Diagnosis, Treatment, and Management of Hair Disorders

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 290

Special Issue Editors


E-Mail Website
Guest Editor
The Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY, USA
Interests: dermatology; dermatological surgery

E-Mail Website
Guest Editor
The Ronald O Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY, USA
Interests: dermatology

Special Issue Information

Dear Colleagues,

This Special Issue of Diagnostics will focus on the diagnosis, treatment, and management of hair disorders. Hair disorders can have a significant impact on patients' quality of life, and this Special Issue aims at providing an overview of current and emerging approaches in the field. Topics of interest include, but are not limited to, novel therapeutic interventions such as excimer laser for hair loss conditions and emerging treatments for psoriatic alopecia. We will also explore the paradoxical role of medications such as dupixent in triggering or exacerbating conditions like alopecia areata. Furthermore, submissions detailing diagnostic techniques, innovative management strategies, and comprehensive reviews of specific hair disorders are encouraged. This Special Issue aims at consolidateing the latest advancements, offering valuable insights for clinicians and researchers dedicated to improving patient outcomes in hair disorders.

Dr. Neil Jairath
Dr. Vignesh Ramachandran
Guest Editors

Manuscript Submission Information

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Keywords

  • hair loss
  • alopecia
  • management
  • cicatricial
  • diagnosis

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Published Papers (1 paper)

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Research

10 pages, 219 KiB  
Article
Alopecia Areata Associated with Dupilumab: National Database Study
by Tarun Sontam, Humaira Nfn, Jodi Yanking Li, Sehar Nadeem, Katie Beier, Neil K. Jairath and Vignesh Ramachandran
Diagnostics 2025, 15(14), 1828; https://doi.org/10.3390/diagnostics15141828 - 21 Jul 2025
Viewed by 218
Abstract
Background: Alopecia areata (AA), an autoimmune condition causing non-scarring hair loss, often coexists with atopic dermatitis (AD) due to shared T-helper cell type 2 (Th2)-mediated pathways. Dupilumab, a monoclonal antibody inhibiting IL-4 and IL-13 signaling, is a cornerstone treatment for AD but has [...] Read more.
Background: Alopecia areata (AA), an autoimmune condition causing non-scarring hair loss, often coexists with atopic dermatitis (AD) due to shared T-helper cell type 2 (Th2)-mediated pathways. Dupilumab, a monoclonal antibody inhibiting IL-4 and IL-13 signaling, is a cornerstone treatment for AD but has conflicting reports regarding its impact on AA, with some suggesting therapeutic benefits and others indicating AA induction. Methods: This retrospective study, utilizing the TriNetX Research Network’s de-identified data from over 300 million patient records, investigates the association between dupilumab use and AA risk in AD patients. Results: After propensity score matching, 23,782 dupilumab users were compared with an equal number of controls. Results revealed a statistically significant increased AA risk in dupilumab users (odds ratio: 1.436, 95% CI: 1.066–1.935, p = 0.0167) after 16 weeks. Cases occurring within 16 weeks were excluded. Conclusions: Potential mechanisms include immune rebalancing, with Th2 suppression possibly upregulating Th1/Th17 pathways or unmasking latent AA in predisposed individuals. These findings challenge dupilumab’s potential as an AA treatment and highlight the need for vigilant monitoring, including routine scalp examinations and patient education. Future research should focus on mechanistic pathways, risk stratification, and comparative studies with other biologics to optimize personalized treatment strategies for AD and AA. Full article
(This article belongs to the Special Issue Diagnosis, Treatment, and Management of Hair Disorders)
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