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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Macrophage Metabolic Reprogramming in Inflammation submission deadline 20 Aug 2026 | 2 articles | Viewed by 2671 | Submission Open
Keywords: inflammation; immunometabolism; metabolic rewiring; glycolysis; krebs cycle; glutaminolysis; innate immune response; macrophages
(This special issue belongs to the Section Molecular Immunology)
Coordination Chemistry: From Fundamental Principles to Multifunctional Applications
edited by
submission deadline 20 Aug 2026 | 4 articles | Viewed by 2647 | Submission Open
Keywords: coordination compounds; metal–ligand interactions; ligand design and synthesis; spectroscopic characterization; coordination geometry; molecular architecture; ion-association complexes; supramolecular chemistry; catalysis and activation mechanisms; functional materials; metal–organic frameworks; magnetism in coordination compounds; redox-active complexes; environmental and green chemistry applications; sensors and molecular devices; bioinorganic chemistry; medicinal coordination chemistry; theoretical and computational coordination chemistry
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Synthesis and Structural Studies of Potential Anticancer Drugs
edited by Janusz Madaj
submission deadline 20 Aug 2026 | 1 articles | Viewed by 2641 | Submission Open
Keywords: medicinal chemistry; drug discovery; design and synthesis of bioactive compounds; molecular modeling; X-ray crystallography; structure–activity relationships; structure-based drug design
(This special issue belongs to the Section Molecular Pharmacology)
Advanced Strategies in Bacterial Antibiotic Resistance
edited by Xuemei Yang
submission deadline 20 Aug 2026 | 3 articles | Viewed by 2605 | Submission Open
Keywords: antibiotic resistance; resistance mechanisms; antibiotic resistance genes (ARGs); antibiotic tolerance; heteroresistance; horizontal gene transfer (HGT); compensatory evolution
(This special issue belongs to the Section Molecular Microbiology)
Molecular Aspects of Diabetes and Its Complications
edited by
submission deadline 20 Aug 2026 | 3 articles | Viewed by 2591 | Submission Open
Keywords: obesity; insulin resistance; type 2 diabetes; atherosclerosis; endothelial dysfunction; cardiovascular disease; peripheral artery disease; diabetic feet; diabetic micoangiopathy; diabetic neuropathy; regenerative medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Epilepsy: Exploring the Molecular Mechanisms and Potential Medications
edited by
submission deadline 20 Aug 2026 | 2 articles | Viewed by 2559 | Submission Open
Keywords: idiopathic epilepsy; genetic epilepsy; transmission; development; signaling; synaptic plasticity; pathophysiology; modulation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Unraveling Synaptic Structure and Function in the Healthy and Diseased Brain
edited by
submission deadline 20 Aug 2026 | 1 articles | Viewed by 2503 | Submission Open
Keywords: molecular studies; axons; synapses; diseases; glial cells
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Developing Methods and Molecular Basis in Plant Biotechnology: 2nd Edition
edited by
submission deadline 20 Aug 2026 | 3 articles | Viewed by 2490 | Submission Open
Keywords: plant biotechnology; plant genetics; plant proteomics; plant metabolomics; stress
(This special issue belongs to the Section Molecular Plant Sciences)
The Cellular and Molecular Mechanisms of Central Nervous System Injury submission deadline 20 Aug 2026 | 2 articles | Viewed by 2427 | Submission Open
Keywords: central nervous system damage; CNS; oxidative stress; DNA damage responses; neuroregeneration; blood–brain barrier disruption
(This special issue belongs to the Section Molecular Neurobiology)
Effects of Radiation in Health and Disease submission deadline 20 Aug 2026 | 4 articles | Viewed by 2427 | Submission Open
Keywords: extremely low-frequency magnetic fields; proteins and gene interaction; ionizing and non-ionizing radiations
(This special issue belongs to the Section Molecular Biology)
From Mechanisms to Medicine: Cellular Insights into Pulmonary Hypertension
edited by
submission deadline 20 Aug 2026 | 2 articles | Viewed by 2411 | Submission Open
Keywords: vascular remodeling; cellular mechanisms; hypoxia; growth factors; inflammation
(This special issue belongs to the Section Molecular Biology)
Autoimmune Diseases: From Molecular Mechanisms to Therapeutic Innovations submission deadline 20 Aug 2026 | 2 articles | Viewed by 2398 | Submission Open
Keywords: autoimmunity; biological biomarkers; personalized therapies; biologics and JAK inhibitors; CAR-T cell therapy
(This special issue belongs to the Section Molecular Immunology)
Molecular and Cellular Targets on Anticancer Research and Perspectives submission deadline 20 Aug 2026 | 1 articles | Viewed by 2358 | Submission Open
Keywords: anticancer; molecular targets; targeted cancer therapies; malignancy
(This special issue belongs to the Section Molecular Oncology)
Molecular Insights into Microbial Adaptations to Marine Plastics
edited by
submission deadline 20 Aug 2026 | 2 articles | Viewed by 2283 | Submission Open
Keywords: plastisphere; marine plastic debris; microbial colonization; biofilms; microbial adaptation; community assembly; quorum sesing; plastic biodegradation; biogeochemical cycling; antibiotic resistance genes; marine microbial ecology; metagenomics; microbe–plastic interactions; microbial succession
(This special issue belongs to the Section Molecular Microbiology)
Advances in Stem Cell Biology and Translational Medicine
edited by Yangluowa Qu
submission deadline 20 Aug 2026 | 1 articles | Viewed by 2105 | Submission Open
Keywords: stem cell regulation; differentiation; proliferation; self-renewal; stem cell-based therapy; tissue engineering; translational research
(This special issue belongs to the Section Molecular Biology)
Biomaterials and Antibacterial Materials for Medical Applications
edited by
submission deadline 20 Aug 2026 | 2 articles | Viewed by 2076 | Submission Open
Keywords: biomaterial science; photodynamic antibacterial materials; photothermal antibacterial materials; advanced antibacterial materials; antimicrobial nanostructured materials; polymer-based biomaterials; infected wound dressings
(This special issue belongs to the Section Materials Science)
Kidney Disease: Molecular Insights and Emerging Therapies
edited by
submission deadline 20 Aug 2026 | 2 articles | Viewed by 1972 | Submission Open
Keywords: kidney disease; molecular mechanism; precision medicine; translational nephrology; targeted molecular therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances and Views in Triple-Negative Breast Cancer
edited by
submission deadline 20 Aug 2026 | 1 articles | Viewed by 1970 | Submission Open
Keywords: breast cancer; molecular biology; personalized medicine; triple-negative breast cancer
(This special issue belongs to the Section Molecular Oncology)
Novel Insights into Mitochondrial Signaling and Homeostasis in Metabolic Diseases
edited by Ching-Yi Chen
submission deadline 20 Aug 2026 | 1 articles | Viewed by 1966 | Submission Open
Keywords: diabetes mellitus; cardiovascular disease; fatty liver; chronic kidney disease; mitochondrial homeostasis
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Significance and Challenges of Plant-Derived Natural Compounds in Cancers
edited by Ba Vinh Le
submission deadline 20 Aug 2026 | 1 articles | Viewed by 1966 | Submission Open
Keywords: metabolomic; bioactive compound; pharmacognosy; oriental medicine; drug discovery; pharmacology; anti-cancer; pharmacological effects
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advances in Fluorescent Sensors submission deadline 20 Aug 2026 | 1 articles | Viewed by 1952 | Submission Open
Keywords: fluorescence probe; fluorescent nanomaterials; analyte recognition; fluorescence imaging; real-time monitoring; photoinduced electron transfer; Förster resonance energy transfer; genetically encoded indicators; sensor devices; fluorescence microscopy
(This special issue belongs to the Section Materials Science)
Molecular Insights into Microglia in Neurological Diseases
edited by
submission deadline 20 Aug 2026 | 1 articles | Viewed by 1885 | Submission Open
Keywords: microglia; neuroinflammation; neurodegenerative diseases; molecular signaling; central nervous system (CNS)
(This special issue belongs to the Section Molecular Neurobiology)
Evolutionary Drivers and Adaptive Mechanisms in Algal Organellar Genomes
edited by
submission deadline 20 Aug 2026 | 2 articles | Viewed by 1856 | Submission Open
Keywords: organellar genome of algae; molecular evolution; secondary structure of intron; evolutionary driving force; horizontal gene transfer
(This special issue belongs to the Section Molecular Plant Sciences)
Telocytes: Unraveling Their Roles in Health and Disease
edited by
submission deadline 20 Aug 2026 | 2 articles | Viewed by 1800 | Submission Open
Keywords: telocytes; telopodes; intercellular communication; stem cell niche; extracellular vesicles; regenerative medicine; tissue remodelling; stromal cells
(This special issue belongs to the Section Molecular Biology)
Natural Compounds in Neurological Diseases
edited by
submission deadline 20 Aug 2026 | 1 articles | Viewed by 1763 | Submission Open
Keywords: natural compounds; neuroprotection; neuroinflammation; oxidative stress; mitochondrial dysfunction; autophagy; bioactive molecules (polyphenols, flavonoids, melatonin, etc.); nutraceuticals (bioactive peptides, hydrolysates, etc.); neurodegenerative diseases
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanisms of Thromboinflammation
edited by Ana B. Arroyo
submission deadline 20 Aug 2026 | 1 articles | Viewed by 1753 | Submission Open
Keywords: thromboinflammation; coagulation; inflammation; immune system; sepsis; stroke; autoimmune diseases; cancer; hematology; biomarkers; translational medicine
(This special issue belongs to the Section Molecular Immunology)
Research on the Key Role of Ubiquitination in Signaling and Cancer
edited by
submission deadline 20 Aug 2026 | 2 articles | Viewed by 1730 | Submission Open
Keywords: ubiquitin; ubiquitination; E3 ligase; deubiquitinating enzymes; protein degradation; mutations; cancer progression; signal transduction; drug development
(This special issue belongs to the Section Molecular Oncology)
Molecular Research in Functional Nanomaterials
edited by
submission deadline 20 Aug 2026 | 1 articles | Viewed by 1724 | Submission Open
Keywords: functional materials; nanomaterials; molecular structure; molecular materials; functional molecules; nanotechnology; self-assembly methods
(This special issue belongs to the Section Molecular Nanoscience)
New Progress in Peptidic Protease Inhibitors
edited by and Carla Di Chio
submission deadline 20 Aug 2026 | 2 articles | Viewed by 1721 | Submission Open
Keywords: peptide inhibitors; infectious diseases; cancer; metabolic disorders; neurological disorders; inflammation
(This special issue belongs to the Section Biochemistry)
Research Progress of Fluorescent Proteins in Molecular Biology
edited by Matteo Grenzi
submission deadline 20 Aug 2026 | 1 articles | Viewed by 1700 | Submission Open
Keywords: fluorescence microscopy; fluorescence live-cell imaging; quantitative imaging; fluorescent biosensors; in vivo imaging; innovative fluorescence microscopy techniques
(This special issue belongs to the Section Molecular Biology)
Molecular Research and Insights into Anti-Cancer Vaccines
edited by
submission deadline 20 Aug 2026 | 1 articles | Viewed by 1666 | Submission Open
Keywords: anti-cancer vaccines; tumor antigens; molecular mechanisms; immunotherapy; molecular oncology
(This special issue belongs to the Section Molecular Oncology)
New Insight into Bacteriophage and Their Potential Applications
edited by Wilfried Moreira
submission deadline 20 Aug 2026 | 2 articles | Viewed by 1645 | Submission Open
Keywords: bacteriophage; phage biology; phage-host interactions; antimicrobial resistance
(This special issue belongs to the Section Molecular Microbiology)
Molecular Biology on Environmental Microorganisms
edited by
submission deadline 20 Aug 2026 | 2 articles | Viewed by 1592 | Submission Open
Keywords: environmental microbiology; metagenomics; microbial interactions; phage–host dynamics; horizontal gene transfer; biogeochemical cycles; antimicrobial resistance; single-cell methods; microbiome engineering; environmental biotechnology
(This special issue belongs to the Section Molecular Microbiology)
Recent Advances in Brain Tumor Research and Treatment submission deadline 20 Aug 2026 | 2 articles | Viewed by 1586 | Submission Open
Keywords: brain tumor; gliomas; brain metastases; translational research; molecular biology
(This special issue belongs to the Section Molecular Oncology)
Molecular Research in Protein–Ligand Interactions
edited by
submission deadline 20 Aug 2026 | 1 articles | Viewed by 1567 | Submission Open
Keywords: interaction; protein–ligand; computer simulation; docking; molecular simulation
(This special issue belongs to the Section Biochemistry)
Decoding the Microbial Influence on Host Gene Expression submission deadline 20 Aug 2026 | 1 articles | Viewed by 1557 | Submission Open
Keywords: microbiota; host; gene expression; in silico; bioinformatics; in vitro; in vivo
(This special issue belongs to the Section Molecular Microbiology)
AIEgens in Action: Design, Mechanisms, and Emerging Applications submission deadline 20 Aug 2026 | 1 articles | Viewed by 1542 | Submission Open
Keywords: fluorescence effects; photophysical properties of small molecules; ion detection; molecular spectroscopy; various nanoparticle-based additives; fluorescent and phosphorescent phenomena in solvents, amorphous states, and crystals; quantum-mechanical calculations for molecular systems and compositions (DFT, TD-DFT); molecular aggregation influencing fluorescence and phosphorescence properties of tested systems
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
State-of-the-Art Electrochemical Reaction Technologies submission deadline 20 Aug 2026 | 1 articles | Viewed by 1514 | Submission Open
Keywords: energy storage; electrochemical sensors; electrocatalysis; supercapacitors; molecular electrochemistry
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Recent Research on Natural Compounds in Cancer Treatment and Prevention submission deadline 20 Aug 2026 | 2 articles | Viewed by 1482 | Submission Open
Keywords: natural compounds; bioactive phytochemicals; anticancer therapy; chemoprevention
(This special issue belongs to the Section Molecular Oncology)
Molecular Advances in Heart Disease: Genomics and Bioinformatics of Heart Research—2nd Edition
edited by Justyna Fert-Bober
submission deadline 20 Aug 2026 | 1 articles | Viewed by 1459 | Submission Open
Keywords: heart disease; cardiovascular disease; coronary artery disease (CAD); heart attack; heart failure; arrhythmia (abnormal heart rhythms); valve disease; high blood pressure; congenital heart conditions; inherited heart conditions; fibrosis; pathobiology of fibrosis; aging; chronic inflammation; inflammatory and cardiovascular diseases; myocarditis; extracellular matrix biology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Dendritic Cell-Based Immunotherapy of Cancer
edited by Helena Haque Chowdhury and Matjaz Jeras
submission deadline 20 Aug 2026 | 1 articles | Viewed by 1452 | Submission Open
Keywords: DC-based immunotherapy of cancer; immunostimulatory dendritic cell (DC) generation; dosage and routes of DC administration; body distribution of DCs post-application; frequency and duration of DC applications; tumour immunosuppressive mechanisms’ modulation; combinatorial DC-based anticancer immunotherapy
(This special issue belongs to the Section Molecular Immunology)
New Optical, Electrical, and Thermal Materials: Recent Advances and Challenges
edited by Luyi Zou
submission deadline 20 Aug 2026 | 1 articles | Viewed by 1403 | Submission Open
Keywords: optical materials; electrical materials; thermal materials; molecular structure; molecular composition; structural performance
(This special issue belongs to the Section Materials Science)
The Role of Diet in Lipid and Lipoprotein Metabolism
edited by
submission deadline 20 Aug 2026 | 1 articles | Viewed by 1402 | Submission Open
Keywords: dyslipidemia; hypertension; diabetes; dementia
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Pregnancy-Related Complications: Molecular Pathogenesis and Therapeutic Strategies
edited by
submission deadline 20 Aug 2026 | 1 articles | Viewed by 1359 | Submission Open
Keywords: pregnancy-related complications; placental dysfunction; maternal-fetal communication; extracellular vesicles; translational research; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Protein-Targeted Therapeutics: Functional Modulation in Disease Pathways submission deadline 20 Aug 2026 | 1 articles | Viewed by 1294 | Submission Open
Keywords: protein-targeted therapeutics; proteins inhibitors; ligand binding; conformational changes
(This special issue belongs to the Section Biochemistry)
Early Diagnosis and Advanced Therapies of Genetic Disorders
edited by
submission deadline 20 Aug 2026 | 2 articles | Viewed by 1286 | Submission Open
Keywords: genetic disorders; rare diseases; disease diagnostics; therapeutic targets; gene variants
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Structure, Properties, and Applications of Carbon Materials submission deadline 20 Aug 2026 | 1 articles | Viewed by 1271 | Submission Open
Keywords: carbon-based structures; diamonds; carbon quantum dots; carbon composites; graphene; nanotubes
(This special issue belongs to the Section Materials Science)
Tumor Specific Immunotherapeutic Targets
edited by
submission deadline 20 Aug 2026 | 2 articles | Viewed by 1262 | Submission Open
Keywords: immunotherapy; immunotherapeutics; tumour-specific antigens; immunotherapeutic targets; multi-omics approaches
(This special issue belongs to the Section Molecular Immunology)
Systems Approaches to Diabetic Complications
edited by
submission deadline 20 Aug 2026 | 1 articles | Viewed by 1258 | Submission Open
Keywords: diabetes; diabetic complications; molecular mechanisms; precision medicine
(This special issue belongs to the Section Molecular Biology)
Chemical Tools for Microbial Functionalization: Bridging Organic Chemistry and Biotechnology
edited by Stefania Cicco and
submission deadline 20 Aug 2026 | Viewed by 1253 | Submission Open
Keywords: organometallic biochemistry; green chemistry; bioorthogonal; living polymers; living functionalization; hybrid materials
(This special issue belongs to the Section Molecular Microbiology)
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