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Diagnostics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Functional Gastrointestinal Disorders (FGIDs): Diagnosis and Pathophysiology, Second Edition

edited by Gengqing Song

submission deadline 30 Sep 2026 | 4 articles | Viewed by 32899 | Submission Open

Keywords: functional gastrointestinal disorders; diagnosis; treatment approach; ROME criteria

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advances in Infectious Disease Diagnosis Technologies

edited by

Dakai Liu

and Fermina Maria Mazzella

submission deadline 30 Sep 2026 | 7 articles | Viewed by 17172 | Submission Open

Keywords: molecular diagnosis; biomarkers; microbial culture and identification; high-throughput sequencing; infectious diseases; artificial intelligence; digital image; radiological imaging; point-of-care testing

(This special issue belongs to the Section Diagnostic Microbiology and Infectious Disease)

Clinical Presentation, Management and Prognosis of Infective Endocarditis

edited by

Arian Arjomandi Rad

, Alexander Weymann and Thanos Athanasiou

submission deadline 30 Sep 2026 | 2 articles | Viewed by 17090 | Submission Open

Keywords: infective endocarditis; clinical presentation; diagnostic modalities; antibiotic stewardship; surgical interventions; prognostic indicators

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Diagnostic Methods for Laboratory Medicine

edited by

Syed M. Shahid

submission deadline 30 Sep 2026 | 3 articles | Viewed by 15121 | Submission Open

Keywords: diabetes mellitus; clinical diagnostics; biomarkers; prevision medicine; glycemic control; digital health

(This special issue belongs to the Section Clinical Laboratory Medicine)

Soft Tissue Sarcoma: From Diagnosis to Prognosis

edited by

Consolato M. Sergi

submission deadline 30 Sep 2026 | 4 articles | Viewed by 13692 | Submission Open

Keywords: soft tissue; mesenchyme; bone; pathogenesis; miRNA; imaging; diagnosis; therapy

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Artificial Intelligence in Diagnostics: From Algorithms to Clinical Impact

edited by

Ali Athar

, David Brown and

Hanem Ellethy

submission deadline 30 Sep 2026 | 11 articles | Viewed by 13165 | Submission Open

Keywords: machine learning in healthcare; artificial intelligence in diagnostics; medical imaging and deep learning; generative AI in medicine; multimodal data integration; explainable and trustworthy AI; translational medical AI; clinical decision support systems; secure and privacy-compliant data utilization

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Diagnosis and Prognosis of Hematological Disease

edited by Sapha Shibeeb

submission deadline 30 Sep 2026 | 6 articles | Viewed by 12909 | Submission Open

Keywords: hematological diseases; leukaemia; molecular diagnostics; next-generation sequencing (NGS); precision medicine; predictive biomarkers; AI-assited diagnosis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Diagnosis and Management of Endometrial Diseases

edited by

Kotaro Kitaya

submission deadline 30 Sep 2026 | 6 articles | Viewed by 10912 | Submission Open

Keywords: endometrial diseases; artificial intelligence; hysteroscopy; ultrasound; minimally invasive surgery

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Innovative Diagnostic Approaches in Retinal Diseases

edited by

Benedetto Falsini

and Andrea Cusumano

submission deadline 30 Sep 2026 | 6 articles | Viewed by 10382 | Submission Open

Keywords: retinal diseases; electrophysiology; imaging; optical coherence tomography

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Revolutionizing Male Infertility: Novel Mechanistic Insights, Diagnostic Innovations, and Management Strategies

edited by

Athanasios Zachariou

submission deadline 30 Sep 2026 | 4 articles | Viewed by 9152 | Submission Open

Keywords: male infertility; andrology; reproductive health; testis; spermatozoa; semen analysis; TESE; mTESE; ultrasound; artificial intelligence; IVF

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnosis and Management of Hematologic Malignancies

edited by

Ankur Varma

submission deadline 30 Sep 2026 | 5 articles | Viewed by 8878 | Submission Open

Keywords: acute myeloid leukemia; chronic myeloid leukemia; myelodysplastic syndrome; myeloproliferative neoplasm; Hodgkin's lymphoma; non-Hodgkin's lymphoma; acute lymphocytic leukemia; chronic lymphocytic leukemia; bone marrow failure syndrome; juvenile myelomonocytic leukemia

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advances in Imaging Diagnosis of Dermatology

edited by Linda Tognetti

submission deadline 30 Sep 2026 | 4 articles | Viewed by 8663 | Submission Open

Keywords: high-resolution imaging; non-invasive diagnosis; LC-OCT; RCM; OCT; US

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Sleep and Respiratory Medicine

edited by Cheng-Yu Tsai

submission deadline 30 Sep 2026 | 4 articles | Viewed by 8045 | Submission Open

Keywords: sleep and respiratory disorders; chest medicine; AI in healthcare; digital technology; precision diagnostics

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Applications of Optical Coherence Tomography and Optical Coherence Tomography Angiography in Ophthalmology

edited by

Daniela Bacherini

submission deadline 30 Sep 2026 | 5 articles | Viewed by 7306 | Submission Open

Keywords: OCT; OCTA; ophthalmology; diagnostics; clinical applications

(This special issue belongs to the Section Biomedical Optics)

New Trends in Cardiovascular Imaging: 2nd Edition

edited by

Hans-Christoph Becker

submission deadline 30 Sep 2026 | 5 articles | Viewed by 6923 | Submission Open

Keywords: cardiac CT; cardiac MRI; hybrid and multimodality imaging; artificial intelligence and machine learning; coronary artery disease; myocardial tissue characterization; congenital heart disease

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advancing Blood-Based Diagnostics: Innovations, Challenges and Clinical Impact

edited by Sapha Shibeeb

submission deadline 30 Sep 2026 | 5 articles | Viewed by 6370 | Submission Open

Keywords: diagnostic biomarkers; analytical performance; test interpretability; prognostic markers; translational diagnostics; artificial intelligence in diagnostics; precision medicine; clinical decision-making

(This special issue belongs to the Section Clinical Laboratory Medicine)

Advances in Laboratory Markers of Human Disease—2nd Edition

edited by

Mina Hur

submission deadline 30 Sep 2026 | 6 articles | Viewed by 6332 | Submission Open

Keywords: laboratory biomarkers; genomics; proteomics; molecular diagnostics; clinical chemistry

(This special issue belongs to the Section Clinical Laboratory Medicine)

Digital Innovation in Salivary Diagnostics for Oral and Systemic Health

edited by

Corina Marilena Cristache

submission deadline 30 Sep 2026 | 2 articles | Viewed by 6304 | Submission Open

Keywords: saliva diagnosis; oral disease; systemic diseases; artificial intelligence; AI driven diagnosis

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Advances in Diagnosis and Management of Liver Diseases

edited by

Po-Heng Chuang

submission deadline 30 Sep 2026 | 5 articles | Viewed by 5967 | Submission Open

Keywords: liver parenchyma diseases; fatty liver; hepatitis; intrahepatic space-occupying lesions; abscess liver cancer; biomarkers; artificial intelligence

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnosis, Prognosis and Management of Cardiovascular Disease in Patients with Rheumatic Conditions

edited by

Patrick H. M. C. Dessein

Miguel Angel Gonzalez-Gay

and

Iván Ferraz-Amaro

submission deadline 30 Sep 2026 | 2 articles | Viewed by 5867 | Submission Open

Keywords: rheumatoid arthritis; rheumatic conditions; cardiovascular risk factors; atherosclerosis; left ventricular structure and function; arterial function; cardiovascular events; ischemic heart disease; ischemic stroke; heart failure; peripheral vascular disease; venous thrombotic disease; cardiovascular drugs; antirheumatic agents

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advancing Diagnostics in Neuroimaging

edited by

Ali Y Mian

submission deadline 30 Sep 2026 | 4 articles | Viewed by 5680 | Submission Open

Keywords: neuroimaging; magnetic resonance imaging (MRI); positron emission tomography (PET); radiomics; neurological disorders; precision medicine; quantitative biomarkers; multimodal integration

(This special issue belongs to the Section Medical Imaging and Theranostics)

Radiomics and Artificial Intelligence Applications in the Diagnosis of Brain Lesions

edited by

Calin G. Buzea

submission deadline 30 Sep 2026 | 3 articles | Viewed by 5375 | Submission Open

Keywords: brain lesions; biomarker; prognosis; diagnosis; radiomics; artificial intelligence

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Physiological Sound Processing for Medical Diagnostics: Innovations, Challenges, and Applications

edited by

Oliver Faust

and Prabal Datta Barua

submission deadline 30 Sep 2026 | 2 articles | Viewed by 5291 | Submission Open

Keywords: heart sounds; lung sounds; cough analysis; sleep apnea and snoring; wearable devices; explainability and ethical AI; standardization and clinical validation

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Endoscopy and Diagnostic Tools in Hepatobiliary and Pancreatic Diseases, Second Edition

edited by

Stefano Francesco Crinò

submission deadline 30 Sep 2026 | 4 articles | Viewed by 5185 | Submission Open

Keywords: endoscopic ultrasound; eRCP; radiomics; tissue acquisition; artificial intelligence; magnetic resonance imaging; cholangioscopy; pancreatic cancer; pancreatic cysts; hepatocellular carcinoma; cholangiocarcinoma

(This special issue belongs to the Section Medical Imaging and Theranostics)

Diagnostics Advances in Peripheral Nerve Injuries

edited by

Jean Noël Goubier

submission deadline 30 Sep 2026 | 2 articles | Viewed by 4910 | Submission Open

Keywords: peripheral nerve injuries; diagnosis challenges; magnetic resonance imaging (MRI); electromyography (EMG); brachial plexus injury; nerve trunk lesions; radicular lesions; nerve recovery assessment; advances in nerve imaging; EMG-guided treatment

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnosis, Treatment, and Management of Hair Disorders

edited by Neil Jairath and

Vignesh Ramachandran

submission deadline 30 Sep 2026 | 1 articles | Viewed by 4868 | Submission Open

Keywords: hair loss; alopecia; management; cicatricial; diagnosis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Complex Digestive Diseases: Diagnosis and Management

edited by

Dong Wu

submission deadline 30 Sep 2026 | 6 articles | Viewed by 4605 | Submission Open

Keywords: complex digestive diseases; precision diagnosis; advanced endoscopy; personalized management; artificial intelligence

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Contemporary Clinical Anatomy in Diagnostic Practice: Imaging, Artificial Intelligence, and Diagnostic Interpretation

edited by

Piotr Karauda

submission deadline 30 Sep 2026 | 3 articles | Viewed by 4599 | Submission Open

Keywords: clinical anatomy; diagnostic interpretation; medical imaging; artificial intelligence; diagnostic accuracy; anatomical variability; translational diagnostics; radiological anatomy

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Ultrasound Imaging: Current Status and Future Perspectives

edited by

Christoph Frank Dietrich

submission deadline 30 Sep 2026 | 3 articles | Viewed by 4228 | Submission Open

Keywords: elastography; CEUS; fat quantification; radiomics/ultrasomics; point-of-care ultrasound

(This special issue belongs to the Section Medical Imaging and Theranostics)

Insights into Imaging Diagnosis of Heart Disease

edited by

Michael Henein

submission deadline 30 Sep 2026 | 4 articles | Viewed by 4074 | Submission Open

Keywords: cardiovascular imaging including echocardiography and CTCA; cardiovascular imaging; echocardiography; cardiac magnetic resonance; myocardial perfusion imaging

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Diagnosis, Treatment and Management of Gastrointestinal Diseases

edited by

Carmen Fierbinteanu-Braticevici

submission deadline 30 Sep 2026 | 3 articles | Viewed by 4047 | Submission Open

Keywords: gastrointestinal diseases; liver diseases; biomarkers in GI disease; imaging in GI diagnosis (CT, MRI, ultrasound); non-invasive diagnostic tools; GI Endoscopic procedures; treatment approaches; personalized medicine

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnosis and Treatment of Kidney Disease—2nd Edition

edited by

Giuseppe Stefano Netti

submission deadline 30 Sep 2026 | 4 articles | Viewed by 3659 | Submission Open

Keywords: kidney diseases; acute kidney injury; nephropathy; biomarkers; diagnosis; chronic renal failure

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Maternal-Fetal Medicine: Diagnosis, Prognosis and Clinical Features

edited by Antonio Braga

submission deadline 30 Sep 2026 | 4 articles | Viewed by 3583 | Submission Open

Keywords: maternal–fetal medicine; prenatal diagnosis; fetal ultrasound and doppler; prediction models; high-risk pregnancy; perinatal outcomes

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Current Trends in Computed Tomography: Optimization and Clinical Practice

edited by

Mohamed Abuzaid

submission deadline 30 Sep 2026 | 4 articles | Viewed by 3552 | Submission Open

Keywords: computed tomography (CT); CT protocol optimization; radiation dose optimization; iterative reconstruction; deep learning reconstruction; artificial intelligence in CT; diagnostic reference levels (DRLs); clinical CT practice

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advancing Medical Imaging with AI: From Cutting-Edge Algorithms to Clinical Integration

edited by

Kyong Joon Lee

submission deadline 30 Sep 2026 | 4 articles | Viewed by 3487 | Submission Open

Keywords: artificial intelligence; medical imaging; deep learning; computer-aided diagnosis (CADx); diagnostic imaging; clinical validation; medical image analysis

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Advances in Diagnostic Approaches for Otologic Diseases in Otolaryngology

edited by Sung-Won Choi

submission deadline 30 Sep 2026 | 4 articles | Viewed by 3466 | Submission Open

Keywords: otologic diseases; diagnostic methods; hearing loss; vestibular disorders; advanced imaging; audiovestibular testing

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Research Updates in Vestibular Dysfunction: Diagnostic Breakthroughs

edited by

Jun Wang

and

Sulin Zhang

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3402 | Submission Open

Keywords: vestibular disorders; vertigo; biomarkers; molecular diagnostics; vestibular compensation; Meniere’s disease; BPPV; vestibular migraine; PPPD; dizziness; balance

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Allergy and Asthma: Clinical Diagnostics and Management

edited by

Askin Gulsen

submission deadline 30 Sep 2026 | 1 articles | Viewed by 3351 | Submission Open

Keywords: allergy; asthma; precision medicine; biomarkers; airway inflammation; clinical diagnostics; biologic therapies; phenotyping; disease management; immunology

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Imaging-Guided Diagnosis and Precision Assessment in Spine and Joint Disorders

edited by Giuliano Lo Bianco, Timothy Deer and Kenneth B. Chapman

submission deadline 30 Sep 2026 | 1 articles | Viewed by 3346 | Submission Open

Keywords: imaging-guided diagnostics; precision pain medicine; chronic pain; spine and joint disorders; artificial intelligence in imaging; radiomics and imaging biomarkers; neuromodulation and image-guided interventions

(This special issue belongs to the Section Medical Imaging and Theranostics)

Recent Advances in Hematology and Oncology, 2nd Edition

edited by Chohao Lee

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3106 | Submission Open

Keywords: hematological malignancies; lymphoma; leukemia; multiple myeloma; precision medicine; immunotherapy; genomics; targeted therapies

(This special issue belongs to the Section Clinical Laboratory Medicine)

Advances in Pain Medicine: Diagnosis and Management

edited by Alessandro Dario

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2996 | Submission Open

Keywords: neuropathic pain; fibromialgia; low back pain; nociplastic pain; artificial intelligence in pain medicine; evidence-based consensus guidelines; pain measuring; cancer pain medicine; interventional pain medicine; topic analgesic for chronic pain; SPECT/CT scan

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Gastrointestinal Pathology

edited by

Ivan R. Ilić

and

Pavle Randjelovic

submission deadline 30 Sep 2026 | 3 articles | Viewed by 2969 | Submission Open

Keywords: gastroesophageal reflux disease; gastritis; dysplasia; gastric cancer; inflammatory bowel disease; microscopic colitis; microbiota; celiac disease; colorectal cancer

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advanced Diagnostics in Women's Health: From Biomarkers to Imaging

edited by

Elena Bernad

submission deadline 30 Sep 2026 | 5 articles | Viewed by 2773 | Submission Open

Keywords: women’s health diagnostics; biomarkers; medical imaging; ultrasound; risk stratification; early diagnosis; precision medicine; obstetrics and gynaecology; non-invasive diagnostics; artificial intelligence

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diabetes Mellitus: Clinical Diagnostics and Management

edited by

Syed M. Shahid

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2768 | Submission Open

Keywords: diabetes mellitus; clinical diagnostics; biomarkers; precision medicine; glycemic control; digital health

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Soft Tissue and Bone Sarcomas: Advances in Diagnosis, Treatment, and Prognosis

edited by

Andrea Angelini

submission deadline 30 Sep 2026 | 1 articles | Viewed by 2652 | Submission Open

Keywords: soft tissue sarcomas; bone sarcomas; diagnosis; prognosis; biomarkers

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

EEG Analysis in Diagnostics, 2nd Edition

edited by

Jae-Ho Han

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2507 | Submission Open

Keywords: advanced EEG Techniques; the characterization of EEG signal patterns; the identification of EEG signal abnormalities; functional connectivity analysis in EEG; sleep studies based on EEG; EEG in epilepsy diagnosis and monitoring; neurofeedback and EEG in cognitive enhancement; event-related potentials in clinical EEG; understanding pathophysiology via EEG

(This special issue belongs to the Section Medical Imaging and Theranostics)

Multilayered Insights into Next-Generation Sequencing (NGS) and Endocrine Tumors/Malignancies: From Molecular Mechanisms to Precision Diagnosis

edited by

Sorina Schipor

and

Dana Manda

submission deadline 30 Sep 2026 | Viewed by 2431 | Submission Open

Keywords: thyroid; adrenal; pituitary; parathyroid; germline; somatic; gene; molecular biology; diagnosis; hormone; gene

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

New Advances in Gastrointestinal Endoscopy

edited by

Gwang Ha Kim

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2356 | Submission Open

Keywords: artificial intelligence; bariatric endoscopy; gastrointestinal bleeding; endoscopic imaging; endoscopic resection; endoscopic ultrasonography; gastrointestinal tumor; third-space endoscopy

(This special issue belongs to the Section Biomedical Optics)

Advances in Hematology Laboratory—2nd Edition

edited by

Eloisa Urrechaga

submission deadline 30 Sep 2026 | 3 articles | Viewed by 2280 | Submission Open

Keywords: complete blood counts; leukocyte differential; reticulocyte indices; immature platelet fraction; cell population data; blood cell analyzers

(This special issue belongs to the Section Clinical Laboratory Medicine)

Ocular Surface Alterations in Eyelid Malpositions: Pathophysiology, Diagnostic Tools, and Therapeutic Approaches

edited by Massimiliano Serafino and

Alessandra Di Maria

submission deadline 30 Sep 2026 | 1 articles | Viewed by 2248 | Submission Open

Keywords: lid malpositions and ocular surface disorders; dry eye syndrome; exposure keratopathy; tear film instability; anterior segment imaging; lid surgery outcomes

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

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