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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cellular and Molecular Progression of Cardiovascular Diseases: 2nd Edition submission deadline 10 Sep 2026 | 5 articles | Viewed by 4227 | Submission Open
Keywords: cardiovascular diseases; multi-omics data; biomarkers; molecular level
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exercise in Health and Diseases: From the Molecular Perspectives
edited by and Danielle Dias
submission deadline 10 Sep 2026 | 4 articles | Viewed by 3477 | Submission Open
Keywords: exercise physiology; molecular mechanisms of exercise; exercise-induced cellular signaling; metabolic signaling pathways; redox biology and exercise
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Properties and Applications of Nanoparticles and Nanomaterials: 4th Edition
edited by Xiaogang Li
submission deadline 10 Sep 2026 | 1 articles | Viewed by 1035 | Submission Open
Keywords: nanostructures; nanoparticles; microstructure characterization; material design; evaluation of mechanical properties; applications of nanomaterials
(This special issue belongs to the Section Molecular Nanoscience)
Molecular and Cellular Advances in Coagulation and Bleeding
edited by
submission deadline 10 Sep 2026 | 1 articles | Viewed by 959 | Submission Open
Keywords: thrombosis; haemostasis; inflammation-coagulation cross ralk; proteomics; molecular biomarkers
(This special issue belongs to the Section Molecular Biology)
Nanomaterials for Targeted Therapy and Drug Delivery
edited by Ceren Kimna
submission deadline 10 Sep 2026 | Viewed by 324 | Submission Open
Keywords: nanocarriers ; targeted therapies ; translational nanomedicine ; nano-bio interactions
(This special issue belongs to the Section Molecular Nanoscience)
Pain: From Bench to Bedside
edited by and Robert J. Yong
submission deadline 20 Sep 2026 | 1 articles | Viewed by 55818 | Submission Open
Keywords: CGRP pathway; chronic pain; drug discovery; ion channels; machine learning; molecular targets; neuroimmune signaling; non-opioid analgesics; translational pain research; Afrikaans; Albanian; Amharic; Arabic; Armenian; Azerbaijani; Bengali; Bulgarian; Catalan; Croatian; Czech; Danish; Dutch; English; Estonian; Finnish; French; German; Greek; Gujarati; Haitian Creole; Hebrew; Hindi; Hungarian; Icelandic; Indonesian; Italian; Japanese; Kannada; Kazakh; Khmer; Korean; Kurdish (Kurmanji); Lao; Latvian; Lithuanian; Malagasy; Malay; Malayalam; Maltese; Maori; Marathi; Myanmar (Burmese); Nepali; Norwegian; Pashto; Persian; Polish; Portuguese; Punjabi; Romanian; Russian; Samoan; Simplified Chinese; Slovak; Slovenian; Spanish; Swedish; Tamil; Telugu; Thai; Traditional Chinese; Turkish; Ukrainian; Urdu; Vietnamese; Welsh
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Autoimmune Diseases: From Pathogenesis to Treatment and Prognostic Markers
edited by Alessandra Bettiol
submission deadline 20 Sep 2026 | 13 articles | Viewed by 43507 | Submission Open
Keywords: autoimmune diseases; inflammation; immunity; pathogenesis; immunosuppressants; biologics; biomarkers
(This special issue belongs to the Section Molecular Immunology)
Drug Delivery to the Central Nervous System: From Design, Synthesis, and Evaluation
edited by
submission deadline 20 Sep 2026 | 6 articles | Viewed by 39731 | Submission Open
Keywords: central nervous system; central nervous system diseases; drug delivery systems; blood–brain barrier; blood–cerebrospinal fluid barrier; drug design; nanomedicine; neuropharmacology; neuroprotective agents; biomarkers
(This special issue belongs to the Section Molecular Neurobiology)
Plant Metabolomics: Uncovering the Hidden World of Plant Secondary Metabolites
edited by
submission deadline 20 Sep 2026 | 13 articles | Viewed by 32953 | Submission Open
Keywords: metabolomics; secondary metabolites; plant biochemistry; mass spectrometry; NMR spectroscopy; plant signaling pathways; natural products; chemical ecology; metabolic profiling; phytochemicals; medicinal plants; herbal medicines
(This special issue belongs to the Section Molecular Plant Sciences)
New Insights in Antibody Therapy
edited by
submission deadline 20 Sep 2026 | 4 articles | Viewed by 20156 | Submission Open
Keywords: biological therapy; antibody therapy; non-communicable diseases; infectious diseases; chronic disease
(This special issue belongs to the Section Molecular Immunology)
Type 2 Diabetes: Molecular Pathophysiology and Treatment
edited by
submission deadline 20 Sep 2026 | 7 articles | Viewed by 19032 | Submission Open
Keywords: type 2 diabetes mellitus and comorbidity; bioinformatics; molecular pathways; genetic background; biomarkers; novel therapies
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Renin-Angiotensin System in Health and Diseases
edited by
submission deadline 20 Sep 2026 | 3 articles | Viewed by 17101 | Submission Open
Keywords: coronavirus disease 2019 (COVID-19); SARS-CoV-2; RAAS; spike protein; angiotensin; ACE2; clinical study; basic experiments
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Understanding Aging in Health and Disease
edited by
submission deadline 20 Sep 2026 | 5 articles | Viewed by 16559 | Submission Open
Keywords: immunosenescence; age-related disease; ageing; oxidative stress; inflammaging
(This special issue belongs to the Section Molecular Biology)
Advances in Burn Wound Healing and Skin Regeneration: Innovations and Insights
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 15901 | Submission Open
Keywords: burn wound healing; skin regeneration; novel biomaterials; wound dressings; regenerative therapies
(This special issue belongs to the Section Biochemistry)
Neurological Diseases: From Pathogenesis to Molecular Diagnosis and Treatment submission deadline 20 Sep 2026 | 13 articles | Viewed by 15844 | Submission Open
Keywords: Alzheimer's disease; Parkinson's disease; Huntington's disease; epilepsy; stroke; neurological diseases; treatment of neurological diseases
(This special issue belongs to the Section Molecular Neurobiology)
25th Anniversary of IJMS: Advances in Physical Chemistry and Chemical Physics submission deadline 20 Sep 2026 | 15 articles | Viewed by 15141 | Submission Open
Keywords: molecular dynamics; quantum chemistry; spectroscopic techniques; supramolecular interactions; computational modeling; AI in chemistry
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Molecular Research of Dystonia and Parkinson’s Disease
edited by
submission deadline 20 Sep 2026 | 4 articles | Viewed by 14580 | Submission Open
Keywords: dystonia; Parkinson’s disease; molecular mechanism; molecular pathology; cell biology; genetic predisposition to disease; physiopathology; neural plasticity; animal models; biomedical translational science
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Latest Advances in Diabetes Research and Practice
edited by Ezekiel Uba Nwose
submission deadline 20 Sep 2026 | 9 articles | Viewed by 13980 | Submission Open
Keywords: diabetes mellitus; cardiovascular risk; metabolic syndrome; antioxidants; oxidative stress; antiplatelet monitoring; evidence-based medicine; laboratory medicine
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Advances in Computer-Aided Drug Design Strategies submission deadline 20 Sep 2026 | 3 articles | Viewed by 13948 | Submission Open
Keywords: computer-aided drug design; artificial intelligence in drug discovery; molecular docking; molecular dynamics simulations; macromolecular systems; quantum mechanics/molecular mechanics (QM/MM); big data analytics in drug development; pharmacokinetics optimization; structure-based drug design (SBDD); ligand-based drug design; virtual screening techniques
(This special issue belongs to the Section Molecular Informatics)
Cancer Drug Treatment and Cancer Cell Drug Resistance submission deadline 20 Sep 2026 | 3 articles | Viewed by 13674 | Submission Open
Keywords: cellular plasticity; heterogeneity; combinational chemotherapy; metastasis; tumor relapse; novel targets; drug delivery
(This special issue belongs to the Section Molecular Pharmacology)
Advances in the Genetics, Epidemiology and Management of Myopathies submission deadline 20 Sep 2026 | 2 articles | Viewed by 13538 | Submission Open
Keywords: myopathies; muscle disorders; muscle weakness; muscle pain; myalgia
(This special issue belongs to the Section Molecular Biology)
Progression of Multiple Sclerosis: Environmental Factors, Genetics, Therapeutics and Immunopathogenesis
edited by Alberto Gajofatto
submission deadline 20 Sep 2026 | 5 articles | Viewed by 13486 | Submission Open
Keywords: multiple sclerosis; disability progression; neurodegeneration; pathogenesis; immunology; risk factor; environment; genetics; treatment
(This special issue belongs to the Section Molecular Neurobiology)
Inner Ear Disorders: From Molecular Mechanisms to Treatment
edited by
submission deadline 20 Sep 2026 | 5 articles | Viewed by 13441 | Submission Open
Keywords: hearing loss; balance disorders; stem cell approaches; precision gene therapy; molecular reprogramming; targeted delivery systems; molecular biomarkers; suppression of oxidative stress and inflammation; tissue engineering; immune response and off-target effects
(This special issue belongs to the Section Molecular Immunology)
Antibody Engineering and Therapeutic Applications
edited by
submission deadline 20 Sep 2026 | 3 articles | Viewed by 13419 | Submission Open
Keywords: monoclonal antibody (mAb) therapies; antibody engineering; antibody-drug conjugate (ADC); chimeric antigen receptor T cell (CAR-T); bispecific antibody; T-cell engager (TCE); cancer immunotherapy; immunocytokine; AI-driven antibody design; antibody structure and mechanism of action
(This special issue belongs to the Section Molecular Pharmacology)
Inflammation in Chronic Disease: Molecular Mechanisms and Signaling Pathways
edited by
submission deadline 20 Sep 2026 | 4 articles | Viewed by 13294 | Submission Open
Keywords: inflammation; neuroinflammation; immune response; inflammation-associated disease; inflammation mediators (proteins, enzymes, ecc); cytokines; macrophages; mast cells; monocytes; dendritic cells; oxidative stress; signaling pathways
(This special issue belongs to the Section Molecular Immunology)
Inflammation in Pregnancy and Childbirth
edited by and Maciej Ziętek
submission deadline 20 Sep 2026 | 2 articles | Viewed by 13196 | Submission Open
Keywords: pregnancy; labor; eicosanoid; chronic inflammation; cytokines; intestinal dysbiosis; mitogen-activated protein kinase; nuclear factor kappa-light-enhancer-activated B cell; maresins, resolvins and protectins
(This special issue belongs to the Section Molecular Immunology)
Identification of Novel Biomarkers Towards Improved Diagnosis and Management of Peripheral Vascular Diseases
edited by
submission deadline 20 Sep 2026 | 7 articles | Viewed by 12765 | Submission Open
Keywords: vascular pathophysiology; peripheral atherosclerosis; aneurysm; venous disorders; congenital vascular malformations; molecular biomarkers; diagnostic biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Elucidating How Chondrocytes Maintain Cartilage Stability
edited by James A. Martin
submission deadline 20 Sep 2026 | 7 articles | Viewed by 12020 | Submission Open
Keywords: chondrocytes; articular cartilage; chondrogenesis; osteoarthritis; mechano-transduction; aging; extracellular matrix
(This special issue belongs to the Section Molecular Biology)
Parkinson’s Disease and Related Diseases: Mechanisms, Genetic Factors and Treatments
edited by
submission deadline 20 Sep 2026 | 5 articles | Viewed by 11977 | Submission Open
Keywords: Parkinson’s disease; neurodegenerative disorders; α-synuclein aggregation; neuroinflammation; gene therapy; biomarkers
(This special issue belongs to the Section Molecular Neurobiology)
Artificial Intelligence and Computer-Aided Design: Molecular Simulation Technology in Exploring Bioactive Compounds for Health Promotion
edited by
submission deadline 20 Sep 2026 | 4 articles | Viewed by 11428 | Submission Open
Keywords: molecular simulation; bioactive compounds; molecular docking; molecular dynamics; quantum mechanics; functional mechanisms
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Structures, Syntheses of Natural Products, and Their Biological Effects
edited by
submission deadline 20 Sep 2026 | 4 articles | Viewed by 11066 | Submission Open
Keywords: structures of natural products; syntheses; biological effects; biomedical applications
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms, Pathogenesis, and Novel Therapeutic Strategies in Cardiovascular Disease, 2nd Edition
edited by
submission deadline 20 Sep 2026 | 3 articles | Viewed by 10767 | Submission Open
Keywords: aneurysm pathobiology; vascular remodeling; extracellular matrix degradation; inflammatory signaling pathways; molecular targets for therapy; autophagy; macrophage; inflammation; immune cell regulation; age-related diseases; therapeutic implications
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of the Aging Process: 2nd Edition submission deadline 20 Sep 2026 | 2 articles | Viewed by 10636 | Submission Open
Keywords: aging process; molecular mechanisms; epigenetic clock; cancer; metabolic disease
(This special issue belongs to the Section Molecular Biology)
Thyroid Function in Human Diseases: From Physiopathology to Clinical Impact on Human Health
edited by and Andrea Corsello
submission deadline 20 Sep 2026 | 5 articles | Viewed by 10617 | Submission Open
Keywords: thyroid physiology; hypothyroidism; hyperthyroidism; central hypothyroidism; inappropriate TSH secretion syndrome; drugs interfering with thyroid function; sick euthyroid syndrome; consumptive hypothyroidism syndrome
(This special issue belongs to the Section Molecular Biology)
The Role of Bioactive Compounds in Human Health and Disease: 3rd Edition
edited by
submission deadline 20 Sep 2026 | 6 articles | Viewed by 10420 | Submission Open
Keywords: cancer; inflammation; cardiovascular diseases; plants; bioactive compounds
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Melanin and Other Pigments: Function, Synthesis and Characterization
edited by Koen P. Vercruysse
submission deadline 20 Sep 2026 | 4 articles | Viewed by 10194 | Submission Open
Keywords: melanin; eumelanin; pheomelanin; allomelanin; catechol; indole; phenol
(This special issue belongs to the Section Biochemistry)
Gluten/Wheat-Related Disorders: The Role of Nutrition, Gut Barrier, Microbiota, and New Therapeutic Strategies
edited by Lisa Lungaro
submission deadline 20 Sep 2026 | 2 articles | Viewed by 10014 | Submission Open
Keywords: gluten-related disorders; celiac disease; non celiac gluten wheat sensitivity; gluten free diet; microbiota; gut barrier; probiotics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biosynthesis of Phytochemicals and Their Applications in Novel Drug Lead Development
edited by
submission deadline 20 Sep 2026 | 5 articles | Viewed by 9927 | Submission Open
Keywords: biosynthesis of phytochemicals in plants; phytochemical isolation; phytochemical structure; animal and human protein targets of phytochemicals; chemical derivatives of phytochemicals
(This special issue belongs to the Section Molecular Pharmacology)
Medicinal Plant Resources—from Molecular Studies to Sustainable Use
edited by Ekaterina Kozuharova
submission deadline 20 Sep 2026 | 3 articles | Viewed by 9724 | Submission Open
Keywords: genetic improvement of medicinal plants; sustainable use; bioactive compounds
(This special issue belongs to the Section Molecular Plant Sciences)
Bioactive Molecules from Food or Other Natural Sources Against Cancer: 2nd Edition submission deadline 20 Sep 2026 | 3 articles | Viewed by 9724 | Submission Open
Keywords: cancer; natural bioactive molecules; natural products; tumor
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Pharmacology and Interventions in Cardiovascular Disease: 2nd Edition submission deadline 20 Sep 2026 | 5 articles | Viewed by 9541 | Submission Open
Keywords: cardiovascular pharmacology; cardiovascular interventions; cardioprotection; myocardial ischemia and infarction; heart failure
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Immunosuppressive Therapy
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 9281 | Submission Open
Keywords: immunosuppressive drugs; calcineurin inhibitors; corticosteroids; inhibitors of purine synthesis; mammalian target of rapamycin inhibitors; biological treatment; cell-based therapies; biomarkers; genetic profiling
(This special issue belongs to the Section Molecular Immunology)
New Challenges of Parkinson’s Disease, 2nd Edition submission deadline 20 Sep 2026 | 5 articles | Viewed by 9249 | Submission Open
Keywords: Parkinson’s disease; neurodegeneration; synuclein; diagnosis; genetics; epigenetics; extracellular vesicles; biomarkers; treatments; rehabilitation
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Insights into Nutrition, Genetics, and Biochemistry: From Mechanisms to Therapeutics submission deadline 20 Sep 2026 | 2 articles | Viewed by 9169 | Submission Open
Keywords: nutrigenomics and nutrigenetics; molecular nutrition; oxidative stress and redox biology; epigenetics and diet; lipid and glucose metabolism; inflammatory pathways; transcriptomics, metabolomics, proteomics; mitochondrial dysfunction and nutrition; biomarkers of diet-related disease; precision nutrition and molecular therapeutics
(This special issue belongs to the Section Molecular Biology)
Cellular and Molecular Study of Neurodevelopmental and Neurological Disorders
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 9011 | Submission Open
Keywords: autism spectrum disorder; ADHD; schizophrenia; intellectual disability; Alzheimer’s disease; Parkinson’s disorder; traumatic brain injury; epilepsy; neurodevelopmental disorders; neurological diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
From Macrophage Biology to Cell and EV-Based Immunotherapies submission deadline 20 Sep 2026 | 2 articles | Viewed by 8988 | Submission Open
Keywords: macrophage-based; macrophage-targeting; cancer immunotherapies; autoimmunity
(This special issue belongs to the Section Molecular Immunology)
Exploring the Complex Interplay Between Metabolic Diseases, MASLD, and Liver Cancer submission deadline 20 Sep 2026 | 4 articles | Viewed by 8746 | Submission Open
Keywords: hepatocellular carcinoma; MASLD; MASH; obesity; insulin resistance; dyslipidemia; liver cancer
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Regenerative Medicine and Therapeutics
edited by
submission deadline 20 Sep 2026 | 3 articles | Viewed by 8668 | Submission Open
Keywords: regenerative medicine; morphology; regenerative dentistry; biomaterials; scaffolds; organoids; tissue regeneration
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Dialogue Between Inflammation and Immunity: From Mechanism to Therapy
edited by
submission deadline 20 Sep 2026 | 4 articles | Viewed by 8560 | Submission Open
Keywords: inflammation; immune activation; immunomodulation; tolerance; immunotherapy; autoimmune diseases; cancer
(This special issue belongs to the Section Molecular Immunology)
Advanced Molecular Research in Brain Tumors
edited by
submission deadline 20 Sep 2026 | 7 articles | Viewed by 8552 | Submission Open
Keywords: targeted therapy; blood–brain barrier; GBM; glioma; immune checkpoint blockers; TME
(This special issue belongs to the Section Molecular Oncology)
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