Targeting Receptor Tyrosine Kinases and Related Signalling Pathways in Cancer: Mechanisms, Resistance, and Therapeutic Advances
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 27 November 2026 | Viewed by 881
Editors
Interests: developmental biology; cell signalling; cancer; pathobiology; physiological diseases; cellular receptors and ligands
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Tyrosine kinase receptors (TKRs) play a pivotal role in cancer progression by driving key cellular processes such as proliferation, migration, differentiation, survival, invasion, and metastasis.
Despite the success of tyrosine kinase inhibitors (TKIs) in cancer therapy, intrinsic and acquired resistance mechanisms remain a significant challenge. This Special Issue aims to explore the latest advances in TKR signaling, resistance mechanisms, and novel therapeutic strategies, including next-generation TKIs, combination treatments, and immunotherapy approaches.
We welcome authors to submit original research and review articles covering diverse aspects of TKR biology, including the identification of predictive biomarkers, the interplay between TKRs and other signaling pathways, the emerging role of non-coding RNAs in modulating TKR function, and strategies to overcome therapeutic resistance.
Topics may include, but are not limited to:
Understanding mechanisms of how tyrosine kinase receptors (TKRs) drive cancer progression and metastasis.
Mechanisms of resistance to TK inhibitors (TKIs) and strategies to overcome them.
Crosstalk between TKRs and other signaling networks in cancer.
Emerging Therapeutic Strategies, such as novel TKIs, allosteric inhibitors, and combination therapies.
Predictive biomarkers for response to TKIs in clinical settings and personalized medicine.
How TKRs influence the tumor microenvironment and immune evasion (i.e., immunotherapy).
The role of miRNAs and lncRNAs in modulating TKR signaling in cancer.
Dr. Athina-Myrto Chioni
Prof. Dr. Richard Grose
Guest Editors
Manuscript Submission Information
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Keywords
- tyrosine kinase receptors (TKRs)
- tyrosine kinase inhibitors (TKIs)
- cancer
- therapeutic resistance/cancer drug resistance/chemotherapy resistance
- signaling pathways
- metastasis
- combination therapy
- targeted therapy
- next-generation inhibitors
- allosteric inhibitors
- personalized medicine
- tumor microenvironment
- immune evasion
- immunotherapy
- crosstalk in cancer signaling
- miRNAs
- lncRNAs
- cancer therapeutics
- biomarkers
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