Drug-Induced Toxicity and Its Role in Disease Progression and Therapeutic Outcomes
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 57
Special Issue Editors
2. Pharmaco-Toxicology Laboratory, UBIMedical, University of Beira Interior, 6200-284 Covilhã, Portugal
3. Centro Académico Clínico das Beiras (CACB)—Grupo de Problemas Relacionados com Toxicofilias, 6200-284 Covilhã, Portugal
Interests: toxicology; analytical method development; recreational drugs; natural psychoactive substances; therapeutic drug monitoring; sample preparation; alternative samples; miniaturized extraction procedures
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2. Laboratório de Farmaco-Toxicologia, UBIMedical, Universidade da Beira Interior (CICS-UBI), 6201-506 Covilhã, Portugal
Interests: chromatographic techniques; sample preparation techniques; bioanalysis; natural products
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue aims to explore the multifaceted impact of drug-induced toxicity on disease management and therapeutic success. While pharmacological treatments combat a wide range of diseases, adverse toxicological effects can compromise their efficacy, lead to treatment discontinuation, or even exacerbate disease progression.
In this Special Issue, we hope to address the following topics:
- Drug-induced toxicity in chronic therapies (e.g., hepatotoxicity, nephrotoxicity, cardiotoxicity associated with antipsychotics, antiretrovirals, chemotherapeutics, etc.).
- Drug–drug interactions and enhanced toxicological risks in polypharmacy.
- The impact of toxicity on treatment adherence and therapeutic resistance.
- The molecular and cellular mechanisms underlying drug toxicity
(e.g., oxidative stress, apoptosis, mitochondrial dysfunction, epigenetic changes) - Using preclinical models (in vitro, in silico, organ-on-chip) to predict toxicity.
- Pharmacogenomics and interindividual variability in drug toxicity susceptibility.
- The toxicological effects of drugs in vulnerable populations
(e.g., elderly people, pregnant women, paediatric patients). - Strategies for mitigating or preventing toxicity without compromising efficacy.
- Drug repurposing and novel applications of compounds with known toxicity profiles.
- Advanced drug delivery systems (e.g., nanotechnology) to minimise systemic toxicity.
Prof. Dr. Eugenia Gallardo
Dr. Tiago Rosado
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- drug-induced toxicity
- drug-drug interactions
- drug delivery systems
- toxicity
- disease
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