Colorectal Cancer: From Pathophysiology to Novel Therapies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 November 2025 | Viewed by 365
Special Issue Editor
Interests: colorectal cancer; gastric cancer; neuroendocrine tumors; hepatobiliary cancer; pancreatic cancer; precision medicine; clinical trials; translational research
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Despite an overall decrease in the incidence of colorectal cancer (CRC) and mortality in recent years, it the third and second most prevalent cancer in males and females, respectively. However, in recent decades, there has been a significant increase in the diagnosis of CRC in young adults, with the definition of early onset colorectal cancer (EOCRC) applying to CRC diagnosed before the age of 50. We have recently witnessed unprecedented advances in the prognosis and treatment of CRC, especially in the setting of metastatic disease, where the availability of high-throughput technologies has enhanced our molecular understanding of this disease and precision medicine has emerged as a focal point in scientific inquiry. In this context, although the advent of molecularly targeted agents and immune checkpoint inhibitors has revolutionized the treatment of patients with metastatic disease, the mechanisms of primary and acquired resistance to these drugs remain to be elucidated. This Special Issue aims to discuss major preclinical and clinical advances in the field and discuss future perspectives regarding the multidisciplinary management of CRC.
Dr. Fabio Gelsomino
Guest Editor
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Keywords
- colorectal cancer
- immunotherapy
- targeted therapy
- biomarkers
- multidisciplinary management
- precision medicine
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