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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Advances in Animal Reproduction
edited by Valdevane Rocha Araújo
submission deadline 10 Aug 2026 | 1 articles | Viewed by 1706 | Submission Open
Keywords: folliculogenesis; oogenesis; oocyte maturation; follicle growth; preantral follicles; antral follicles; spermatogenesis; spermatozoa; bioengineering; scaffolds
(This special issue belongs to the Section Molecular Biology)
Molecular Pathogenesis and Treatments of Pediatric Leukemias
edited by
submission deadline 10 Aug 2026 | Viewed by 433 | Submission Open
Keywords: monoclonal antibodies; tyrosine kinase inhibitors; CAR-T; chemotherapy; drug induced toxicity
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Pathological and Genetic Studies of Alzheimer's Disease and Parkinson's Disease submission deadline 10 Aug 2026 | Viewed by 313 | Submission Open
Keywords: Alzheimer’s disease; Parkinson’s disease; neurodegeneration; genetics; epigenetics; neuroinflammation; biomarkers; multi-omics; gut–brain axis; precision medicine
(This special issue belongs to the Section Molecular Neurobiology)
Thyroid-Related Diseases: Molecular Pathology, Diagnosis and Treatment: 2nd Edition submission deadline 20 Aug 2026 | 8 articles | Viewed by 62421 | Submission Open
Keywords: thyroid disease; thyroid nodules; thyroid cancer; thyroid carcinoma; thyroid radiology; thyroid–gut axis; autoimmune thyroid disorders; thyroid hormone; molecular mechanisms; molecular tests
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Mechanisms Underlying Vulnerability to Stress-Related Disorders
edited by Marta Pardo
submission deadline 20 Aug 2026 | 4 articles | Viewed by 52324 | Submission Open
Keywords: stress-related disorders; post-traumatic stress disorder; molecular mechanisms; pharmacological targets
(This special issue belongs to the Section Molecular Neurobiology)
25th Anniversary of IJMS: Updates and Advances in Molecular Neurobiology
edited by
submission deadline 20 Aug 2026 | 19 articles | Viewed by 44207 | Submission Open
Keywords: molecular neurobiology; neural signaling and gene regulation; synaptic plasticity; neurodevelopment; neurodegeneration; neuroregeneration; neuroinflammation; epigenetics in neuroscience; non-coding RNAs; protein misfolding and aggregation; exosomes and extracellular vesicles; stem cells and neural repair; biomarkers of neurological disease; translational neuroscience; neuropharmacology; brain omics (genomics, proteomics, transcriptomics); neuronal-glial interactions; mitochondrial dysfunction in the nervous system
(This special issue belongs to the Section Molecular Neurobiology)
25th Anniversary of IJMS: Updates and Advances in Molecular Oncology
edited by
submission deadline 20 Aug 2026 | 21 articles | Viewed by 37116 | Submission Open
Keywords: molecular oncology; cancer epigenetics; tumour heterogeneity; tumour microenvironment; precision oncology; liquid biopsy; cancer immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms of Bioactive Nutrients Promoting Health Through Gut Microbiota: 3rd Edition
edited by and
submission deadline 20 Aug 2026 | 4 articles | Viewed by 24218 | Submission Open
Keywords: phytochemicals; complex carbohydrates; gut microbiota; prebiotics; probiotics; inflammation; molecular mechanisms; human health
(This special issue belongs to the Section Bioactives and Nutraceuticals)
IJMS 25th Anniversary: Updates and Progress on Bioactives and Nutraceuticals
edited by
submission deadline 20 Aug 2026 | 11 articles | Viewed by 21197 | Submission Open
Keywords: natural products; bioactive; nutraceutical; nutrient; health; dietary; functional food; vitamins; phytochemicals
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Plant Development and Hormonal Signaling
edited by
submission deadline 20 Aug 2026 | 7 articles | Viewed by 20692 | Submission Open
Keywords: plant growth; reproductive growth; phytohormones; signal transduction; transcription factors; root development; shoot development; floral development; seed development; environmental interactions; regulatory networks; apical dominance
(This special issue belongs to the Section Molecular Plant Sciences)
Multiple Sclerosis: From Molecular Pathology to Novel Therapeutic Approaches submission deadline 20 Aug 2026 | 11 articles | Viewed by 19145 | Submission Open
Keywords: progression-independent relapses (PIRAs); smouldering-associated worsening (SAW); lack of new relapses and of new magnetic resonance imaging activity (NEIDA); slowly expanding lesions (SEL); no evidence of smouldering disease activity (NESDA); neurofilament (NfL); glial fibrillary acidic protein (GFAP); patient-reported outcome (PRO); paramagnetic rim lesions (PRLs); relapse-associated worsening (RAW)
(This special issue belongs to the Section Molecular Neurobiology)
Health-Promoting Effects of Medicinal and Edible Plants and Their Molecular Mechanism
edited by and
submission deadline 20 Aug 2026 | 7 articles | Viewed by 18240 | Submission Open
Keywords: medicinal plants; edible plants; health-promoting effect; molecular mechanism; phytochemicals; diseases; curing targets; signaling pathway
(This special issue belongs to the Section Bioactives and Nutraceuticals)
25th Anniversary of IJMS: Updates and Advances in “Molecular Immunology”
edited by
submission deadline 20 Aug 2026 | 10 articles | Viewed by 18088 | Submission Open
Keywords: inflammation; innate immunity; adaptive immunity; genetics; epigenetics; immunometabolism; receptors; cytokines; cell therapy; immune checkpoint inhibitors
(This special issue belongs to the Section Molecular Immunology)
New Advances in the Treatment and Diagnosis of Neuromuscular Diseases
edited by Silvia Consalvi
submission deadline 20 Aug 2026 | 2 articles | Viewed by 17594 | Submission Open
Keywords: neuromuscular diseases; gene therapies; stem cell therapy; treatment and diagnosis
(This special issue belongs to the Section Molecular Neurobiology)
Metals and Metal Ions in Human Health, Diseases, and Environment submission deadline 20 Aug 2026 | 7 articles | Viewed by 17374 | Submission Open
Keywords: metal toxicity; metal-based drugs; polyoxometalates; protein metalation; human health problems; diseases; in vitro/in vivo studies; human studies; environmental pollution
(This special issue belongs to the Section Molecular Biology)
Molecular Research in Asthma and Allergy
edited by
submission deadline 20 Aug 2026 | 6 articles | Viewed by 15386 | Submission Open
Keywords: asthma; allergy; molecular mechanisms; exposome; treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
25th Anniversary of IJMS: Updates and Advances in Molecular Informatics submission deadline 20 Aug 2026 | 14 articles | Viewed by 15375 | Submission Open
Keywords: AI-guided drug repurposing; virtual screening in personalized medicine; machine learning for toxicity prediction; network-based biomarkers in complex diseases; in silico pharmacokinetics and ADMET profiling; data-driven materials design; deep learning for molecular property prediction; AI-assisted nanomaterial synthesis; systems biology models for metabolic engineering
(This special issue belongs to the Section Molecular Informatics)
Studies on Lactic Acid Bacteria and Their Products in Health and Diseases: 3rd Edition submission deadline 20 Aug 2026 | 8 articles | Viewed by 15009 | Submission Open
Keywords: lactic acid bacteria; probiotics health benefits; gut microbiota modulation; functional foods with biological applications; immunomodulatory mechanisms; antimicrobial peptide production and its mechanisms; host-microbe interactions; functional dairy and meat products; inflammatory bowel diseases; metabolic health improvement; bioactive microbial metabolites; food safety and management; metabolic diseases and disorders; antibiotic-associated complications
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Plant–Microbe Interactions: 2nd Edition
edited by Jian Jin
submission deadline 20 Aug 2026 | 6 articles | Viewed by 14478 | Submission Open
Keywords: plant; crop; rhizosphere microbiome; microbial colonization; quorum sensing; endophytic microbes
(This special issue belongs to the Section Molecular Plant Sciences)
Anti-Cancer Drugs: Natural Products, Synthetic Compounds and Potential Pharmacological Effects and Applications
edited by Kaiqun Ren and Hui Zou
submission deadline 20 Aug 2026 | 4 articles | Viewed by 13872 | Submission Open
Keywords: cancer; natural product; synthetic compounds; mechanism; structural modification; pharmacological action
(This special issue belongs to the Section Molecular Pharmacology)
New Advances in Cancer Genomics
edited by
submission deadline 20 Aug 2026 | 8 articles | Viewed by 13391 | Submission Open
Keywords: cancer genomics; biomarker discovery; precision oncology; KRAS and undruggable targets; artificial intelligence in oncology; multi-omics data integration; drug discovery
(This special issue belongs to the Section Molecular Biology)
New Insights into Plant Stress submission deadline 20 Aug 2026 | 5 articles | Viewed by 12985 | Submission Open
Keywords: abiotic stress; biotic stress; bioinformatics; artificial intelligence; biotechnology; breeding; crop plants; horticultural plants; GWAS; CRISPR-Cas; multi-omics; genomics; epigenomics; transcriptomics; proteomics; genetic diversity; gene expression
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular and Cellular Mechanisms of Skin Diseases (Second Edition)
edited by
submission deadline 20 Aug 2026 | 7 articles | Viewed by 12747 | Submission Open
Keywords: hyperproliferative skin diseases; psoriasis; keratinocyte carcinoma; actinic keratosis; atopic dermatitis; skin inflammation; inflammation-associated skin diseases; epidermal differentiation; epidermal cell metabolism; 3D models; in vivo models
(This special issue belongs to the Section Molecular Biology)
The Role of Cytokines and Autoantibodies Against Cytokines in Health and Disease submission deadline 20 Aug 2026 | 1 articles | Viewed by 12740 | Submission Open
Keywords: cytokine; autoantibodies; cytokine therapy; cytokine inhibition
(This special issue belongs to the Section Molecular Immunology)
Toxicity Mechanism of Emerging Pollutants: 2nd Edition submission deadline 20 Aug 2026 | 8 articles | Viewed by 12327 | Submission Open
Keywords: emerging pollutant; toxicology; cancer; EDC; pesticides; microplastic; human cell lines; environment; molecular mechanisms
(This special issue belongs to the Section Molecular Toxicology)
Chronic Kidney Disease: From Molecular Mechanisms to Therapeutic Approaches
edited by
submission deadline 20 Aug 2026 | 6 articles | Viewed by 12314 | Submission Open
Keywords: genetics; epigenetics; inflammation; metabolomics; oxiative stress
(This special issue belongs to the Section Molecular Biology)
Circulating Non-Coding RNAs as Diagnostic and Prognostic Markers of Human Diseases: 3rd Edition submission deadline 20 Aug 2026 | 7 articles | Viewed by 12199 | Submission Open
Keywords: miRNA; gene expression regulation; diagnosis; prognosis; therapy; biomarkers
(This special issue belongs to the Section Biochemistry)
Plant Molecular Regulatory Networks and Stress Responses
edited by
submission deadline 20 Aug 2026 | 5 articles | Viewed by 11874 | Submission Open
Keywords: plant stress response; stress response gene; regulatory mechanism; gene regulatory network; transcriptional regulation; post-transcriptional regulation; multi-omics integration; single-cell RNA-seq; spatial genomics; bioinformatics
(This special issue belongs to the Section Molecular Plant Sciences)
MicroRNAs and mRNA in Human Health and Disease
edited by
submission deadline 20 Aug 2026 | 8 articles | Viewed by 11816 | Submission Open
Keywords: stem cells; mesenchymal stem cells; gene expression; microRNA; mRNA
(This special issue belongs to the Section Molecular Biology)
Biochemistry and Molecular Biology of Coronaviruses
edited by
submission deadline 20 Aug 2026 | 7 articles | Viewed by 11482 | Submission Open
Keywords: SARS-CoV; MERS-CoV; COVID-19; RNA viruses; infection; antivirals; vaccines; therapeutics; host-virus interactions
(This special issue belongs to the Section Molecular Microbiology)
Molecular Research on Depression—2nd Edition submission deadline 20 Aug 2026 | 2 articles | Viewed by 11167 | Submission Open
Keywords: depression; epigenetics; animal models of depression; serotonin; glutamate; dopamine; neurotrophic factors
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Amyloid Aggregation and Its Inhibition: Implementing Insights from Physiological Conditions submission deadline 20 Aug 2026 | 4 articles | Viewed by 10812 | Submission Open
Keywords: protein aggregation; amyloid; physiological conditions; aggregation inhibition; neurodegenerative diseases; amyloidosis
(This special issue belongs to the Section Molecular Neurobiology)
Recent Advances in Brain Cancers: Second Edition submission deadline 20 Aug 2026 | 1 articles | Viewed by 10575 | Submission Open
Keywords: brain tumors; malignant brain tumor; advanced cancer biology
(This special issue belongs to the Section Molecular Oncology)
Plant Stress Biology
edited by
submission deadline 20 Aug 2026 | 10 articles | Viewed by 10326 | Submission Open
Keywords: abiotic stress; biotic stress; stress response mechanisms; oxidative stress; phytohormones signaling; stress tolerance
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Antimicrobial Nanomaterials 2.0
edited by
submission deadline 20 Aug 2026 | 4 articles | Viewed by 10298 | Submission Open
Keywords: metallic nanoparticles; bimetallic nanoparticles; antimicrobial activity; polymeric nanomaterials; nanoplatforms; nanoparticle functionalization; delivery of antimicrobial agents
(This special issue belongs to the Section Molecular Nanoscience)
Nutraceuticals and Healthy Aging: Molecular Mechanisms and Therapeutic Perspectives
edited by
submission deadline 20 Aug 2026 | 4 articles | Viewed by 9997 | Submission Open
Keywords: molecular mechanisms of the action of nutraceuticals on cellular aging; nutraceuticals and neuroprotection; effects of nutraceuticals on skin aging; nutraceuticals in the prevention or management of age-related metabolic diseases; interaction between nutraceuticals and gut microbiota in aging; nutraceuticals in bone and joint health; role of nutraceuticals in menopausal management; impact of nutraceuticals on BPH and prostate health; multi-target approaches of nutraceuticals in healthy aging; innovative nutraceutical delivery and formulation strategies to increase bioavailability; clinical and preclinical studies of nutraceuticals in the elderly population
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Insights into Antimicrobial Activity submission deadline 20 Aug 2026 | 2 articles | Viewed by 9331 | Submission Open
Keywords: antimicrobial activity; antimicrobial agents; antimicrobial peptides; phytochemicals with antimicrobial properties; antimicrobial synergy; pathogen-specific targeting; antimicrobial resistance; biomedical science; nanotechnology in antimicrobials; genomic
(This special issue belongs to the Section Molecular Microbiology)
25th Anniversary of IJMS: Updates and Advances in Molecular Plant Sciences
edited by
submission deadline 20 Aug 2026 | 8 articles | Viewed by 9301 | Submission Open
Keywords: plant science; plant biochemistry; mechanisms; plant development; stress responses; plant physiology; genetics
(This special issue belongs to the Section Molecular Plant Sciences)
Urologic Cancers: Molecular Basis for Novel Therapeutic Approaches
edited by
submission deadline 20 Aug 2026 | 7 articles | Viewed by 9271 | Submission Open
Keywords: urologic cancers; prostate cancer; urothelial cancer; renal cell cancer; genomics; proteomics; biomarkers; molecular pathways
(This special issue belongs to the Section Molecular Oncology)
Advances in Post-Mortem Toxicology
edited by
submission deadline 20 Aug 2026 | 2 articles | Viewed by 9258 | Submission Open
Keywords: post-mortem toxicology; fatal poisoning; new psychoactive substances; opioids; analytical methods; interpretation of test results
(This special issue belongs to the Section Molecular Toxicology)
Rapeseed: Genetic Breeding, Key Trait Mining and Genome
edited by Hongbo Chao
submission deadline 20 Aug 2026 | 4 articles | Viewed by 9124 | Submission Open
Keywords: rapeseed (Brassica napus L.); genetic breeding; genomic improvement; molecular markers; genome-wide association studies (GWAS); multi-omics integration; CRISPR gene editing; marker-assisted selection (MAS); stress resistance traits; yield and oil content improvement
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms of Neutrophil Extracellular Traps (Nets) in Human Diseases
edited by Eisuke F. Sato
submission deadline 20 Aug 2026 | 3 articles | Viewed by 8561 | Submission Open
Keywords: neutrophil extracellular traps (NETs); neutrophils; inflammation; autoimmune diseases; cardiovascular diseases; tumor metastasis; thrombosis; molecular mechanisms; disease progression; therapeutic targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Seed Development and Germination submission deadline 20 Aug 2026 | 5 articles | Viewed by 8433 | Submission Open
Keywords: seed aging; seed development; seed dormancy; seed germination; seed metabolism; seed preservation; seed priming; seed responses to stress
(This special issue belongs to the Section Molecular Plant Sciences)
Antimicrobial Nanomaterials: Approaches, Strategies and Applications
edited by
submission deadline 20 Aug 2026 | 3 articles | Viewed by 8418 | Submission Open
Keywords: nanotechnology; biocides; antimicrobials; controlled release; drug delivery; antimicrobial agents; antimicrobial resistance; infection; nanoparticles
(This special issue belongs to the Section Materials Science)
Extracellular Vesicles (EVs) in Cancer Progression and Metastasis: Molecular Insights and Clinical Outlook
edited by Alfredo Cappariello
submission deadline 20 Aug 2026 | 4 articles | Viewed by 8201 | Submission Open
Keywords: mammalian extracellular vesicles; plant-derived extracellular vesicles; bacterial-derived extracellular vesicles; cancer progression; cell migration and invasion; tumor microenvironment; epithelial-to-mesenchymal transition (EMT); drug delivery; diagnostics; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Obesity: From Cellular Mechanism to Potential Molecular Therapies
edited by
submission deadline 20 Aug 2026 | 4 articles | Viewed by 8093 | Submission Open
Keywords: metabolic pathways; gene expression; epigenetics; obesity-related comorbidities; molecular biomarkers; adipogenesis; therapeutic interventions; small molecules; gene therapy/gene editing; obesity and cancer
(This special issue belongs to the Section Molecular Biology)
Biomarkers in Precision Medicine
edited by
submission deadline 20 Aug 2026 | 1 articles | Viewed by 8087 | Submission Open
Keywords: biomarkers; precision medicine; novel techniques; artificial intelligence
(This special issue belongs to the Section Molecular Biology)
Molecular Imaging for Cancer Theranostics
edited by and Kai Bao
submission deadline 20 Aug 2026 | 2 articles | Viewed by 7868 | Submission Open
Keywords: molecular imaging; cancer theranostics; precision medicine; targeted therapy; diagnostic imaging; theranostic agents; multimodal imaging; molecular probes
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Insights into the Mechanisms of Neurodegeneration and Regeneration: From Bench to Bedside
edited by Irina Ivanova Stoyanova
submission deadline 20 Aug 2026 | 4 articles | Viewed by 7504 | Submission Open
Keywords: neurodegeneration; neuroregeneration; molecular neurobiology; brain development; developmental brain disorders; synaptogenesis; synaptic plasticity; cognitive neuroscience; neurotrauma
(This special issue belongs to the Section Molecular Neurobiology)
Zebrafish: A Model Organism for Human Health and Disease: 2nd Edition
edited by
submission deadline 20 Aug 2026 | 5 articles | Viewed by 7481 | Submission Open
Keywords: zebrafish; drug discovery; high-throughput screens; genome editing/CRISPR mutants; cancer; neuronal disorders; drug toxicity; drug effect mechanisms; developmental disorders
(This special issue belongs to the Section Molecular Biology)
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