Anti-Inflammatory Strategies and Cell Models for Alzheimer’s Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 20 November 2025 | Viewed by 1643
Special Issue Editor
Special Issue Information
Dear Colleagues,
Neuroinflammation has been implicated in the development of a variety of CNS diseases, including late-onset Alzheimer’s disease (LOAD). The development of inflammation is a complex process involving multiple molecular interactions that remain to be further characterized in the CNS. The development of neuroinflammation may represent an important link between the early stages of LOAD and its pathological outcomes. It is thought that LOAD risk factors, including genetic, biological, and environmental factors, may all contribute to the impairment of normal CNS regulation and function. The links between risk factors and the development of neuroinflammation are numerous and involve many complex interactions that lead to vascular damage, oxidative stress, and ultimately neuroinflammation. Once this chain of events is initiated, the neuroinflammatory process becomes overactivated, resulting in further cellular damage and loss of neuronal function. Furthermore, neuroinflammation is associated with the formation of amyloid plaques and neurofibrillary tangles, which are pathological hallmarks of LOAD. Elevated levels of inflammatory markers are associated with late cognitive impairment. Based on this knowledge, new therapies aimed at limiting the onset of neuroinflammation could halt or even reverse the progression of the disease. Alzheimer's disease (AD) is characterized by multiple cellular and molecular insults. Therefore, there is a growing and justifiable interest in multi-targeted molecular therapies. This Special Issue welcomes discussions on inflammation in AD as well as on cell models.
Dr. Sophia Lavrentiadou
Guest Editor
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Keywords
- Alzheimer’s disease
- neuroinflammation
- anti-inflammatory strategies
- cell models
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