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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Biosynthesis, Regulation and Applications of Plant Secondary Metabolites

edited by Quanliang Xie

submission deadline 30 Sep 2026 | Viewed by 181 | Submission Open

Keywords: plant physiology; plant stress tolerance; biotic/abiotic stresses; secondary metabolites; multi-omics integration; functional genes; plant hormones; plant molecular biology; plant resistant mechanism

(This special issue belongs to the Section Molecular Plant Sciences)

Microbial Biopolymers: Molecular Insights and Functional Innovations

edited by

Tsolanku Sidney Maliehe

and

Ofentse Jacob Pooe

submission deadline 30 Sep 2026 | Viewed by 177 | Submission Open

Keywords: microbial biopolymers; functional biomaterials; biosynthesis; optimisation; multi-omics; synthetic biology; characterisation; medical and environmental application; metabolic pathway engineering; machine learning-assisted optimisation

(This special issue belongs to the Section Molecular Microbiology)

Adsorption Materials Design and Mechanism of Molecular Interface Interaction

edited by

Jun Wang

submission deadline 30 Sep 2026 | Viewed by 174 | Submission Open

Keywords: adsorption; adsorption materials; adsorption behavior; adsorption mechanism; interface interaction

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Engineering for Advanced Energy Materials and Catalytic Systems

edited by

Ye Yuan

submission deadline 30 Sep 2026 | Viewed by 173 | Submission Open

Keywords: molecular engineering; energy materials; catalytic systems; batteries; supercapacitors; energy conversion; self-assembled monolayers; CO2 utilization

(This special issue belongs to the Section Materials Science)

Cellular and Molecular Mechanisms in Autoimmune Diseases

edited by

Luis M. Amezcua-Guerra

submission deadline 30 Sep 2026 | Viewed by 167 | Submission Open

Keywords: autoimmune disease; immunological tolerance; T-cell/B-cell dysregulation; innate immunity; cytokine signaling; autoantibody

(This special issue belongs to the Section Molecular Immunology)

Physical Activity and Nutraceuticals as Synergistic Mechanisms for Healthy Aging

edited by

Chiara Porro

submission deadline 30 Sep 2026 | Viewed by 160 | Submission Open

Keywords: healthy aging; nutraceuticals; cellular senescence; mitochondrial function; oxidative stress; redox balance; autophagy; homeostasis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Pathology Techniques to Define Target Safety Risks for Novel Therapeutic Modalities

edited by Rebecca Kohnken

submission deadline 30 Sep 2026 | Viewed by 159 | Submission Open

Keywords: molecular pathology; immunohistochemistry; multiplexing; immunofluorescence; high-content imaging; confocal; biologics; therapeutics; target expression; drug safety

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pancreatic Neuroendocrine Tumors: Current Evidence and Future Horizons

edited by Roberto Cammarata

submission deadline 30 Sep 2026 | Viewed by 138 | Submission Open

Keywords: pancreatic neuroendocrine tumors; surgical oncology; PRRT; somatostatin analogues; liver metastases; molecular targeted therapy; biomarkers; WHO grading; functional tumors; minimally invasive surgery

(This special issue belongs to the Section Molecular Oncology)

Molecular Design of Electrospun Fibers with Natural Bioactives for Biomedical Application

edited by

Fatma Nur Parın

submission deadline 30 Sep 2026 | Viewed by 135 | Submission Open

Keywords: electrospun fibers; molecular design; natural bioactives; core-shell nanofibers; functional biomaterials; controlled drug release; wound healing; tissue scaffolds; stimuli-responsive systems; antimicrobial polymers

(This special issue belongs to the Section Materials Science)

Molecular Mechanisms and Therapy of Heart Failure

edited by

Ruth Magaye

submission deadline 10 Oct 2026 | 2 articles | Viewed by 1243 | Submission Open

Keywords: heart failure; organ-cross talk; metabolic derangements; molecular mechansims; sex differences

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Study on Biofunctional Properties of Plant Bioactives

edited by

Isidora Milosavljevic

and

Jovana N. Novakovic

submission deadline 10 Oct 2026 | 1 articles | Viewed by 1097 | Submission Open

Keywords: plant bioactives; bioactive compounds; phytochemicals; molecular mechanisms; oxidative stress; anti-inflammatory activity; therapeutic potential; structure–activity relationship; cell culture models; animal models

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Sustainable Bioactives from Plants: From Molecular Function to Fermentation

edited by Zofia Nizioł–Łukaszewska and

Martyna Zagórska-Dziok

submission deadline 10 Oct 2026 | 2 articles | Viewed by 940 | Submission Open

Keywords: agro-industrial by-products; plant-based waste materials; microbial fermentation; biotransformation; molecular characterization; phytochemical profiling; anti-aging activity; dermatological applications

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Multi-Omics Insights into Cardiovascular and Cerebrovascular Diseases

edited by Alicia Aliena-Valero and María Castelló-Ruiz

submission deadline 10 Oct 2026 | Viewed by 252 | Submission Open

Keywords: multi-omics integration; atherosclerosis; stroke; cerebral small vessel disease (cSVD); heart failure; coronary artery disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nucleic Acid Therapeutics: From Molecular Mechanisms to Delivery, Manufacturing, and Clinical Translation

edited by

Zongjie Wang

and

Jie Wang

submission deadline 15 Oct 2026 | Viewed by 179 | Submission Open

Keywords: nucleic acid delivery; nanoparticle delivery systems; intracellular trafficking; endosomal escape; cellular metabolism; immunogenicity; process development

(This special issue belongs to the Section Molecular Pharmacology)

RNA Modification Databases and Bioinformatic Tools for Epitranscriptome Research

edited by

Bowen Song

and Yue Wang

submission deadline 17 Oct 2026 | Viewed by 230 | Submission Open

Keywords: epitranscriptomics; RNA modification; bioinformatics; computational tools; biological databases; machine learning; high-throughput sequencing; direct RNA sequencing; multi-omics integration; post-transcriptional regulation

(This special issue belongs to the Section Molecular Informatics)

Advancements in Hematology: Molecular Biology and Targeted Therapies

edited by Fabio Stagno and

Stefania Stella

submission deadline 20 Oct 2026 | 7 articles | Viewed by 21769 | Submission Open

Keywords: hematological disorders; leukemia; lymphoma; anemia; blood malignancies; targeted therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Therapies and Strategies in the Treatment of Neurodegenerative Diseases

edited by

Polina Petkova-Kirova

submission deadline 20 Oct 2026 | 7 articles | Viewed by 20928 | Submission Open

Keywords: neurodegenerative diseases; Alzheimer’s disease; Parkinson’s disease; Huntington’s disease; aging; memory; dementia; motor dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Precision Medicine: Unraveling Novel Mechanisms and Delivery Strategies in Complex Diseases

edited by

Nuno Vale

submission deadline 20 Oct 2026 | 6 articles | Viewed by 18765 | Submission Open

Keywords: molecular precision therapeutics; disease biomarkers; novel therapeutic molecules; drug delivery strategies; personalized medicine; bioinformatics; nanotechnology; synthetic biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mitochondria: Central Players in Cancer

edited by

Annamaria Piscazzi

and

Domenica Mangieri

submission deadline 20 Oct 2026 | 4 articles | Viewed by 15978 | Submission Open

Keywords: mitochondria; cancer; tumorigenesis; oxidative phosphorylation; glycolysis; Warburg effect; reactive oxygen species (ROS); apoptosis; mitochondrial dysfunction; metabolic reprogram-ming; cancer therapy

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Therapies for Melanoma

edited by Anna Piotrowska

submission deadline 20 Oct 2026 | 4 articles | Viewed by 14520 | Submission Open

Keywords: melanoma; targeted therapy; BRAF/MEK inhibitors; immunotherapy; anti-PD-1 and anti-CTLA-4 immunotherapy; melanoma microenvironment; cancer-associated fibroblasts (CAFs)/melanoma-associated fibroblasts (MAFs); MAPK (mitogen-activated protein kinase) signaling pathway

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Bioactive Compounds in Human Health

edited by

Dorota Gumul

submission deadline 20 Oct 2026 | 8 articles | Viewed by 12308 | Submission Open

Keywords: bioactive compounds; antioxidants; food by-products; functional foods; innovative food technologies; molecular food science

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Cutaneous Biology, Molecular Dermatology and Dermatopathology, 2nd Edition

edited by

Bijan Safai

submission deadline 20 Oct 2026 | 4 articles | Viewed by 12243 | Submission Open

Keywords: molecular dermatology; targeted therapy; cutaneous oncology; immunodermatology; cutaneous biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights and Treatments for Gynecological Cancers

edited by

Nicoletta D'Alessandris

submission deadline 20 Oct 2026 | 2 articles | Viewed by 11748 | Submission Open

Keywords: gynecological cancers; cancers; endometrial cancers; cervical cancer; tumor microenvironment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Macro- and Micronutrients in Health and Diseases

edited by

Karolina Orywal

and Mariusz Gryko

submission deadline 20 Oct 2026 | 4 articles | Viewed by 11697 | Submission Open

Keywords: macronutrients; micronutrients; vitamins; macrominerals; trace elements; cancer; obesity; cardiovascular diseases; diabetes; osteoporosis; immune disorders; neurodegenerative diseases

(This special issue belongs to the Section Molecular Biology)

Bioactive Compounds of Natural Origin: 2nd Edition

edited by

Katarzyna Pacyga

submission deadline 20 Oct 2026 | 6 articles | Viewed by 10840 | Submission Open

Keywords: plants; extraction methods; bioactive compounds; natural products; application

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Sperm Oxidative Stress and Male Infertility

edited by

Kamil Gill

submission deadline 20 Oct 2026 | 5 articles | Viewed by 10369 | Submission Open

Keywords: oxidative stress; antioxidant system; free radical scavengers; sperm DNA oxidation; sperm DNA fragmentatio; antioxidant therapy; male infertility; male oxidative stress infertility

(This special issue belongs to the Section Molecular Biology)

Molecular Pathologies and Treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome—2nd Edition

edited by

Elisa Oltra

submission deadline 20 Oct 2026 | 3 articles | Viewed by 10296 | Submission Open

Keywords: myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); diagnosis; post-exertional malaise (PEM); comorbidity; biomarker; therapy; immunity; microbiome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Oxidative Stress Responses in Cardiovascular Diseases

edited by Vladimir Jakovljevic

submission deadline 20 Oct 2026 | 2 articles | Viewed by 10261 | Submission Open

Keywords: antioxidant capacity; cardiovascular disease; cell death; endothelial dysfunction; ischemia/reperfusion injury; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antimicrobial Agents: Natural Products or Synthetic Compounds 2nd Edition

edited by

Anna Duda-Madej

submission deadline 20 Oct 2026 | 2 articles | Viewed by 9370 | Submission Open

Keywords: multidrug resistance; natural antimicrobial agents; synthetic antimicrobial compounds; combination therapy; severe infectious diseases

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research on Micropollutants in Various Enviroments

edited by

Anna Lenart-Boroń

submission deadline 20 Oct 2026 | 4 articles | Viewed by 8629 | Submission Open

Keywords: airborne microorganisms; antibiotics; antibiotic resistance; circular economy of water; environmental bacteria and fungi; wastewater treatment; waterborne microorganisms; water quality

(This special issue belongs to the Section Molecular Toxicology)

Recent Advances in Osteoarthritis Pathways and Biomarker Research

edited by

Előd Ernő Nagy

submission deadline 20 Oct 2026 | 6 articles | Viewed by 8622 | Submission Open

Keywords: osteoarthritis; low-grade inflammation; cartilage chondrocyte; synovial membrane; synovial fluid; subchondral bone; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Plant–Microbe Interaction

edited by

Raja Ben-Laouane

and

Mohamed Ait-El-Mokhtar

submission deadline 20 Oct 2026 | 6 articles | Viewed by 7969 | Submission Open

Keywords: biomarkers; molecular biotechnology; cell signalling; microbiota signaling; genetic editing of microbes; plant-microbe stress response; plant-microbe stress mitigation; plant-microbe underlying mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Pathogenesis and Therapeutic Innovations in Oral Diseases

edited by Tatsuji Nishihara

submission deadline 20 Oct 2026 | 4 articles | Viewed by 7804 | Submission Open

Keywords: molecular-based analysis; diagnosis of oral disease; oral disease treatment; regeneration therapy; drug therapy; periodontitis; implantitis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Adsorbing Materials

edited by Mounia Achak

submission deadline 20 Oct 2026 | 4 articles | Viewed by 7645 | Submission Open

Keywords: adsorption process; adsorbing materials; bio-based adsorbents; regeneration and reusability; pollutant removal; wastewater treatment; industrial and environmental applications

(This special issue belongs to the Section Materials Science)

Molecular Research in Animal Nutrition

edited by Jie Fu

submission deadline 20 Oct 2026 | 7 articles | Viewed by 7456 | Submission Open

Keywords: animal nutrition; animal immunity; epigenetics; m6A methylation; gut microbiota; host–microbiome interaction; metabolic reprogramming

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights into the Role of Exercise in Disease and Health, 2nd Edition

edited by

Brisamar Estébanez

, María José Cuevas-González and Chun-Jung Huang

submission deadline 20 Oct 2026 | 4 articles | Viewed by 7398 | Submission Open

Keywords: physical activity; molecular mechanisms; disease prevention; metabolic health; cardiovascular diseases; neurodegenerative diseases; sarcopenia; immune function; healthy aging; epigenetics

(This special issue belongs to the Section Molecular Biology)

Functional Genomics of Insects: Unraveling Genetic Mechanisms and Applications

edited by

Bin Li

submission deadline 20 Oct 2026 | 5 articles | Viewed by 7147 | Submission Open

Keywords: genomics; comparative genomics; gene regulation networks; developmental biology; metamorphosis; vector biology; insecticide resistance mechanisms; insect–plant interactions; environmental adaptation

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Research on Parasitic Infection

edited by Marcin Wiśniewski and

Piotr Bąska

submission deadline 20 Oct 2026 | 6 articles | Viewed by 6793 | Submission Open

Keywords: parasitic infections; host–parasite interactions; parasite genomics; drug-resistance mechanisms; transcriptomics; proteomics; diagnostic tools; immune evasion; therapeutic strategies

(This special issue belongs to the Section Molecular Microbiology)

HIV Expression in Diverse Cell Types: Mechanisms, Regulation, and Pathogenesis

edited by

Rosemary Kiernan

submission deadline 20 Oct 2026 | 6 articles | Viewed by 6487 | Submission Open

Keywords: hiv transcription; latency; reactivation; host transcription factors; chromatin modifications; viral-host protein interactions

(This special issue belongs to the Section Molecular Immunology)

Fundamental and Translational Insights into Colorectal Cancer

edited by Giuseppe Broggi

submission deadline 20 Oct 2026 | 3 articles | Viewed by 6409 | Submission Open

Keywords: colorectal cancer (CRC); molecular pathways; translational research; immune checkpoint inhibitors; drug resistance

(This special issue belongs to the Section Molecular Oncology)

RNA in Human Diseases: Challenges and Opportunities: 2nd Edition

edited by

Nicoletta Potenza

submission deadline 20 Oct 2026 | 7 articles | Viewed by 6369 | Submission Open

Keywords: microRNA; piRNA; lncRNA; circRNA; RNA therapeutics; ceRNET; RNA disease; RNA processing; RNA modification

(This special issue belongs to the Section Molecular Biology)

Forest Tree Genetics, Breeding and Environmental Adaption

edited by

Jingli Yang

and

Huiyu Li

submission deadline 20 Oct 2026 | 2 articles | Viewed by 6196 | Submission Open

Keywords: forest trees; genetic breeding; biotic stress; abiotic stress; tree physiology; gene regulation; genetic engineering

(This special issue belongs to the Section Molecular Plant Sciences)

Zebrafish Model for Neurological Research

edited by

Mattia Toni

submission deadline 20 Oct 2026 | 3 articles | Viewed by 6028 | Submission Open

Keywords: zebrafish ; Danio rerio ; brain ; nervous system

(This special issue belongs to the Section Molecular Neurobiology)

Metabolic Regulators of Bone Health

edited by

Akkouch Adil

submission deadline 20 Oct 2026 | 3 articles | Viewed by 5626 | Submission Open

Keywords: bone; osteoporosis; diabetes; obesity; glucose; insulin; lipids; estrogen; microRNA; osteoblasts

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Environment, Human Stress, and Gut Microbiome: A Triad in Disease Development

edited by

Natalia Kurhaluk

and Halina Tkaczenko

submission deadline 20 Oct 2026 | 2 articles | Viewed by 5589 | Submission Open

Keywords: gut microbiome stress interactions; environmental microbiome disease linkages; stress-driven microbiome dysbiosis; microbiome environment disease pathways; human microbiome stress responses; environmental stress disease mechanisms; gut microbiome oxidative stress interactions; environmental oxidative stress impacts; stress-driven microbiome oxidative imbalance; oxidative stress microbiome diseases; human oxidative stress pathways; oxidative stress disease mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Transforming in Cancer Therapy: Advances in Immunotherapy and Tyrosine Kinase Inhibitors

edited by

Walid Shalata

submission deadline 20 Oct 2026 | 2 articles | Viewed by 5579 | Submission Open

Keywords: tyrosine kinase inhibitors; immunotherapy; monoclonal antibodies; CAR-T cells

(This special issue belongs to the Section Molecular Oncology)

P53 and Tumours: Strategies to Overcome Chemoresistance in a p53-Dependent Way

edited by

Mariano Francesco Caratozzolo

submission deadline 20 Oct 2026 | 1 articles | Viewed by 5211 | Submission Open

Keywords: P53; chemoresistant tumours; drug design; regulatory RNAs; drugs targeting; NGS; transcriptional regulation; molecular networks

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Drugs Targeting Cancer Signaling Pathways: Dissecting Mechanisms to Unlock New Therapeutic Targets

edited by Souleymane Abdoul-Azize

submission deadline 20 Oct 2026 | 3 articles | Viewed by 5202 | Submission Open

Keywords: small-molecule drugs; signal transduction; therapeutic targets; therapeutic resistance; oncogenic signaling; novel biomarkers; cancer therapy; cancer signaling pathways; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Molecular Research in Orofacial Pain and Headache

edited by

Adriana Elena Bulboaca

submission deadline 20 Oct 2026 | 4 articles | Viewed by 5179 | Submission Open

Keywords: neuropathic pain; trigeminal neuralgia; temporomandibular joint disorders; headache; migraine; neuroplasticity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Lipopolysaccharide in the Health and Disease

edited by

Gen-Ichiro Soma

and Hiroyuki Inagawa

submission deadline 20 Oct 2026 | 1 articles | Viewed by 4496 | Submission Open

Keywords: usefulness of LPS; oral and/or dermal administration of LPS; lifestyle disease; cognitive dysfunction; allergy; autoimmune disorder; wound healing; cancer

(This special issue belongs to the Section Biochemistry)

Displaying special issue 651-700 on page 14 of 62.

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