Shaping Macrophages Polarization as an Emerging Therapeutic Approach

Dear Colleagues,

Macrophages play a crucial role in maintaining homeostasis and defending against pathogens. Their ability to adopt different functional states, known as polarization, makes them key players in various physiological and pathological processes. Harnessing the ability to shape macrophage polarization holds promising therapeutic potential for a wide range of diseases, including cancer, chronic inflammation, and autoimmune disorders. Several strategies are being explored to influence macrophage polarization, including the use of cytokines, small molecules, and nanoparticles. Small molecules and drugs can also be designed to target specific signaling pathways involved in macrophage polarization. Despite the promising potential, several challenges remain in translating macrophage polarization modulation into clinical therapies. Further research is necessary to understand the detailed mechanisms of macrophage polarization and to develop more precise and effective methods for their modulation. In this special issue we will focus on molecular studies unravelling the detailed mechanisms of macrophage polarization, as well as on innovative strategies for macrophages plasticity modulation and on their use in specific disease conditions, including drug resistance. Original research articles and reviews will be considered for publication.

Dr. Cristina Maccallini
Guest Editor

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