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Diagnostics
Special Issues
Advancing Blood-Based Diagnostics: Innovations, Challenges and Clinical Impact
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Advancing Blood-Based Diagnostics: Innovations, Challenges and Clinical Impact

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Laboratory Medicine".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 1070

Special Issue Editor

Dr. Sapha Shibeeb

E-Mail Website
Guest Editor
School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia
Interests: novel modulators of platelet function; role of platelets in cardiovascular diseases; advances in AI and diagnosis of hematological conditions
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Blood-based diagnostic testing remains one of the most widely utilized and clinically valuable tools in modern medicine, underpinning critical decisions across nearly every medical specialty. As healthcare shifts toward personalized, data-driven, and preventive models, blood tests are evolving rapidly, driven by advances in analytical techniques, biomarker discovery, and computational interpretation.

This Special Issue invites original research, reviews, and methodological papers that explore the development, evaluation, and clinical application of blood-based diagnostics.

By focusing on innovation, existing challenges, and clinical outcomes, this Special Issue aims to provide a comprehensive overview of how blood testing is advancing to meet the demands of modern clinical practice.

Dr. Sapha Shibeeb
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diagnostic biomarkers
  • analytical performance
  • test interpretability
  • prognostic markers
  • translational diagnostics
  • artificial intelligence in diagnostics
  • precision medicine
  • clinical decision-making

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

15 pages, 3223 KB  
Article
First Clinical Description of Coagulation of Whole Blood with Resonant Acoustic Rheometry
by Connor M. Bunch, Weiping Li, Kiera Downey, Timothy L. Hall, Allen Chehimi, Samuel J. Thomas, Afsheen Mansoori, Miguel Velasco, Marie N. Karam, Jenny Chen, Jacob Tuttle, Matthew R. Walsh, Scott G. Thomas, Mark M. Walsh, Joseph B. Miller, Jan P. Stegemann and Cheri X. Deng
Diagnostics 2026, 16(1), 47; https://doi.org/10.3390/diagnostics16010047 - 23 Dec 2025
Viewed by 897
Abstract
Background/Objectives: The timely evaluation of blood clot formation and breakdown is essential in the care of patients with severe bleeding or critical illness. Resonant acoustic rheometry is a novel, non-contact ultrasound method that measures changes in the viscoelastic properties of blood in [...] Read more.
Background/Objectives: The timely evaluation of blood clot formation and breakdown is essential in the care of patients with severe bleeding or critical illness. Resonant acoustic rheometry is a novel, non-contact ultrasound method that measures changes in the viscoelastic properties of blood in a standard microplate format. Here, we present the first clinical description of whole blood coagulation and fibrinolysis assessed with resonant acoustic rheometry, with paired thromboelastography measurements for comparison. Methods: In this retrospective analysis, whole blood samples from three critically ill patients were divided and tested under four different conditions that included a control mixture, kaolin activation, tissue factor activation, and a tissue factor mixture supplemented with tissue plasminogen activator. The resonant acoustic rheometry system obtained real time measurements of resonant surface waves and displacements from the samples. Heat maps and spectrograms of the resonant surface waves were analyzed to determine the onset of clotting, the rate of viscoelastic stiffening, the time to maximum rigidity, and the onset as well as magnitude of fibrinolysis. These measurements were compared with thromboelastography reaction time, clot strength, fibrinogen contribution, and lysis values. Results: Resonant acoustic rheometry detected reproducible transitions from liquid to clot and from clot to lysis in all samples. Activator-dependent changes in clot initiation and propagation matched the expected hierarchy observed in thromboelastography. Significantly, samples exposed to tissue plasminogen activator demonstrated a clear fall in resonant frequency and a corresponding rise in surface displacement that reflected fibrinolysis. The technique also reproduced clinically meaningful patterns of hemostasis that aligned with each patient’s underlying disease. Conclusions: Whole blood clotting can be measured with resonant acoustic rheometry in a manner that aligns with established clinical assays. These results suggest strong potential for future use of resonant acoustic rheometry as a cost-effective, complementary platform for rapid, scalable, and clinically informative hemostatic assessment. Full article
(This article belongs to the Special Issue Advancing Blood-Based Diagnostics: Innovations, Challenges and Clinical Impact)
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