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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Pain: From Molecular Basis to Therapy

edited by Samuel J. Lin

submission deadline 20 Nov 2025 | 2 articles | Viewed by 4873

Keywords: pain mechanisms; molecular signaling; neurotransmitters; ion channels; genetic predisposition; epigenetic regulation; immune– neuron interaction; pharmacological therapy; gene therapy; neuromodulation; regenerative medicine

(This special issue belongs to the Section Molecular Neurobiology)

Targeted Therapies and Molecular Methods in Cancer, 3rd Edition

edited by

Julita Kulbacka

submission deadline 20 Nov 2025 | 3 articles | Viewed by 4803

Keywords: immunotherapy; radiotherapy; methods using facilitated drug delivery such as electroporation; sonoporation; and magnetic fields; nanotechnology and nanocarriers; gene electrotherapy; intelligent predicting methods with AI

(This special issue belongs to the Section Molecular Oncology)

Editorial Board Members’ Collection Series: “Protein Biophysics”

edited by

Vladimir N. Uversky

and

Assaf Friedler

submission deadline 20 Nov 2025 | 2 articles | Viewed by 4624

Keywords: protein structure and prediction; protein biophysics; protein dynamics; peptide and protein aggregation; protein misfolding; protein folding; protein stability; protein function; posttranslational modifications; intrinsically disordered proteins; protein– ligand interactions; protein– protein interactions; protein– nucleic acid interactions; membrane proteins; liquid– liquid phase separation

(This special issue belongs to the Section Molecular Biophysics)

Rheumatoid Arthritis: From Molecular Basis to Therapies

edited by

Gabriella Sármay

submission deadline 20 Nov 2025 | 3 articles | Viewed by 4594

Keywords: rheumatoid arthritis; autoimmune; intracellular signaling pathways; targeted therapy; inflammation; immunometabolic reprogramming; CD40; CD40 ligand; GM-CSF; PD-1; inhibitors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Therapeutic Potential of Antioxidants in the Prevention of Human Diseases, 2nd Edition

edited by

Kota V. Ramana

submission deadline 20 Nov 2025 | 2 articles | Viewed by 4515

Keywords: antioxidants; vitamins; inflammation; cancer; neurological complications; diabetes; flavonoids; natural compounds; cancer; infections; COVID-19

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Extracellular Vesicles (EVs) in Cancer Progression and Metastasis: Molecular Insights and Clinical Outlook

edited by Alfredo Cappariello

submission deadline 20 Nov 2025 | 2 articles | Viewed by 4463

Keywords: mammalian extracellular vesicles; plant-derived extracellular vesicles; bacterial-derived extracellular vesicles; cancer progression; cell migration and invasion; tumor microenvironment; epithelial-to-mesenchymal transition (EMT); drug delivery; diagnostics; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomarkers in Precision Medicine

edited by

Zhidong Zhou

submission deadline 20 Nov 2025 | 1 articles | Viewed by 4452

Keywords: biomarkers; precision medicine; novel techniques; artificial intelligence

(This special issue belongs to the Section Molecular Biology)

Advanced Research on Cholangiocarcinoma: From Bench to Bedside

edited by

Masaru Katoh

, Simona Tavolari and

Giovanni Brandi

submission deadline 20 Nov 2025 | 3 articles | Viewed by 4437

Keywords: risk factors; next-generation sequencing; actionable targets; FGFR2; BAP1; IDH1; tissular/circulating biomarkers; cancer resistance; immune microenvironment; in vitro and in vivo models; clinical trials

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanism in Multiple Sclerosis and Related Disorders: 3rd Edition

edited by

Hans-Peter Hartung

and Kazuo Fujihara

submission deadline 20 Nov 2025 | 3 articles | Viewed by 4318

Keywords: neurodegeneration; multiple sclerosis; NMOSD; MOGAD; disease-modifying treatments

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Male Reproductive Physiology, Pathophysiology, and Contraception

edited by Gustavo G. Blanco

submission deadline 20 Nov 2025 | 2 articles | Viewed by 4302

Keywords: spermatogenesis; spermiogenesis; testis; epididymis; sperm function; sperm motility; sperm capacitation; acrosome reaction; male reproduction; male fertility; male infertility; male contraception

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Sjögren’s Syndrome: From Pathogenesis to Therapy

edited by Alexandru Emil Caraba

submission deadline 20 Nov 2025 | 2 articles | Viewed by 4209

Keywords: Sjö gren's syndrome; salivary glands; lacrimal glands; T and B cells; macrophage; dendritic cells; salivary gland epithelial cells; inflammatory mediators (cytokines; chemokines; antibodies); intracellular signaling pathways (IFN; TLR; BAFF/BAFF-R; PI3K/Akt/mTOR); atherosclerosis; lymphoma; novel therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mechanisms and Implications of Traumatic Brain Injury and Neuroinflammation

edited by

Kwang Choi

submission deadline 20 Nov 2025 | 3 articles | Viewed by 4192

Keywords: traumatic brain injury; head trauma; neuroinflammation; secondary injury; microglia

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Perspectives in the Diagnosis, Prevention, Treatment, and Vaccination Against Parasitic Diseases

edited by

Bartłomiej Tomasz Ferra

and Anna Lass

submission deadline 20 Nov 2025 | 3 articles | Viewed by 4191

Keywords: parasitoses; vaccines; diagnostic; epidemiology; prevention; antibodies; cytokines; immune system; treatment; native antigen; recombinant protein; chimeric recombinant protein; multiepitope recombinant protein; pharmaceutical analogues; PCR; molecular techniques

(This special issue belongs to the Section Molecular Microbiology)

TGF-β Signaling in Immunity, Inflammation, Fibrosis and Cancer

edited by

Isabel Fabregat

and

Gianluigi Giannelli

submission deadline 20 Nov 2025 | 1 articles | Viewed by 4184

Keywords: TGF-beta; fibrosis; inflammation; cancer; immune cells; fibroblasts; EMT; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Colorectal Cancer: From Pathophysiology to Novel Therapies

edited by

Fabio Gelsomino

submission deadline 20 Nov 2025 | 2 articles | Viewed by 4183

Keywords: colorectal cancer; immunotherapy; targeted therapy; biomarkers; multidisciplinary management; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research in Immunotoxicity and Oxidative Stress

edited by

Soo-Jin Choi

submission deadline 20 Nov 2025 | 1 articles | Viewed by 4008

Keywords: toxicity; macrophage activation; pro-inflammation; anti-inflammation; oxidative stress; foods; food additives; nanomaterials; toxicants; natural compounds

(This special issue belongs to the Section Molecular Toxicology)

Regulatory Network of Bone Metabolism

edited by

Kazunori Hamamura

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3952

Keywords: osteoblasts; osteoclasts; osteocytes; mesenchymal stem cells; bone metabolism; bone formation; bone resorption

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

New Insights in Artificial Intelligence for Drug Design and Target Discovery

edited by

Yanjing Wang

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3949

Keywords: pre-trained language models; generative models; drug prediction; binding site prediction; peptides; multi-omics; deep learning; QSAR modeling; molecular dynamics (MD) simulations

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Insights into Placental Pathology

edited by

Mary Wallingford

and Ana Correia-Branco

submission deadline 20 Nov 2025 | 3 articles | Viewed by 3894

Keywords: placenta; trophoblast; implantation; obstetrics; pre-eclampsia; placentation; maternal– fetal interface; pregnancy health; placenta diagnostics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Plant–Environment Interactions

edited by

Magdalena Pawełkowicz

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3891

Keywords: vascular biology; floral development; sex expression; fruit development; grafting; source– sink interactions; genetic resources; stress tolerance; molecular breeding; gene regulation; resistance to biotic and abiotic stresses

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Amyloid in Neurological Diseases

edited by Silvia Purro

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3796

Keywords: amyloid-beta (Aβ ); tau protein; TDP43; synuclein; huntingtin; prion-like mechanisms; amyloid structures; genetic factors; cell-to-cell transmission; pathogenesis mechanisms; protein aggregation; Biomarkers; CNS amyloid clearance and degradation

(This special issue belongs to the Section Molecular Neurobiology)

Endothelial-to-Mesenchymal Transition: A Key Driver of Tumor Progression and Therapeutic Resistance

edited by

Gabriella Doronzo

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3770

Keywords: Endothelial-to-Mesenchymal Transition; wound healing and fibrosis; tumor progression; abnormal blood vessel formation; cancer therapy

(This special issue belongs to the Section Molecular Biology)

Platelets at the Intersection of Atherosclerosis Processes

edited by

Maria Greabu

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3752

Keywords: platelets; inflammation; atherosclerosis; endothelial cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Nanoparticles in Molecular Biology: Second Edition

edited by

Maciej Monedeiro-Milanowski

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3747

Keywords: nanoparticles; nanomedicine; biomolecules; nanoparticle– cell interactions; organic– inorganic hybrid; cytotoxic potential

(This special issue belongs to the Section Molecular Nanoscience)

Phytohormone Signaling and Crosstalk in Regulation of Plant Growth and Environmental Stress Responses: 2nd Edition

edited by

Lam-Son Phan Tran

and Mohammad G. Mostofa

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3694

Keywords: plant hormones; hormonal crosstalk; signal transduction; stress signaling; root system architecture; shoot branching; leaf development; phytohormone-responsive factors; transcriptional regulators; gene expression; plant physiology; senescence; plant plasticity; regulatory mechanisms; hormone homeostasis; stress adaptation/acclimatization

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Design of Artificial Receptors Using Virtual Approaches

edited by Houjin Zhang

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3688

Keywords: artificial receptors; protein design; computational biology; drug targeting; biosensors; tissue engineering; synthetic biology

(This special issue belongs to the Section Molecular Biophysics)

Regenerative Medicine: Molecular Mechanisms Driving Tissue Regeneration and Repair

edited by

Christopher Robinson

and Paul Jordan Christo

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3594

Keywords: stem cell; cell signaling; immune modulation; extracellular matrix; remodeling; gene regulation; gene editing; growth factors; extracellular vesicles; small molecules

(This special issue belongs to the Section Molecular Biology)

Computational Approaches for Protein Design

edited by Livija Jakaite and

Mahesh Narayan

submission deadline 20 Nov 2025 | 3 articles | Viewed by 3565

Keywords: computational protein design; molecular structure prediction; deep learning; protein structure and function prediction

(This special issue belongs to the Section Molecular Biophysics)

Biological Hallmarks and Therapeutic Strategies in Cancer

edited by Ramesh Kumar

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3477

Keywords: hallmarks of cancer; cancer progression; chemotherapy; tumorigenesis; oncogenic signaling

(This special issue belongs to the Section Molecular Oncology)

Advances in Molecular Mechanisms of Kidney Disease: Integrating Renal Tumorigenesis

edited by

Michele Marchioni

and

Luigi Schips

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3455

Keywords: molecular pathogenesis; renal cell carcinoma; genomic profiling; targeted therapy; immunotherapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

MicroRNA (miRNA) Technology in Cancer

edited by

Duncan Ayers

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3370

Keywords: miRNA; microRNA; cancer; oncology; drug delivery; technology; non-coding RNA

(This special issue belongs to the Section Molecular Oncology)

Computational Design and Therapeutic Applications of Peptide-Based Drugs

edited by

Shayon Bhattacharya

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3359

Keywords: peptide drug design; in silico drug discovery; peptide– protein interactions; therapeutic peptides

(This special issue belongs to the Section Molecular Biology)

New Advances in Germ Cell Research

edited by

Sheng-Hsiang Li

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3281

Keywords: spermatogenesis; sperm capacitation; oogenesis; oocyte maturation; cumulus cells; fertilization; gene expression; biomarkers; exosomes; infertility

(This special issue belongs to the Section Molecular Biology)

Molecular Research in Animal Reproduction

edited by

Zhongliang Jiang

submission deadline 20 Nov 2025 | 3 articles | Viewed by 3279

Keywords: spermatogenesis; follicular atresia; oocyte maturation; granulosa cells; hormone regulation; autophagy; apoptosis; miRNA; signaling regulation

(This special issue belongs to the Section Molecular Biology)

Molecular Diagnostics in Neurological Diseases

edited by

Julián Benito-León

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3264

Keywords: neurological diseases; biomarkers; translational research; precision medicine; diagnosis; prognosis

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Advances in Semiconductor Materials

edited by Tarek Hidouri

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3240

Keywords: optoelectronics; hybrid materials; power devices; III– V materials; advanced characterization; modeling; molecular advances; semiconductors; biophysics

(This special issue belongs to the Section Materials Science)

Whole-Cell System and Synthetic Biology, 2nd Edition

edited by

Jingjing Tian

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3184

Keywords: synthesis biology; molecular biology; functional nucleic acids; biosensor; CRISPR-Cas; directed evolution; whole-cell system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Anti-Inflammatory Strategies and Cell Models for Alzheimer’s Disease

edited by Sophia Lavrentiadou

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3165

Keywords: Alzheimer’ s disease; neuroinflammation; anti-inflammatory strategies; cell models

(This special issue belongs to the Section Molecular Neurobiology)

Peptides and Peptidomimetics for Targeting Protein-Protein Interactions

edited by

Giacomo Rossino

and

Pasquale Linciano

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3148

Keywords: protein– protein interactions; peptide– protein interactions; interactome; proteomics; peptides; modified peptides; peptidomimetics; molecular glues; drug discovery; medicinal chemistry; rule of five; biophysical assays; molecular modelling; cancer; neurodegenerative diseases; orphan diseases; antimicrobial resistance; PROTAC

(This special issue belongs to the Section Biochemistry)

Effects of Ionizing Radiation in Cancer Radiotherapy: 2nd Edition

edited by

François Chevalier

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3141

Keywords: non-targeted effects; radiation-induced bystander effect; abscopal effect; genomic instability; low dose effects; radioprotection; circulating biomarkers; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomaterials for Tissue Regeneration: Current Progress and Future Directions

edited by

Ana Caruntu

and Horia Barbu

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3123

Keywords: biomaterials; biocompatibility; tissue engineering; tissue defect; rehabilitation; scaffolds; regenerative medicine; angiogenesis; stem cells; antimicrobial

(This special issue belongs to the Section Materials Science)

Plant Tolerance to Stress

edited by

Xingguo Li

submission deadline 20 Nov 2025 | 5 articles | Viewed by 3108

Keywords: plant; genetic breeding; biotic stress; abiotic stress; gene regulation

(This special issue belongs to the Section Molecular Plant Sciences)

Multi-Omics Analysis and Application of Plant Natural Products (2nd Edition)

edited by

Qiang Zhang

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3052

Keywords: omics; plant components; bioactivity; signaling; pathway; target; mechanism

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Protein Dynamics, Binding and Allostery

edited by

Beatriz Ibarra-Molero

Raquel Godoy-Ruiz

and

Encarnación Medina Carmona

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2988

Keywords: proteins dynamics; enzyme catalysis; conformational changes; allosteric regulation; signal transduction; neurodegenerative disorders; cancer; computational methods; therapeutic interventions

(This special issue belongs to the Section Biochemistry)

Molecular Advances in Alcohol Metabolism

edited by Takeshi Haseba

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2955

Keywords: alcohol metabolism; ADH1; ADH3; ADH4; MEOS; catalase; ALDH2; pharmacology and toxicology; ROS; alcohol-related disease

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Fruit Tree Physiology, Breeding and Genetic Research

edited by Jiangping Mao

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2952

Keywords: fruit tree; genetic breeding; fruit tree physiology; gene functional identification

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms, Biomarkers, and Therapeutic Targets for Endometriosis

edited by Katharina Proestling and

Iveta Yotova

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2890

Keywords: endometriosis; biomarkers; inflammation; fibrosis; oxidative stress; epigenetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Challenges of Immune Checkpoint Inhibitor Therapy

edited by

Tibor Bakacs

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2846

Keywords: immune checkpoint inhibitor; ICI; safety of ICI drugs; irAE of ICI drugs; ultra-low-dose ICI; cost saving with ICI drugs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Synapse Dynamics: From Molecular Mechanisms to Functional Plasticity

edited by

Maria Bykhovskaia

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2819

Keywords: synaptic plasticiy; neuronal transmitters; molecular dynamics; neuronal networks; dendritic spines; synapse formation; synaptic vesicles; active zones; axonal transport

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms and Precision Medicine During Surgery and Postoperative Care

edited by Lukas Andereggen and Markus M. Luedi

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2814

Keywords: genomics & pharmacogenomics; molecular mechanisms of anesthesia; perioperative biomarkers; perioperative care; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

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