Recent Advances in Hematology and Oncology, 2nd Edition

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Laboratory Medicine".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 566

Special Issue Editor


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Guest Editor
1. Department of Internal Medicine, School of Medicine, National Defense Medical Center, Taipei City, Taiwan
2. Division of Hematology and Oncology, Department of Internal Medicine, Tri-Service General Hospital, Taipei City, Taiwan
Interests: hematology; oncology; evidence-based medicine
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Special Issue Information

Dear Colleagues,

This Special Issue is dedicated to showcasing recent breakthroughs in hematology and oncology, providing a comprehensive overview of cutting-edge research that contributes to our understanding of oncological and hematological malignancies.

We welcome submissions that explore emerging therapies, diagnostic techniques, and molecular insights, offering valuable perspectives for researchers, clinicians, and healthcare practitioners alike. Key themes include precision medicine, immunotherapy, genomics, and targeted therapies. Through this Special Issue, we will provide an indispensable resource, bridging knowledge gaps and fostering further advancements in the dynamic fields of hematology and oncology.

We look forward to receiving your contributions to this Special Issue, and we believe that your insights will significantly contribute to advancing our collective knowledge in these crucial fields. 

Dr. Chohao Lee
Guest Editor

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Keywords

  • hematological malignancies
  • lymphoma
  • leukemia
  • multiple myeloma
  • precision medicine
  • immunotherapy
  • genomics
  • targeted therapies

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Published Papers (1 paper)

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Research

12 pages, 812 KiB  
Article
Clinical Utility of Plasma Microbial Cell-Free DNA Surveillance in Neutropenic Patients with Acute Myeloid Leukemia Undergoing Outpatient Chemotherapy: A Case Series
by Maria Lampou, Elizabeth C. Trull, Hailey M. Warren, Musie S. Ghebremichael, Raja Nakka, Daniel J. Floyd, Amir T. Fathi, Andrew M. Brunner and Michael K. Mansour
Diagnostics 2025, 15(13), 1715; https://doi.org/10.3390/diagnostics15131715 - 5 Jul 2025
Viewed by 476
Abstract
Background/Objectives: The main objective of the study is to assess the clinical utility of microbial cell-free DNA (mcfDNA) in neutropenic patients diagnosed with acute myeloid leukemia (AML) undergoing chemotherapy in the outpatient setting. Neutropenia is a common complication in this patient cohort [...] Read more.
Background/Objectives: The main objective of the study is to assess the clinical utility of microbial cell-free DNA (mcfDNA) in neutropenic patients diagnosed with acute myeloid leukemia (AML) undergoing chemotherapy in the outpatient setting. Neutropenia is a common complication in this patient cohort and enhances the risk of fatal opportunistic bacterial and fungal infections. Accurate and timely diagnosis of these infections in outpatient asymptomatic individuals is critical. Methods: Fourteen patients were studied in this prospective observational case series. Traditional blood cultures (BCs) were obtained when clinically indicated and blood samples were collected for plasma mcfDNA metagenomic sequencing up to two times a week at outpatient oncology appointments. Results were compared in identifying potential infectious agents. Results: BCs identified pathogens in only two patients, despite several cases where infection was suspected. In contrast, mcfDNA testing detected pathogens in 11 of the 14 patients, including bacteria, such as Staphylococcus aureus, and invasive fungi, such as Candida and Aspergillus species, and Pneumocystis jirovecii. Conclusions: In the outpatient setting, mcfDNA surveillance offers a more reliable method for detecting pathogens. This approach identified actionable microbiologic results in immunocompromised individuals who did not meet standard clinical criteria for suspicion of infection. Further research is required to confirm the potential of mcfDNA surveillance in an outpatient setting to guide more accurate treatment decisions, reduce extensive clinical investigations, and improve neutropenic patient outcomes. Full article
(This article belongs to the Special Issue Recent Advances in Hematology and Oncology, 2nd Edition)
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