Bone Microenvironment and Bone Metastasis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 53
Special Issue Editor
Interests: bone; osteocyte differentiation; bone marrow microenvironment; bone metabolism; oxidative stress; cancer research; bone metastasis; microfluidics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The aim of this Special Issue is to highlight recent advances in understanding the bone microenvironment and bone metastasis through the lens of molecular and cellular mechanisms. Bone metastasis remains a major clinical challenge, particularly in patients with breast, prostate, and lung cancers. These tumor cells colonize and modify the bone microenvironment (comprising osteoblasts, osteoclasts, mesenchymal stem cells, immune cells, and adipocytes), disrupting bone homeostasis and promoting disease progression.
We encourage the submission of original research and reviews that provide new insights into the molecular pathways, signaling mechanisms, and gene or protein interactions that govern tumor–bone interactions, metastatic colonization, resistance to therapy, or bone remodeling in the context of cancer. Clinical or in vivo/in vitro model studies are welcomed only if they are accompanied by biomolecular analyses that elucidate underlying mechanisms. Studies that integrate molecular biology with well-designed models or patient-derived data are highly encouraged, as they offer translational relevance and mechanistic depth.
Our goal is to foster a multidisciplinary dialog and support the dissemination of scientifically sound, mechanistically focused research that advances our understanding of bone metastasis biology.
Dr. Cristina Sanchez de Diego
Guest Editor
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Keywords
- bone metastasis
- tumor–bone interaction
- bone microenvironment
- osteoclastogenesis
- osteoblast signaling
- bone remodeling
- dormancy
- immune evasion
- extracellular matrix
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