Molecular Advances in Alcohol Metabolism
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 20 November 2025 | Viewed by 254
Special Issue Editor
Special Issue Information
Dear Colleagues,
Alcohol metabolism (AM) is the primary internal factor that regulates the effects of alcohol, such as cell toxicity, intoxication, and dependence formation.
AM has been known to be changed by the amount of alcohol consumed, the kind of alcoholic beverage, eating and dietary ingredients, drinking history, age, organ diseases, heredity factors including sex, and so on. However, the molecular mechanisms are not yet well understood, although ADH in the liver has been recognized as the key enzyme. In humans, the ADH1B genotype (ADH1B*1 or *2) shows a different activity to modify the biological effects of alcohol, but its relationship to AM is unclear compared to the case with the ALDH2 genotype. MEOS and catalase have been proposed as candidates for a non-ADH pathway, but these hypotheses remain unproven even in subsequent experiments using KO mice. ADH3 (or 5) and ADH4 isozymes were also revealed to contribute to systemic AM in ADH3 and ADH4 KO mice experiments, but their modifications to the biological effects of alcohol are unknown.
This Special Issue, Molecular Advances in Alcohol Metabolism, welcomes reviews and articles on the latest studies on the contribution of alcohol metabolizing enzymes to AM in vivo and their relationship with the biological effects of alcohol.
A comprehensive understanding of the molecular mechanism of AM, coupled with the biological effects of alcohol, can provide the most important foundation in alcohol medical research, which aims to solve, treat, and prevent social and health problems caused by drinking.
Dr. Takeshi Haseba
Guest Editor
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Keywords
- alcohol metabolism
- ADH1
- ADH3
- ADH4
- MEOS
- catalase
- ALDH2
- pharmacology and toxicology
- ROS
- alcohol-related disease
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