Alzheimer’s Disease: Molecular Mechanisms and Novel Therapies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 85
Special Issue Editors
Interests: Alzheimer’s disease; Down syndrome; apolipoprotein E; hiPSC models; cerebral organoids; high-throughput screening; neurodegeneration; microglia
Interests: intrinsically disordered protein; oligomerization; aggregation; protein-protein interaction; fluorescence resonance energy transfer (FRET); high-throughput screening; neuroinflammation; neurodegeneration
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
As the first drugs targeting the amyloid cascade become available clinically, it becomes ever clearer that just as Alzheimer’s disease does not follow a simple linear process, neither will its treatment. The heterogeneity of patient genetics and epigenetics indicates that monotherapy using monoclonal antibodies directed to the amyloid-β peptide will have variable efficacy and a wide range of potential adverse effects. While important first steps, the complexity of the disease and the variety of pathways involved indicate that a personalized medicine approach will almost certainly be necessary for comprehensive Alzheimer’s treatment. The first step towards developing each combinatorial therapy is a thorough understanding of the molecular mechanisms and pathways involved and their precise contributions to the disease progression. Pathways of high importance include, but are not limited to, tau oligomerization and aggregation, neuroinflammation and neuroimmune reactivity, autolysosomal and mitochondrial dysfunction, lipid metabolism and apolipoprotein E-driven processes, and endothelial and cerebrovascular injury. We invite primary research articles providing new molecular insight into these pathways and others related to the pathogenesis of Alzheimer’s disease and related dementia. We also invite translational studies developing new biochemical, cell, organoid, or rodent models incorporating multiple aspects of disease modeling or the testing of novel therapeutics. Together, this Special Issue seeks to highlight novel molecular targets and promising therapeutic strategies that might contribute to the development of drugs for Alzheimer’s disease and related dementia.
Dr. Noah R. Johnson
Dr. Chih Hung Lo
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- intrinsically disordered proteins
- apolipoproteins
- neuroinflammation and neuroimmune
- autolysosomal and mitochondrial functions
- lipid metabolism
- blood-brain barrier
- biosensors
- nanomedicine
- high-throughput screening
- therapeutic discovery
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
