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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Interactions Between Microbes and Hosts: Physiology, Pathology and Treatment—Second Edition
edited by
submission deadline 30 Jun 2026 | Viewed by 4 | Submission Open
Keywords: microbial infection; microbes– host interaction; virulence factors; molecular and cell biology; antimicrobial therapy; antibiotics; antimicrobial peptides; resistance mechanisms
(This special issue belongs to the Section Molecular Microbiology)
Advances in Research on Cotton Breeding and Genetics
edited by
submission deadline 30 Jun 2026 | Viewed by 4 | Submission Open
Keywords: cotton genomics; molecular breeding; gene regulation; abiotic stress tolerance; fiber quality improvement; disease resistance; genetic engineering; marker-assisted selection; transcriptomics; genome editing
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Molecular Research in Animal Reproduction
edited by
submission deadline 30 Jun 2026 | Viewed by 4 | Submission Open
Keywords: animal reproduction; molecular regulation; spermatogenesis; embryonic development; epigenetics; reproductive hormones; oogenesis; environmental factors
(This special issue belongs to the Section Molecular Biology)
Exosomes and Extracellular Vesicles in Health and Diseases: 4th Edition submission deadline 30 Jun 2026 | Viewed by 3 | Submission Open
Keywords: exosome; extracellular vesicles; network signals; biomarkers; pathological conditions
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Alcohol Metabolism: Molecular, Physiological, and Behavioral Consequences from Basic Research to Translational Applications
edited by Analia G. Karadayian
submission deadline 30 Jun 2026 | Viewed by 3 | Submission Open
Keywords: alcohol metabolism; acetaldehyde; mitochondrial dysfunction; oxidative stress; behavioral outcomes; animal models; translational research
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Microfluidic-Assisted Synthesis of Nanomaterials: Precise Control of Size, Surface Chemistry and Molecular Interactions
edited by Adelina-Gabriela Niculescu and
submission deadline 30 Jun 2026 | Viewed by 2 | Submission Open
Keywords: microfluidics; nanomaterials; nanocomposites; microreactors; controlled synthesis; surface chemistry; molecular interactions; flow simulation; physicochemical characterization; advanced applications
(This special issue belongs to the Section Molecular Nanoscience)
KCTD Proteins in Cellular Processes Regulation: Advances and Challenges
edited by
submission deadline 30 Jun 2026 | Viewed by 2 | Submission Open
Keywords: KCTD proteins; cancer biology; cell signaling pathway; ubiquitination; genetic disorder; protein–protein interaction; developmental biology; protein stability; gene expression; new therapeutic target
(This special issue belongs to the Section Molecular Biology)
Phenolic Compounds as Adjunct Therapy in Cardiometabolic Disorders submission deadline 30 Jun 2026 | Viewed by 1 | Submission Open
Keywords: phenolic compounds; cardiovascular diseases; metabolism; diabetes; obesity; hypertension; mitochondria; oxidative stress; gut microbiota; inflammation
(This special issue belongs to the Section Bioactives and Nutraceuticals)
New Perspectives and Challenges in the Mechanisms, Diagnosis and Management of Skin Diseases
edited by , Daniela Kovacs and
submission deadline 30 Jun 2026 | Viewed by 1 | Submission Open
Keywords: skin diseases; precision medicine; molecular pathogenesis; regenerative medicine; lipidomics; targeted biologics; inflammatory skin diseases; skin cancers; skin aging; gut– skin axis; skin regeneration
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research on Inflammasome Signaling
edited by
submission deadline 30 Jun 2026 | Submission Open
Keywords: PANoptosis; NLRP6; NLRP12; CARD8; non-immune cells; viral proteins; gasdermin family; inflammasome-independent signaling; inflammaging; MxA inflammasome
(This special issue belongs to the Section Biochemistry)
Molecular Mechanisms of Adipose Tissue Dysfunction
edited by
submission deadline 30 Jun 2026 | Submission Open
Keywords: adipose tissue dysfunction; adipogenesis; immunometabolism and adipokines; mitochondrial dysfunction; extracellular vesicles; fibrosis and ECM remodeling; lipid metabolism; browning and beigeing; metabolic biomarkers and therapeutic targets; adipose-derived stem cells
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Plant Molecular Ecology and Genomic Perspectives
edited by
submission deadline 1 Jul 2026 | Viewed by 269 | Submission Open
Keywords: genome assembly and annotaion; genomic structure and function of plants; plant molecular ecology; genome prediction and GWAS; gene-editing technologies; transcriptomics and metabolomics; nuclear and organelle genomics
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Physiopathological Role of Hypoxia submission deadline 10 Jul 2026 | Viewed by 61 | Submission Open
Keywords: hypoxia; cell metabolism; inflammation; tumor microenvironment; cancer progression; EMT; chronic inflammation; obesity; inflammatory microenvironment; storage disorders
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Breast Cancer: From Molecular Mechanism to Therapeutic Strategy
edited by
submission deadline 10 Jul 2026 | Viewed by 52 | Submission Open
Keywords: breast cancer; molecular mechanisms; therapeutic strategies; tumor microenvironment; precision oncology
(This special issue belongs to the Section Molecular Oncology)
Molecular Structure and Characterization of Optical Materials
edited by
submission deadline 10 Jul 2026 | Viewed by 39 | Submission Open
Keywords: luminescence; structure modification; spectroscopy; measurement techniques; Kerr effect; Faraday effects; doping; molecular structure
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Molecular Mechanism of Circadian Rhythm
edited by Rosângela Vieira de Andrade
submission deadline 20 Jul 2026 | 3 articles | Viewed by 29501 | Submission Open
Keywords: circadian cycle; exercise; aging; clock genes; health
(This special issue belongs to the Section Molecular Biology)
High-Density Lipoproteins in Health and Disease
edited by
submission deadline 20 Jul 2026 | 7 articles | Viewed by 25291 | Submission Open
Keywords: omics; protein; lipid; cardiovascular; neurodegenerative disease; inflammation; preclinical studies; therapy
(This special issue belongs to the Section Molecular Biology)
Interplay Between the Human Microbiome and Diseases submission deadline 20 Jul 2026 | 9 articles | Viewed by 17596 | Submission Open
Keywords: microbiome; metagenome; gastrointestinal tract; skin; seminal fluid; lung; saliva; oral mucosa; conjunctiva; dysbiosis; fecal microbiota transplantation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Research for Legume Genomics, Genetics, and Breeding, 2nd Edition
edited by
submission deadline 20 Jul 2026 | 5 articles | Viewed by 11031 | Submission Open
Keywords: legumes; genomics; plant breeding; seed composition; gene function; biotic and abiotic stress; legume pathogen resistance/mechanisms
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Progression of Genome-Related Diseases: 2nd Edition
edited by
submission deadline 20 Jul 2026 | 3 articles | Viewed by 10100 | Submission Open
Keywords: next-generation sequencing; genetic diseases; multifactorial diseases; diagnostic tolls; human health
(This special issue belongs to the Section Molecular Genetics and Genomics)
Nanoparticles in Molecular Pharmaceutics
edited by
submission deadline 20 Jul 2026 | 5 articles | Viewed by 8622 | Submission Open
Keywords: nanoparticles; molecular pharmaceutics; drug delivery; nanomedicine; nanoformulation
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Insights into Bioactive Compounds from Agro-Industrial Waste Biomass submission deadline 20 Jul 2026 | 3 articles | Viewed by 8175 | Submission Open
Keywords: by-product; biocompound; bioactivity; component analysis; in vitro/in vivo experiments; circular economy; sustainability; biomass residues valorization
(This special issue belongs to the Section Biochemistry)
Hypoxia: Molecular Mechanism and Health Effects submission deadline 20 Jul 2026 | 4 articles | Viewed by 5960 | Submission Open
Keywords: hypoxia; inflammation; oxidative stress; metabolic conditions; hypoxia-inducible factors (HIFs); oxidative stress; mitochondrial dysfunction; angiogenesis; metabolic reprogramming; apoptosis
(This special issue belongs to the Section Molecular Biology)
Molecular Insights into Glioblastoma Pathogenesis and Therapeutics submission deadline 20 Jul 2026 | 3 articles | Viewed by 5851 | Submission Open
Keywords: glioblastoma; proteomics; immunopeptidomics; genomics; extracellular vesicles; biomarkers; molecular mechanisms; i-knife mass spectrometry; intra-operative imaging; cancer stem cells; cancer progression; neurosurgery; radiomics; personalized medicine
(This special issue belongs to the Section Molecular Oncology)
Bone Metabolism and Bone Diseases
edited by
submission deadline 20 Jul 2026 | 5 articles | Viewed by 5283 | Submission Open
Keywords: bone metabolism; bone diseases; osteoclast; osteoblasts and osteocytes; bone remodelling
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Placental Pathology
edited by and Ana Correia-Branco
submission deadline 20 Jul 2026 | 3 articles | Viewed by 4993 | Submission Open
Keywords: placenta; trophoblast; implantation; obstetrics; pre-eclampsia; placentation; maternal– fetal interface; pregnancy health; placenta diagnostics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Power Up Plant Genetic Research with Genomic Data: 3rd Edition submission deadline 20 Jul 2026 | 2 articles | Viewed by 4319 | Submission Open
Keywords: genome sequencing; optical mapping; genome editing; population genomics; genome-wide; association mapping; functional genomics; epigenomics; genetic interaction; chromatin; biodiversity
(This special issue belongs to the Section Molecular Genetics and Genomics)
Innovative Strategies in Cancer Therapy submission deadline 20 Jul 2026 | 1 articles | Viewed by 3169 | Submission Open
Keywords: tumor microenvironment; small molecules; IDO1 inhibition; checkpoint inhibitor therapy; adoptive T cell therapy; metabolic reprogram; resistance mechanisms; immune modulation; immune reconstitution; combination therapy; immunosuppression
(This special issue belongs to the Section Molecular Oncology)
Molecular Insights into Addiction submission deadline 20 Jul 2026 | 2 articles | Viewed by 2870 | Submission Open
Keywords: addiction; dependence; neurobiology; reward; neuroplasticity; biostatistics
(This special issue belongs to the Section Molecular Neurobiology)
Research Progress in Cellular Senescence in Health and Disease
edited by and Mirella Falconi
submission deadline 20 Jul 2026 | 2 articles | Viewed by 2641 | Submission Open
Keywords: senotherapy; cellular senescence; physiological relations; pathological relations; cell biology in aging; age-related diseases; senescence in mesenchymal stroma cells
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Molecular Biology on Mycobacteria: 2nd Edition
edited by
submission deadline 20 Jul 2026 | 2 articles | Viewed by 2561 | Submission Open
Keywords: genus Mycobacterium; non-tuberculous mycobacteria; Mycobacterium tuberculosis; Mycobacterium leprae; molecular diagnosis; molecular surveillance methodologies; molecular resistance prediction
(This special issue belongs to the Section Molecular Microbiology)
Biomolecular Structure, Function and Interactions: 2nd Edition
edited by
submission deadline 20 Jul 2026 | 3 articles | Viewed by 2361 | Submission Open
Keywords: biophysical chemistry; protein– protein interactions; protein– DNA interactions; protein– ligand interactions; receptor– ligand interactions; biomolecular structure and function; protein folding and stability
(This special issue belongs to the Section Biochemistry)
Recent Advances in Gastrointestinal Cancer, 3rd Edition
edited by
submission deadline 20 Jul 2026 | 1 articles | Viewed by 2242 | Submission Open
Keywords: gastrointestinal cancer; chemotherapeutic agents; innovative therapies; human nutrition; nutrigenomics; nutrition and immunity epigenetics; cytotoxicity; apoptosis
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms of Sjögren's Syndrome, 4th Edition submission deadline 20 Jul 2026 | 2 articles | Viewed by 2104 | Submission Open
Keywords: autoimmunity; sjö gren’ s syndrome; autoantibodies; salivary gland; lacrimal gland; dry eyes/mouth
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bioactive Compounds in Neurodegenerative Diseases
edited by
submission deadline 20 Jul 2026 | 2 articles | Viewed by 1935 | Submission Open
Keywords: bioactive compounds; neurodegenerative diseases; neuroinflammation; oxidative stress
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Supplements and Drug-Based Strategies in Neonatal and Paediatric Health submission deadline 20 Jul 2026 | 1 articles | Viewed by 1620 | Submission Open
Keywords: neonatal pharmacology; paediatric supplements; nutraceuticals in early life; microbiota– host interactions; infectious diseases in children; neurodevelopmental disorders; drug– nutrient interactions; dosing and delivery routes; molecular paediatrics; critical analysis of paediatric interventions
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Insights into the Pathogenesis, Molecular Landscape and Therapeutics of Triple-Negative Breast Cancer
edited by Rebecca Chin
submission deadline 20 Jul 2026 | 2 articles | Viewed by 1450 | Submission Open
Keywords: breast cancer; cancer stemness; therapeutic resistance; brain metastasis; epigenetic mechanisms; chromatin remodeling; multi-omics approaches; high-throughput screening; patient-derived organoids
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms Governing Lipid Metabolism in Health and Disease submission deadline 20 Jul 2026 | 1 articles | Viewed by 1332 | Submission Open
Keywords: lipidomics; lipid biomarkers; lipid metabolism; cardiovascular disease; cardiometabolic diseases; non-alcoholic fatty liver disease; diabetes; lipoproteins; NMR spectroscopy; mass spectrometry
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
In Silico Approaches to Unravelling Toxicity Mechanisms in Molecular Drugs
edited by
submission deadline 20 Jul 2026 | 1 articles | Viewed by 1319 | Submission Open
Keywords: cheminformatics; in silico analysis; QSAR; toxicity prediction; machine learning; toxicity mechanisms; omics data integration; toxicity biomarkers; artificial intelligence; adverse event database
(This special issue belongs to the Section Molecular Pharmacology)
Recent Nanotechnology in Drug Delivery
edited by
submission deadline 20 Jul 2026 | 1 articles | Viewed by 1274 | Submission Open
Keywords: smart nanoparticles; hybrid nanomaterial; functionalization; drug targeting; liposome; cubosome; polypeptide; polymers; biomolecules; cancer; vaccine; antimicrobial; antiparasite; antioxidant; immunomodulatory; genetic therapy; nanomedicine
(This special issue belongs to the Section Molecular Nanoscience)
Pathogenesis and Treatments of Head and Neck Cancer: 2nd Edition
edited by
submission deadline 20 Jul 2026 | 1 articles | Viewed by 1217 | Submission Open
Keywords: HNSCC; premalignant changes; tumor microenvironment; molecular biomarkers; targeted therapy; oral tumorigenesis; molecular pathogenesis; tumor biology; tumor immunology
(This special issue belongs to the Section Molecular Oncology)
Nanoparticle-Based Biosensors and Their Applications
edited by
submission deadline 20 Jul 2026 | 1 articles | Viewed by 1158 | Submission Open
Keywords: biosensors; metal nanoparticles (MNPs); synthesis methods; molecular spectroscopy characteristics; molecular medicine; molecular biology
(This special issue belongs to the Section Molecular Nanoscience)
Circulating Tumor Cells in Oncology: From Liquid Biopsy to Clinical Decision-Making submission deadline 20 Jul 2026 | 1 articles | Viewed by 1145 | Submission Open
Keywords: circulating tumor cells (CTCs); liquid biopsy; cancer biomarkers; precision oncology; metastasis; cancer diagnostics; cancer prognosis; CTC enrichment; CTC isolation techniques; single-cell analysis; tumor microenvironment; CTC culture; immune surveillance; blood-based biomarkers; molecular profiling; CTC-derived cell lines; treatment resistance; personalized cancer therapy; cell reprogramming; anti-tumor immunity
(This special issue belongs to the Section Molecular Oncology)
25th Anniversary of IJMS: Updates and Advances in Molecular Biophysics submission deadline 20 Jul 2026 | 1 articles | Viewed by 1025 | Submission Open
Keywords: biomolecular interactions; biomolecular NMR; biophysics; chaperones; computational modeling; computer simulations; crystal thermodynamics; DNA structure and dynamics; drug– receptor interactions; enzymology; fluorescence imaging; genome structure; inter-molecular interactions; intrinsically disordered proteins; ion channels; macromolecular crystallography; macromolecular structure and dynamics; membrane dynamics; microcalorimetry; molecular dynamics; molecular imprinting; molecular mechanics; molecular modeling; molecular simulations; molecular modeling; molecular structure; molecular recognition; nucleic acid– protein interactions; post-translational modifications; protein design; protein– DNA interactions; protein engineering; protein– ligand binding; protein– membrane interactions; protein structure and folding; RNA structure; single-molecule techniques; spectroscopic techniques; statistical mechanics; structure– function relationships; structure prediction; thermodynamics; transient kinetic techniques; transmembrane proteins; x-ray crystallography
(This special issue belongs to the Section Molecular Biophysics)
G Protein-Coupled Receptors: Signaling, Regulation and Therapeutic Opportunities, 2nd Edition
edited by
submission deadline 20 Jul 2026 | 1 articles | Viewed by 593 | Submission Open
Keywords: GPCR; cell signaling; small-molecule drugs; biased signaling; endosomal signaling; post-translational modification; GPCR internalization; phosphorylation barcode
(This special issue belongs to the Section Molecular Pharmacology)
Biological Pathways and Nutraceutical Compounds in Genetic Disease Treatment
edited by
submission deadline 20 Jul 2026 | Viewed by 523 | Submission Open
Keywords: micronutrients; supplements; functional foods; inherited disease; microbiome; RNA expression; protein expression; signaling pathways; DNA methylation; animal models; cell lines; clinical trials
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Pathophysiology of Chronic Lung Diseases: Mechanisms and Therapeutics
edited by Gary C. Mouradian
submission deadline 20 Jul 2026 | 1 articles | Viewed by 483 | Submission Open
Keywords: chronic lung disease; vagal sensory neurons; inflammation; airway remodeling; molecular mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Nucleic Acid Aptamers in Molecular Medicine
edited by
submission deadline 20 Jul 2026 | Viewed by 412 | Submission Open
Keywords: aptamers; SELEX; targeted therapy; drug delivery; diagnosis; biomarker discovery
(This special issue belongs to the Section Molecular Biology)
Neuronal Differentiation: From Pathology to Therapeutic Strategies
edited by
submission deadline 20 Jul 2026 | Viewed by 363 | Submission Open
Keywords: neuronal differentiation; molecular mechanisms of neurodifferentiation; neurodegenerative diseases; ischemic stroke; spinal cord and brain injury; neural tissue recovery; regeneration therapy; stem cells
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Insights in Medical Microbiology and Infectious Diseases: The Role of Artificial Intelligence and Machine Learning
edited by
submission deadline 20 Jul 2026 | Viewed by 213 | Submission Open
Keywords: molecular diagnostics; pathogen genomics; antimicrobial resistance; host– pathogen interaction; infectious diseases surveillance; artificial intelligence; machine learning
(This special issue belongs to the Section Molecular Informatics)
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