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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The New Developments in Third-Generation Sequencing Methods in Human Rare Diseases

edited by

Rick Kamps

submission deadline 20 Apr 2026 | Viewed by 259 | Submission Open

Keywords: short-read sequencing; long-read sequencing; single-cell rna sequencing; spatial-transcriptomic sequencing; single-nucleotide sequencing; structural-variant sequencing; protein-omics sequencing

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancements in Antioxidant Molecules: From Discovery to Therapeutic Applications

edited by

Davide Moi

submission deadline 20 Apr 2026 | Viewed by 257 | Submission Open

Keywords: antioxidants; natural products; small molecules; polyphenols; reactive oxygen species; drug discovery; oxidative stress; apoptosis; target validation

(This special issue belongs to the Section Molecular Pharmacology)

Recent Molecular Research in Colitis

edited by

Pablo García-Miranda

and

María Vázquez-Carretero

submission deadline 20 Apr 2026 | Viewed by 252 | Submission Open

Keywords: colitis; inflammatory bowel disease (IBD); gut-brain axis; intestinal barrier; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Magnetic Materials: Synthesis, and Applications

edited by Artur Chrobak

submission deadline 20 Apr 2026 | Viewed by 251 | Submission Open

Keywords: magnetic materials; properties; synthesis; applications

(This special issue belongs to the Section Materials Science)

The Role of Medicinal Plants in the Treatment of Neurodegenerative Diseases: Advances, Challenges, and Future Perspectives

edited by

Katarzyna E. Stȩpnik

submission deadline 20 Apr 2026 | Viewed by 244 | Submission Open

Keywords: medicinal plants; neuroprotection; neurodegeneration; plant secondary metabolites; molecular mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Drug-Induced Toxicity and Its Role in Disease Progression and Therapeutic Outcomes

edited by

Eugenia Gallardo

and

Tiago Rosado

submission deadline 20 Apr 2026 | Viewed by 236 | Submission Open

Keywords: drug-induced toxicity; drug-drug interactions; drug delivery systems; toxicity; disease

(This special issue belongs to the Section Molecular Toxicology)

MDSCs in Health and Disease

edited by

Víctor Sánchez-Margalet

submission deadline 20 Apr 2026 | Viewed by 232 | Submission Open

Keywords: MDSCs; inflammation; immune regulation; cancer; autoimmune diseases; pregnancy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Alzheimer’s Disease: Molecular Mechanisms and Novel Therapies

edited by Noah R. Johnson and

Chih Hung Lo

submission deadline 20 Apr 2026 | Viewed by 231 | Submission Open

Keywords: intrinsically disordered proteins; apolipoproteins; neuroinflammation and neuroimmune; autolysosomal and mitochondrial functions; lipid metabolism; blood-brain barrier; biosensors; nanomedicine; high-throughput screening; therapeutic discovery

(This special issue belongs to the Section Molecular Neurobiology)

Serum Amyloid A: Established Roles and Emerging Questions in Health and Disease

edited by Preetha Shridas

submission deadline 20 Apr 2026 | Viewed by 226 | Submission Open

Keywords: Serum Amyloid A; high-density lipoprotein; acute inflammation; chronic inflammatory

(This special issue belongs to the Section Biochemistry)

3D Printing in Pharmaceutical Drug Delivery

edited by

Sagar Narala

and

Dinesh Nyavanandi

submission deadline 20 Apr 2026 | Viewed by 225 | Submission Open

Keywords: personalized medication; 3-dimensional printing; solubility and bioavailability enhancement; polymers for 3D printing; bio-inks; 3D-printed implants; additive manufacturing

(This special issue belongs to the Section Molecular Pharmacology)

The Positive Impact of DNA-Derived Substances on Inflammation, Aging and Associated Symptoms

edited by

Mi Young Lee

submission deadline 20 Apr 2026 | Viewed by 224 | Submission Open

Keywords: PDRN; PN; DNA-derived substances; nucleic acid-based therapeutics; inflammation; aging

(This special issue belongs to the Section Molecular Biology)

Molecular Application of Biomaterial in Skin Diseases

edited by

Danuta Nowicka

submission deadline 20 Apr 2026 | Viewed by 224 | Submission Open

Keywords: chronic dermatoses; autologus material; PRP; stem cells; growth factors

(This special issue belongs to the Section Materials Science)

Autosomal Dominant Polycystic Kidney Disease (ADPKD): Molecular Mechanism, Management and Therapy

edited by

Maria Teresa Sciarrone Alibrandi

submission deadline 20 Apr 2026 | Viewed by 223 | Submission Open

Keywords: autosomal dominant polycystic kidney disease; ADPKD progression; cystic kidney disease; cardiovascular complications in ADPKD; biomarkers of ADPKD; genetics of polycystic kidney disease; renal imaging; targeted therapies in ADPKD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antibacterial and Antioxidant Effects of Plant-Sourced Compounds: 2nd Edition

edited by Johana Rondevaldova

submission deadline 20 Apr 2026 | Viewed by 221 | Submission Open

Keywords: antibacterial effect; antioxidants; medicinal plants; anti-infective agents; phytochemicals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular, Cellular and Systems Research on Neuroanatomy, Brain Function and Its Impact on Human Behavior

edited by

Frank Schmitz

submission deadline 20 Apr 2026 | Viewed by 219 | Submission Open

Keywords: central nervous system; neuroanatomy; human behavior; nuclei; neuronal circuits; connectivity channels

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Cellular Research on Cardiac Repair and Regeneration

edited by

Francesca Pagano

and

Vittorio Picchio

submission deadline 20 Apr 2026 | Viewed by 219 | Submission Open

Keywords: cardiac repair; cardiomyocyte differentiation; cardiac fibroblast activation; cardiac fibrosis; cardiac tissue microenvironment; cardiac remodeling

(This special issue belongs to the Section Molecular Biology)

Bone Microenvironment and Bone Metastasis

edited by

Cristina Sanchez de Diego

submission deadline 20 Apr 2026 | Viewed by 219 | Submission Open

Keywords: bone metastasis; tumor– bone interaction; bone microenvironment; osteoclastogenesis; osteoblast signaling; bone remodeling; dormancy; immune evasion; extracellular matrix

(This special issue belongs to the Section Molecular Oncology)

Molecular Research on Proglucagon-Derived Peptides

edited by

Camilla Krizhanovskii

submission deadline 20 Apr 2026 | Viewed by 219 | Submission Open

Keywords: proglucagon; peptide hormones; post-translational processing; prohormone convertase; G-protein-coupled receptors; tissue specificity

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Research of Cardiovascular Disease

edited by

John A. St. Cyr

submission deadline 20 Apr 2026 | Viewed by 218 | Submission Open

Keywords: myocardium; metabolism; ischemia; function; integrity; cardiovascular; disease; infarction; failure

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microbial Metabolism: From Pathway Analysis to Metabolic Engineering and Synthetic Biology

edited by

Elias R. Olivera

submission deadline 20 Apr 2026 | Viewed by 218 | Submission Open

Keywords: bacteria; fungi; archeobacteria; metabolic pathways; biodegradation; biosynthesis; biotransformation; omic sciences; metabolic engineering; synthetic regulatory circuits

(This special issue belongs to the Section Molecular Microbiology)

Molecular Insights into Probiotics and Prebiotics in Gut Health and Disease

edited by

Hikmate Abriouel

submission deadline 20 Apr 2026 | Viewed by 218 | Submission Open

Keywords: probiotics; prebiotics; gut microbiota; intestinal health; dysbiosis; host– microbe interactions; omics; gut– brain axis

(This special issue belongs to the Section Molecular Microbiology)

The Impact of Circulating Biomarkers and Metabolites on Cardiometabolic Disease and Cancer: New Insights and Therapeutic Opportunities

edited by Melania Gaggini and

Cristina Vassalle

submission deadline 20 Apr 2026 | Viewed by 217 | Submission Open

Keywords: lipidomic; metabolomic; lipotoxicity; oxidative stress; amino acids; metabolic disease; cardiovascular risk; tumorigenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

RNA in Human Diseases: Challenges and Opportunities: 2nd Edition

edited by

Nicoletta Potenza

submission deadline 20 Apr 2026 | Viewed by 215 | Submission Open

Keywords: microRNA; piRNA; lncRNA; circRNA; RNA therapeutics; ceRNET; RNA disease; RNA processing; RNA modification

(This special issue belongs to the Section Molecular Biology)

Cracking the Molecular Code of Breast Cancer

edited by Bartlomiej Taciak

submission deadline 20 Apr 2026 | Viewed by 212 | Submission Open

Keywords: breast cancer; TNBC; immunotherapy; microRNAs; NGS; therapeutics; biomarkers; epigenetics

(This special issue belongs to the Section Molecular Oncology)

Intercellular Adhesion and Inflammatory Response in Cancer

edited by Anna Pryczynicz

submission deadline 20 Apr 2026 | Viewed by 210 | Submission Open

Keywords: adhesion; cancer; cancer therapy; inflammation; microenvironment

(This special issue belongs to the Section Molecular Biology)

Targeting Receptor Tyrosine Kinases and Related Signalling Pathways in Cancer: Mechanisms, Resistance, and Therapeutic Advances

edited by

Athina-Myrto Chioni

and

Richard Grose

submission deadline 20 Apr 2026 | Viewed by 206 | Submission Open

Keywords: tyrosine kinase receptors (TKRs); tyrosine kinase inhibitors (TKIs); cancer; therapeutic resistance/cancer drug resistance/chemotherapy resistance; signaling pathways; metastasis; combination therapy; targeted therapy; next-generation inhibitors; allosteric inhibitors; personalized medicine; tumor microenvironment; immune evasion; immunotherapy; crosstalk in cancer signaling; miRNAs; lncRNAs; cancer therapeutics; biomarkers

(This special issue belongs to the Section Molecular Oncology)

Applications of Polymers in Organic Functional Materials

edited by

Paola Manini

submission deadline 20 Apr 2026 | Viewed by 203 | Submission Open

Keywords: functional polymers; polymer synthesis; stimuli-responsive polymers; self-healing polymers; nanostructured polymers; polymer composites; smart materials; polymeric catalysts; polymers in (bio)electronics; polymers for sustainable processes

(This special issue belongs to the Section Macromolecules)

Heavy Metal and Fluoride Stress: Toxicity and Tolerance Mechanisms in Plants

edited by

Hatem Rouached

submission deadline 20 Apr 2026 | Viewed by 200 | Submission Open

Keywords: heavy metal toxicity; fluoride stress; stress tolerance mechanisms; phytoremediation; oxidative stress response

(This special issue belongs to the Section Molecular Plant Sciences)

Bioactive Compounds in Bee Products: Chemistry, Mechanisms of Action and Nutritional Applications

edited by

Jarosław Widelski

and

Ioanna Chinou

submission deadline 20 Apr 2026 | Viewed by 197 | Submission Open

Keywords: honey; propolis; royal jelly; polyphenols; nutritional properties; bioactivity; analytical and isolation methods; bee pollen

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanism and Pharmacological Target of Neuroprotection

edited by

Pietro Cacialli

submission deadline 20 Apr 2026 | Viewed by 193 | Submission Open

Keywords: neurodegeneration; animal model; brain regeneration; pharmacological drug; molecular analysis

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms of Immunotherapy in Cancer

edited by Magdalena Król

submission deadline 20 Apr 2026 | Viewed by 190 | Submission Open

Keywords: cancer immunotherapy; tumor microenvironment; immune checkpoint inhibitors; monoclonal antibodies; cytokine signaling; tumor immune evasion; metabolic regulation in cancer; cell-based therapies

(This special issue belongs to the Section Molecular Immunology)

Molecular Research on Andrology

edited by Elikanah Olusayo Adegoke

submission deadline 20 Apr 2026 | Viewed by 190 | Submission Open

Keywords: fertilty; assisted reproduction technology; endocrine disrupting chemicals; hormones; male reproductive aging; semen analysis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Metabolic Dependencies of the Influence of Intestinal Microbiota During Pregnancy, Childbirth and Infancy

edited by Małgorzata Szczuko and Maciej Ziętek

submission deadline 20 Apr 2026 | Viewed by 189 | Submission Open

Keywords: microbiota; dysbiosis; intestinal microbiome; LPS; zonulin; calprotectin; occludin; SCFA; citrulline; glucagon-like peptide (GLP)-2; LPS binding protein (LBP); amyloid A; intestinal leakage

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Influence of Genetics on Lymphatic System Diseases

edited by

Tomomi Watanabe-Asaka

submission deadline 20 Apr 2026 | Viewed by 188 | Submission Open

Keywords: lymphatic system; gene expression; disease model; medical application; lymphatic development; lymphatic function

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Role of Micronutrients in Cancer Prevention

edited by Jacek Baj

submission deadline 20 Apr 2026 | Viewed by 186 | Submission Open

Keywords: micronutrient; metallomics; metallomic analysis; nutrient; ICP-MS; ICP-OES; prevention; carcinogenesis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular-Scale Design, Synthesis, and Applications of (Photo)Electrochemical Materials for Sustainable Energy and Environmental Solutions

edited by

Shiwei Lin

and

Zhaohui Xiao

submission deadline 20 Apr 2026 | Viewed by 185 | Submission Open

Keywords: molecular-scale material engineering; photoelectrocatalysis/electrocatalysis; sustainable energy conversion; atomic-precision synthesis; environmental remediation technologies

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Surfactant Sciences: Design, Synthesis, and Applications

edited by Zakaria Hafidi

submission deadline 20 Apr 2026 | Viewed by 185 | Submission Open

Keywords: surfactants; synthesis; biodegradation; catalysis; biological activity; nanoparticles; design; green chemistry; self-assembly; surface chemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Latest Research on Probiotics: Molecular Mechanisms and Health Applications

edited by

Ying Zhang

submission deadline 20 Apr 2026 | Viewed by 184 | Submission Open

Keywords: probiotics; molecular signaling; microbial– host crosstalk; metabolomic profiling; microbiome modulation; metabolite– receptor interaction

(This special issue belongs to the Section Molecular Microbiology)

The Role of Transcription Factors in Cancer

edited by

Tomasz Wilanowski

submission deadline 20 Apr 2026 | Viewed by 181 | Submission Open

Keywords: transcription factor; oncogene; tumor suppressor; nuclear receptor; genetic regulation; post-translational regulation; biomarker; drug target

(This special issue belongs to the Section Molecular Oncology)

Pleiotropic NME Proteins: Nucleoside Diphosphate Kinases and Histidine-Protein Kinases

edited by

Krisztina Takács-Vellai

submission deadline 20 Apr 2026 | Viewed by 180 | Submission Open

Keywords: NDPK ; NME ; NM23 ; AWD ; protein-histidine kinase ; cancer ; metastasis ; bioenergetics ; cell signaling ; cardiovascular diseases

(This special issue belongs to the Section Biochemistry)

Advances in Plant–Pathogen Interactions (4th Edition)

edited by

Fucheng Lin

submission deadline 20 Apr 2026 | Viewed by 177 | Submission Open

Keywords: host; effection; pathogenicity; pathogen; plant immunity; interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Antimicrobial Agents and the Quest for Resistance Breakthroughs

edited by

Inês Bártolo

submission deadline 20 Apr 2026 | Viewed by 168 | Submission Open

Keywords: drug resistance; antimicrobial resistance (AMR); drug-resistant bacteria; drug-resistant viruses; drug-resistant fungi; drug-resistant parasite; drug resistance biomolecular studies; mechanism of resistance; novel antimicrobial agents; treatment of infectious diseases

(This special issue belongs to the Section Molecular Pharmacology)

Unraveling the Molecular Crosstalk Between Ferroptosis and Tumorigenesis

edited by

Ji Hoon Jung

submission deadline 20 Apr 2026 | Viewed by 165 | Submission Open

Keywords: tumorigenesis; ferroptosis; cancer biology; tumor development

(This special issue belongs to the Section Molecular Oncology)

Molecular Techniques to Study Food Safety Challenges

edited by

María J. Andrade

and

Micaela Álvarez

submission deadline 20 Apr 2026 | Viewed by 164 | Submission Open

Keywords: food safety; hazards; foodborne pathogens; advanced microbial detection technologies; omics techniques; preventive measures

(This special issue belongs to the Section Molecular Microbiology)

Novel Therapeutic Strategies and Targets in Rheumatoid Arthritis

edited by David Fox and

James J. Moon

submission deadline 20 Apr 2026 | Viewed by 154 | Submission Open

Keywords: RA; synovium; FLS; synovial fluid; microbiome; autoimmunity; DMARD; joint inflammation; joint damage; nanoparticle

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Magnetic Nanoparticles: From Synthesis and Modification to Biomedical Applications

edited by

Ahmet Kertmen

submission deadline 20 Apr 2026 | Viewed by 153 | Submission Open

Keywords: magnetite nanoparticles; colloidal interactions; X-ray characterizations; biomedical applications; method development; imaging

(This special issue belongs to the Section Molecular Nanoscience)

Nanomedicine: Application of Nanostructured Biomaterials in the Biomedical Field

edited by

Yaser Dahman

submission deadline 20 Apr 2026 | Viewed by 153 | Submission Open

Keywords: nanomedicine; nanostructured biomaterials; targeted drug delivery; tissue regeneration; biosensing

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Research in Leukemia

edited by Juan Manuel Mejia-Arangure

submission deadline 20 Apr 2026 | Viewed by 151 | Submission Open

Keywords: leukemia; molecular biology; genetic testing; epigenomics; targeted therapy; precision medicine; diagnostic techniques; molecular pathways

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mitochondria-Associated Non-Coding RNAs

edited by

Verónica A. Burzio

, Jaime E. Villegas and

Sam Das

submission deadline 20 Apr 2026 | Viewed by 150 | Submission Open

Keywords: mitochondrial-encoded ncRNAs; mitochondrial miRNAs; mitochondrial lncRNAs; mitochondrial circRNAs; nuclear-encoded mitochondrial ncRNAs

(This special issue belongs to the Section Molecular Biology)

Eco-Conscious Therapeutics: Molecular Foundations and Future Directions in Green Medicine

edited by

Adi Lahat

and

Kassem Sharif

submission deadline 20 Apr 2026 | Viewed by 147 | Submission Open

Keywords: green medicine; molecular therapeutics; sustainable healthcare; biomarker profiling; predictive toxicology; eco-friendly drug design; environmental impact; biodegradable materials

(This special issue belongs to the Section Molecular Toxicology)

Displaying special issue 2351-2400 on page 48 of 68.

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