Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.9
3.3
Journals
Diagnostics
Special Issues
Digital Innovation in Salivary Diagnostics for Oral and Systemic Health
share announcement

Digital Innovation in Salivary Diagnostics for Oral and Systemic Health

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Machine Learning and Artificial Intelligence in Diagnostics".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 189

Special Issue Editor

Prof. Dr. Corina Marilena Cristache

E-Mail Website
Guest Editor
Department of Dental Techniques, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania
Interests: oral and maxillofacial surgery; implant dentistry; maxillofacial prosthodontics; dental materials; digital dentistry; artificial intelligence in dentistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Saliva is increasingly recognized as a powerful, non-invasive biofluid with significant potential for the early detection and monitoring of both oral and systemic diseases. This Special Issue aims to highlight the expanding role of saliva in precision diagnostics, focusing on its clinical utility across a spectrum of conditions, including dental caries, periodontal disease, oral cancer, diabetes, cardiovascular disorders, and chronic kidney disease. We invite original research articles, reviews, and case studies that explore emerging salivary biomarkers, innovative biosensing technologies for real-time monitoring, and the integration of artificial intelligence (AI) for the analysis of complex salivary data. Given its ease of collection, low cost, and patient-friendly nature, saliva represents a transformative medium for accessible and routine health monitoring. This Special Issue seeks to showcase interdisciplinary advances that position saliva-based diagnostics at the forefront of personalized and preventive medicine, with the ultimate goal of enhancing early detection, improving patient outcomes, and contributing to the future of smart, data-driven healthcare.

Prof. Dr. Corina Marilena Cristache
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • saliva diagnosis
  • oral disease
  • systemic diseases
  • artificial intelligence
  • AI driven diagnosis

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Review

19 pages, 2113 KB  
Review
From Saliva to Diagnosis: A Scoping Review of Conventional and Biosensor-Based Methods for Salivary Biomarkers in Chronic Kidney Disease
by Elena Valentina Vacarel, Eliza Denisa Barbulescu (Sgiea) and Corina Marilena Cristache
Diagnostics 2025, 15(17), 2226; https://doi.org/10.3390/diagnostics15172226 - 2 Sep 2025
Abstract
Chronic kidney disease (CKD) is a progressive global health burden often diagnosed in late stages due to reliance on invasive and centralized blood and urine tests. Saliva, as a non-invasive diagnostic fluid, has emerged as a promising alternative for assessing renal function. This [...] Read more.
Chronic kidney disease (CKD) is a progressive global health burden often diagnosed in late stages due to reliance on invasive and centralized blood and urine tests. Saliva, as a non-invasive diagnostic fluid, has emerged as a promising alternative for assessing renal function. This scoping review aims to evaluate the diagnostic accuracy of salivary biomarkers compared to traditional methods, and to explore the potential of emerging biosensing technologies for CKD detection and monitoring. Methods: A comprehensive literature search was conducted in PubMed/MEDLINE, Scopus, Web of Science, and Cochrane Library up to 1 July 2025, following the PRISMA-ScR guidelines. Studies involving adult CKD patients and healthy controls that assessed the diagnostic performance of salivary biomarkers against validated reference standards (e.g., serum creatinine, eGFR) were included. A total of 29 eligible studies were selected after applying predefined inclusion and exclusion criteria. Results: Salivary creatinine and urea were the most frequently assessed biomarkers and demonstrated strong correlations with serum levels (AUCs up to 1.00; sensitivity and specificity frequently >85%). Several studies reported high diagnostic potential for novel salivary markers such as Trimethylamine N-oxide (TMAO), cystatin C, and amino acids. Technological innovations, including electrochemical biosensors and ATR-FTIR spectroscopy, showed promise for enhancing sensitivity and enabling point-of-care testing. However, heterogeneity in sampling protocols and limited data for early-stage CKD were notable limitations. Conclusions: Salivary diagnostics, supported by biosensor technologies, offer a feasible and non-invasive alternative for CKD screening and monitoring. Standardization, broader clinical validation, and integration into dental workflows are key to clinical implementation. Full article
(This article belongs to the Special Issue Digital Innovation in Salivary Diagnostics for Oral and Systemic Health)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop