD); autoimmune encephalitis; paraneoplastic neurological syndrome; Guillain-Barre syndrome (GBS); myositis; blood-brain barrier; blood-nerve barrier

(This special issue belongs to the Section Molecular Neurobiology)

Recent Applications of Programmable Nanobiomaterials in Cancer Targeting and Therapy

edited by Wensheng Xie

submission deadline 20 Jan 2026 | Viewed by 184 | Submission Open

Keywords: programmable nanobiomaterials; cancer targeting; cancer combined therapy; tumor imaging; field-responsive nanomaterials

(This special issue belongs to the Section Molecular Biophysics)

Molecular Mechanisms of Ozone Therapy

edited by

Francisco Rodríguez-Esparragón

Bernadino Clavo

and

Jacob Lorenzo-Morales

submission deadline 20 Jan 2026 | Viewed by 181 | Submission Open

Keywords: antioxidant response; cellular stress responses; inflammatory signaling; mitochondrial function; molecular pathways; Nrf2; oxidative stress; ozone therapy; redox regulation; antimicrobial resistance; infectious diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Hormonal and Metabolic Markers in Health and Disease

edited by

Rafał Podgórski

and

Kornelia Łach

submission deadline 20 Jan 2026 | Viewed by 178 | Submission Open

Keywords: hormonal biomarkers; molecular mechanism of endocrine disorders; steroidogenesis; hormonal dysregulation; endocrine disruptors; metabolomics; metabolic regulation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Plant Molecular Regulatory Networks and Stress Responses

edited by

Xiujun Zhang

submission deadline 20 Jan 2026 | Viewed by 177 | Submission Open

Keywords: plant stress response; stress response gene; regulatory mechanism; gene regulatory network; transcriptional regulation; post-transcriptional regulation; multi-omics integration; single-cell RNA-seq; spatial genomics; bioinformatics

(This special issue belongs to the Section Molecular Plant Sciences)

Radiolabeled Compounds for Theranostic Applications in Oncology

edited by

Cyril Fersing

submission deadline 20 Jan 2026 | Viewed by 176 | Submission Open

Keywords: radiopharmaceuticals; theranostic; cancer therapy; targeted radionuclide therapy; molecular imaging; positron emission tomography; single-photon emission tomography; radiolabeling

(This special issue belongs to the Section Molecular Oncology)

Tuberculosis: Host Immunity, Diagnosis and Treatment

edited by

Veronica Edith Garcia

submission deadline 20 Jan 2026 | Viewed by 169 | Submission Open

Keywords: tuberculosis; immune response; diagnosis; treatment; antibiotics; resistance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring the New Cancer Biomarkers: Progress and Prospects

edited by

Marcelo José Barbosa Silva

submission deadline 20 Jan 2026 | Viewed by 169 | Submission Open

Keywords: prevention; diagnostic; prognostic; response; liquid biopsy; image biomarkers; clinicopathological biomarkers

(This special issue belongs to the Section Molecular Oncology)

Density Functional Theory and Its Application in Atomic Collision Models

edited by

Feng Wang

submission deadline 20 Jan 2026 | Viewed by 168 | Submission Open

Keywords: density functional theory; time-dependent density functional theory; finite-temperature density functional theory; ensemble density functional theory; atom collision models; electron stopping power

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Recent Developments in Obesity: Metabolism, Pathophysiology and Treatment

edited by

Peteris Tretjakovs

submission deadline 20 Jan 2026 | Viewed by 168 | Submission Open

Keywords: obesity; adipokines; insulin sensitivity; lipid metabolism; pro-inflammatory cytokines; gut microbiota; GLP-1 receptor agonists; personalized nutrition; lifestyle interventions

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Mechanisms and Therapies of Gastrointestinal Cancer

edited by

Donatella Delle Cave

submission deadline 20 Jan 2026 | Viewed by 163 | Submission Open

Keywords: tumor microenvironment; therapy resistance; genetic mutations; oncogenes; molecular diagnostics

(This special issue belongs to the Section Molecular Oncology)

Polymer Materials Related to Food Packaging

edited by

Rosie Yagmur Yegin

submission deadline 20 Jan 2026 | Viewed by 163 | Submission Open

Keywords: polymeric materials; food packaging; biodegradable polymers; active packaging; intelligent packaging; nanocomposites; sustainability; circular economy; barrier properties; life cycle assessment

(This special issue belongs to the Section Macromolecules)

The Role of Extracellular Vesicles in Drug Delivery

edited by

Sara Biagiotti

and

Michele Guescini

submission deadline 20 Jan 2026 | Viewed by 162 | Submission Open

Keywords: red blood cells; red blood cell-extracellular vesicles; drug delivery systems; RNA therapies; EV engineering

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Coagulation Proteins

edited by

Arijit Biswas

submission deadline 20 Jan 2026 | Viewed by 154 | Submission Open

Keywords: coagulation proteins; hemostasis; thrombosis; structural biology; Cryo-EM; inherited coagulation disorders

(This special issue belongs to the Section Molecular Biology)

Cutting-Edge Advances in Transcriptional Therapy and Nucleic Acid-Based Therapeutics

edited by

Vincenza Barresi

submission deadline 20 Jan 2026 | Viewed by 154 | Submission Open

Keywords: antisense oligonucleotides (ASOs); siRNAs; peptide nucleic acids (PNAs); aptamers; transcriptional therapy; nanocarriers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Photosynthesis and Stress Signaling

edited by

Liangsheng Wang

submission deadline 20 Jan 2026 | Viewed by 138 | Submission Open

Keywords: photosynthesis; chloroplasts; stress; signaling

(This special issue belongs to the Section Molecular Plant Sciences)

Psoriasis and Associated Complications: Pathogenic Mechanisms, Gene Biomarkers and Treatments

edited by

Anna Michalak-Stoma

submission deadline 20 Jan 2026 | Viewed by 133 | Submission Open

Keywords: psoriasis; autoimmune disease; autoinflammatory disease; psoriatic arthritis; diabetes; hypertension; lipid disorders; obesity; cardiovascular diseases (CVDs); immunological biomarkers; genetic biomarkers; epigenetic biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Environmental and Human Adverse Effects of Micro and Nanoplastics: 2nd Edition

edited by

Elena Niccolai

submission deadline 20 Jan 2026 | Viewed by 133 | Submission Open

Keywords: micro and nanoplastics; environmental pollution; micro and nanoplastic toxicity; human health

(This special issue belongs to the Section Molecular Toxicology)

The Role of Bioactive Natural Products in Human Health

edited by

Eleonora Di Salvo

submission deadline 20 Jan 2026 | Viewed by 132 | Submission Open

Keywords: bioactive compound; human health; functional foods; nutraceutical products; food toxicology; antioxidant properties; anti-inflammation; antimicrobial molecules

(This special issue belongs to the Section Molecular Pharmacology)

Novel Insights into Mitochondrial Signaling and Homeostasis in Metabolic Diseases

edited by Ching-Yi Chen

submission deadline 20 Jan 2026 | Viewed by 130 | Submission Open

Keywords: diabetes mellitus; cardiovascular disease; fatty liver; chronic kidney disease; mitochondrial homeostasis

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Neurohormones in Cardiac Fibrosis and Heart Failure

edited by

Helmy M. Siragy

submission deadline 20 Jan 2026 | Viewed by 128 | Submission Open

Keywords: heart failure; neurohormones; cardiac fibrosis; angiotensin II; aldosterone; endothelin; catecholamines

(This special issue belongs to the Section Molecular Biology)

Coagulation Factors and Natural Anticoagulants in Health and Disease

edited by

Zsuzsanna Bereczky

submission deadline 20 Jan 2026 | Viewed by 127 | Submission Open

Keywords: coagulation factor; natural anticoagulant; hemostasis; thrombosis; molecular studies; molecular interactions; structure; functional studies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancements in Cytopathology: Challenges and Changes

edited by Panagiota Mikou

submission deadline 20 Jan 2026 | Viewed by 122 | Submission Open

Keywords: cytopathology; cancer diagnosis; cytology; early cancer detection; exfoliative cytology

(This special issue belongs to the Section Molecular Biology)

Oxidative Stress Responses in Cardiovascular Diseases

edited by Vladimir Jakovljevic

submission deadline 20 Jan 2026 | Viewed by 121 | Submission Open

Keywords: antioxidant capacity; cardiovascular disease; cell death; endothelial dysfunction; ischemia/reperfusion injury; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Effects of Co-Exposure of Pollutants on Animal Models

edited by

Chiara Maria Motta

submission deadline 20 Jan 2026 | Viewed by 121 | Submission Open

Keywords: environmental health; biological systems; toxic exposure; co-exposure; physiological mechanisms; behavioral responses; gene expression; epigenetic effects; molecular research

(This special issue belongs to the Section Molecular Toxicology)

Research in Alzheimer’s Disease: Advances and Perspectives

edited by

Silvia Boschi

submission deadline 20 Jan 2026 | Viewed by 117 | Submission Open

Keywords: neuroinflammation; synaptic dysfunction; oxidative stress; neurofibrillary tangles; mitochondrial dysfunction; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancing Precision Medicine in Urological Cancers: Integrating Multi-Omics and Optimizing Therapeutic Approaches

edited by Magaly Martinez-Ferrer

submission deadline 20 Jan 2026 | Viewed by 103 | Submission Open

Keywords: prostate cancer; proteomics; metabolomics; precision medicine; biomarker

(This special issue belongs to the Section Molecular Oncology)

Molecular Issues in Optic Neuropathy

edited by

Nitza Goldenberg-Cohen

submission deadline 20 Jan 2026 | Viewed by 100 | Submission Open

Keywords: optic neuropathy; neuroprotection; glaucoma induced neuropathy; molecular pathways; novel therapeutics strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in the Molecular Diagnosis and Treatment of Neurodegenerative Diseases

edited by

Bruno Manadas

submission deadline 20 Jan 2026 | Viewed by 94 | Submission Open

Keywords: neurodegenerative disorders; biomarkers; treatment; omics; systems biology

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research in Animal Nutrition

edited by Jie Fu

submission deadline 20 Jan 2026 | Viewed by 42 | Submission Open

Keywords: animal nutrition; animal immunity; epigenetics; m6A methylation; gut microbiota; host– microbiome interaction; metabolic reprogramming

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Protein Structure and Its Interactions

edited by

Dong Hae Shin

submission deadline 20 Jan 2026 | Viewed by 15 | Submission Open

Keywords: protein– protein interactions (PPIs); protein– ligand binding; molecular recognition; binding affinity and specificity; molecular interface analysis

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Microglia in Neurological Diseases

edited by

Pyung-Hwan Kim

submission deadline 20 Jan 2026 | Viewed by 9 | Submission Open

Keywords: microglia; neuroinflammation; neurodegenerative diseases; molecular signaling; central nervous system (CNS)

(This special issue belongs to the Section Molecular Neurobiology)

Endothelial Cells in Healthy

edited by

Alessia Ricci

and

Amelia Cataldi

submission deadline 20 Jan 2026 | Viewed by 9 | Submission Open

Keywords: endothelial cells; vascular homeostasis; tissue homeostasis; endothelial cell biology; endothelial cells dysfunction; oxidative stress; redox signaling; aging; endothelial regulation of tissue repair

(This special issue belongs to the Section Molecular Biology)

Latest Molecular Research on Muscle Atrophy

edited by

Elena Bresciani

submission deadline 20 Jan 2026 | Viewed by 7 | Submission Open

Keywords: muscle atrophy; molecular mechanisms; protein degradation; inflammation; oxidative stress; sarcopenia; cachexia; autophagy; therapeutics; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cellulose and Its Applications, 2nd Edition

edited by

Suresh Valiyaveettil

and Ce Sun

submission deadline 20 Jan 2026 | Submission Open

Keywords: cellulose; biomedical applications; nanocomposites; biodegradable polymers; water purification; nanocellulose

(This special issue belongs to the Section Macromolecules)

Cardiovascular Diseases: Molecular Mechanisms and Potential Therapy (2nd Edition)

edited by

Andrea Ghiroldi

submission deadline 25 Jan 2026 | Viewed by 249 | Submission Open

Keywords: cardiovascular diseases; pathogenic mechanisms; genetics; cardiomyopathy; myocardial infarction; cardiac fibrosis; pharmacogenomics; drug discovery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 3301-3350 on page 67 of 70.

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