Molecular Therapeutics for Diabetes and Related Complications, 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 954
Special Issue Editor
Interests: oxidative stress-induced signal transduction mechanisms; pathophysiology of secondary diabetic complications; carcinogenesis; inflammatory complications; therapeutic development of small molecular inhibitors and antioxidants
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Diabetes poses a significant threat to global health, demanding attention due to its escalating prevalence and associated complications. Conventional treatments, such as insulin therapy, alongside newer glucose-lowering medications such as metformin, GLP-1 receptor agonists, SGLT-2 inhibitors, and insulin sensitizers, offer some effectiveness; however, they are also associated with some unwanted side effects, which necessitates the further exploration of novel therapeutic options. Worldwide, healthcare costs of this pathology increase every year, and there is a need to discover novel drug targets and molecular pathways for managing diabetes and its associated complications, such as diabetic nephropathy, retinopathy, neuropathy, and cardiovascular diseases. These targets not only promise to ameliorate diabetes but also offer avenues for mitigating the associated complications. Connecting these novel pathways will help to surpass the benefits of conventional therapies, thereby reducing the morbidity and mortality linked with diabetic complications. While recent preclinical studies have identified promising molecular pathways and targets, further clinical trials are needed in order to translate these findings into clinical practice. Additionally, research continues to explore means of reducing oxidative stress; enhancing antioxidant status; manipulating molecular and metabolic pathways using the innate immune response; and exploring microRNAs, stem cell therapy, and gene therapy as potential diagnostic and therapeutic tools. Thus, while conventional therapies remain crucial, the pursuit of novel molecular therapeutics holds promise regarding revolutionizing diabetes management and improving patient outcomes. This Special Issue aims to compile state-of-the-art insights into the role of novel molecular therapeutics in ameliorating diabetes and related complications and welcomes the submission of original research and review articles addressing all aspects of molecular and cellular pathways, therapeutic drug development, biomarker identification and verification, novel techniques, and computational, structural, and functional studies in the field of diabetes and its complications.
Dr. Kota V. Ramana
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- diabetes
- diabetes complications
- molecular therapeutics
- drug development
- hyperglycemia
- insulin resistance
- cell signaling and oxidative stress
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