Endothelial-to-Mesenchymal Transition: A Key Driver of Tumor Progression and Therapeutic Resistance
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 November 2025 | Viewed by 979
Special Issue Editor
Special Issue Information
Dear Colleagues,
Endothelial-to-Mesenchymal Transition (EndMT) is a process in which endothelial cells lose their characteristic features and acquire a mesenchymal phenotype, gaining migratory, invasive, and fibrotic properties. This transition is a key mechanism in both physiological processes, such as wound healing and fibrosis, and in pathological conditions, including tumor progression. During EndMT, endothelial cells within the tumor vasculature transform into mesenchymal-like cells, which not only promote abnormal blood vessel formation but also enhance the tumor's ability to grow, invade surrounding tissues, form metastases, and evade the immune system. For these reasons, EndMT has emerged as a potential target for cancer therapy and overcoming treatment resistance.
We invite the submission of research manuscripts and reviews focusing on the following topics: EndMT molecular mechanisms in physiology and tumors; the impact of drugs on the regulation of EndMT; the role of EndMT in tumor development, metastasis, immune evasion, and drug resistance; and targeting EndMT for therapy.
Dr. Gabriella Doronzo
Guest Editor
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Keywords
- Endothelial-to-Mesenchymal Transition
- wound healing and fibrosis
- tumor progression
- abnormal blood vessel formation
- cancer therapy
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