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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Therapeutics for Diabetes and Related Complications, 2nd Edition
edited by
submission deadline 25 Dec 2026 | 10 articles | Viewed by 37865 | Submission Open
Keywords: diabetes; diabetes complications; molecular therapeutics; drug development; hyperglycemia; insulin resistance; cell signaling and oxidative stress
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Understanding Allergy and Asthma at the Molecular Level
edited by
submission deadline 25 Dec 2026 | 5 articles | Viewed by 20806 | Submission Open
Keywords: allergy; asthma; allergens; allergic asthma; thunderstorm asthma; cell culture; biomarkers; proteomics; metabolomics; lipidomics; genomics; recombinant allergens; recombinant hypoallergens; signalling; inhibitors; cytokines
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Emerging Biological and Molecular Targets in Schizophrenia
edited by Jacopo Sapienza
submission deadline 25 Dec 2026 | 4 articles | Viewed by 17062 | Submission Open
Keywords: schizophrenia; cognition; negative symptoms; synapses; kynurenine pathway; TAAR1; psychedelics; new treatments
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Research in Hematologic Malignancies
edited by and
submission deadline 25 Dec 2026 | 7 articles | Viewed by 13780 | Submission Open
Keywords: therapeutic targets; leukemogenesis; molecular regulation; cancer stem cells; epigenetics; novel biomarkers; non-coding RNA; DNA methylation; chemotherapy and genetic changes; cancer; hematologic malignancies
(This special issue belongs to the Section Molecular Oncology)
Antitumor Activity of Natural Products submission deadline 25 Dec 2026 | 7 articles | Viewed by 12566 | Submission Open
Keywords: natural compounds and extracts with antitumor activity; studies on molecular mechanisms; signal transduction modulation in tumor cells; immunomodulating activity; mitosis inhibition; cell differentiation; cell death induction (apoptosis/autophagy)
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms and Therapeutic Targets in Cardiovascular Health and Cardiotoxicity
edited by
submission deadline 25 Dec 2026 | 8 articles | Viewed by 11794 | Submission Open
Keywords: cardiovascular; ischemia, heart failure; arrhythmogenesis; myocardial remodeling; endothelial dysfunction; cardiology; cardio-oncology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Liver Diseases: Causes, Molecular Mechanism and Treatment/Prevention
edited by
submission deadline 25 Dec 2026 | 4 articles | Viewed by 11070 | Submission Open
Keywords: liver diseases; pathophysiology; molecular mechanisms; genetics and epigenetics; non-alcoholic fatty liver disease (NAFLD); hepatitis; liver injury and repair; gene therapy; pharmacological interventions; treatment and prevention; gut–liver axis; spleen–liver axis; alcoholic liver disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Insights and Discoveries in the Pathogenesis, Diagnosis and Therapy of Neuromuscular Diseases
edited by
submission deadline 25 Dec 2026 | 4 articles | Viewed by 10957 | Submission Open
Keywords: neuromuscular diseases; autophagy; mitochondrial dysfunction; molecular genetics; blood-based biomarkers; antisense oligonucleotides; monoclonal antibodies
(This special issue belongs to the Section Molecular Neurobiology)
Techniques and Strategies in Drug Design and Discovery, 3rd Edition submission deadline 25 Dec 2026 | 3 articles | Viewed by 10669 | Submission Open
Keywords: drug discovery; drug development; target identification; computational drug design; structure-based drug design; ligand-based drug design
(This special issue belongs to the Section Molecular Pharmacology)
Advanced Molecular Diagnostic Approaches for Neurodevelopmental Disorders: Applications and Future Perspectives
edited by and Michele Pinelli
submission deadline 25 Dec 2026 | 6 articles | Viewed by 10546 | Submission Open
Keywords: neurodevelopmental disorders; array CGH; NGS
(This special issue belongs to the Section Molecular Neurobiology)
Biomarkers in Diabetes Mellitus: From Discovery to Clinical Application submission deadline 25 Dec 2026 | 8 articles | Viewed by 10526 | Submission Open
Keywords: diabetes mellitus; biomarkers; diabetes complications; omics technologies; risk stratification; therapeutic response; personalized medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Dementia with Lewy Bodies and Alzheimer’s Disease
edited by
submission deadline 25 Dec 2026 | 3 articles | Viewed by 10203 | Submission Open
Keywords: dementia with Lewy bodies; Alzheimer’s disease; dementing disorders in advanced age
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms Associated with Exercise for Health and Performance
edited by Ciro José Brito
submission deadline 25 Dec 2026 | 6 articles | Viewed by 9884 | Submission Open
Keywords: exercise science; sports medicine; aging; genetic and exercise; endocrinology; immunology
(This special issue belongs to the Section Molecular Biology)
Advances in Biomathematics, Computational Biology, and Bioengineering submission deadline 25 Dec 2026 | 6 articles | Viewed by 9340 | Submission Open
Keywords: biomathematics; machine learning; artificial intelligence; data science; systems biology; reaction–diffusion systems; nonlinear dynamics; bioreactors; biochemical reaction engineering
(This special issue belongs to the Section Molecular Informatics)
Medical Applications of Polymer Materials
edited by Zhen Zhang
submission deadline 25 Dec 2026 | 4 articles | Viewed by 9117 | Submission Open
Keywords: medical polymers; drug delivery; tissue engineering; medical devices; diagnostics
(This special issue belongs to the Section Macromolecules)
Antisense Oligonucleotides: Versatile Tools with Broad Applications
edited by
submission deadline 25 Dec 2026 | 4 articles | Viewed by 9107 | Submission Open
Keywords: antisense oligonucleotide; RNase H; splice switching; exon skipping; therapeutics; pesticide
(This special issue belongs to the Section Molecular Biology)
Current Advances in Infectious and Inflammatory Diseases submission deadline 25 Dec 2026 | 2 articles | Viewed by 8768 | Submission Open
Keywords: inflammatory diseases; infectious diseases; host–pathogen interactions; antimicrobial resistance; immune modulation; cytokine signaling
(This special issue belongs to the Section Molecular Microbiology)
Genetics and Omics in Autoimmune Diseases submission deadline 25 Dec 2026 | 5 articles | Viewed by 8698 | Submission Open
Keywords: autoimmune diseases; genetics; genomics; omics; single-nucleotide variants; copy number variants; variation; susceptibility; mRNAs; microRNAs; long non-coding RNAs; masive sequencing
(This special issue belongs to the Section Molecular Genetics and Genomics)
Food Allergy: Molecular Mechanisms, Clinical Challenges, and Future Directions
edited by
submission deadline 25 Dec 2026 | 5 articles | Viewed by 8233 | Submission Open
Keywords: food allergy; allergen; environmental exposures; gut microbiome; non-IgE-mediated pathways
(This special issue belongs to the Section Molecular Immunology)
Pain in Human Health and Disease
edited by
submission deadline 25 Dec 2026 | 3 articles | Viewed by 8176 | Submission Open
Keywords: pain signaling; molecular pathways; chronic pain; neuropathic pain; inflammation neuro–immune interactions; epigenetics pharmacogenetics; precion medicine; sleep disorders
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Inflammatory Bowel Disease: Molecular Advances in Pathogenesis and Therapies, 2nd Edition submission deadline 25 Dec 2026 | 8 articles | Viewed by 8121 | Submission Open
Keywords: Crohn’s disease; inflammatory bowel disease; immunologic and molecular mechanisms; therapies in IBD; ulcerative colitis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Underpinnings of Schizophrenia Spectrum Disorders, 2nd Edition
edited by and
submission deadline 25 Dec 2026 | 4 articles | Viewed by 7929 | Submission Open
Keywords: schizophrenia spectrum disorders; central nervous system (CNS); psychotic disorders
(This special issue belongs to the Section Molecular Neurobiology)
Roles of Lipid Rafts in the Regulation of Cellular Processes and Diseases
edited by
submission deadline 25 Dec 2026 | 1 articles | Viewed by 7817 | Submission Open
Keywords: lipid rafts; glycosphingolipid; ganglioside; sphingomyelin; cholesterol; GPI-anchored proteins; caveolae; detergent-resistant membrane; signal transduction; disease
(This special issue belongs to the Section Biochemistry)
Peptide and Protein Drugs Against Infectious Diseases and Allergic Diseases
edited by
submission deadline 25 Dec 2026 | 2 articles | Viewed by 7230 | Submission Open
Keywords: peptide and protein drugs; infectious diseases; allergic diseases; hormones; antimicrobial peptides; neuropeptides; cell-penetrating peptides; enzyme inhibitors; vaccines; antibodies
(This special issue belongs to the Section Molecular Pharmacology)
Advances in Molecular Target and Anti-Cancer Therapies
edited by Laura Denisa Dragu
submission deadline 25 Dec 2026 | 6 articles | Viewed by 7026 | Submission Open
Keywords: cancer; conventional therapy; targeted therapy; immunotherapy; natural compounds; combinatorial therapy; molecular target; molecular mechanism; drug design; drug resistance
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Accelerating Therapeutic Innovation: Advances in Computer-Aided Drug Discovery
edited by Pietro Delre and
submission deadline 25 Dec 2026 | 5 articles | Viewed by 6847 | Submission Open
Keywords: CADD; drug discovery; machine learning; virtual screening; drug-target interaction
(This special issue belongs to the Section Molecular Informatics)
Molecular and Structural Research Advances in Model Plants (Second Edition) submission deadline 25 Dec 2026 | 3 articles | Viewed by 6831 | Submission Open
Keywords: A. thaliana; plant biology; model organisms; plant models; non-model plant models
(This special issue belongs to the Section Molecular Plant Sciences)
New Research Perspectives in Protein Glycosylation
edited by
submission deadline 25 Dec 2026 | 5 articles | Viewed by 6601 | Submission Open
Keywords: glycan function; glycan structural analysis; glycoproteomics; glycoengineering; systems glycobiology
(This special issue belongs to the Section Biochemistry)
Advancements in Inflammatory and Oxidative Disease Research
edited by
submission deadline 25 Dec 2026 | 4 articles | Viewed by 6457 | Submission Open
Keywords: diabetes; cancer; neurological diseases; inflammation; oxidative stress; endocrinology; gastroenterology; pulmonology; rheumatology; cardiology; neurology; nephrology; dermatology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Roles of Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists in Health and Disease submission deadline 25 Dec 2026 | 2 articles | Viewed by 6238 | Submission Open
Keywords: GLP-1; GLP-1 receptor; GLP-1 signaling pathway; mechanism of action; GLP-1 agonists; human diseases; adverse effects
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Food Allergens: Latest Molecular Advancements
edited by and
submission deadline 25 Dec 2026 | 4 articles | Viewed by 6156 | Submission Open
Keywords: food allergies; allergen; allergenicity; epitope; desensitization; immunity reaction; hypoallergen; Ig E binding; Abkhazian; Acehnese; Acholi; Afar; Afrikaans; Albanian; Alur; Amharic; Arabic; Armenian; Assamese; Avaric; Awadhi; Aymara; Azerbaijani; Balinese; Baluchi; Bambara; Baoulé; Bashkir; Basque; Batak; Batak Simalungun; Batak Toba; Belarusian; Bemba; Bengali; Betawi; Bhojpuri; Bikol; Bosnian; Breton; Bulgarian; Buryat; Cantonese; Catalan; Cebuano; Chamorro; Chechen; Chichewa; Chuukese; Chuvash; Corsican; Crimean Tatar; Crimean Tatar (Latin); Croatian; Czech; Danish; Dari; Dinka; Divehi; Dogri; Dombe; Dutch; Dyula; Dzongkha; English; English (USA); Esperanto; Estonian; Ewe; Faroese; Fijian; Filipino; Finnish; Fon; French; French (Canadian); Frisian; Friulian; Fulah; Ga; Galician; Georgian; German; Greek; Guarani; Gujarati; Haitian Creole; Hakha Falam; Hausa; Hawaiian; Hebrew; Hiligaynon; Hindi; Hmong; Hungarian; Hunsrik; Iban; Icelandic; Igbo; Ilocano; Indonesian; Inuktitut; Inuktitut (Latin); Irish; Italian; Jamaican Patois; Japanese; Javanese; Jingpho; Kalaallisut; Kannada; Kanuri; Kapampangan; Kazakh; Khasi; Khmer; Kiga; Kikongo; Kinyarwanda; Kokborok; Komi; Konkani (Latin); Korean; Krio; Kurdish (Kurmanji); Kurdish (Sorani); Kyrgyz; Lao; Latgalian; Latin; Latvian; Ligurian; Limburgish; Lingala; Lithuanian; Lombard; Luganda; Luo; Luxembourgish; Macedonian; Madurese; Maithili; Makassarese; Malagasy; Malay; Malay (Arabic); Malayalam; Maltese; Mam; Manx; Maori; Marathi; Mari; Marshallese; Marwari; Mauritian Creole; Meitei/Meetei (Mayek); Minangkabau; Mizo; Mongolian; Myanmar (Burmese); N'Ko Bambara; Nahuatl; Ndau (Zimbabwe); Ndebele; Nepali; Newari; Northern Sami; Norwegian; Nuer; Occitan; Odia; Oromo; Ossetian; Pangasinan; Papiamento; Pashto; Persian; Polish; Portuguese; Portuguese (Portugal); Punjabi; Punjabi (Arabic); Q'eqchi'; Quechua; Romani; Romanian; Rundi; Russian; Samoan; Sango; Sanskrit; Santali; Santali (Latin); Scots Gaelic; Sepedi; Serbian; Sesotho; Seychellois Creole; Shan; Shona; Sicilian; Silesian; Simplified Chinese; Sindhi; Sinhala; Slovak; Slovenian; Somali; Spanish; Sundanese; Susu; Swahili; Swati; Swedish; Tahitian; Tajik; Tamazight; Tamazight (Latin); Tamil; Tatar; Telugu; Tetum; Thai; Tibetan; Tigrinya; Tiv; Tok Pisin; Tongan; Traditional Chinese; Tshiluba; Tsonga; Tswana; Tulu; Tumbuka; Turkish; Turkmen; Tuvan; Twi; Udmurt; Ukrainian; Urdu; Uyghur; Uzbek; Venda; Venetian; Vietnamese; Waray; Welsh; Wolof; Xhosa; Yakut; Yiddish; Yoruba; Yucatec Maya; Zapotec; Zulu
(This special issue belongs to the Section Molecular Biology)
Neuroendocrine Tumors: From Molecular Pathology to Novel Therapeutic Approaches, Including Theranostics
edited by
submission deadline 25 Dec 2026 | 3 articles | Viewed by 6125 | Submission Open
Keywords: neuroendocrine tumors; NETs; molecular pathology; therapeutic strategies
(This special issue belongs to the Section Molecular Oncology)
Synthetic Chemistry in Drug Discovery
edited by Kathiravan Suppan
submission deadline 25 Dec 2026 | 3 articles | Viewed by 6092 | Submission Open
Keywords: late-stage functionalization; AI-driven synthesis; drug discovery; synthetic chemistry; transition metal catalysis
(This special issue belongs to the Section Molecular Pharmacology)
Microbial Genomics in the Omics Era
edited by
submission deadline 25 Dec 2026 | 4 articles | Viewed by 6057 | Submission Open
Keywords: microbe; bioinformatics; DNA; RNA; protein; sequencing; structure; omics
(This special issue belongs to the Section Molecular Microbiology)
Inflammatory Bowel Disease: Pathogenesis and Novel Therapeutic Approaches
edited by Francisco Giner
submission deadline 25 Dec 2026 | 2 articles | Viewed by 5864 | Submission Open
Keywords: coeliac disease; microscopic colitis; Crohn’s disease; ulcerative colitis; microbiota; biological therapies; refractory disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Mitigating Metal Toxicity: Contaminated Environment, Animal Studies and Human Health submission deadline 25 Dec 2026 | 3 articles | Viewed by 5740 | Submission Open
Keywords: heavy metal toxicity; heavy metal pollution; heavy metal bioaccumulation and interactions; health risk; mechanistic analysis; dysregulation of cellular homeostasis; natural plant bioactive compounds; human diseases; environmental pollution; in vitro/animal studies; innovative strategies; polyoxometalates (POMs); metal-organic frameworks (MOFs)
(This special issue belongs to the Section Molecular Toxicology)
Applications of Mass Spectrometry in the Analysis of Bioactive and Plant Organic Compounds
edited by
submission deadline 25 Dec 2026 | 3 articles | Viewed by 5705 | Submission Open
Keywords: mass spectrometry; VOCs; bioactive compounds; plant organic compounds; pharmaceutical research; metabolites
(This special issue belongs to the Section Biochemistry)
Recent Advances in Graphene-Based Nanocomposites and Perspectives on Their Design
edited by Aleksey E. Kuznetsov
submission deadline 25 Dec 2026 | 3 articles | Viewed by 5702 | Submission Open
Keywords: graphene; graphene oxide; nanocomposite; synthesis; computational study; characterization; application; design
(This special issue belongs to the Section Molecular Nanoscience)
Liver Disease and Primary Liver Cancer: Translational Advances and Therapeutic Perspectives
edited by
submission deadline 25 Dec 2026 | 6 articles | Viewed by 5624 | Submission Open
Keywords: liver disease; hepatocellular carcinoma; cholangiocarcinoma; molecular mechanisms; translational research; 3D models and organoids; biomarkers and therapeutic strategies; MASH/MASLD: pathogenesis, diagnosis, and management; primary liver cancer: pathogenesis, detection, and treatment; inflammation in liver disease; 3D liver models; microbiota and liver disease; mechanisms of damage and repair: ischemia-reperfusion injury; cellular pathology in acute and chronic liver damage of different origin; biomarkers in liver disease: emerging methods and potential applications; immunology in the liver—from homeostasis to disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Nature-Inspired and Synthetic Compounds: New Frontiers in Bioactivity and Drug Discovery
edited by and
submission deadline 25 Dec 2026 | 5 articles | Viewed by 5596 | Submission Open
Keywords: natural and synthetic products; drug discovery and development; drug repurposing; artificial intelligence and machine learning; biological evaluation; healthcare; green and sustainable chemistry; natural and synthetic drug applications
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Exploring Abiotic Stress in Plants: Mechanisms, Adaptations, and Mitigation Strategies (2nd Edition)
edited by
submission deadline 25 Dec 2026 | 4 articles | Viewed by 5548 | Submission Open
Keywords: abiotic stress; plant physiology; stress tolerance; crop resilience; molecular mechanisms; biotechnological interventions
(This special issue belongs to the Section Molecular Plant Sciences)
Innovative Therapeutic Approaches to Endocrine Disorders submission deadline 25 Dec 2026 | 3 articles | Viewed by 5490 | Submission Open
Keywords: endocrine disorders; osteoporosis; diabetes; obesity; synthetic drugs; nutraceuticals; biomarkers
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Advances in Traits in Animals and Aquatic Species, and Their Improvement Technologies
edited by
submission deadline 25 Dec 2026 | 5 articles | Viewed by 5461 | Submission Open
Keywords: biotechnology; genetic breeding; stress responses; epigenetics; non-coding RNAs; gene regulation; molecular ecology; animals; aquaculture; development
(This special issue belongs to the Section Molecular Biology)
Antimicrobial Nanoparticles: Mechanisms, Applications, and Future Directions submission deadline 25 Dec 2026 | 5 articles | Viewed by 5457 | Submission Open
Keywords: antimicrobial activity; nanoparticles; biofilm nano-modulators; antibiotic resistence; wastewater treatment; preservative properties of nanoparticles
(This special issue belongs to the Section Molecular Microbiology)
Immunological Control of Vascular Plasticity: Insights into Arteriogenesis, Angiogenesis, and Atherosclerosis submission deadline 25 Dec 2026 | 2 articles | Viewed by 5443 | Submission Open
Keywords: vascular plasticity; arteriogenesis; angiogenesis; atherosclerosis; immune modulation; inflammation and vascular remodeling; translational vascular immunology; smooth muscle cell-/endothelial cell proliferation; sterile inflammation; collateral artery growth
(This special issue belongs to the Section Molecular Immunology)
Eukaryotic DNA Replication—from Bench to Bedside
edited by Heinz-Peter Nasheuer
submission deadline 25 Dec 2026 | 1 articles | Viewed by 5289 | Submission Open
Keywords: genome stability; cell cycle; DNA replication; chromatin replication; replication origins—selection, licensing and firing; replication forks—smoothly progressing and under stress; role of DNA replication in cancer and other human diseases; disease treatment opportunities
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Endocrine Regulation in Health and Diseases
edited by Fady Hannah-Shmouni
submission deadline 25 Dec 2026 | 1 articles | Viewed by 5070 | Submission Open
Keywords: exposome and endocrine disruptors; endocrine-disrupting chemicals (EDCs); environmental toxicology and hormonal health; epigenetics and endocrine function; endocrine regulation and chronic disease; public health and exposure mitigation; endocrine disruptors in the home and community
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Heat Shock Proteins (HSPs): Biological Functions and Mechanisms of Actions submission deadline 25 Dec 2026 | 4 articles | Viewed by 5049 | Submission Open
Keywords: heat shock proteins; apoptosis; immune cell activation; stress responses; misfolded proteins; cellular chaperones; cell signaling
(This special issue belongs to the Section Biochemistry)
Targeting Epigenetic Complexes and Alternative Protein Degradation Pathways in Medicinal Chemistry
edited by Jean Leandro Dos Santos
submission deadline 25 Dec 2026 | 2 articles | Viewed by 4889 | Submission Open
Keywords: protein degradation; LYTAC; AUTAC; ATTEC; epigenetics; NuRD; HDAC; BRD; SWI/SNF; PRC2; chromatin; conjugates; lysosome; autophagy; drug discovery
(This special issue belongs to the Section Biochemistry)
Medicinal Plants, Animal-Derived Products, and Natural Compounds: Roles in Health and Disease submission deadline 25 Dec 2026 | 6 articles | Viewed by 4879 | Submission Open
Keywords: natural bioactive compounds; medicinal plants; animal-derived products; marine natural products; chronic diseases; inflammation; oxidative stress; molecular mechanisms; therapeutic peptides; natural toxins; antioxidant activity; anti-inflammatory agents; nanoformulations; nanodelivery systems; drug delivery; pharmacological properties; translational research; integrative medicine; natural therapeutics; disease prevention
(This special issue belongs to the Section Bioactives and Nutraceuticals)
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