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Advances in Molecular Mechanisms of Kidney Disease: Integrating Renal Tumorigenesis

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 1969

Special Issue Editors


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Guest Editor
Laboratory of Biostatistics, Department of Medical, Oral and Biotechnological Sciences, “G. d'Annunzio” University of Chieti, Chieti, Italy
Interests: kidney disease; kidney damage; kidney inflammation
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Urology, “Padre Pio da Pietrelcina” Hospital, Via S. Camillo del Lellis, 66054 Vasto, Italy
Interests: prostate cancer; urology; kidney cancer; prostate; urologic oncology; endourology; urolithiasis; robotics & minimally invasive urology; surgical oncology; BPH
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue offers a comprehensive examination of the cutting-edge advancements in understanding the molecular mechanisms of kidney diseases, including an insightful exploration into renal tumorigenesis. It encapsulates a multidisciplinary approach to dissecting the complex interplay between genetic, epigenetic, and environmental factors contributing to both chronic kidney diseases and kidney cancers, such as renal cell carcinoma (RCC).

Articles within this Special Issue issue shed light on the identification of novel genetic markers and the role of disruptive mutations in key regulatory genes, providing a deeper understanding of the etiology and progression of renal pathologies. Emphasis is placed on the transformative impact of high-throughput sequencing technologies and systems biology in unveiling the molecular heterogeneity of kidney diseases and the distinct molecular subtypes of renal tumors.

Contributions explore the potential of targeted therapy and immunotherapy in treating renal cancers, underscoring the shift towards personalized medicine. The Special Issue issue also delves into the emerging role of non-coding RNAs and the tumor microenvironment in renal disease pathogenesis and cancer metastasis, highlighting potential therapeutic targets.

Dr. Michele Marchioni
Prof. Dr. Luigi Schips
Guest Editors

Manuscript Submission Information

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Keywords

  • molecular pathogenesis
  • renal cell carcinoma
  • genomic profiling
  • targeted therapy
  • immunotherapy

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Published Papers (1 paper)

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Review

30 pages, 2248 KiB  
Review
Advances in Molecular Mechanisms of Kidney Disease: Integrating Renal Tumorigenesis of Hereditary Cancer Syndrome
by Rossella Cicchetti, Martina Basconi, Giulio Litterio, Marco Mascitti, Flavia Tamborino, Angelo Orsini, Alessio Digiacomo, Matteo Ferro, Luigi Schips and Michele Marchioni
Int. J. Mol. Sci. 2024, 25(16), 9060; https://doi.org/10.3390/ijms25169060 - 21 Aug 2024
Viewed by 1587
Abstract
Renal cell carcinoma (RCC) comprises various histologically distinct subtypes, each characterized by specific genetic alterations, necessitating individualized management and treatment strategies for each subtype. An exhaustive search of the PubMed database was conducted without any filters or restrictions. Inclusion criteria encompassed original English [...] Read more.
Renal cell carcinoma (RCC) comprises various histologically distinct subtypes, each characterized by specific genetic alterations, necessitating individualized management and treatment strategies for each subtype. An exhaustive search of the PubMed database was conducted without any filters or restrictions. Inclusion criteria encompassed original English articles focusing on molecular mechanisms of kidney cancer. On the other hand, all non-original articles and articles published in any language other than English were excluded. Hereditary kidney cancer represents 5–8% of all kidney cancer cases and is associated with syndromes such as von Hippel–Lindau syndrome, Birt–Hogg–Dubè syndrome, succinate dehydrogenase-deficient renal cell cancer syndrome, tuberous sclerosis complex, hereditary papillary renal cell carcinoma, fumarate hydratase deficiency syndrome, BAP1 tumor predisposition syndrome, and other uncommon hereditary cancer syndromes. These conditions are characterized by distinct genetic mutations and related extra-renal symptoms. The majority of renal cell carcinoma predispositions stem from loss-of-function mutations in tumor suppressor genes. These mutations promote malignant advancement through the somatic inactivation of the remaining allele. This review aims to elucidate the main molecular mechanisms underlying the pathophysiology of major syndromes associated with renal cell carcinoma. By providing a comprehensive overview, it aims to facilitate early diagnosis and to highlight the principal therapeutic options available. Full article
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