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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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AIEgens in Action: Design, Mechanisms, and Emerging Applications

edited by

Arkadiusz Matwijczuk

submission deadline 20 Feb 2026 | 1 articles | Viewed by 470 | Submission Open

Keywords: fluorescence effects; photophysical properties of small molecules; ion detection; molecular spectroscopy; various nanoparticle-based additives; fluorescent and phosphorescent phenomena in solvents; amorphous states; and crystals; quantum-mechanical calculations for molecular systems and compositions (DFT; TD-DFT); molecular aggregation influencing fluorescence and phosphorescence properties of tested systems

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Nerve Growth Factor (NGF): Molecular Functions and Therapeutic Implications

edited by

Elena Fico

and Pamela Rosso

submission deadline 20 Feb 2026 | Viewed by 463 | Submission Open

Keywords: nerve growth factor; neurotrophic therapy; biomolecules; neurotrophic molecular pathways; neuroprotection; preclinical research; clinical research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Innovative Materials and Procedures for Implant and Prosthodontics

edited by

Margherita Tumedei

and

Massimo Del Fabbro

submission deadline 20 Feb 2026 | Viewed by 460 | Submission Open

Keywords: alloys; biomaterials; dental materials; dental implants; implant dentistry; implant-abutment connection; peri-implant diseases; prosthodontics; surface treatments; tissue regeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cardiovascular Diseases: Histopathological and Molecular Diagnostics, 2nd Edition

edited by

Simona Gurzu

submission deadline 20 Feb 2026 | Viewed by 459 | Submission Open

Keywords: cardiovascular disorders; heart failure; aortic diseases; cardiomyocytes; cardiac function; myocarditis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring the Role of Antioxidants in Supplements and Drug Responses

edited by

Maria Greabu

submission deadline 20 Feb 2026 | Viewed by 446 | Submission Open

Keywords: NSAIDs; glucocorticoids; vitamin E; antioxidants; oxidative stress; inflammation

(This special issue belongs to the Section Molecular Immunology)

Reactive Oxygen Species (ROS) and Metal Ions in Biological Systems

edited by

Chryssoula Drouza

and

Debbie C. Crans

submission deadline 20 Feb 2026 | Viewed by 443 | Submission Open

Keywords: reactive oxygen species; reactive oxygen species metabolism; diseases and reactive oxygen species; lipid peroxidation; metal ions and reactive oxygen species; metal based drugs; oxidative stress

(This special issue belongs to the Section Biochemistry)

Unraveling Synaptic Structure and Function in the Healthy and Diseased Brain

edited by

Jacopo Meldolesi

submission deadline 20 Feb 2026 | Viewed by 433 | Submission Open

Keywords: molecular studies; axons; synapses; diseases; glial cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Stem Cell Therapy for Neurological Disorders

edited by Gabriele Bonaventura

submission deadline 20 Feb 2026 | Viewed by 431 | Submission Open

Keywords: neurodegenerative disease; cell therapy; stem cells; induced pluripotent stem cells; disease modeling; drug target validation

(This special issue belongs to the Section Molecular Neurobiology)

Environmental Contributors to Oxidative Stress: Mechanisms and Effects

edited by Halina Tkaczenko and

Natalia Kurhaluk

submission deadline 20 Feb 2026 | Viewed by 423 | Submission Open

Keywords: oxidative stress; environmental pollution; climate change; antioxidants; biological effects; toxicology; health risks; reactive oxygen species (ROS); public health; mitigation strategies; cellular damage in human and animal disorders; environmental stressors in human and animal health

(This special issue belongs to the Section Molecular Biology)

Molecular Regulation and Mechanisms of Nitric Oxide in Endothelial Cells and Beyond

edited by

Roberto Berra-Romani

and

Francesco Moccia

submission deadline 20 Feb 2026 | Viewed by 419 | Submission Open

Keywords: nitric oxide (NO); endothelial cells; endothelial nitric oxide synthase (eNOS); vascular homeostasis; vasodilation; endothelial dysfunction; molecular signaling; vascular diseases; reactive oxygen species (ROS); nitric oxide regulation

(This special issue belongs to the Section Biochemistry)

Monoamine Signalling Pathways as a Target for Pathomechanism of Mental Disorders and Pharmacotherapy

edited by

Agnieszka Zelek-Molik

submission deadline 20 Feb 2026 | Viewed by 408 | Submission Open

Keywords: monoaminergic system; psychiatric disorders; neurotransmission regulation; biomarkers; novel therapies

(This special issue belongs to the Section Molecular Neurobiology)

Algae-Derived Bioactives: Key Molecular Interactions Govern High-Value Applications

edited by Evan Stephens and Kirsten Heimann

submission deadline 20 Feb 2026 | 1 articles | Viewed by 408 | Submission Open

Keywords: microalgae; macroalgae; cyanobacteria; bioactive compounds; health and nutrition; algal food products; market analysis

(This special issue belongs to the Section Molecular Microbiology)

Signaling Pathways in Neuroinflammation or Neurodegenerative Disorders

edited by

Marika Cordaro

submission deadline 20 Feb 2026 | Viewed by 391 | Submission Open

Keywords: inflammation; neuroinflammation; oxidative stress; neurodegenerative disorders; pathology; molecular pathways; dysregulation; mitochondrial dysfunction

(This special issue belongs to the Section Molecular Neurobiology)

Recent Research on Optoelectronic Materials

edited by

Meysam Tayebi

submission deadline 20 Feb 2026 | Viewed by 380 | Submission Open

Keywords: photoelectrochemistry; optoelectronic materials; perovskite materials; semiconductor interfaces; molecular-level catalysis; solar fuel conversion; nanostructured materials; light-harvesting systems

(This special issue belongs to the Section Materials Science)

Molecular Advances in the Relationship Between Diabetes and Cancers

edited by

Zsuzsanna Németh

submission deadline 20 Feb 2026 | Viewed by 379 | Submission Open

Keywords: diabetes; insulin resistance; glucose intolerance; glucolipotoxicity; ER stress; oxidative stress; cancer development

(This special issue belongs to the Section Molecular Oncology)

Molecular Effects of Exercise Training in the Prevention and Treatment of Cardiovascular Diseases

edited by

Maxime Pellegrin

submission deadline 20 Feb 2026 | Viewed by 378 | Submission Open

Keywords: atherosclerosis; cardiovascular disease; exercise training; molecular mechanisms; training modalities

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Insights into the Molecular Mechanisms of Pancreatitis

edited by

Gi-Sang Bae

submission deadline 20 Feb 2026 | Viewed by 376 | Submission Open

Keywords: acute pancreatitis; chronic pancreatitis; pancreatic fibrosis; mechanisms; digestive enzymes; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pathogenic Mechanisms of Candida auris

edited by

Anastasia Spiliopoulou

submission deadline 20 Feb 2026 | Viewed by 370 | Submission Open

Keywords: C. auris; antifungal resistance; immune evasion

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms of Plant Adaptation to Stress

edited by Yuanchun Ma

submission deadline 20 Feb 2026 | Viewed by 359 | Submission Open

Keywords: plant; environmental stresses; signaling pathways; stress-responsive genes; transcription factors; phytohormones; crop resilience; breeding; genetic engineering

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research Progress of Optoelectronic Materials and Devices

edited by Moon Jong Han

submission deadline 20 Feb 2026 | Viewed by 356 | Submission Open

Keywords: semiconductors; multifunctionalities; optoelectronics; structure-driven properties; thin films; polymers

(This special issue belongs to the Section Materials Science)

Mitochondrial Disorders: From Molecular Mechanisms to New Therapies

edited by

Yury Ladilov

and

Muhammad Aslam

submission deadline 20 Feb 2026 | Viewed by 354 | Submission Open

Keywords: mitochondrial disorders; mitochondrial dysfunction; molecular mechanisms; targeted therapeutic approaches; mitochondrial biology regulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Synthesis and Transformations of Bioactive Cyclic Imides

edited by

István Szatmári

submission deadline 20 Feb 2026 | Viewed by 342 | Submission Open

Keywords: PROTAC; phthalimides; maleimides; cyclic imides; targeted protein degradation; protein labeling; antibody–drug conjugates; drug design and synthesis; drug conjugation

(This special issue belongs to the Section Biochemistry)

Advances in the Nanoparticles-Based Drug Delivery in Cancer Therapy

edited by

André F. Moreira

submission deadline 20 Feb 2026 | Viewed by 330 | Submission Open

Keywords: nanoparticle-based drug delivery; stimuli responsive; cancer targeting; theragnostic nanoparticles; protein corona; combinatorial drug therapies; tumor penetration; cancer cells uptake

(This special issue belongs to the Section Molecular Nanoscience)

Antioxidants: Design, Synthesis, and Mechanism of Actions

edited by Choon Young Lee

submission deadline 20 Feb 2026 | 1 articles | Viewed by 330 | Submission Open

Keywords: antioxidant synthesis; multifunctional antioxidants; oxidant-generating enzyme inhibitors; activators of antioxidant-generating enzymes; phenolic antioxidant; thiol-based antioxidant; nitrogen-based antioxidants; anti-inflammatory; oxidative stress; free radical scavenging; reactive oxygen species; reactive nitrogen species; mechanisms of action; metal chelator

(This special issue belongs to the Section Macromolecules)

Osteoporosis: From Molecular Research to Novel Therapies

edited by

Agostino Gaudio

and Anastasia Xourafa

submission deadline 20 Feb 2026 | Viewed by 323 | Submission Open

Keywords: osteoporosis; bone metabolism; OPG/RANK/RANKL system; Wnt/beta catenin signalling; secondary osteoporosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Neuro and Immune Mechanisms Behind Cannabinoids Effects

edited by

Babak Baban

submission deadline 20 Feb 2026 | Viewed by 319 | Submission Open

Keywords: cannabinoids; neuroinflammation; endocannabinoid system (ECS); non-cannabinoid receptors; immune modulation; synaptic plasticity

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms Behind Plant–Virus Interactions: Pathogenesis and Defense

edited by

Katarzyna Otulak-Kozieł

submission deadline 20 Feb 2026 | 1 articles | Viewed by 316 | Submission Open

Keywords: plant viruses; plant resistance; plant signaling; plant defense; biotic stress; plant– virus interactions; molecular mechanism

(This special issue belongs to the Section Molecular Plant Sciences)

Neuroinflammation, and Alcohol Use Disorders: Molecular Mechanisms and Treatment

edited by

Marco Fiore

submission deadline 20 Feb 2026 | Viewed by 307 | Submission Open

Keywords: alcohol; addiction; abuse; inflammation; neurodegeneration; cognition; neuroimmunology; oxidative stress

(This special issue belongs to the Section Molecular Biology)

Artificial Intelligence in Nano- and Bio-Technology Systems: Focus on Molecular Research

edited by

Abbas Amini

submission deadline 20 Feb 2026 | Viewed by 307 | Submission Open

Keywords: artificial intelligence; nanotechnology; biotechnology; medicine; energy systems; blockchain

(This special issue belongs to the Section Molecular Nanoscience)

Diverse Biomolecular Probes in the Development of Single-Molecule Biosensors

edited by

Kevin D. Belfield

and

Xiaohan Chen

submission deadline 20 Feb 2026 | Viewed by 300 | Submission Open

Keywords: biomolecular probes; single-molecule method; biosensors; diseases diagnosis; biomarkers; nanotechnology

(This special issue belongs to the Section Materials Science)

Neurodegenerative Disorders: Advances in Mechanisms, Models, and Therapeutics

edited by Craig Bennett

submission deadline 20 Feb 2026 | Viewed by 298 | Submission Open

Keywords: TDP-43; C9orf72; dipeptide repeat; proteotoxicity; cryptic exon exclusion; L-BMAA

(This special issue belongs to the Section Molecular Neurobiology)

Antioxidant, Anti-Inflammatory, and Antiproliferative Activities of Natural Products—3rd Edition

edited by

Bruno Eto

submission deadline 20 Feb 2026 | Viewed by 290 | Submission Open

Keywords: bioactive products; anti-infectives; antioxidants; anti-inflammatory; antiproliferative; clinical phytopharmacology; phytopharmacology; polyphytotherapy

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Translation Process, Molecular Mechanism, and Recognition Methods of Post-Translational Modifications of Proteins

edited by

Hao Lin

submission deadline 20 Feb 2026 | Viewed by 289 | Submission Open

Keywords: DNA replication; repair; and transcription; post-translational modifications; chromatin; acetylation; methylation; phosphorylation; ubiquitination and ubiquitin-like modifiers; histone modifications

(This special issue belongs to the Section Molecular Informatics)

The Roles of Oxidative Stress in Metabolic Syndrome

edited by

Maria Magdalena Quetglas-Llabrés

and

Margalida Monserrat-Mesquida

submission deadline 20 Feb 2026 | Viewed by 283 | Submission Open

Keywords: oxidative stress; metabolic syndrome; inflammation; antioxidants; human chronic diseases; cardiometabolic diseases; nutrition; lifestyle

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Natural Compounds: Biosynthesis and Application

edited by

Abdellah Zinedine

, Marya Raji and El Habib Ait Addi

submission deadline 20 Feb 2026 | Viewed by 282 | Submission Open

Keywords: natural compounds; chemical composition; biological activities; biosynthesis; bioconversion; application

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advanced Research on Nanosensors for Molecular Sensing Applications

edited by

Giorgio Rispoli

submission deadline 20 Feb 2026 | Viewed by 277 | Submission Open

Keywords: nanostructure; microfabrication; nanoparticles; nanotechnology; nanomaterials; sensor response; sensitivity; miniaturization; analyte selectivity; molecular recognition; biosensor; sensing mechanism; nanowires; affinity sensor

(This special issue belongs to the Section Molecular Nanoscience)

PD-L1 – PD1 Signaling Axis: From Mechanism to Therapeutics

edited by

Grazyna Kochan

and

David Escors

submission deadline 20 Feb 2026 | Viewed by 276 | Submission Open

Keywords: PD-L1/PD1 immune checkpoints; cancer; mechnistic insights and resistances; adaptive immune regulation; therapeutic strategies

(This special issue belongs to the Section Molecular Oncology)

Gene Mining and Germplasm Innovation for the Important Traits in Rice (Second Edition)

edited by

Shimin Zuo

and

Yongmei Bao

submission deadline 20 Feb 2026 | Viewed by 275 | Submission Open

Keywords: rice; gene mining; important traits; molecular design; gene editing; germplasm innovation

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Progress in Biological and Molecular Mechanisms and Targeted Therapies of Leukemia

edited by Anna Sicuranza

submission deadline 20 Feb 2026 | Viewed by 272 | Submission Open

Keywords: leukemia-targeted therapies; AML; CML; venetoclax combination therapy; tyrosine kinase inhibitors (TKIs); hypomethylating agents; ALL; CLL; CAR-T cell therapy; monoclonal antibodies; immune checkpoint inhibitors; resistance mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights in Biomodelling

edited by

Jacques Demongeot

submission deadline 20 Feb 2026 | Viewed by 267 | Submission Open

Keywords: biomodelling; biomathematics; bioinformatics; biostatistics; biophysics; theoretical biology; theoretical ecology; mathematical biology; theoretical physics; physical chemistry

(This special issue belongs to the Section Molecular Informatics)

Advances in Molecular Biology of Ovarian Cancer

edited by

Stefania Scicchitano

and Cinzia Garofalo

submission deadline 20 Feb 2026 | Viewed by 266 | Submission Open

Keywords: ovarian cancer; signaling pathways; transcription factors; cancer metabolism; chemoresistance; tumor microenvironment; ovarian cancer stem cells; cancer therapies

(This special issue belongs to the Section Molecular Oncology)

Anticancer Agents of the Future: From Specific Molecular Targets to Individual Patient Profile

edited by

Zofia Mazerska

submission deadline 20 Feb 2026 | Viewed by 262 | Submission Open

Keywords: anticancer drug research; selective antitumor therapy; tumor cell molecular targets; tumor healthy cells selectivity; cancer cell metabolism; anticancer drug delivery; individual anticancer therapy; dual targeting anticancer therapy

(This special issue belongs to the Section Molecular Oncology)

Biosensors: Emerging Technologies and Real-Time Monitoring

edited by

Velmurugan Thavasi

submission deadline 20 Feb 2026 | Viewed by 260 | Submission Open

Keywords: biosensors; real-time monitoring; wearable sensors; electrochemical detection; optical biosensors; point-of-care (POC) diagnostics; biomarker identification and analysis; wireless technologies

(This special issue belongs to the Section Biochemistry)

Recent Advances in Herpesviruses (2nd Edition)

edited by

Marisa Granato

submission deadline 20 Feb 2026 | Viewed by 253 | Submission Open

Keywords: α -herpesviridae; β -herpesviridae; γ -herpesviridae; herpesviruses associated diseases

(This special issue belongs to the Section Molecular Microbiology)

Advances in Ferrocene-Based Molecular Research: Synthesis, Properties, and Applications

edited by

Mojca Čakić Semenčić

submission deadline 20 Feb 2026 | Viewed by 252 | Submission Open

Keywords: ferrocene; organometallic chemistry; bioorganometallic chemistry; ferrocene derivatives; synthesis; applications; bioconjugates

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Targets in Alzheimer’s Disease: From Mechanisms to Therapeutic Strategies

edited by

Mohammad Ejaz Ahmed

submission deadline 20 Feb 2026 | Viewed by 251 | Submission Open

Keywords: amyloid beta; neurodegeneration; neuroinflammation; microglia; mitochondrial dysfucntion; oxidative stress; molecular pathway; biomarkers of AD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Autophagy and Viral Infections: The Era of New Therapeutical Strategies

edited by

Marisa Granato

submission deadline 20 Feb 2026 | Viewed by 243 | Submission Open

Keywords: autophagy; macroautophagy system; virus; viral infection; influenzae virus

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms, Therapeutic Challenges, and Pathogenesis of Complications in Liver Cirrhosis

edited by

Hiroteru Kamimura

submission deadline 20 Feb 2026 | Viewed by 239 | Submission Open

Keywords: muscle spasm; pruritus; sleep disturbances; sarcopenia; osteoporosis; infection; hepatopulmonary syndrome; hepatorenal syndrome; cirrhotic cardiomyopathy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancing Mycorrhizal Research for Promoting Plant Growth Under Abiotic Stress

edited by

Catarina Campos

and

Hélia Cardoso

submission deadline 20 Feb 2026 | Viewed by 238 | Submission Open

Keywords: plant-mycorrhizal symbiosis; climate changes; environmental stress; plant stress-tolerance

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Forensics at Trial

edited by

Guido Viel

submission deadline 20 Feb 2026 | Viewed by 237 | Submission Open

Keywords: forensic science; molecular biology; evidence; proof; justice; trial; forensic pathology; forensic genetics; forensic histology; forensic toxicology

(This special issue belongs to the Section Molecular Toxicology)

Displaying special issue 1801-1850 on page 37 of 70.

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