Drug-Induced Toxicity and Its Role in Disease Progression and Therapeutic Outcomes

Dear Colleagues,

This Special Issue aims to explore the multifaceted impact of drug-induced toxicity on disease management and therapeutic success. While pharmacological treatments combat a wide range of diseases, adverse toxicological effects can compromise their efficacy, lead to treatment discontinuation, or even exacerbate disease progression.

In this Special Issue, we hope to address the following topics:

• Drug-induced toxicity in chronic therapies (e.g., hepatotoxicity, nephrotoxicity, cardiotoxicity associated with antipsychotics, antiretrovirals, chemotherapeutics, etc.).
• Drug–drug interactions and enhanced toxicological risks in polypharmacy.
• The impact of toxicity on treatment adherence and therapeutic resistance.
• The molecular and cellular mechanisms underlying drug toxicity
  (e.g., oxidative stress, apoptosis, mitochondrial dysfunction, epigenetic changes)
• Using preclinical models (in vitro, in silico, organ-on-chip) to predict toxicity.
• Pharmacogenomics and interindividual variability in drug toxicity susceptibility.
• The toxicological effects of drugs in vulnerable populations
  (e.g., elderly people, pregnant women, paediatric patients).
• Strategies for mitigating or preventing toxicity without compromising efficacy.
• Drug repurposing and novel applications of compounds with known toxicity profiles.
• Advanced drug delivery systems (e.g., nanotechnology) to minimise systemic toxicity.
• Drug-induced toxicity in specific and emerging diseases (e.g., rare diseases, neurodegenerative disorders, chronic inflammatory diseases).
• Late-onset toxicity and cumulative adverse effects after prolonged therapies.
• Predictive biomarkers of toxicity (including omics-based approaches).
• Toxicity related to emerging therapies (gene therapy, immunotherapy, CAR-T cells, nanoparticle-based treatments).
• The interplay between drug toxicity and environmental/lifestyle factors (microbiome, diet, pollutants, smoking, alcohol).

Prof. Dr. Eugenia Gallardo
Dr. Tiago Rosado
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.