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Targeting Tyrosine Kinase Receptors in Cancer: Mechanisms, Resistance and Therapeutic Advances

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 20 September 2025 | Viewed by 28

Special Issue Editors


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Guest Editor
School of Life Sciences Pharmacy and Chemistry, Kingston University, Penrhyn Road, Kingston upon Thames KT1 2EE, UK
Interests: developmental biology; cell signalling; cancer; pathobiology; physiological diseases; cellular receptors and ligands
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Centre for Tumor Biology, Barts Cancer Institute, CRUK Centre of Excellence, Queen Mary University of London, London, UK
Interests: microenvironment; breast cancer; pancreatic cancer; precision oncology; targeted therapy

Special Issue Information

Dear Colleagues,

Tyrosine kinase receptors (TKRs) play a pivotal role in cancer progression by driving key cellular processes such as proliferation, migration, differentiation, survival, invasion, and metastasis.

Despite the success of tyrosine kinase inhibitors (TKIs) in cancer therapy, intrinsic and acquired resistance mechanisms remain a significant challenge. This Special Issue aims to explore the latest advances in TKR signaling, resistance mechanisms, and novel therapeutic strategies, including next-generation TKIs, combination treatments, and immunotherapy approaches.

We welcome authors to submit original research and review articles covering diverse aspects of TKR biology, including the identification of predictive biomarkers, the interplay between TKRs and other signaling pathways, the emerging role of non-coding RNAs in modulating TKR function, and strategies to overcome therapeutic resistance.

Topics may include, but are not limited to:

Understanding mechanisms of how tyrosine kinase receptors (TKRs) drive cancer progression and metastasis.

Mechanisms of resistance to TK inhibitors (TKIs) and strategies to overcome them.

Crosstalk between TKRs and other signaling networks in cancer.

Emerging Therapeutic Strategies, such as novel TKIs, allosteric inhibitors, and combination therapies.

Predictive biomarkers for response to TKIs in clinical settings and personalized medicine.

How TKRs influence the tumor microenvironment and immune evasion (i.e., immunotherapy).

The role of miRNAs and lncRNAs in modulating TKR signaling in cancer.

Dr. Athina-Myrto Chioni
Prof. Dr. Richard Grose
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tyrosine kinase receptors (TKRs)
  • tyrosine kinase inhibitors (TKIs)
  • cancer
  • therapeutic resistance/cancer drug resistance/chemotherapy resistance
  • signaling pathways
  • metastasis
  • combination therapy
  • targeted therapy
  • next-generation inhibitors
  • allosteric inhibitors
  • personalized medicine
  • tumor microenvironment
  • immune evasion
  • immunotherapy
  • crosstalk in cancer signaling
  • miRNAs
  • lncRNAs
  • cancer therapeutics
  • biomarkers

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Published Papers

This special issue is now open for submission.
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