Alzheimer’s Disease: Molecular Mechanisms and Novel Therapies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 20 November 2026 | Viewed by 1844
Editors
Interests: Alzheimer’s disease; Down syndrome; apolipoprotein E; hiPSC models; cerebral organoids; high-throughput screening; neurodegeneration; microglia
Interests: intrinsically disordered protein; oligomerization; aggregation; protein-protein interaction; fluorescence resonance energy transfer (FRET); high-throughput screening; neuroinflammation; neurodegeneration
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
As the first drugs targeting the amyloid cascade become available clinically, it becomes ever clearer that just as Alzheimer’s disease does not follow a simple linear process, neither will its treatment. The heterogeneity of patient genetics and epigenetics indicates that monotherapy using monoclonal antibodies directed to the amyloid-β peptide will have variable efficacy and a wide range of potential adverse effects. While important first steps, the complexity of the disease and the variety of pathways involved indicate that a personalized medicine approach will almost certainly be necessary for comprehensive Alzheimer’s treatment. The first step towards developing each combinatorial therapy is a thorough understanding of the molecular mechanisms and pathways involved and their precise contributions to the disease progression. Pathways of high importance include, but are not limited to, tau oligomerization and aggregation, neuroinflammation and neuroimmune reactivity, autolysosomal and mitochondrial dysfunction, lipid metabolism and apolipoprotein E-driven processes, and endothelial and cerebrovascular injury. We invite primary research articles providing new molecular insight into these pathways and others related to the pathogenesis of Alzheimer’s disease and related dementia. We also invite translational studies developing new biochemical, cell, organoid, or rodent models incorporating multiple aspects of disease modeling or the testing of novel therapeutics. Together, this Special Issue seeks to highlight novel molecular targets and promising therapeutic strategies that might contribute to the development of drugs for Alzheimer’s disease and related dementia.
Dr. Noah R. Johnson
Dr. Chih Hung Lo
Guest Editors
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Keywords
- intrinsically disordered proteins
- apolipoproteins
- neuroinflammation and neuroimmune
- autolysosomal and mitochondrial functions
- lipid metabolism
- blood-brain barrier
- biosensors
- nanomedicine
- high-throughput screening
- therapeutic discovery
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