The Role of Amyloid in Neurological Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 20 November 2025 | Viewed by 200
Special Issue Editor
Special Issue Information
Dear Colleagues,
Amyloids are key pathological hallmarks in various neurodegenerative diseases, such as Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis. This Special Issue focuses on understanding the early stages of amyloid formation, leveraging cryo-EM structures to unravel the complex mechanisms behind their nucleation and polymerization. Additionally, we will explore genetic factors and mutations that influence amyloid formation and toxicity, alongside the mechanisms driving pathogenesis in the CNS. Understanding these processes is essential not only for uncovering the fundamental biological mechanisms of amyloid aggregation but also for developing therapeutics based on these mechanisms and structures to combat amyloid-related diseases.
This Special Issue welcomes the submission of original research manuscripts or review manuscripts focusing on the following areas of amyloid biochemistry in neurodegenerative diseases, including, but not limited to, the following:
- APP processing and Aβ formation—biomarkers, mutations, and chaperons;
- Tau protein and aggregation to neurofibrillary tangles—mutations and post-translational modifications;
- Interactions of Aβ and Tau with proteins, organelles, synapses, and cell membranes;
- Methods for studying amyloid structures and aggregation;
- Nucleated polymerization of monomers to oligomers, protofibrils, and fibrils;
- Proteostasis pathways—amyloid degradation and clearance;
- Development and comparison of amyloidosis animal models;
- Prion-like templating and propagation of proteins;
- Role of non-neuronal cells in amyloid production and clearance;
- Structural studies of amyloid assemblies and protein self-assembly complexes;
- Studies of the cellular and molecular mechanisms driving pathogenesis.
Dr. Silvia Purro
Guest Editor
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Keywords
- amyloid-beta (Aβ)
- tau protein
- TDP43
- synuclein
- huntingtin
- prion-like mechanisms
- amyloid structures
- genetic factors
- cell-to-cell transmission
- pathogenesis mechanisms
- protein aggregation
- Biomarkers
- CNS amyloid clearance and degradation
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