Advances in Diagnosis, Treatment and Management of Gastrointestinal Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 503

Special Issue Editor


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Guest Editor
1. Medical Clinic II and Gastroenterology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania
2. Department of Gastroenterology, Emergency University Hospital Bucharest, 050098 Bucharest, Romania
Interests: viral hepatitis; NAFLD; non-invasive methods for liver fibrosis; breath tests for liver function; inflammatory bowel disease
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Special Issue Information

Dear Colleagues,

As the Guest Editor of the upcoming Special Issue titled ‘Advances in Diagnosis, Treatment and Management of Gastrointestinal Diseases’ in Diagnostics, I am pleased to invite you to contribute a high-quality manuscript based on your expertise and recent work in this important field.

This Special Issue aims to showcase the latest research and clinical innovations that enhance our understanding and management of gastrointestinal disorders. We welcome original research articles, comprehensive reviews, and insightful case reports covering topics such as novel diagnostic techniques, emerging therapeutic strategies, minimally invasive interventions, and interdisciplinary approaches to GI disease management.

We believe your contribution would be a valuable addition to this Issue and will help drive forward clinical and research excellence in the field of gastroenterology.

Thank you for considering this invitation. We look forward to your response and the possibility of including your work in this Special Issue.

Prof. Dr. Carmen Fierbinteanu-Braticevici
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gastrointestinal diseases
  • liver diseases
  • biomarkers in GI disease
  • imaging in GI diagnosis (CT, MRI, ultrasound)
  • non-invasive diagnostic tools
  • GI Endoscopic procedures
  • treatment approaches
  • personalized medicine

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Published Papers (2 papers)

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Research

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11 pages, 484 KB  
Article
Sex-Related Differences in the Diagnosis and Evolution of Parietal Cell Antibody-Positive Autoimmune Gastritis: A Large Single-Center Retrospective Cohort Study
by Esteban Fuentes-Valenzuela, Santiago Blanco, Sergio Escribano Cruz, Javier Parra Villanueva, Almudena Calvache Rodríguez, Ariadna Gil Diaz, María del Carmen López-Martín, Itziar Rubio de la Plaza, Irene Chivato Martín-Falquina, Beatriz Rodríguez-Batllori Aran, Raquel Latorre Martínez, Luis Alonso Castillo Herrera, Daniel Alcalde Rodríguez, Karina Guzmán López and Alicia Bejerano Domínguez
Diagnostics 2026, 16(3), 387; https://doi.org/10.3390/diagnostics16030387 (registering DOI) - 26 Jan 2026
Abstract
Background/Objectives: Autoimmune gastritis (AIG) is more common in females, although studies assessing the differences between females and males are scarce. Therefore, this retrospective observational study aimed to assess differences at diagnosis and the evolution of the full spectrum of AIG between females [...] Read more.
Background/Objectives: Autoimmune gastritis (AIG) is more common in females, although studies assessing the differences between females and males are scarce. Therefore, this retrospective observational study aimed to assess differences at diagnosis and the evolution of the full spectrum of AIG between females and males. Methods: A large retrospective single-center cohort study was performed. Two cohorts were included: patients newly diagnosed with AIG with positive parietal cell antibodies between June 2013 and June 2023, and those who underwent at least one follow-up endoscopy, constituted the second cohort. Both cohorts were categorized by sex. Results: A total of four hundred twenty-six patients were included. Three hundred seventeen were females (74.4%) and 109 males, with a median age of 53.5 years (IQR 44.7–65.3). Females were more likely to be non-smokers (71.5%, 226 patients versus 57.8%, 63 patients; p = 0.01), higher prevalence of autoimmune hypothyroidism (72 females, 22.7% versus nine males, 8.3%; p = 0.001), dyspepsia (130 individuals, 41% versus 28 individuals, 25.7%; p = 0.004), and iron deficiency anemia (100 females, 31.6% versus 18 males, 16.5%; p = 0.002), while vitamin B12 deficiency was higher amongst males (22, 21.6% versus 36; 11.6%; p = 0.012). Histological and endoscopic stages were similar at the diagnosis. The logistic regression identified iron deficiency anemia (OR 2.9; 95% CI 1.47–5.72; p = 0.002), dyspepsia (OR 2.3; 95% CI 1.28–3.9; p = 0.005), lower ferritin levels (OR 0.99; 95% CI 0.98–0.99; p < 0.001), and autoimmune hypothyroidism (OR 2.7; 95% CI 1.24–5.8, p = 0.012) associated with females at diagnosis. No significant differences were observed regarding progression to a worse stage (47 females, 39.1% versus 9 males, 28.1%; p = 0.26). Conclusions: In conclusion, this large retrospective study showed some differences in clinical factors associated with AIG, although the evolution was similar. Clinicians should be particularly vigilant for the diagnosis of AIG in female patients with iron deficiency anemia, dyspeptic symptoms, and autoimmune hypothyroidism. Full article
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Review

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16 pages, 355 KB  
Review
Colonoscopy Quality Indicators in Transition: From Adenoma Detection Rate to Serrated Lesion Detection and Beyond
by Aryan Jain, James Javier, Jr., Kyle Nguyen-Ngo and Micheal Tadros
Diagnostics 2026, 16(2), 258; https://doi.org/10.3390/diagnostics16020258 - 14 Jan 2026
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Abstract
Colonoscopy is central to colorectal cancer (CRC) prevention, and its effectiveness is determined by the quality of mucosal inspection and lesion detection. The adenoma detection rate (ADR) remains the most widely validated quality benchmark due to its strong inverse association with interval CRC. [...] Read more.
Colonoscopy is central to colorectal cancer (CRC) prevention, and its effectiveness is determined by the quality of mucosal inspection and lesion detection. The adenoma detection rate (ADR) remains the most widely validated quality benchmark due to its strong inverse association with interval CRC. However, reliance on ADR alone is increasingly recognized as insufficient, particularly given the growing understanding of the serrated neoplasia pathway, which contributes up to one-third of sporadic CRCs. This has driven the emergence of complementary metrics, such as the sessile polyp detection rate (SPDR) and adenomas per colonoscopy (APC). Although SPDR offers important advantages for capturing serrated pathology, challenges persist, including interobserver variability, inconsistent pathology thresholds, limited endoscopist training, and the absence of standardized benchmarks. Alongside these evolving metrics, technological advancements such as image-enhanced endoscopy, computer-aided detection, high-definition optics, and distal attachment devices have demonstrated measurable improvements in detecting subtle lesions and reducing operator-dependent variability. Large real-world registries, including GIQuIC, now support the development and validation of composite models that integrate ADR, SPDR, and APC to better reflect the full spectrum of neoplasia detection. As the field advances, redefining colonoscopy quality will require reconciling established metrics with newer indicators that more comprehensively address both conventional adenomas and serrated lesions. Full article
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