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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Hormone Replacement Therapy

edited by

Marco Antonio Botelho

and

Raouf A. Khalil

submission deadline 31 Aug 2026 | 3 articles | Viewed by 39075

Keywords: hormone replacement therapy; molecular insights; endocrine signaling; precision medicine; gene expression; epigenetics; non-coding RNAs; personalized regimens

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Dopamine, Histamine, Serotonin—Receptors, Ligands and Their Biological Role in Central Nervous System Diseases, 2nd Edition

edited by

Dorota Łażewska

and

Anna Stasiak

submission deadline 31 Aug 2026 | 6 articles | Viewed by 21904

Keywords: biogenic amines (histamine, dopamine, serotonin); receptors; ligands; antagonist/inverse agonist; affinity; intrinsic activity; multitarget ligands; molecular modeling; CNS diseases; neurodegeneration; psychiatric disorders; pain; in vitro studies; in silico studies; in vivo studies

(This special issue belongs to the Section Molecular Neurobiology)

Novel Biomarkers and Emerging Therapeutic Targets for Breast and Gynecologic Cancers

edited by

Hisham Bahmad

submission deadline 31 Aug 2026 | 11 articles | Viewed by 18051

Keywords: cancer; uterus; cervix; breast; ovary; endometrial cancer; ovarian cancer; cervical cancer; breast cancer; biomarkers; therapeutic target; personalized medicine; targeted therapy; molecular signatures; diagnosis; prognosis

(This special issue belongs to the Section Molecular Oncology)

Skin Microbiome and Skin Health: Molecular Interactions

edited by

Terenzio Cosio

submission deadline 31 Aug 2026 | 4 articles | Viewed by 14977

Keywords: skin microbiota; human disease; human health; omics; microbiota–host interactions; microbiota manipulation; microbiota; virota; inflammatory diseases; dysbiosis

(This special issue belongs to the Section Molecular Immunology)

Neuroinflammation and Cellular Senescence in Brain Aging and Neurodegeneration: From Molecular Mechanisms to Therapeutic Applications

edited by Jordi Olloquequi and M. Emília Juan

submission deadline 31 Aug 2026 | 3 articles | Viewed by 10747

Keywords: SASP; glial activation; age-related disorders; neurotherapeutics; molecular signaling

(This special issue belongs to the Section Molecular Neurobiology)

Exploring the Genetics in Rare Diseases: A Genomic Odyssey

edited by

Klaus Brusgaard

submission deadline 31 Aug 2026 | 3 articles | Viewed by 6419

Keywords: novel discoveries in rare disorders; polygenic risk scores; mosaicism; protein interaction; tools utilized to engineer DNA; somatic variants; patient advocacy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Anti-Inflammatory Strategies and Cell Models for Alzheimer’s Disease

edited by Sophia Lavrentiadou

submission deadline 31 Aug 2026 | 1 articles | Viewed by 4275

Keywords: Alzheimer’s disease; neuroinflammation; anti-inflammatory strategies; cell models

(This special issue belongs to the Section Molecular Neurobiology)

Algae-Derived Bioactives: Key Molecular Interactions Govern High-Value Applications

edited by Evan Stephens and Kirsten Heimann

submission deadline 31 Aug 2026 | 4 articles | Viewed by 4219

Keywords: microalgae; macroalgae; cyanobacteria; bioactive compounds; health and nutrition; algal food products; market analysis

(This special issue belongs to the Section Molecular Microbiology)

Genetic and Epigenetic Regulation of Ageing

edited by Hidekazu Yamada

submission deadline 31 Aug 2026 | 1 articles | Viewed by 3711

Keywords: epigenetic clocks; biological resilience; DNA methylation; chromatin architecture; multi-omics integration; geroscience; cellular reprogramming; longevity interventions; immunosenescence; precision medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Ruminant Physiology: Digestion, Metabolism, and Endocrine System

edited by Rui Hu

submission deadline 31 Aug 2026 | 2 articles | Viewed by 3434

Keywords: ruminant physiology; digestive health; metabolic regulation; endocrine signaling; rumen microbiome; nutrient partitioning; methane mitigation; epigenetic modulation; nutritional stress adaptation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Sjogren's Disease: Multidimensional Perspectives on Pathogenesis, Clinical Manifestations, and Therapeutic Advancements (2nd Edition)

edited by

Xiang Lin

submission deadline 31 Aug 2026 | 5 articles | Viewed by 2930

Keywords: Sjögren's disease; diagnosis; therapeutics; bioinformatics; pre-clinical; cytokine; lymphocytes; autoantibodies; exocrine glands

(This special issue belongs to the Section Molecular Immunology)

Exploring Melatonin and Related Indolic Agents

edited by

Burkhard Poeggeler

submission deadline 31 Aug 2026 | 3 articles | Viewed by 2823

Keywords: aging; antioxidant; bioenergetic agent; biological clock; immunomodulation; indole-3-propionic acid; indole-3-propionamide; melatonin; senescence; tryptophan

(This special issue belongs to the Section Molecular Pharmacology)

Role of Integrins in Cytokine Signaling

edited by

Yoshikazu Takada

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2388

Keywords: integrins; cytokines; FGF1; CX3CL1; ternary-complex; antagonist; inside-out signaling; integrin-binding motif; cytokine-integrin crosstalk; ligand-induced activation

(This special issue belongs to the Section Molecular Biology)

Nutrition, Inflammation and Chronic Kidney Diseases

edited by

Rodolfo A. Valtuille

submission deadline 31 Aug 2026 | 3 articles | Viewed by 2322

Keywords: chronic kidney disease; nutrition; inflammation; bioimpedance; gut-kidney axis; uremic toxins; oxidative stress; protein-energy wasting; precision nutrition; biomarkers

(This special issue belongs to the Section Molecular Immunology)

DNA Methylation Dynamics Due to Environmental Factors and in Human Diseases

edited by

Naila Francis Paulo De Oliveira

and

José Maria Chagas Viana Filho

submission deadline 31 Aug 2026 | 3 articles | Viewed by 2286

Keywords: inflammatory diseases; mental diseases; tumour diseases; epidrugs; exposure biomarkers; epigenetic drugs

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in the Molecular Diagnosis and Treatment of Neurodegenerative Diseases

edited by

Bruno Manadas

submission deadline 31 Aug 2026 | 1 articles | Viewed by 2235

Keywords: neurodegenerative disorders; biomarkers; treatment; omics; systems biology

(This special issue belongs to the Section Molecular Neurobiology)

Techniques and Applications of Forensic Molecular Biology: From Pathology to Clinical Practice

edited by

Angelo Montana

submission deadline 31 Aug 2026 | 1 articles | Viewed by 2217

Keywords: biomarkers; immunohistochemistry; histopathology; forensic pathology; forensic toxicology; forensic biomarkers; toxicological biomarkers; neuropathology; mRNA; post-mortem interval; cerebral damage; in vitro, in vivo, and in silico models; hypoxic–ischemic brain injury; pregnancy biomarkers; vitality

(This special issue belongs to the Section Molecular Biology)

The Toxicity of Bisphenol A and Its Analogs

edited by

Krystyna Makowska

submission deadline 31 Aug 2026 | 1 articles | Viewed by 2186

Keywords: bisphenols; endocrine disruptors; bisphenol A and analogs; toxicology

(This special issue belongs to the Section Molecular Toxicology)

Molecular and Cellular Mechanisms of Vaccine-Induced Immune Responses

edited by In Ohk Ouh

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2010

Keywords: vaccine platforms; molecular mechanisms; innate immune sensing; adaptive immune responses; adjuvants and signaling pathways; antigen processing and presentation; immunological memory; systems immunology

(This special issue belongs to the Section Molecular Immunology)

Hydrogen Medicine: From Molecular Insights to Disease Intervention

edited by

Fei Xie

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1999

Keywords: hydrogen medicine; molecular hydrogen; oxidative stress; inflammation; mitochondrial function; gasotransmitters; ischemia–reperfusion injury; clinical trials; signal transduction; bioinformatics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Intermittent Hypoxia and Physiological Effects: Interplay Between Oxidative Stress, Inflammation, and Autonomic Dysregulation

edited by

Rodrigo L. Castillo

and

Esteban G. Figueroa

submission deadline 31 Aug 2026 | 3 articles | Viewed by 1957

Keywords: intermittent hypoxia; cardiovascular and pulmonary effects; oxidative stress; autonomic dysfunction; neuroinflammation; renal effects; animal models

(This special issue belongs to the Section Molecular Biology)

Molecular Targets and Toxic Interactomes of Pathogenic Proteins in Neurodegeneration

edited by

Kohji Fukunaga

and Ichiro Kawahata

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1886

Keywords: neurodegenerative diseases; tau protein; TDP-43; α-synuclein; endoplasmic reticulum stress; mitochondrial toxicity; liquid–liquid phase separation; toxic Interactomes

(This special issue belongs to the Section Molecular Neurobiology)

Degradable Polymers: Synthesis, Applications, and Environmental Impact

edited by Ce Sun and

Haiyang Gao

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1798

Keywords: degradable polymer; synthesis; degradation mechanisms; sustainability

(This special issue belongs to the Section Macromolecules)

Feature Papers in ‘Physical Chemistry and Chemical Physics’: Fifth Edition

edited by

Dongho Kim

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1713

Keywords: heterogeneous structures; alignment and surface phenomena; quantum theory; mathematical physics; statistical and classical mechanics; molecular structure; chemical kinetics; laser physics; dynamics; kinetics; photochemistry; spectroscopy; exciton dynamics; statistical mechanics; thermodynamics; electrochemistry; catalysis; surface science; quantum mechanics; theoretical developments; fundamental aspects of catalysis; solar energy conversion; polymer dynamics

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Advances in Vascular Function, Senescence and Remodeling: A New Direction for Therapeutic Approach to Prevent CVDs

edited by

Gautham Yepuri

submission deadline 31 Aug 2026 | 3 articles | Viewed by 1635

Keywords: vascular dysfunction; senescence; endothelial cells; small molecules; anti-aging; cardiovascular diseases; sudden death

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Non-Coding RNAs in Human Research

edited by

Jesús Adrián López

submission deadline 31 Aug 2026 | 4 articles | Viewed by 1631

Keywords: microRNAs; lncRNAs; mRNA regulation; cell signaling pathways; RNA methylation; RNA phosphorylation; RNA deamidation; cell communication; chemoresistance; RNA inhibitors or activators

(This special issue belongs to the Section Molecular Genetics and Genomics)

Programmed Cell Death and Oxidative Stress: 4th Edition

edited by

Takuya Noguchi

submission deadline 31 Aug 2026 | 3 articles | Viewed by 1563

Keywords: oxidative stress; programmed cell death; cellular stresses; senescence; cytotoxicity; cancer; neurodegenerative disease; inflammatory disease; organelle stress

(This special issue belongs to the Section Biochemistry)

Metabolic Sensing and Adaptive Stress Responses in Aging and Chronic Disease

edited by Mark Slevin

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1540

Keywords: metabolic sensing; aging and healthspan; exercise physiology; AMPK–mTOR signaling; autophagy and mitophagy; redox biology; mitochondrial quality control; cellular stress adaptation; chronic disease prevention; inflammaging

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Metabolic Bone Disorders

edited by

Harish K. Datta

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1495

Keywords: metabolic bone disease; bone cells; rare diseases; genetics; molecular biology; skeletal development disorders

(This special issue belongs to the Section Molecular Biology)

Immune Regulatory Mechanisms in the Pathogenesis of Autoimmunity

edited by

Elias Toubi

and

Vadasz Zahava

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1437

Keywords: immune regulation; soluble regulatory molecules; autoimmunity

(This special issue belongs to the Section Molecular Immunology)

Molecular and Nanostructured Materials for Energy, Environmental, and Biomedical Applications

edited by

Balaji Murugan

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1245

Keywords: advanced sustainable materials; molecular engineering; energy conversion and storage (supercapacitor, solar cells, and batteries); electrocatalysis and photocatalysis; environmental remediation; biomedical applications; bio/electrochemical sensing and bioelectronics; molecular surface structure and interface chemistry; in situ/operando spectroscopy

(This special issue belongs to the Section Molecular Nanoscience)

Advanced Optical Imaging and Spectroscopy: Bridging Technical Innovation and Molecular Insights in Biomedicine

edited by Kanwarpal Singh and Sharma Gargi

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1229

Keywords: optical imaging; biomedical spectroscopy; multimodal imaging; molecular imaging; label-free diagnostics; photonic instrumentation; in vivo imaging; computational imaging

(This special issue belongs to the Section Molecular Biophysics)

Molecular Imprinting Technologies for Biological and Biomedical Applications

edited by

Urtė Prentice

and

Simonas Ramanavičius

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1185

Keywords: molecularly imprinted polymers; biosensors and diagnostics; biomolecular recognition; molecular imprinting; nanomaterials; molecular biology applications

(This special issue belongs to the Section Molecular Informatics)

Molecular Mechanisms of Endothelial Dysfunction, Fifth Edition

edited by

Catherine Davis

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1135

Keywords: vascular permeability; atherosclerosis; blood–brain barrier; endothelial adhesion molecules; vasodilation; thrombosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Research Trends on Enzyme Structure, Dynamics, and Mechanisms of Action

edited by

Amarendra Nath Maity

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1072

Keywords: enzyme mechanism; enzyme dynamics; metalloenzymes; cofactor; X-ray crystallography; cryo-electron microscopy; QM/MM; DFT; EPR; drug target

(This special issue belongs to the Section Biochemistry)

Global Challenges in Fungal Diseases: Pathogenesis, Host Interactions, and Novel Antifungal Approaches

edited by Samir Jawhara

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1064

Keywords: Candida species; Aspergillus spp.; Mucorales; Fusarium spp.; multidrug-resistant fungi; immune response; opportunistic mycoses; host–pathogen interactions fungal cell wall glycans anti-fungal drugs

(This special issue belongs to the Section Molecular Microbiology)

Bacterial–Host Interactions: Molecular Mechanisms Governing Mutualism and Pathogenicity

edited by

Charles Viau

submission deadline 31 Aug 2026 | 1 articles | Viewed by 866

Keywords: bacterial–host interactions; bacteria; host; host–microbe

(This special issue belongs to the Section Molecular Microbiology)

New Insights in Microalgae and Cyanobacteria-Derived Bioactive Compounds

edited by

Tarik Aanniz

submission deadline 31 Aug 2026 | 1 articles | Viewed by 827

Keywords: microalgal bioactive compounds; cyanobacterial bioactive compounds; mechanisms of action; structure–activity relationship; antimicrobial activity; anti-inflammatory agents; anticancer compounds; neuroprotective agents; nutraceuticals; therapeutic applications; biotechnological production

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Gut Microbiota and Host Immune Interactions in Inflammatory Diseases

edited by

Tomomi Kuwahara

submission deadline 31 Aug 2026 | 1 articles | Viewed by 795

Keywords: gut microbiota; host–microbe interactions; innate and adaptive immunity; microbial metabolites; short-chain fatty acids; intestinal dysbiosis; inflammatory bowel disease (IBD); metabolic syndrome; autoimmune diseases; gut–organ axis; microbiome-targeted therapies

(This special issue belongs to the Section Molecular Microbiology)

Molecular Neuropathology of Alzheimer’s Disease: Tau, Amyloid-β, and Novel Protein Associations

edited by

José Luna-Muñoz

and Alejandra Morlett-Paredes

submission deadline 31 Aug 2026 | Viewed by 737

Keywords: tauopathies and protein aggregation; amyloid beta and neurotoxicity; emerging proteins in neurodegeneration; molecular and morphological biomarkers; innovative therapies and experimental targets; artificial intelligence and neuropathological analysis

(This special issue belongs to the Section Molecular Neurobiology)

Lipid Metabolism in Aging and Diseases: From Mechanisms to Therapy

edited by

Dominique Delmas

submission deadline 31 Aug 2026 | 1 articles | Viewed by 725

Keywords: lipid metabolism; degenerative diseases; cardiovascular pathologies; neurodegeneration; inflammation; autoimmunity; cancer; lipid droplets; bioactive molecules; drug repositioning; oxidative stress; mitochondrial dysfunction; inflammatory processes

(This special issue belongs to the Section Biochemistry)

Effects of Diet and Nutrients on Prediabetes/Diabetes

edited by Flavio Francini and Luis Flores

submission deadline 31 Aug 2026 | Viewed by 723

Keywords: diabetes; prediabetes; insulin resistance; hyperglycemia; diet; dietary patterns; nutrients; molecular biology; pharmacology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Metabolomics Research of Environmental Stress in Plants

edited by

Manish Kumar Patel

and Sonika Pandey

submission deadline 31 Aug 2026 | Viewed by 706

Keywords: agricultural applications of primary and secondary metabolite;; crop improvement; integration of metabolomics with genomics and transcriptomics; medicinal plants; natural products in agriculture; plant metabolomics; plant biochemistry; primary metabolites; secondary metabolites; tools and techniques of plant metabolites in agriculture research

(This special issue belongs to the Section Molecular Plant Sciences)

Chimeric Antigen Receptors Against Cancers and Autoimmune Diseases: 2nd Edition

edited by

Niels Schaft

submission deadline 31 Aug 2026 | 1 articles | Viewed by 624

Keywords: chimeric antigen receptor (CAR); cancer; autoimmune disease; solid tumor; effector cell; CAR format; CAR transfer; tumor microenvironment; targeted antigen

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms and Advanced Diagnostic Technologies in Hair Disorders

edited by Maria Fernanda Reis Gavazzoni-Dias

submission deadline 31 Aug 2026 | 1 articles | Viewed by 617

Keywords: inflammatory hair disorders; scarring and non-scarring alopecias; trichoscopy and scalp pathology; immunologic mechanisms in hair loss

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Extracts and Bioactive Molecules with Potential Benefits for Human Health—2nd Edition

edited by

Violeta Popovici

and

Cerasela Elena Gîrd

submission deadline 31 Aug 2026 | 1 articles | Viewed by 611

Keywords: medicinal plants; plant extracts; bioactive phytocompound identification and quantification; pharmacological activity; health benefits; phytotherapy; plant-based diet; functional foods

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Periodontitis: From Cellular Mechanism to Therapy

edited by Mahmoud Elashiry

submission deadline 31 Aug 2026 | Viewed by 570

Keywords: periodontitis; inflammatory bone disease; host–microbe interactions; innate and adaptive immunity; osteoimmunology; cellular signaling; immune dysregulation; tissue destruction; translational therapy; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring the New Cancer Biomarkers: Progress and Prospects

edited by

Marcelo José Barbosa Silva

submission deadline 31 Aug 2026 | Viewed by 555

Keywords: prevention; diagnostic; prognostic; response; liquid biopsy; image biomarkers; clinicopathological biomarkers

(This special issue belongs to the Section Molecular Oncology)

Current Advances and Challenges in Nanomedicine Delivery Systems

edited by

Shiyan Dong

submission deadline 31 Aug 2026 | 1 articles | Viewed by 545

Keywords: nanomedicine; drug delivery; gene delivery; mRNA delivery; lipid nanoparticles (LNPs); liposomes; extracellular vesicles; biomimetic nanocarriers; targeted delivery; translational nanomedicine

(This special issue belongs to the Section Molecular Nanoscience)

Cell Penetrating Peptides: Novel Therapeutic Tools for Drug Delivery

edited by

Betty Revon Liu

submission deadline 31 Aug 2026 | Viewed by 468

Keywords: cell-penetrating peptides; peptide design; drug delivery; controlled and release; clinical applica-tions; penetration mechanisms

(This special issue belongs to the Section Molecular Pharmacology)

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