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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular and Translational Research on Bone Tumors, 2nd Edition

edited by

Michela Rossi

and

Andrea Del Fattore

submission deadline 31 May 2026 | 2 articles | Viewed by 12655 | Submission Open

Keywords: primary bone tumours; metastatic bone tumour; therapy; biomarkers; epigenetic factors; immune-oncology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Pulmonary Hypertension and Interstitial Lung Diseases: Mechanisms and Treatments

edited by

Katarzyna B. Lewandowska

and

Monika Szturmowicz

submission deadline 31 May 2026 | 2 articles | Viewed by 1359 | Submission Open

Keywords: pulmonary hypertension; interstitial lung disease; lung fibrosis; pulmonary hemodynamics; pulmonary function testing; pathogenesis; prognosis; survival; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microbiota-Mediated Regulation of Stem Cells in Cancer Initiation, Progression, and Treatment Response

edited by

Ciro Gargiulo Isacco

submission deadline 31 May 2026 | Viewed by 340 | Submission Open

Keywords: microbiota stem cell cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Viral Infections and Viral Pathogenesis

edited by

Shymaa E. Bilasy

submission deadline 31 May 2026 | Viewed by 92 | Submission Open

Keywords: viral pathogenesis; viral– host interactions; viral persistence; long COVID; molecular virology; immune dysregulation; diagnosis; vaccines; oncoviruses; antiviral and gene therapy

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms of Natural Products: Redox Balance, Inflammation Control, and Apoptosis Modulation

edited by Rosanna Avola

submission deadline 31 May 2026 | Viewed by 77 | Submission Open

Keywords: natural antioxidants; inflammation; apoptosis; bioactive natural products; oxidative stress

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Cellular and Molecular Mechanisms of Neuroinflammation

edited by

Maria Anttonietta Panaro

submission deadline 31 May 2026 | Viewed by 74 | Submission Open

Keywords: neuroinflammation; astrocytes; microglia; CNS; cytokines; brain; diseases; immune response

(This special issue belongs to the Section Molecular Neurobiology)

Advances in the Pharmacology of Depression and Mood Disorders

edited by

Guillaume Lucas

submission deadline 31 May 2026 | Viewed by 72 | Submission Open

Keywords: new antidepressants; rapid antidepressant action; ketamine in depression; glutamatergic antidepressants; psychedelics in depression; 5-HT receptors as targets for antidepressant research; neu-roplasticity and antidepressant action

(This special issue belongs to the Section Molecular Pharmacology)

Molecular and Systems Mechanisms of Neural Circuit Function and Plasticity

edited by

Hyunjung Oh

submission deadline 31 May 2026 | Viewed by 63 | Submission Open

Keywords: neural circuits; neuroplasticity; synaptic organization; brain aging; mood disorders; neurodegenerative disorders; cognitive function

(This special issue belongs to the Section Molecular Neurobiology)

Bioactive Molecules in Infection and Toxicity: Antimicrobial Peptides and Drug-Induced Damage in Disease Models

edited by

Oleksii Skorokhod

submission deadline 31 May 2026 | Viewed by 63 | Submission Open

Keywords: antimicrobial peptides (AMPs); infectious diseases; drug-induced toxicity; disease models; therapeutic strategies; drug delivery systems

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Microorganisms and Invertebrates in Molecular Dialogue: Mechanisms, Dynamics, and Applications

edited by

Monika Mioduchowska

submission deadline 31 May 2026 | Viewed by 60 | Submission Open

Keywords: microorganism– invertebrate interactions; symbiosis; stress tolerance; co-evolution; omics approaches; biotechnological applications

(This special issue belongs to the Section Molecular Microbiology)

Physiological and Molecular Responses of Plants to Drought Stress

edited by

Muhammad Waseem

submission deadline 31 May 2026 | Viewed by 53 | Submission Open

Keywords: drought stress; photosynthesis; stomatal regulation; signal transduction; phytohormones; anti-oxidants

(This special issue belongs to the Section Molecular Plant Sciences)

Functional Materials for Biomedical Applications and Uses

edited by

Magdalena Laskowska

submission deadline 31 May 2026 | Viewed by 51 | Submission Open

Keywords: functional materials; nanomaterials; biomedical applications; molecular engineering

(This special issue belongs to the Section Materials Science)

Genetic and Molecular Insights into Aging in Vertebrate Models

edited by Antonio Palladino

submission deadline 31 May 2026 | Viewed by 39 | Submission Open

Keywords: aging; vertebrate models; molecular mechanisms; cellular senescence; translational medicine

(This special issue belongs to the Section Molecular Biology)

Platelet-Mediated Immune Regulation in Cancer

edited by

Bennett D. Elzey

submission deadline 31 May 2026 | Viewed by 36 | Submission Open

Keywords: platelets; tumor immunity; megakaryocyte; immunotherapy; lymphocytes; microvesicles; immune suppression; metastasis

(This special issue belongs to the Section Molecular Immunology)

Cryo-EM and Cryo-Tomography in Macromolecular Structure Analysis

edited by

R. Holland Cheng

submission deadline 31 May 2026 | Viewed by 35 | Submission Open

Keywords: macromolecular structure; precision nanomedicine; cryo-electron microscopy (cryo-EM); cryo-electron tomography (cryo-ET); viral capsids; AI/ML in structural analysis; time-resolved imaging; nanoparticle delivery; in-cell tomography; structural dynamics; molecular mechanisms; protein complexes; membrane proteins; macromolecular assemblies; conformational changes; integrative structural biology; cellular structural biology; drug delivery systems; therapeutic design

(This special issue belongs to the Section Macromolecules)

The Role of Ferroptosis in Cancer Biology and Therapy

edited by Alessandra Di Paola and Elvira Pota

submission deadline 31 May 2026 | Viewed by 33 | Submission Open

Keywords: ferroptosis; cancer biology; tumor microenvironment; therapeutic targeting; anticancer immunity; targeted therapy

(This special issue belongs to the Section Molecular Oncology)

Metabolic Alterations in Health and Disease: From Molecular Mechanisms to Biomarkers in Clinical Applications

edited by

Ramona D'Amico

and

Rosalba Siracusa

submission deadline 31 May 2026 | Viewed by 27 | Submission Open

Keywords: metabolic syndrome; diabetes; oxidative stress; cellular metabolism; biomarkers; molecular pathways; metabolic disorders

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Exploring the Functional Activity of Natural Products

edited by

Antonio Speciale

submission deadline 31 May 2026 | Viewed by 24 | Submission Open

Keywords: natural products; natural drug discovery; bioactive compounds; biological activity; molecular mechanisms; anti-inflammatory activity; anticancer properties; therapeutic potential

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Human Virome and Emerging Viruses: Characterization, Interactions, and Molecular Insights

edited by

Luigi Rosa

and

Pietro Giorgio Spezia

submission deadline 31 May 2026 | Viewed by 21 | Submission Open

Keywords: human virome; molecular virology; functional virology; metagenomics; virus– host interactions; immune modulation; pseudovirus assays; antiviral screening; omics integration; molecular immunology

(This special issue belongs to the Section Molecular Microbiology)

Molecular and Computational Innovations in Forensic Genetics: From Degraded DNA to Predictive Models

edited by Eugenio Alladio and

Elena Pilli

submission deadline 31 May 2026 | Viewed by 19 | Submission Open

Keywords: degraded DNA; low-template DNA; molecular forensics; NGS; machine learning; deep learning; chemometrics; data integration; predictive models; forensic applications

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Crosstalk in Allergy, Barrier Dysfunction, and Asthma

edited by

Elisa Boni

submission deadline 31 May 2026 | Viewed by 18 | Submission Open

Keywords: barrier dysfunction; asthma; allergy; molecular pathways; molecular crosstalks

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Biology, Genetics, Diagnosis, Management and Therapy of Dermatological Diseases

edited by

Elisa Molinelli

and Corrado Tagliati

submission deadline 31 May 2026 | Viewed by 16 | Submission Open

Keywords: genodermatoses; hydradenitis suppurativa; inflammatory dermatoses; metabolic disorders; infections; esthetic medicine; neoplastic diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Biomarkers in Cardiovascular Risk Assessment and Myocardial Injury

edited by Beatriz Martín-Carro

submission deadline 31 May 2026 | Viewed by 14 | Submission Open

Keywords: cardiovascular disease; myocardial injury; heart failure; biomarkers; risk stratification

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genetics and Molecular Mechanisms of Cancer Immunotherapy Response

edited by

Javier Oliver

submission deadline 31 May 2026 | Viewed by 11 | Submission Open

Keywords: cancer immunotherapy; genetic biomarkers; immunogenomics; immune checkpoint inhibitors; resistance mechanisms; precision oncology; germline variants; molecular response prediction; immune-related adverse events

(This special issue belongs to the Section Molecular Oncology)

Molecular Research of Gastrointestinal Disease, 3rd Edition

edited by

Ainsley Robinson

and

Kulmira Nurgali

submission deadline 31 May 2026 | Viewed by 10 | Submission Open

Keywords: gastrointestinal health; gastrointestinal disorders; gastrointestinal disease; gastrointestinal homeostasis; molecular targets; mechanisms; pathways; molecular markers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Drug Treatment for Bacterial Infections: 2nd Edition

edited by Janusz Madaj

submission deadline 31 May 2026 | Viewed by 10 | Submission Open

Keywords: bacterial infection; antibiotic-resistant bacteria; new agents in the treatment of bacterial infections; optimization of the use of already registered drugs; single antibacterial agents; combined antibacterial agents; new drug forms

(This special issue belongs to the Section Molecular Pharmacology)

Signaling and Stress Adaptation in Plants: 2nd Edition

edited by

Kangdi Hu

submission deadline 31 May 2026 | Viewed by 7 | Submission Open

Keywords: plants; environmental stress; stress signaling; reactive oxygen/nitrogen species; calcium; protein kinases; stress resistance; adaptive mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Discovery of Plant-Derived Compounds and Their Immunomodulatory Applications

edited by

Jun Jiang

submission deadline 31 May 2026 | Viewed by 5 | Submission Open

Keywords: plant-derived compounds; immunomodulators; phytochemicals; immune signaling; natural products; autoimmune diseases; intestinal flora; in vitro evaluation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Myocardial Disease: Molecular and Cellular Mechanisms

edited by

Maicon Landim-Vieira

submission deadline 31 May 2026 | Submission Open

Keywords: cardiac muscle; calcium; sarcomere; troponin; desmossomal complex; hypertrophic cardiomyopathy; dilated cardiomyopathy; arrhythmogenic cardiomyopathy; mitochondria; calmodulin

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Curcumin Derivatives and Curcuminoids with Potential Biomedical Applications

edited by

Paola Bonaccorsi

and

Chiara Maria Antonietta Gangemi

submission deadline 31 May 2026 | Submission Open

Keywords: curcumin; curcuminoids; synthesis; biomedicine; bioimaging; supramolecular; sensors; photodynamic therapy; antitumor properties; antiviral properties; antibacterial properties; antioxidant properties

(This special issue belongs to the Section Molecular Pharmacology)

Eosinophils: Function and Related Disorders

edited by Giulia Costanzo

submission deadline 31 May 2026 | Submission Open

Keywords: eosinophils; polymorphonuclear cells; interleukin; cytotoxic proteins; host defense; tissue remodeling; dysregulation; eosinophilic disorders; therapeutics

(This special issue belongs to the Section Biochemistry)

Advances in Cancer Epigenetics for Precision Medicine

edited by

Alessandro Lavoro

and

Saverio Candido

submission deadline 31 May 2026 | Submission Open

Keywords: cancer epigenetics; DNA methylation; precision medicine; cancer biomarker; therapeutic target; epidrugs

(This special issue belongs to the Section Molecular Oncology)

Exploring Abiotic Stress in Plants: Mechanisms, Adaptations, and Mitigation Strategies (2nd Edition)

edited by

Tarek Ali Ahmed Ibrahim Alshaal

submission deadline 31 May 2026 | Submission Open

Keywords: abiotic stress; plant physiology; stress tolerance; crop resilience; molecular mechanisms; biotechnological interventions

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms and Therapeutic Targeting of Inflammatory Complications

edited by

Kota V. Ramana

submission deadline 20 Jun 2026 | 10 articles | Viewed by 17739 | Submission Open

Keywords: inflammation; oxidative stress; cytokines; autoimmune diseases; infectious diseases; cancer; targeted therapies; molecular pathways; asthma; sepsis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Neurodegenerative Diseases and Inflammation: Pathogenesis, Biomarkers and Treatments

edited by

Luisa Agnello

and Anna Maria Ciaccio

submission deadline 20 Jun 2026 | 3 articles | Viewed by 9043 | Submission Open

Keywords: neurodegeneration; inflammation; biomarkers; Alzheimer’ s disease; molecular mechanism; pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Myocardial Disease: Molecular Pathology and Treatments

edited by

Kazufumi Nakamura

submission deadline 20 Jun 2026 | 3 articles | Viewed by 8552 | Submission Open

Keywords: hypertrophic cardiomyopathy; dilated cardiomyopathy; arrhythmogenic right ventricular cardiomyopathy; amyloidosis; myocarditis; sarcoidosis; genetic abnormalities; immune mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanism of Acute Myeloid Leukemia

edited by

Walter Fiedler

submission deadline 20 Jun 2026 | 4 articles | Viewed by 8417 | Submission Open

Keywords: leukemia; cytokine; signal transduction; apoptosis; immune therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Skin Diseases: 3rd Edition

edited by

Naoko Kanda

submission deadline 20 Jun 2026 | 3 articles | Viewed by 7819 | Submission Open

Keywords: infection; inflammation; molecular; neoplasm; pathogenesis; skin diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role and Application of Stem Cells in Regenerative Medicine (Volume 5)

edited by

Oriana Trubiani

Francesca Diomede

and

Jacopo Pizzicannella

submission deadline 20 Jun 2026 | 2 articles | Viewed by 6430 | Submission Open

Keywords: mesenchymal stem cells; tissue regeneration; regenerative medicine; immunomodulatory process

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Cardiac Disease

edited by

Daniela Rossin

submission deadline 20 Jun 2026 | 2 articles | Viewed by 6189 | Submission Open

Keywords: innovative cardiac research; multidisciplinary cardiovascular approaches; advances in cardio-vascular diagnosis; novel cardiac therapies; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Products and Synthetic Compounds for Drug Development: 3rd Edition

edited by

Guan-Jhong Huang

submission deadline 20 Jun 2026 | 4 articles | Viewed by 5884 | Submission Open

Keywords: reactive oxygen; anti-inflammation; cancer; infectious diseases; liver diseases; lung disease; kidney disease; cardiac disease; neuro disease

(This special issue belongs to the Section Molecular Pharmacology)

Deciphering Molecular Complexity of Pancreatic Cancer

edited by

Dimitrios H. Roukos

submission deadline 20 Jun 2026 | 3 articles | Viewed by 5883 | Submission Open

Keywords: pancreatic cancer; intratumor heterogeneity; bulk and single-cell multiomics; tumor microenvironment; cancer immunotherapy; targeted therapy

(This special issue belongs to the Section Molecular Oncology)

Molecular Biology of Soybean

edited by Zhengjun Xia

submission deadline 20 Jun 2026 | 6 articles | Viewed by 5611 | Submission Open

Keywords: soybean; growth and development; disease resistance; nodulation; nolecular mechanism; plant interaction

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research and Potential Effects of Medicinal Plants

edited by

Guan-Jhong Huang

submission deadline 20 Jun 2026 | 4 articles | Viewed by 5572 | Submission Open

Keywords: medicinal plants; natural products; disease treatment; drug screening; bioassays

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Micro- and Nanomaterials for Biomedical Applications

edited by

Silvana Alfei

submission deadline 20 Jun 2026 | 2 articles | Viewed by 5285 | Submission Open

Keywords: biomaterials; medical applications; natural and synthetic polymers; tissue engineering; hydrogels; bone cement; drug delivery systems; dendrimers; micro- and nanocomposites; nanotechnology; bioceramics; biopharmaceutics; biosensing

(This special issue belongs to the Section Molecular Nanoscience)

Tissue Engineering Related Biomaterials: Progress and Challenges

edited by

Mihaela Violeta Ghica

Lacramioara Popa

and Cristina Elena Dinu-Pirvu

submission deadline 20 Jun 2026 | 2 articles | Viewed by 4741 | Submission Open

Keywords: biomaterials; tissue engineering; scaffold materials; regenerative medicine; cell– material interactions; tissue regeneration; bioactive materials; nanotechnology in tissue engineering; electrospinning; 3D printing; biodegradable materials; growth factors

(This special issue belongs to the Section Materials Science)

Editorial Board Members’ Collection Series: “Protein Biophysics”

edited by

Vladimir N. Uversky

and

Assaf Friedler

submission deadline 20 Jun 2026 | 2 articles | Viewed by 4658 | Submission Open

Keywords: protein structure and prediction; protein biophysics; protein dynamics; peptide and protein aggregation; protein misfolding; protein folding; protein stability; protein function; posttranslational modifications; intrinsically disordered proteins; protein– ligand interactions; protein– protein interactions; protein– nucleic acid interactions; membrane proteins; liquid– liquid phase separation

(This special issue belongs to the Section Molecular Biophysics)

Therapeutic Potential of Antioxidants in the Prevention of Human Diseases, 2nd Edition

edited by

Kota V. Ramana

submission deadline 20 Jun 2026 | 2 articles | Viewed by 4604 | Submission Open

Keywords: antioxidants; vitamins; inflammation; cancer; neurological complications; diabetes; flavonoids; natural compounds; cancer; infections; COVID-19

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Radiation-Induced DNA Damage and Toxicity

edited by

Mohammad Asif Sherwani

and

Muhammad Maqbool

submission deadline 20 Jun 2026 | 3 articles | Viewed by 4590 | Submission Open

Keywords: radiation; DNA damage; toxicity; immune response

(This special issue belongs to the Section Molecular Biology)

Glycoconjugates: From Structure to Therapeutic Application

edited by Rosana Ribić

submission deadline 20 Jun 2026 | 4 articles | Viewed by 3928 | Submission Open

Keywords: glycoconjugates (glycoproteins and glycopeptides; glycolipids; proteoglycans); glyconanoparticles; carbohydrate-based therapeutics; glycomics; glycosylation; glycoengineering; glycobiology; synthesis of glycoconjugates; vaccine development; drug delivery; biomarkers; diagnostics; immunotherapy; regenerative medicine; therapeutic applications

(This special issue belongs to the Section Molecular Pharmacology)

Displaying special issue 3101-3150 on page 63 of 66.

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