MDSCs in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 10 October 2025 | Viewed by 16
Special Issue Editor
Interests: leptin structure; leptin expression regulation; leptin receptor; leptin signaling; leptin action at central level; leptin as adipokine; leptin as a cornerstone of immunometabolism; leptin as link between obesity and associated pathophysiology, such as diabetes, cancer, rheumatologic diseases, or cardiovascular diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells with immunosuppressive functions, particularly on T lymphocytes. They exhibit remarkable plasticity, allowing them to either remain in this suppressive state or differentiate into monocytes/macrophages, dendritic cells, or neutrophils.
MDSCs play key roles in physiological processes such as wound healing and the response to acute organ injury. However, they are also implicated in the persistence of chronic inflammation and have been proposed as critical mediators of immunosuppression during viral infections and tumor immune evasion.
MDSCs are associated with various pathophysiological conditions characterized by the coexistence of inflammation and immunosuppression.
The aim of this Special Issue is to provide a dedicated forum to summarize current knowledge and promote further research into the physiology of MDSCs and their roles in pathophysiology.
Possible topics for this Special Issue include, but are not limited to, the following:
- The identification and functional analysis of MDSCs;
- Roles of MDSC in different physiological contexts:
- The intersection between innate and cognate immune responses;
- Pregnancy and maternal–fetal tolerance;
- Tissue repair;
- Immunotolerance;
- Homeostasis.
- Roles of MDSCs in different pathophysiological conditions:
- Cancer;
- Infection;
- Autoimmune diseases;
- Fibrotic diseases;
- Pathological pregnancy.
Prof. Dr. Víctor Sánchez-Margalet
Guest Editor
Manuscript Submission Information
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Keywords
- MDSCs
- inflammation
- immune regulation
- cancer
- autoimmune diseases
- pregnancy
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