ijms-logo

Journal Browser

Journal Browser

Molecular Research on Andrology

Editor


E-Mail Website
Guest Editor
Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Interests: reproductive biology; reproductive toxicology; reproductive gerontology and environmental health

Special Issue Information

Dear Colleagues,

Male fertility is a critical component of human reproduction, yet it is often overshadowed by the more intensive study of the female reproductive study. Recent decades have seen a growing recognition of male factors as central contributors to infertility, accounting for nearly 50% of all infertility cases. Male fertility is influenced by a complex interplay of genetic, physiological, environmental, and lifestyle factors. While intrinsic factors such as hormonal imbalances, genetic abnormalities, and testicular dysfunctions have long been studied, there is growing concern over the impact of extrinsic influences—especially environmental exposures—on male reproductive health.

The integration of molecular biology techniques into andrology allows researchers to conduct investigations, assessing parameters such as DNA fragmentation, oxidative stress, epigenetic modifications, and transcriptomic and proteomic profiles. These advances are reshaping the diagnostic and therapeutic landscape of male infertility, providing novel biomarkers and potential targets for intervention against declining male fertility and impaired male reproductive potential globally.

This research topic welcomes the submission of original research, reviews, mini-reviews, and systematic reviews that explore a wide range of topics including, but not limited to, the following areas:

  • Assisted reproductive technology.
  • Interplay of genetic, physiological, and environmental factors on male fertility.
  • Biomarkers and therapeutic target.
  • Extrinsic and intrinsic factors promoting male infertility.

Dr. Elikanah Olusayo Adegoke
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fertilty
  • assisted reproduction technology
  • endocrine disrupting chemicals
  • hormones
  • male reproductive aging
  • semen analysis

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

14 pages, 1854 KB  
Article
Sperm DNA Fragmentation in Native Semen: A Reflection of Apoptotic and Non-Viable Spermatozoa and Its Implications for Assisted Reproduction
by András Balló, Natália Honétzy and Gábor Máté
Int. J. Mol. Sci. 2026, 27(17), 7854; https://doi.org/10.3390/ijms27177854 - 2 Sep 2026
Viewed by 179
Abstract
Sperm DNA fragmentation (SDF) is widely used as a biomarker of male fertility, although its predictive value for assisted reproductive technology (ART) outcomes remains controversial. We hypothesised that this discrepancy reflects the inclusion of non-viable spermatozoa in conventional SDF assessment of native semen. [...] Read more.
Sperm DNA fragmentation (SDF) is widely used as a biomarker of male fertility, although its predictive value for assisted reproductive technology (ART) outcomes remains controversial. We hypothesised that this discrepancy reflects the inclusion of non-viable spermatozoa in conventional SDF assessment of native semen. We retrospectively analysed semen samples from 1394 men to evaluate associations between DNA fragmentation index (DFI), sperm vitality, motility, and concentration. In addition, the viability-gated sperm chromatin structure assay (SCSA) was performed in a prospective cohort of 11 samples, and DFI was assessed before and after density gradient centrifugation, swim-up, microfluidic selection, and magnetic-activated cell sorting. Native semen DFI showed significant negative correlations with sperm vitality, motility, and concentration. Viability-gated analysis demonstrated a 3.5-fold lower mean DFI in viable spermatozoa than in the total ejaculate (11.27% vs. 39.64%, p < 0.001). All sperm preparation methods significantly reduced DFI while enriching motile and viable spermatozoa. These findings suggest that a substantial proportion of SDF detected in native semen originates from non-viable spermatozoa and that native semen DFI may not fully represent the DNA integrity of the fertilisation-competent sperm fraction, providing a potential biological explanation for its limited predictive value in ART. Full article
(This article belongs to the Special Issue Molecular Research on Andrology)
Show Figures

Figure 1

15 pages, 928 KB  
Article
Neonatal Clomipramine Exposure Disrupts Epididymal Serotonin Signaling and Programs Sperm Dysfunction in Adult Rats
by Herlinda Bonilla-Jaime, Ofelia Limón-Morales, Ernesto Rodríguez-Tobón, José Edwin Mendoza-Sánchez, David Yoab Jaimes, José Luis Cortés-Altamirano, Alfonso Alfaro-Rodríguez, Marcela Arteaga-Silva, Gilberto Pérez-Sánchez, Lenin Pavón and Edith Arenas-Rios
Int. J. Mol. Sci. 2026, 27(3), 1535; https://doi.org/10.3390/ijms27031535 - 4 Feb 2026
Cited by 1 | Viewed by 1181
Abstract
Studies of adult depressed patients report that selective serotonin (5-HT) reuptake inhibitors (SSRIs) like clomipramine (CMI) have secondary effects on sperm quality. The epididymis possesses an autonomous serotonergic system critical for sperm maturation, whose establishment during neonatal development remains unexplored as a target [...] Read more.
Studies of adult depressed patients report that selective serotonin (5-HT) reuptake inhibitors (SSRIs) like clomipramine (CMI) have secondary effects on sperm quality. The epididymis possesses an autonomous serotonergic system critical for sperm maturation, whose establishment during neonatal development remains unexplored as a target for SSRI programming. We hypothesized that neonatal CMI exposure would disrupt the developing epididymal 5-HT system, leading to permanent sperm dysfunction. CMI (30 mg/kg s.c.) was administered to male rats between postnatal days 8–21. At 3 months, sperm from the epididymal cauda was evaluated, and 5-HT levels were measured in the testis, caput, and cauda epididymis. Our novel findings demonstrate that neonatal CMI exposure induces region-specific, long-term alterations in epididymal 5-HT levels (decreased in caput, increased in cauda) without affecting testicular 5-HT. This reprogramming of the local serotonergic milieu was associated with reduced sperm concentration, viability, normal morphology, and motility, alongside increased mitochondrial activity and reactive oxygen species. This study reveals, for the first time, that the epididymal serotonergic system is a key target for neonatal SSRI programming, providing a mechanistic link (altered 5-HT homeostasis) between early-life exposure and persistent sperm defects in adulthood. Full article
(This article belongs to the Special Issue Molecular Research on Andrology)
Show Figures

Figure 1

Back to TopTop