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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Molecular Biomarkers in Cancer and Metabolic Diseases

edited by

José Antonio Morales-González

and

Angel Morales-González

submission deadline 28 Feb 2026 | 1 articles | Viewed by 675 | Submission Open

Keywords: biomarkers; cancer; metabolic disease; diagnosis; prognosis; treatment

(This special issue belongs to the Section Molecular Biology)

Marine Natural Products as a Source of Therapeutics—Recent Trends

edited by

Komal Anjum

submission deadline 28 Feb 2026 | 1 articles | Viewed by 593 | Submission Open

Keywords: marine natural products; marine-associated microbes; antimicrobial drug; antibiotics; marine-derived peptides; anti-inflammatory; molecular pharmacology; targeted therapies; extraction

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular and Cellular Biology of Germ Cells

edited by

Anna Tabęcka-Łonczyńska

submission deadline 28 Feb 2026 | 1 articles | Viewed by 586 | Submission Open

Keywords: germ cell development; meiosis; epigenetic regulation; autophagy; mitochondrial dynamics; infertility; reproductive medicine; germ cell tumors; steroidogenesis; endocrine disrupting chemicals; reproductive toxicity

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Heart Disease: Genomics and Bioinformatics of Heart Research—2nd Edition

edited by Justyna Fert-Bober

submission deadline 28 Feb 2026 | 1 articles | Viewed by 443 | Submission Open

Keywords: heart disease; cardiovascular disease; coronary artery disease (CAD); heart attack; heart failure; arrhythmia (abnormal heart rhythms); valve disease; high blood pressure; congenital heart conditions; inherited heart conditions; fibrosis; pathobiology of fibrosis; aging; chronic inflammation; inflammatory and cardiovascular diseases; myocarditis; extracellular matrix biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bridging Molecules and Reactions: Next-Generation Approaches for Advancing Electrocatalytic Efficiency

edited by

Abu Talha Aqueel Ahmed

submission deadline 28 Feb 2026 | 1 articles | Viewed by 412 | Submission Open

Keywords: electrochemical nanomaterials; energy storage and conversion; electrocatalysis and reaction mechanisms; photoelectrochemical water splitting; electrochemical energy storage devices; nanocomposites and functionalized materials; molecular-level electrocatalysis; electrocatalyst and photocatalysts; in-situ spectroscopy and atomistic modeling; hybrid molecular– nanostructured systems; sustainable and natural resource– derived materials; DFT related to reaction kinetics; AOP

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Advanced Functionalization of Biopolymers and Bio-Oligomers for Precision Therapeutics

edited by

Dayong Wang

submission deadline 28 Feb 2026 | 1 articles | Viewed by 390 | Submission Open

Keywords: precision therapeutics; biopolymers; drug delivery; biopharmaceuticals; pharmacology

(This special issue belongs to the Section Materials Science)

Role of Integrins in Cytokine Signaling

edited by

Yoshikazu Takada

submission deadline 28 Feb 2026 | 1 articles | Viewed by 383 | Submission Open

Keywords: integrins; cytokines; FGF1; CX3CL1; ternary-complex; antagonist; inside-out signaling; integrin-binding motif; cytokine-integrin crosstalk; ligand-induced activation

(This special issue belongs to the Section Molecular Biology)

Metabolic Syndrome: New Insights in Pathogenesis, Diagnosis, Prevention, and Management—2nd Edition

edited by

Lucia Maria Procopciuc

and

Roxana Liana Lucaciu

submission deadline 28 Feb 2026 | 1 articles | Viewed by 352 | Submission Open

Keywords: insulin resistance; hypertension; diabetes mellitus; obesity; inflammation; stress; metabolic disorders; reproductive endocrine disorders; polycystic ovarian syndrome; waist circumference; estrogen deficiency; disturbances in adipose tissue; physical inactivity; overnutrition; cardiovascular diseases; abdominal obesity; genetics and epigenetics of metabolic syndrome; computational analysis

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Pathophysiology and Molecular Mechanisms of Cardiovascular, Cardiometabolic, and Cardiorenal Diseases

edited by

Carmine Savoia

submission deadline 28 Feb 2026 | 1 articles | Viewed by 349 | Submission Open

Keywords: heart failure; cardiorenal syndrome; oxidative stress; inflammation; endothelial dysfunction; fibrosis and remodeling; mitochondrial function and energy metabolism; insulin resistance; epigenetics and microRNAs; biomarkers and precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Plant Protein and Enzyme Inhibitors

edited by Yan Zhang

submission deadline 28 Feb 2026 | Viewed by 346 | Submission Open

Keywords: plant proteins; active substances; bioactive compounds; enzyme inhibitors

(This special issue belongs to the Section Molecular Plant Sciences)

Schiff Bases and Their Metal Complexes: Structure, Synthesis, and Biological Application

edited by Nenad Filipovic

submission deadline 28 Feb 2026 | Viewed by 312 | Submission Open

Keywords: hydrazones; (thio/seleno)semicarbazones; oximes; antimicrobial activity; anticancer activity; enzyme inhibition; metal complexes; diagnostic agents; photothermal therapy; photodynamic therapy

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms of Toxicity Caused by Environmental Pollutants

edited by Ivan Girón-Perez

submission deadline 28 Feb 2026 | 1 articles | Viewed by 295 | Submission Open

Keywords: environmental pollutant; molecular toxicity; immunotoxicology; neurotoxicity

(This special issue belongs to the Section Molecular Toxicology)

Environmental Exposures and Chronic Obstructive Pulmonary Disease Pathogenesis

edited by

Abderrazzak Bentaher

submission deadline 28 Feb 2026 | Viewed by 254 | Submission Open

Keywords: chronic obstructive pulmonary disease; environmental exposures; disease pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring Molecular Insights in Oral Health and Disease

edited by

Iulia-Ioana Stanescu-Spinu

and

Tudor Claudiu Spînu

submission deadline 28 Feb 2026 | Viewed by 226 | Submission Open

Keywords: oral health; saliva; oral diseases; molecular insights; molecular targets; oral cavity physiology; wound healing; oral microbiome; oral biocompatibility; material interactions

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomaterials and Antibacterial Materials for Medical Applications

edited by

Shixiong Yi

submission deadline 28 Feb 2026 | 1 articles | Viewed by 226 | Submission Open

Keywords: biomaterial science; photodynamic antibacterial materials; photothermal antibacterial materials; advanced antibacterial materials; antimicrobial nanostructured materials; polymer-based biomaterials; infected wound dressings

(This special issue belongs to the Section Materials Science)

Recent Advances in Regenerative and Anti-Aging Medicine

edited by

Takayuki Yoshimoto

submission deadline 28 Feb 2026 | Viewed by 187 | Submission Open

Keywords: induced pluripotent stem cells (iPSCs); mesenchymal stem cells (MSCs); platelet-rich plasma (PRP); placenta; organoid; secretome; exosome; senolytics; nicotinamide mononucleotide (NMN); nicotinamide adenine dinucleotide+ (NAD+)

(This special issue belongs to the Section Molecular Biology)

Strategies for Enhancing Skeletal Muscle Recovery and Regeneration in Health and Disease Conditions

edited by

Elen Miyabara

and

Atsushi Asakura

submission deadline 28 Feb 2026 | Viewed by 178 | Submission Open

Keywords: skeletal muscle; regeneration; muscle wasting; aging; muscle diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Progress in Peptidic Protease Inhibitors

edited by

Roberta Ettari

and Carla Di Chio

submission deadline 28 Feb 2026 | Viewed by 177 | Submission Open

Keywords: peptide inhibitors; infectious diseases; cancer; metabolic disorders; neurological disorders; inflammation

(This special issue belongs to the Section Biochemistry)

The Role of Dietary Polyphenols and Dietary Polysaccharides in Human Diseases

edited by

Francisco Les

submission deadline 28 Feb 2026 | Viewed by 169 | Submission Open

Keywords: dietary polyphenols; dietary polysaccharides; bioactive compounds; chronic diseases prevention; functional foods

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Biosynthesis and Regulatory Mechanism of Secondary Metabolites in Medicinal Plants: 3rd Edition

edited by

Shanfa Lu

submission deadline 28 Feb 2026 | Viewed by 169 | Submission Open

Keywords: biosynthetic pathway; epigenetic regulation; high-throughput sequencing; medicinal plant; metabolic engineering; omics; regulatory mechanism; secondary metabolite; synthetic biology; transcription factor

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Imprinting Technologies for Biological and Biomedical Applications

edited by

Urtė Prentice

and

Simonas Ramanavičius

submission deadline 28 Feb 2026 | 1 articles | Viewed by 163 | Submission Open

Keywords: molecularly imprinted polymers; biosensors and diagnostics; biomolecular recognition; molecular imprinting; nanomaterials; molecular biology applications

(This special issue belongs to the Section Molecular Informatics)

Abnormal Production and Structure of Hemoglobin Molecules

edited by Maria Dimopoulou

submission deadline 28 Feb 2026 | Viewed by 159 | Submission Open

Keywords: hemoglobin; hemoglobinopathies; thalassemias; sickle cell disease; structural hemoglobin variants; alpha globin; beta globin; globin chain genes; unstable hemoglobins; oxygen affinity

(This special issue belongs to the Section Biochemistry)

Interactions and Functions Between Peptides and Polysaccharides

edited by

Kexue Zhu

and

Xianxiang Chen

submission deadline 28 Feb 2026 | Viewed by 156 | Submission Open

Keywords: polysaccharides; peptides; bioactivity; structural analysis; polysaccharide– peptide complexes; interactions; gut microbiota; immune regulation; interaction dynamics

(This special issue belongs to the Section Biochemistry)

Role of Extracellular Vesicles in Immune Regulation

edited by Rachel Crossland

submission deadline 28 Feb 2026 | Viewed by 156 | Submission Open

Keywords: extracellular vesicle; immune regulation; immunomodulation; antigen presentation; inflammation; autoimmunity

(This special issue belongs to the Section Molecular Immunology)

Oxidative-Stress in Human Health and Diseases

edited by

Ramoji Kosuru

submission deadline 28 Feb 2026 | Viewed by 153 | Submission Open

Keywords: oxidative stress; ROS; redox signaling; metabolic adaptation; oxidative homeostasis; endothelial dysfunction

(This special issue belongs to the Section Biochemistry)

Biomaterials: From Design, Synthesis and Characterization to Application—2nd Edition

edited by

Tao Sun

and

Xujin Bao

submission deadline 28 Feb 2026 | Viewed by 145 | Submission Open

Keywords: biomaterials; synthesis; characterization; therapeutics; diagnosis

(This special issue belongs to the Section Materials Science)

Molecular Mechanism in Cardiac Remodeling

edited by Xianming Lin and

Xiaobo Wu

submission deadline 28 Feb 2026 | Viewed by 143 | Submission Open

Keywords: cardiomyopathy; cardiac arrhythmias; ion channel; calcium transient

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Using Model Organisms to Study Complex Human Diseases—2nd Edition

edited by

Roberto Piergentili

submission deadline 28 Feb 2026 | Viewed by 135 | Submission Open

Keywords: model organism; Escherichia coli; yeast; Caenorhabditis elegans; Drosophila melanogaster; zebrafish; Arabidopsis thaliana; Xenopus laevis; rat and mouse model; human disease; inherited disease; cancer; rare disease; genetics

(This special issue belongs to the Section Molecular Biology)

Neurofibromatosis Type 1 and NF2-Related Schwannomatosis: Advances from Basic Research to Current Therapies

edited by

Bumjoon Park

and

Baehoon Kim

submission deadline 28 Feb 2026 | Viewed by 134 | Submission Open

Keywords: neurofibromatosis type 1 (NF1); neurofibromin; RAS/MAPK pathway; malignant peripheral nerve sheath tumor (MPNST); NF2-related schwannomatosis (NF2 syndrome); Merlin (Schwannomin); vestibular schwannoma; meningioma; ependymoma

(This special issue belongs to the Section Molecular Neurobiology)

Flowers: Molecular and Genetic Regulation of Growth and Development

edited by Yaqin Wang

submission deadline 28 Feb 2026 | Viewed by 130 | Submission Open

Keywords: flower; growth and development; molecular regulation; genetic breeding

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Trace Elements in Nutrition and Health, 2nd Edition

edited by Jie Feng

submission deadline 28 Feb 2026 | Viewed by 129 | Submission Open

Keywords: trace elements; nutrition; health; function; disease; metabolism; homeostasis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Applications of Photodynamic Therapy in Cancer

edited by

Natalia Belén Rumie Vittar

submission deadline 28 Feb 2026 | Viewed by 123 | Submission Open

Keywords: tumor microenvironment; CAF; hypoxia; immune evasion; combined therapies; new cellular or molecular targets

(This special issue belongs to the Section Molecular Oncology)

Alcohol Use Disorder: From Molecular Mechanisms to Therapeutics

edited by

Giampiero Ferraguti

submission deadline 28 Feb 2026 | Viewed by 118 | Submission Open

Keywords: alcohol; addiction; FASD; alcohol-related damage

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Strategies for the Discovery, Optimization, and Efficient Use of Green Pesticides

edited by

Hongjian Song

submission deadline 28 Feb 2026 | Viewed by 118 | Submission Open

Keywords: natural-product-based pesticides; total synthesis; structural optimization; bioactivity evaluation; structure– activity relationship

(This special issue belongs to the Section Molecular Pharmacology)

Dermatological Perspectives on Connective Tissue Diseases

edited by Yoshihide Asano

submission deadline 28 Feb 2026 | Viewed by 115 | Submission Open

Keywords: connective tissue diseases; systemic sclerosis; systemic lupus erythematosus; dermatomyo-sitis; rheumatoid arthritis; Sjö gren’ s syndrome; skin immunology; fibrosis; cytokines; targeted therapy

(This special issue belongs to the Section Molecular Biology)

Functional Foods: Molecular Insights into Nutrition and Health

edited by Patroklos Vareltzis

submission deadline 28 Feb 2026 | Viewed by 114 | Submission Open

Keywords: functional foods; bioactive compounds; disease prevention; nutritional health; food innovation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Osteogenesis: 2nd Edition

edited by

Andrea Del Fattore

submission deadline 28 Feb 2026 | Viewed by 110 | Submission Open

Keywords: osteogenesis; osteoblast; bone formation; disease; bone

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Studies on Wnt Signaling

edited by Katalin Mészáros

submission deadline 28 Feb 2026 | Viewed by 109 | Submission Open

Keywords: Wnt signaling pathway; inhibitor; cancer; treatment; drugs

(This special issue belongs to the Section Molecular Biology)

Oral and Dental Infectious Diseases: Molecular Pathology, Diagnosis and Therapy (2nd Edition)

edited by

Keiji Murakami

and

Hiromichi Yumoto

submission deadline 28 Feb 2026 | Viewed by 108 | Submission Open

Keywords: oral; dental; periodontitis; tooth decay; periodontal diseases; gingivitis; oral microorganism; oral infections; dental infections; dental caries; microbial pathogenicity; porphyromonas gingivalis; antimicrobials; oral biofilm

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neurodegenerative Diseases: Molecular Mechanisms, Drug Targets and Therapeutic Strategies

edited by

Andrea Kwakowsky

submission deadline 28 Feb 2026 | Viewed by 107 | Submission Open

Keywords: beta amyloid peptide; tau protein; alpha-synuclein protein; huntingtin protein; autophagy; neuromodulators; neurotrophins; natural compounds; neuroinflammation; vascular dysfunction; neuronal death; drug development; therapeutic biomarkers; blood– brain barrier; small-molecule therapeutics

(This special issue belongs to the Section Molecular Neurobiology)

Insights into Multiple Myeloma: Immune Microenvironment, Disease Mechanisms, and Therapeutic Innovations

edited by

Ichiro Hanamura

submission deadline 28 Feb 2026 | Viewed by 107 | Submission Open

Keywords: multiple myeloma; bone marrow microenvironment; disease biology; disease progression; treatment resistance; CAR-T cells; bispecific antibodies (BsAbs); antibody-drug conjugates (ADCs); tumor– host interaction

(This special issue belongs to the Section Molecular Oncology)

Structural Studies of Phosphorus Compounds Today

edited by

Irina Rusakova

submission deadline 28 Feb 2026 | Viewed by 107 | Submission Open

Keywords: 31P NMR; NMR; organophosphorus compounds; transition-metal complexes with organophosphorus ligands; relativistic effects; solvent effects; quantum chemistry methods for NMR; chemical structure studies; chemistry of organophosphorus compounds

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Hepatocardiac Interactions and the Utility of Hepatic Biomarkers in Cardiovascular Disease

edited by

Wioletta Szczurek-Wasilewicz

submission deadline 28 Feb 2026 | Viewed by 106 | Submission Open

Keywords: hepatocardiac interactions; hepatic biomarkers; cardiovascular disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring Melatonin and Related Indolic Agents

edited by

Burkhard Poeggeler

submission deadline 28 Feb 2026 | Viewed by 105 | Submission Open

Keywords: aging; antioxidant; bioenergetic agent; biological clock; immunomodulation; indole-3-propionic acid; indole-3-propionamide; melatonin; senescence; tryptophan

(This special issue belongs to the Section Molecular Pharmacology)

From Molecules to Cognition: Biomarkers and Neuropsychological Tools in Neurological Disorders

edited by

Silvia Boschi

submission deadline 28 Feb 2026 | Viewed by 105 | Submission Open

Keywords: biomarkers; neuropsychological assessment; neurological disorders; neuroimaging; cognitive function; translational neuroscience

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms of Vascular Sclerosis

edited by Michishige Terasaki

submission deadline 28 Feb 2026 | Viewed by 105 | Submission Open

Keywords: atherosclerosis; genes; dyslipidemia; diabetes; macrophages; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular, Cellular Mechanisms and Pathophysiology of Glioblastoma

edited by Agnieszka Rusak

submission deadline 28 Feb 2026 | Viewed by 105 | Submission Open

Keywords: glioblastoma; targeted terapy; molecular patchway; drug carriers; biomaterials

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Sigma-1 Receptor: Signaling, Functions and Therapeutic Potential

edited by Gabriela Cristina Brailoiu and Eugen Brailoiu

submission deadline 28 Feb 2026 | Viewed by 104 | Submission Open

Keywords: Sigma-1R; intracellular receptor; molecular mechanisms; calcium signaling; neurological diseases; neurodegenerative diseases; pain; cancer; addiction

(This special issue belongs to the Section Molecular Biology)

Immune Responses, Viral Infection and Neurodegenerative Diseases

edited by

Xin Dang

and Barbara Hanson

submission deadline 28 Feb 2026 | Viewed by 103 | Submission Open

Keywords: immune response; innate immunity; viral neuropathogenesis; viral biomarker; AD; PD; neurodegenerative diseases

(This special issue belongs to the Section Molecular Immunology)

Neutrophil Extracellular Traps (NETs) in Human Disease: From Molecular Mechanisms to Therapeutic Translation

edited by