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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Research on Intracellular Signal Transduction Systems

edited by

Takaya Satoh

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2764 | Submission Open

Keywords: signal transduction; receptor; G protein; kinase; second messenger; gene expression; cytoskeleton; human disease

(This special issue belongs to the Section Molecular Biology)

Synthesis and Application of Chiral Ligands and Heterocycles in Pharmacological Studies

edited by

István Szatmári

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2738 | Submission Open

Keywords: nonracemic amino acids; enantioselective synthesis; chiral catalysis; enantiopure bioconjugates; electron-rich hydroxyquinoline; indole; β -carboline; bioactive compounds

(This special issue belongs to the Section Molecular Pharmacology)

The Role of microRNA in Human Diseases: 3rd Edition

edited by

Andrey Turchinovich

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2711 | Submission Open

Keywords: microRNA (miRNA); non-coding RNAs; human diseases; cancer; fatty liver; cardiovascular diseases; neurological diseases; viral infection

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Breakthroughs in Cardiac Tissue Remodeling: From Mechanisms to Therapeutics

edited by

Antonio Lax

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2682 | Submission Open

Keywords: myocardial infarction; heart failure; adverse remodeling; cardiac fibrosis; cardiomyopathy; cardiotoxicity; ventricular remodeling; cardiac dysfunction; biomarkers; cardiac regeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Cellular and Molecular Insights into Glaucoma

edited by

Meritxell López-Gallardo

and

José A. Fernández-Albarral

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2666 | Submission Open

Keywords: neuroinflammation; microglia; macroglia; retinal ganglion cells; therapeutical approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Pathology and Treatment of Heart Failure

edited by

Giuseppe Armentaro

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2652 | Submission Open

Keywords: heart failure; oxidative stress; platelet activation; inflammation; biomarkers; pathophysiology; comorbidities

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Developments in Molecular Genetic Breeding of Forest Trees

edited by

Su Chen

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2612 | Submission Open

Keywords: tree genetics; tree breeding; molecular breeding; genetic improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Role of Extracellular Vesicles in Diseases

edited by

Gorjana Rackov

and

Aoife Ward Gahlawat

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2599 | Submission Open

Keywords: extracellular vesicles (EVs); biomarkers; disease pathophysiology; miRNAs; intercellular communication; therapeutic targets; mitochondrial transfer; cancer; neurodegenerative disorders; precision medicine

(This special issue belongs to the Section Biochemistry)

Interactions between Plants and Nematodes

edited by Qian Liu

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2594 | Submission Open

Keywords: plant nematodes; hosts; interaction; effectors; giant cells; syncytia

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Omics in Cancer Diagnosis and Treatment

edited by Xiaohu Tang

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2560 | Submission Open

Keywords: cancer; heterogeneity; omics; biomarker; therapeutic targets; drug resistance; molecular profile; algorithm

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Signaling Pathways in Neuroinflammatory Disorders

edited by

Martina Schmidt

and

Karim Rafie

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2547 | Submission Open

Keywords: blood– brain barrier; inducible pluripotent stem cells; organoids; scaffolds; neuroinflammation; microglia; mitochondria; endothelial cells; drug screening; virus infections; cryo-EM

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pathogenesis and Antiviral Treatment of Emerging and Reemerging Viral Infections

edited by

Luciana Barros de Arruda

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2510 | Submission Open

Keywords: viral replication; antiviral; inflammation; vaccine; arbovirus; respiratory virus; hemorrhagic virus; neurotropic virus

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Glial Cells in Neurodegenerative Disorders

edited by Daniel Souza Monteiro de Araujo

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2455 | Submission Open

Keywords: glial cells; microglia; astrocytes; oligodendrocytes; neurodegenerative disorders

(This special issue belongs to the Section Molecular Neurobiology)

Basic, Translational and Clinical Research on Dementia—Second Edition

edited by

Giacinto Bagetta

Damiana Scuteri

and Daniele Bano

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2433 | Submission Open

Keywords: dementia; Alzheimer’ s disease; amyloid-beta; tau protein

(This special issue belongs to the Section Molecular Neurobiology)

Precision Medicine in Cancers

edited by

Mehdi Kardoust Parizi

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2424 | Submission Open

Keywords: precision medicine; cancer biomarkers; targeted therapy; genomic profiling; personalized treatment; tumor heterogeneity; molecular diagnostics; clinical research

(This special issue belongs to the Section Molecular Oncology)

Lipopolysaccharide in the Health and Disease

edited by

Gen-Ichiro Soma

and Hiroyuki Inagawa

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2379 | Submission Open

Keywords: usefulness of LPS; oral and/or dermal administration of LPS; lifestyle disease; cognitive dysfunction; allergy; autoimmune disorder; wound healing; cancer

(This special issue belongs to the Section Biochemistry)

Advances in Molecular Biology on Mycobacteria: 2nd Edition

edited by

Rita Macedo

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2251 | Submission Open

Keywords: genus Mycobacterium; non-tuberculous mycobacteria; Mycobacterium tuberculosis; Mycobacterium leprae; molecular diagnosis; molecular surveillance methodologies; molecular resistance prediction

(This special issue belongs to the Section Molecular Microbiology)

Computational Modelling at the Blood–Brain Barrier

edited by Christian Jorgensen

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2210 | Submission Open

Keywords: blood– brain barrier models; molecular dynamics simulations; artificial intelligence; CNS penetration predictive models; asymmetric membranes; efflux pumps

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights and Innovations in Brain Cancer Research

edited by Vinay K. Sharma

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2205 | Submission Open

Keywords: glioblastomas; astrocytomas; brain tumors; targeted therapies; immunotherapy; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Advancing Interdisciplinary Science with Quantum/Molecular Mechanics (QM/MM) in Computational Chemistry

edited by

Yang Gao

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2201 | Submission Open

Keywords: QM/MM; computational methods; electronic structure; f-electron systems; materials science; nanoclusters; nuclear medicine; computational catalysis; drug design; machine learning in computational chemistry

(This special issue belongs to the Section Materials Science)

Sulfur-Containing Compounds: Synthesis, Characterization and Antimicrobial or Anticancer Activity

edited by

Paola Bonaccorsi

Chiara Maria Antonietta Gangemi

and

Anna Barattucci

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2173 | Submission Open

Keywords: sulfurated compounds; sulfoxides; disulfides; sulfides; thiosulfinates; xanthates; antibacterial; antivirus; anticancer; antimicrobial

(This special issue belongs to the Section Biochemistry)

Molecular and Cellular Mechanisms of Comorbidities in Rheumatic Diseases

edited by

Marino Paroli

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2168 | Submission Open

Keywords: inflammatory and autoimmune rheumatic diseases; comorbidities; autoimmunity; T-cell response

(This special issue belongs to the Section Molecular Immunology)

Cancer Biology: From Genetic Aspects to Treatment, 2nd Edition

edited by

Silvia Cantara

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2151 | Submission Open

Keywords: cancer biology; cancer biomarker; cancer progression; cancer metastasis; genetic of cancer

(This special issue belongs to the Section Molecular Oncology)

ROS Signalling and Cell Turnover

edited by

Micol Silic-Benussi

submission deadline 20 Nov 2025 | 2 articles | Viewed by 1963 | Submission Open

Keywords: metabolism; lipid droplets; nanoparticles; ROS; cancer therapy; redox homeostasis; mitochondria; cell death

(This special issue belongs to the Section Biochemistry)

Molecular Crosstalk Between Bone and Inflammation

edited by Jessica Cottrell

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1831 | Submission Open

Keywords: bone; inflammation; immunology; bone metabolism; inflammatory disease

(This special issue belongs to the Section Molecular Immunology)

Molecular Pathophysiology and Treatment of Coronary Artery Disease

edited by

Kazufumi Nakamura

submission deadline 20 Nov 2025 | 2 articles | Viewed by 1623 | Submission Open

Keywords: coronary artery disease; ischemic cardiomyopathy; immune-related adverse events; CAD associated with autoimmune diseases; coronary artery disease-related cardiomyopathy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Compounds in Neurodegenerative Diseases

edited by

Silvia Lima Costa

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1607 | Submission Open

Keywords: bioactive compounds; neurodegenerative diseases; neuroinflammation; oxidative stress

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular and Physiological Analysis of Stress in Plants

edited by

Yong Li

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1604 | Submission Open

Keywords: plant stress; biotic stress; abiotic stress; stress response; gene expression; epigenetic stress memory; ABA; SA

(This special issue belongs to the Section Molecular Plant Sciences)

Reproductive Physiology and miRNA-Mediated Gene Regulation in Domestic Animals

edited by

Margherita Maranesi

and

Gabriella Guelfi

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1603 | Submission Open

Keywords: reproductive physiology; microRNAs; miRNAs; gene regulation; domestic animals

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Antifungal Resistance and Virulence

edited by

Francisco E. Nicolás

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1593 | Submission Open

Keywords: fungal infections; antifungal therapies; antifungal resistance; fungal virulence

(This special issue belongs to the Section Molecular Microbiology)

Toxicants and Their Effects on Innate Immune Function and Inflammatory Response

edited by

James M. Harper

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1545 | Submission Open

Keywords: ecotoxicology; innate immunity; inflammation; pesticides; plasticizers; pattern-recognition receptors

(This special issue belongs to the Section Molecular Toxicology)

New Advances of Free-Radical Reactions in Organic Chemistry

edited by

José Justicia

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1542 | Submission Open

Keywords: free-radical reactions; organic chemistry; organic synthesis; fotoredox reactions; organometallics reactions; computational calculations; free radicals in biology; free radicals in green chemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Nanodiagnosis and Treatment System for Human Health

edited by

Nan Gao

submission deadline 20 Nov 2025 | 2 articles | Viewed by 1530 | Submission Open

Keywords: nanodiagnosis; nanodrugs; nano-antibody; nanosensor; nanoprobe technology

(This special issue belongs to the Section Molecular Nanoscience)

Composites of Carbon Nanomaterials and Transition Metals: Preparation, Properties, Bioapplications

edited by

Robert Piech

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1484 | Submission Open

Keywords: composite materials; carbon nanomaterials; nanoparticles of transition metals and their compounds; preparation and functionalization of composite materials; biosensors; bioapplications

(This special issue belongs to the Section Molecular Nanoscience)

Applications of Phytochemicals in Drug Synthesis

edited by

Gregorio Peron

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1456 | Submission Open

Keywords: natural products; phytochemistry; chemical synthesis; drugs; medicinal plants; natural sources; byproducts

(This special issue belongs to the Section Bioactives and Nutraceuticals)

DNA Replication, Damage and Repair in Repeat Instability: Their Role from Bacteria to Genetic Disorders in Humans

edited by

Enrique Viguera

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1420 | Submission Open

Keywords: DNA repeat instability; DNA replication; DNA damage; DNA repair; tandem repeats; trinucleotide repeats; repeat expansion diseases; microsatellite instability; replication slippage; phenotypic variability; bacteria; genetic disorders

(This special issue belongs to the Section Molecular Genetics and Genomics)

Toxicology and Pharmacology of Natural Products

edited by

Yibin Feng

, Cheng Zhang and Sha Li

submission deadline 20 Nov 2025 | Viewed by 1360 | Submission Open

Keywords: pharmacology; toxicology; natural products; Chinese medicine; drug discovery; safety assessment; ethnopharmacology; analytical techniques; regulatory frameworks

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Drug Repositioning: Current Challenges and Future Perspectives of a Sustainable Experimental and In Silico Approach

edited by

Maria Francesca Armentano

and

Rocchina Miglionico

submission deadline 20 Nov 2025 | 2 articles | Viewed by 1344 | Submission Open

Keywords: drug discovery; drug repositioning; biologics; small molecules; artificial intelligence (AI); cancer; neurodegenerative diseases; therapeutic strategies

(This special issue belongs to the Section Molecular Pharmacology)

Genomic Research in Carcinogenesis, Cancer Progression and Recurrence

edited by

Magdalena Orzechowska

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1303 | Submission Open

Keywords: genomic profiling; carcinogenesis; metastasis; recurrence; precision medicine; tumor evolution metrics; sequencing; tumor markers

(This special issue belongs to the Section Molecular Oncology)

Molecular Research on Orchid Plants: 2nd Edition

edited by Wen‑Chieh Tsai

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1240 | Submission Open

Keywords: orchid; genomics; genome; genes; tumor; inflammation; drug; transcriptomics

(This special issue belongs to the Section Molecular Plant Sciences)

Cutting-Edge Advances in New Anticancer Agents: Design, Synthesis and Application

edited by Mahendiran Dharmasivam

submission deadline 20 Nov 2025 | 2 articles | Viewed by 1215 | Submission Open

Keywords: combination therapies in oncology; small-molecule inhibitors in cancer treatment; natural-product-based cancer therapeutics; immunotherapy advancements in oncology; targeting metastatic dormancy in cancer; modulating the tumour microenvironment for therapeutic benefit; three-dimensional cancer models in drug discovery; predictive biomarkers for chemoresistance; medicinal chemistry approaches in anticancer agent design; drug development strategies for resistant cancers

(This special issue belongs to the Section Molecular Oncology)

Conversion and Valorization of Lignocellulosic Biomass

edited by

Loredana Marcolongo

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1211 | Submission Open

Keywords: lignocellulosic biomass; vegetal and agro processing wast; catalytic and biocatalytic conversion; value added products; lignocellulosic platform; bioprocessing; biorefinery; green chemistry; circular economy; bioeconomy

(This special issue belongs to the Section Biochemistry)

Melanoma: From Molecular Mechanisms to Therapeutics

edited by Dorota Ciołczyk-Wierzbicka

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1104 | Submission Open

Keywords: melanoma; molecular mechanism; signaling pathways; genetic mutations; cancer therapy/treatment; drug resistance

(This special issue belongs to the Section Molecular Oncology)

Chemical and Biotechnological Strategies to Tailor the Properties of Biomaterials

edited by

Eduardo García-Junceda

and

Julia Revuelta

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1057 | Submission Open

Keywords: biomaterial functionalization; green chemistry in biomaterials; biotechnological modification; stimuli-responsive materials; translational biomaterials

(This special issue belongs to the Section Materials Science)

Molecular Genetics and Breeding Mechanisms in Crops: 3rd Edition

edited by

Shaozhen He

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1049 | Submission Open

Keywords: crops; molecular genetics; breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Role of Protein Post-Translational Modifications in Cancer: Mechanisms and Therapeutic Opportunities

edited by

Mauro Salvi

Wei-Chien Huang

and

Josefa León

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1046 | Submission Open

Keywords: phosphorylation; acetylation; methylation; sumoylation; ubiquitination; glycosylation; acylation; signal transduction; inhibitors

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms of Sprouty Proteins in Cancer

edited by Barbara Hausott and

Lars Klimaschewski

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1024 | Submission Open

Keywords: sprouty; tumor growth; apoptosis; migration; signaling

(This special issue belongs to the Section Molecular Biology)

Nucleolus, Nucleolar Stress, and Ribosome Biogenesis in the Nervous System

edited by

Theologos Michaelidis

submission deadline 20 Nov 2025 | Viewed by 968 | Submission Open

Keywords: nucleolus; nucleolar stress; nucleolar homeostasis; polymerase I; rDNA transcription; ribosome biogenesis; translation; ribosomopathies; apoptosis; autophagy; senescence; neurodegeneration; tumorigenesis

(This special issue belongs to the Section Molecular Neurobiology)

Cancer Models: Development and Applications

edited by

Yong Teng

submission deadline 20 Nov 2025 | 1 articles | Viewed by 917 | Submission Open

Keywords: tumor organoids; animal models of cancer; drug screening models; highly clinically relevant cancer models; technologies related to cancer model development

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Aquatic Organisms Models Dedicated to Disease

edited by