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Molecular Mechanisms and Precision Medicine During Surgery and Postoperative Care

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (28 April 2025) | Viewed by 600

Special Issue Editors


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Guest Editor
1. Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland
2. Faculty of Medicine, University of Bern, Bern, Switzerland
Interests: vascular neurosurgery; tumor surgery; spine surgery; neuroplasticity; neuroregeneration; interventional neuroradiology; pituitary adenoma; prolactinoma; ACTH-secreting pituitary adenoma; cushing syndrome

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Guest Editor
1. Department of Anaesthesiology Rescue- and Pain Medicine, Cantonal Hospital of St. Gallen, St. Gallen, Switzerland
2. Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Interests: anesthesiology; management; neuro-oncology; medical statistics; anaesthesiology; resuscitation; anesthesia
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Aiming for more individualized and effective perioperative care, integrating molecular data into clinical decision-making is gaining momentum. We invite submissions for a special issue focused on the latest advances in molecular sciences applied to perioperative medicine. This issue aims to explore cutting-edge research on molecular mechanisms, biomarkers, and precision medicine approaches that are transforming perioperative care. Topics of interest include e.g.,

  • Genomics & Pharmacogenomics: Genetic markers influencing anesthetic sensitivity and postoperative outcomes.
  • Molecular Mechanisms of Anesthesia: Insights into anesthetic action and potential neurotoxic effects.
  • Inflammatory & Immune Responses: Molecular pathways driving perioperative inflammation and immune modulation.
  • Microbiome Dynamics: The role of the microbiome in surgical outcomes and recovery.
  • Mitochondrial Function & Oxidative Stress: Protecting organs from surgery-induced oxidative damage.
  • Perioperative Biomarkers: Early detection of organ injury and surgical complications.
  • Epigenetics & Metabolomics: Personalized medicine through molecular profiling and metabolic biomarkers.
  • Ischemia-Reperfusion Injury: Novel strategies for minimizing tissue damage during surgery.
  • Cognitive Dysfunction: Molecular pathways underlying postoperative cognitive decline and delirium.

We warmly invite clinicians and scientists to submit their manuscripts for consideration in this special issue. If your work advances our understanding of molecular mechanisms in novel clinical applications, your contribution is invaluable to shaping the future of perioperative care. Join us in this exciting endeavor to foster innovation and improve patient outcomes through cutting-edge molecular science. We look forward to receiving your submissions and sharing your breakthroughs with the global medical and scientific community.

Prof. Dr. Lukas Andereggen
Prof. Dr. Markus M. Luedi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • genomics & pharmacogenomics
  • molecular mechanisms of anesthesia
  • perioperative biomarkers
  • perioperative care
  • precision medicine

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Published Papers (1 paper)

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Research

22 pages, 5601 KiB  
Article
The Role of Extracellular-Vesicle-Derived miRNAs in Postoperative Organ Dysfunction in Neonates and Infants Undergoing Congenital Cardiac Surgery: An Exploratory Study
by Fahd Alhamdan, Wiriya Maisat, LeeAnn Higgins, Yue Chen, Juan Ibla and Koichi Yuki
Int. J. Mol. Sci. 2025, 26(8), 3837; https://doi.org/10.3390/ijms26083837 - 18 Apr 2025
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Abstract
Despite significant advancements in medical and surgical care, the morbidity and mortality rates of neonates and infants undergoing congenital cardiac surgery remain high. To identify new pathomechanisms associated with postoperative organ dysfunction, extracellular vesicles (EVs) were isolated from plasma from neonates and infants [...] Read more.
Despite significant advancements in medical and surgical care, the morbidity and mortality rates of neonates and infants undergoing congenital cardiac surgery remain high. To identify new pathomechanisms associated with postoperative organ dysfunction, extracellular vesicles (EVs) were isolated from plasma from neonates and infants with or without organ dysfunction at three different time points around congenital cardiac surgery, and the EV miRNA expression profiles in the plasma were analyzed. A clear distinction was observed between the organ dysfunction (OD) and non-organ dysfunction (NOD) groups based on their EV miRNA expression profiles. Apoptosis and proinflammatory pathways were consistently upregulated across all time points in the OD group. Complement and coagulation cascades unexpectedly displayed downregulation at the end of the surgery in the OD group, which was verified further at the proteomic level in an independent patient cohort. The neutrophil extracellular trap (NET) formation was enhanced in the OD group across all time points compared to that in the NOD group. As NETs are known to consume complement components, these observed events might be interconnected. A feature selection machine learning method identified miR-200b-5p, miR-4800-5p, miR-363-3p, and miR-483-5p as robustly linked to organ dysfunction following congenital cardiac surgery (accuracy score = 9; SD in accuracy = 0.3162). In conclusion, our study suggested that neonates and infants with postoperative organ dysfunction were associated with enhanced NET formation and complement consumption. Full article
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