Liver Disease and Primary Liver Cancer: Translational Advances and Therapeutic Perspectives

Dear Colleagues,

Liver disease and primary liver cancer remain major global health challenges, with hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) ranking among the most prevalent and lethal malignancies worldwide. Despite progress in diagnostic and therapeutic approaches, patient outcomes remain poor due to late detection, limited treatment efficacy, and high recurrence rates. A deeper understanding of the molecular mechanisms underlying liver disease progression and hepatocarcinogenesis is essential to enable effective translational applications.

This Special Issue will focus on molecular science and translational advances in liver disease and liver cancer, with emphasis on innovative models and therapeutic strategies. Areas of interest include molecular pathways of inflammation and fibrosis, genetic and epigenetic regulation of hepatocarcinogenesis, tumor microenvironment and immune modulation, and novel biomarkers for diagnosis and prognosis. The issue will also cover the development and application of advanced experimental systems, such as 3D models, organoids, and bioengineered platforms, which provide powerful tools for studying disease mechanisms and testing new therapies. Furthermore, contributions addressing targeted therapies, immunotherapy, and combinatorial treatment strategies are welcome.

By assembling high-quality studies in these areas, this Special Issue aims to provide an updated overview of molecular insights and translational perspectives, ultimately supporting the development of innovative approaches for prevention, diagnosis, and treatment of liver disease and liver cancer.

Dr. Cristian Turato
Guest Editor

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