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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms Underlying the Pathogenesis of Genetic Diseases

edited by

Debora Baroni

submission deadline 10 Sep 2026 | 7 articles | Viewed by 11793 | Submission Open

Keywords: genetic diseases; genotype–phenotype correlations; multi-omics approaches; current and investigational therapeutical approaches; personalized medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Cellular and Molecular Progression of Cardiovascular Diseases: 2nd Edition

edited by

Andrea Borghini

Antonio Rizza

and

Alessandro Tonacci

submission deadline 10 Sep 2026 | 5 articles | Viewed by 4471 | Submission Open

Keywords: cardiovascular diseases; multi-omics data; biomarkers; molecular level

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exercise in Health and Diseases: From the Molecular Perspectives

edited by

Nathalia Bernardes

and Danielle Dias

submission deadline 10 Sep 2026 | 4 articles | Viewed by 3690 | Submission Open

Keywords: exercise physiology; molecular mechanisms of exercise; exercise-induced cellular signaling; metabolic signaling pathways; redox biology and exercise

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Properties and Applications of Nanoparticles and Nanomaterials: 4th Edition

edited by Xiaogang Li

submission deadline 10 Sep 2026 | 1 articles | Viewed by 1078 | Submission Open

Keywords: nanostructures; nanoparticles; microstructure characterization; material design; evaluation of mechanical properties; applications of nanomaterials

(This special issue belongs to the Section Molecular Nanoscience)

Nanomaterials for Targeted Therapy and Drug Delivery

edited by Ceren Kimna

submission deadline 10 Sep 2026 | Viewed by 366 | Submission Open

Keywords: nanocarriers ; targeted therapies ; translational nanomedicine ; nano-bio interactions

(This special issue belongs to the Section Molecular Nanoscience)

Pain: From Bench to Bedside

edited by

Christopher Robinson

and Robert J. Yong

submission deadline 20 Sep 2026 | 1 articles | Viewed by 56151 | Submission Open

Keywords: CGRP pathway; chronic pain; drug discovery; ion channels; machine learning; molecular targets; neuroimmune signaling; non-opioid analgesics; translational pain research; Afrikaans; Albanian; Amharic; Arabic; Armenian; Azerbaijani; Bengali; Bulgarian; Catalan; Croatian; Czech; Danish; Dutch; English; Estonian; Finnish; French; German; Greek; Gujarati; Haitian Creole; Hebrew; Hindi; Hungarian; Icelandic; Indonesian; Italian; Japanese; Kannada; Kazakh; Khmer; Korean; Kurdish (Kurmanji); Lao; Latvian; Lithuanian; Malagasy; Malay; Malayalam; Maltese; Maori; Marathi; Myanmar (Burmese); Nepali; Norwegian; Pashto; Persian; Polish; Portuguese; Punjabi; Romanian; Russian; Samoan; Simplified Chinese; Slovak; Slovenian; Spanish; Swedish; Tamil; Telugu; Thai; Traditional Chinese; Turkish; Ukrainian; Urdu; Vietnamese; Welsh

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Autoimmune Diseases: From Pathogenesis to Treatment and Prognostic Markers

edited by Alessandra Bettiol

submission deadline 20 Sep 2026 | 13 articles | Viewed by 44436 | Submission Open

Keywords: autoimmune diseases; inflammation; immunity; pathogenesis; immunosuppressants; biologics; biomarkers

(This special issue belongs to the Section Molecular Immunology)

Drug Delivery to the Central Nervous System: From Design, Synthesis, and Evaluation

edited by

Masaru Tanaka

submission deadline 20 Sep 2026 | 6 articles | Viewed by 40504 | Submission Open

Keywords: central nervous system; central nervous system diseases; drug delivery systems; blood–brain barrier; blood–cerebrospinal fluid barrier; drug design; nanomedicine; neuropharmacology; neuroprotective agents; biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

Plant Metabolomics: Uncovering the Hidden World of Plant Secondary Metabolites

edited by

Jen-Tsung Chen

submission deadline 20 Sep 2026 | 14 articles | Viewed by 33445 | Submission Open

Keywords: metabolomics; secondary metabolites; plant biochemistry; mass spectrometry; NMR spectroscopy; plant signaling pathways; natural products; chemical ecology; metabolic profiling; phytochemicals; medicinal plants; herbal medicines

(This special issue belongs to the Section Molecular Plant Sciences)

New Insights in Antibody Therapy

edited by

Loredana Frasca

submission deadline 20 Sep 2026 | 4 articles | Viewed by 20351 | Submission Open

Keywords: biological therapy; antibody therapy; non-communicable diseases; infectious diseases; chronic disease

(This special issue belongs to the Section Molecular Immunology)

Type 2 Diabetes: Molecular Pathophysiology and Treatment

edited by

Edit Szabó

submission deadline 20 Sep 2026 | 7 articles | Viewed by 19579 | Submission Open

Keywords: type 2 diabetes mellitus and comorbidity; bioinformatics; molecular pathways; genetic background; biomarkers; novel therapies

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Understanding Aging in Health and Disease

edited by

Laura Cianfruglia

submission deadline 20 Sep 2026 | 6 articles | Viewed by 17412 | Submission Open

Keywords: immunosenescence; age-related disease; ageing; oxidative stress; inflammaging

(This special issue belongs to the Section Molecular Biology)

Renin-Angiotensin System in Health and Diseases

edited by

Keiko Hosohata

submission deadline 20 Sep 2026 | 3 articles | Viewed by 17266 | Submission Open

Keywords: coronavirus disease 2019 (COVID-19); SARS-CoV-2; RAAS; spike protein; angiotensin; ACE2; clinical study; basic experiments

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neurological Diseases: From Pathogenesis to Molecular Diagnosis and Treatment

edited by

Barbara Miziak

and

Stanisław Jerzy Czuczwar

submission deadline 20 Sep 2026 | 13 articles | Viewed by 16562 | Submission Open

Keywords: Alzheimer's disease; Parkinson's disease; Huntington's disease; epilepsy; stroke; neurological diseases; treatment of neurological diseases

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Burn Wound Healing and Skin Regeneration: Innovations and Insights

edited by

H. Ibrahim Korkmaz

submission deadline 20 Sep 2026 | 2 articles | Viewed by 16075 | Submission Open

Keywords: burn wound healing; skin regeneration; novel biomaterials; wound dressings; regenerative therapies

(This special issue belongs to the Section Biochemistry)

25th Anniversary of IJMS: Advances in Physical Chemistry and Chemical Physics

edited by

Mihai V. Putz

Hyotcherl Ihee

and

Carlos Miguel Costa

submission deadline 20 Sep 2026 | 15 articles | Viewed by 15549 | Submission Open

Keywords: molecular dynamics; quantum chemistry; spectroscopic techniques; supramolecular interactions; computational modeling; AI in chemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Research of Dystonia and Parkinson’s Disease

edited by

Ryoma Morigaki

submission deadline 20 Sep 2026 | 4 articles | Viewed by 14767 | Submission Open

Keywords: dystonia; Parkinson’s disease; molecular mechanism; molecular pathology; cell biology; genetic predisposition to disease; physiopathology; neural plasticity; animal models; biomedical translational science

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Latest Advances in Diabetes Research and Practice

edited by Ezekiel Uba Nwose

submission deadline 20 Sep 2026 | 9 articles | Viewed by 14306 | Submission Open

Keywords: diabetes mellitus; cardiovascular risk; metabolic syndrome; antioxidants; oxidative stress; antiplatelet monitoring; evidence-based medicine; laboratory medicine

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Computer-Aided Drug Design Strategies

edited by

Alexandre G. De Brevern

submission deadline 20 Sep 2026 | 3 articles | Viewed by 14105 | Submission Open

Keywords: computer-aided drug design; artificial intelligence in drug discovery; molecular docking; molecular dynamics simulations; macromolecular systems; quantum mechanics/molecular mechanics (QM/MM); big data analytics in drug development; pharmacokinetics optimization; structure-based drug design (SBDD); ligand-based drug design; virtual screening techniques

(This special issue belongs to the Section Molecular Informatics)

Antibody Engineering and Therapeutic Applications

edited by

Yong-Seok Heo

submission deadline 20 Sep 2026 | 4 articles | Viewed by 13981 | Submission Open

Keywords: monoclonal antibody (mAb) therapies; antibody engineering; antibody-drug conjugate (ADC); chimeric antigen receptor T cell (CAR-T); bispecific antibody; T-cell engager (TCE); cancer immunotherapy; immunocytokine; AI-driven antibody design; antibody structure and mechanism of action

(This special issue belongs to the Section Molecular Pharmacology)

Inner Ear Disorders: From Molecular Mechanisms to Treatment

edited by

Srdjan Vlajkovic

submission deadline 20 Sep 2026 | 5 articles | Viewed by 13832 | Submission Open

Keywords: hearing loss; balance disorders; stem cell approaches; precision gene therapy; molecular reprogramming; targeted delivery systems; molecular biomarkers; suppression of oxidative stress and inflammation; tissue engineering; immune response and off-target effects

(This special issue belongs to the Section Molecular Immunology)

Cancer Drug Treatment and Cancer Cell Drug Resistance

edited by

Juan Sebastian Yakisich

submission deadline 20 Sep 2026 | 3 articles | Viewed by 13828 | Submission Open

Keywords: cellular plasticity; heterogeneity; combinational chemotherapy; metastasis; tumor relapse; novel targets; drug delivery

(This special issue belongs to the Section Molecular Pharmacology)

Advances in the Genetics, Epidemiology and Management of Myopathies

edited by

Efthimios Dardiotis

and

Vasileios Siokas

submission deadline 20 Sep 2026 | 2 articles | Viewed by 13719 | Submission Open

Keywords: myopathies; muscle disorders; muscle weakness; muscle pain; myalgia

(This special issue belongs to the Section Molecular Biology)

Progression of Multiple Sclerosis: Environmental Factors, Genetics, Therapeutics and Immunopathogenesis

edited by Alberto Gajofatto

submission deadline 20 Sep 2026 | 5 articles | Viewed by 13688 | Submission Open

Keywords: multiple sclerosis; disability progression; neurodegeneration; pathogenesis; immunology; risk factor; environment; genetics; treatment

(This special issue belongs to the Section Molecular Neurobiology)

Inflammation in Pregnancy and Childbirth

edited by

Małgorzata Szczuko

and Maciej Ziętek

submission deadline 20 Sep 2026 | 3 articles | Viewed by 13688 | Submission Open

Keywords: pregnancy; labor; eicosanoid; chronic inflammation; cytokines; intestinal dysbiosis; mitogen-activated protein kinase; nuclear factor kappa-light-enhancer-activated B cell; maresins, resolvins and protectins

(This special issue belongs to the Section Molecular Immunology)

Inflammation in Chronic Disease: Molecular Mechanisms and Signaling Pathways

edited by

Nadia Lampiasi

submission deadline 20 Sep 2026 | 4 articles | Viewed by 13386 | Submission Open

Keywords: inflammation; neuroinflammation; immune response; inflammation-associated disease; inflammation mediators (proteins, enzymes, ecc); cytokines; macrophages; mast cells; monocytes; dendritic cells; oxidative stress; signaling pathways

(This special issue belongs to the Section Molecular Immunology)

Identification of Novel Biomarkers Towards Improved Diagnosis and Management of Peripheral Vascular Diseases

edited by

Daniel P. Zalewski

submission deadline 20 Sep 2026 | 7 articles | Viewed by 12935 | Submission Open

Keywords: vascular pathophysiology; peripheral atherosclerosis; aneurysm; venous disorders; congenital vascular malformations; molecular biomarkers; diagnostic biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Elucidating How Chondrocytes Maintain Cartilage Stability

edited by James A. Martin

submission deadline 20 Sep 2026 | 7 articles | Viewed by 12247 | Submission Open

Keywords: chondrocytes; articular cartilage; chondrogenesis; osteoarthritis; mechano-transduction; aging; extracellular matrix

(This special issue belongs to the Section Molecular Biology)

Parkinson’s Disease and Related Diseases: Mechanisms, Genetic Factors and Treatments

edited by

Stergios Boussios

submission deadline 20 Sep 2026 | 5 articles | Viewed by 12219 | Submission Open

Keywords: Parkinson’s disease; neurodegenerative disorders; α-synuclein aggregation; neuroinflammation; gene therapy; biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

Artificial Intelligence and Computer-Aided Design: Molecular Simulation Technology in Exploring Bioactive Compounds for Health Promotion

edited by

Baojun Xu

submission deadline 20 Sep 2026 | 4 articles | Viewed by 11552 | Submission Open

Keywords: molecular simulation; bioactive compounds; molecular docking; molecular dynamics; quantum mechanics; functional mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Structures, Syntheses of Natural Products, and Their Biological Effects

edited by

Ran Jia

submission deadline 20 Sep 2026 | 4 articles | Viewed by 11263 | Submission Open

Keywords: structures of natural products; syntheses; biological effects; biomedical applications

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms, Pathogenesis, and Novel Therapeutic Strategies in Cardiovascular Disease, 2nd Edition

edited by

Dai Yamanouchi

submission deadline 20 Sep 2026 | 3 articles | Viewed by 11104 | Submission Open

Keywords: aneurysm pathobiology; vascular remodeling; extracellular matrix degradation; inflammatory signaling pathways; molecular targets for therapy; autophagy; macrophage; inflammation; immune cell regulation; age-related diseases; therapeutic implications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Thyroid Function in Human Diseases: From Physiopathology to Clinical Impact on Human Health

edited by

Rosa Maria Paragliola

and Andrea Corsello

submission deadline 20 Sep 2026 | 5 articles | Viewed by 10970 | Submission Open

Keywords: thyroid physiology; hypothyroidism; hyperthyroidism; central hypothyroidism; inappropriate TSH secretion syndrome; drugs interfering with thyroid function; sick euthyroid syndrome; consumptive hypothyroidism syndrome

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of the Aging Process: 2nd Edition

edited by

Giuseppe Coppotelli

and

Jaime M. Ross

submission deadline 20 Sep 2026 | 2 articles | Viewed by 10918 | Submission Open

Keywords: aging process; molecular mechanisms; epigenetic clock; cancer; metabolic disease

(This special issue belongs to the Section Molecular Biology)

The Role of Bioactive Compounds in Human Health and Disease: 3rd Edition

edited by

Guan-Jhong Huang

submission deadline 20 Sep 2026 | 6 articles | Viewed by 10665 | Submission Open

Keywords: cancer; inflammation; cardiovascular diseases; plants; bioactive compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Melanin and Other Pigments: Function, Synthesis and Characterization

edited by Koen P. Vercruysse

submission deadline 20 Sep 2026 | 4 articles | Viewed by 10319 | Submission Open

Keywords: melanin; eumelanin; pheomelanin; allomelanin; catechol; indole; phenol

(This special issue belongs to the Section Biochemistry)

Gluten/Wheat-Related Disorders: The Role of Nutrition, Gut Barrier, Microbiota, and New Therapeutic Strategies

edited by Lisa Lungaro

submission deadline 20 Sep 2026 | 2 articles | Viewed by 10142 | Submission Open

Keywords: gluten-related disorders; celiac disease; non celiac gluten wheat sensitivity; gluten free diet; microbiota; gut barrier; probiotics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biosynthesis of Phytochemicals and Their Applications in Novel Drug Lead Development

edited by

Piotr Szymczyk

submission deadline 20 Sep 2026 | 5 articles | Viewed by 10099 | Submission Open

Keywords: biosynthesis of phytochemicals in plants; phytochemical isolation; phytochemical structure; animal and human protein targets of phytochemicals; chemical derivatives of phytochemicals

(This special issue belongs to the Section Molecular Pharmacology)

Medicinal Plant Resources—from Molecular Studies to Sustainable Use

edited by Ekaterina Kozuharova

submission deadline 20 Sep 2026 | 3 articles | Viewed by 9867 | Submission Open

Keywords: genetic improvement of medicinal plants; sustainable use; bioactive compounds

(This special issue belongs to the Section Molecular Plant Sciences)

Bioactive Molecules from Food or Other Natural Sources Against Cancer: 2nd Edition

edited by

Alessandro Maugeri

and

Michele Navarra

submission deadline 20 Sep 2026 | 3 articles | Viewed by 9837 | Submission Open

Keywords: cancer; natural bioactive molecules; natural products; tumor

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Pharmacology and Interventions in Cardiovascular Disease: 2nd Edition

edited by

Magdalena Zabielska-Kaczorowska

submission deadline 20 Sep 2026 | 5 articles | Viewed by 9797 | Submission Open

Keywords: cardiovascular pharmacology; cardiovascular interventions; cardioprotection; myocardial ischemia and infarction; heart failure

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Challenges of Parkinson’s Disease, 2nd Edition

edited by

Franca Rosa Guerini

and

Cristina Agliardi

submission deadline 20 Sep 2026 | 5 articles | Viewed by 9422 | Submission Open

Keywords: Parkinson’s disease; neurodegeneration; synuclein; diagnosis; genetics; epigenetics; extracellular vesicles; biomarkers; treatments; rehabilitation

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights into Nutrition, Genetics, and Biochemistry: From Mechanisms to Therapeutics

edited by

Anna Cieslinska

and

Edyta Sienkiewicz-Szłapka

submission deadline 20 Sep 2026 | 2 articles | Viewed by 9396 | Submission Open

Keywords: nutrigenomics and nutrigenetics; molecular nutrition; oxidative stress and redox biology; epigenetics and diet; lipid and glucose metabolism; inflammatory pathways; transcriptomics, metabolomics, proteomics; mitochondrial dysfunction and nutrition; biomarkers of diet-related disease; precision nutrition and molecular therapeutics

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Immunosuppressive Therapy

edited by

Marta Grabowska

submission deadline 20 Sep 2026 | 2 articles | Viewed by 9390 | Submission Open

Keywords: immunosuppressive drugs; calcineurin inhibitors; corticosteroids; inhibitors of purine synthesis; mammalian target of rapamycin inhibitors; biological treatment; cell-based therapies; biomarkers; genetic profiling

(This special issue belongs to the Section Molecular Immunology)

Cellular and Molecular Study of Neurodevelopmental and Neurological Disorders

edited by

Kazuhito Toyooka

submission deadline 20 Sep 2026 | 2 articles | Viewed by 9197 | Submission Open

Keywords: autism spectrum disorder; ADHD; schizophrenia; intellectual disability; Alzheimer’s disease; Parkinson’s disorder; traumatic brain injury; epilepsy; neurodevelopmental disorders; neurological diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

From Macrophage Biology to Cell and EV-Based Immunotherapies

edited by

Katarzyna Nazimek

and

Krzysztof Bryniarski

submission deadline 20 Sep 2026 | 2 articles | Viewed by 9107 | Submission Open

Keywords: macrophage-based; macrophage-targeting; cancer immunotherapies; autoimmunity

(This special issue belongs to the Section Molecular Immunology)

Exploring the Complex Interplay Between Metabolic Diseases, MASLD, and Liver Cancer

edited by

Daniela Gabbia

and

Sara De Martin

submission deadline 20 Sep 2026 | 4 articles | Viewed by 8896 | Submission Open

Keywords: hepatocellular carcinoma; MASLD; MASH; obesity; insulin resistance; dyslipidemia; liver cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Molecular Research in Brain Tumors

edited by

Shiv K. Gupta

submission deadline 20 Sep 2026 | 7 articles | Viewed by 8866 | Submission Open

Keywords: targeted therapy; blood–brain barrier; GBM; glioma; immune checkpoint blockers; TME

(This special issue belongs to the Section Molecular Oncology)

Dialogue Between Inflammation and Immunity: From Mechanism to Therapy

edited by

Nikolina Mihaylova

submission deadline 20 Sep 2026 | 5 articles | Viewed by 8818 | Submission Open

Keywords: inflammation; immune activation; immunomodulation; tolerance; immunotherapy; autoimmune diseases; cancer

(This special issue belongs to the Section Molecular Immunology)

Molecular Advances in Regenerative Medicine and Therapeutics

edited by

Diana Torge

submission deadline 20 Sep 2026 | 3 articles | Viewed by 8817 | Submission Open

Keywords: regenerative medicine; morphology; regenerative dentistry; biomaterials; scaffolds; organoids; tissue regeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

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