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Diagnostics
Special Issues
Innovative Diagnostic Approaches in Retinal Diseases
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Innovative Diagnostic Approaches in Retinal Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 257

Special Issue Editors

Dr. Benedetto Falsini

E-Mail Website
Guest Editor
1. Ophthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
2. Ophthalmology Unit, Catholic University “Sacro Cuore”, 00168 Rome, Italy
Interests: ophthalmology; OCT angiography; retinal; age-related macular degeneration; degenerative retinal diseases; retina; pathologies
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Andrea Cusumano

E-Mail Website
Guest Editor
Department of Ophthalmology, Tor Vergata University, 00133 Rome, Italy
Interests: retina; ophthalmology; ultrastructural analysis; laser techniques; hereditary retinal diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Retinal diseases, such as age-related macular degeneration, diabetic retinopathy, and retinal vein occlusion, remain leading causes of visual impairment worldwide. Recent advances in imaging technologies, molecular diagnostics, and artificial intelligence have opened new frontiers in early detection, disease monitoring, and personalized treatment planning.

This Special Issue aims to highlight cutting-edge diagnostic strategies in the field of retinal diseases, including, but not limited to, the following: optical coherence tomography (OCT), OCT angiography, fundus autofluorescence, retinal biomarkers, AI-assisted diagnostic tools, and teleophthalmology. We welcome original research articles, clinical studies, and comprehensive reviews that explore novel methodologies, validation studies, and the clinical utility of emerging diagnostic tools.

By bringing together interdisciplinary research, this Special Issue seeks to advance our understanding of retinal pathologies and contribute to improved patient outcomes through earlier and more precise diagnoses.

I look forward to receiving your contributions.

Dr. Benedetto Falsini
Prof. Dr. Andrea Cusumano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • retinal diseases
  • electrophysiology
  • imaging
  • optical coherence tomography

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Published Papers (1 paper)

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Research

12 pages, 1042 KiB  
Article
Steady-State PERG Adaptation Reveals Temporal Abnormalities of Retinal Ganglion Cells in Treated Ocular Hypertension and Glaucoma
by Tommaso Salgarello, Andrea Giudiceandrea, Grazia Maria Cozzupoli, Martina Cocuzza, Romolo Fedeli, Donato Errico, Antonello Fadda, Filippo Amore, Marco Sulfaro, Epifanio Giudiceandrea, Matteo Salgarello, Stanislao Rizzo and Benedetto Falsini
Diagnostics 2025, 15(14), 1797; https://doi.org/10.3390/diagnostics15141797 - 16 Jul 2025
Viewed by 197
Abstract
Background/Objectives: This study investigates adaptive changes in long-lasting pattern electroretinogram (PERG) responses in ocular hypertension (OHT) and open-angle glaucoma (OAG) patients, and in healthy subjects. Methods: Sixty consecutive individuals were recruited, including 20 OHT, 20 OAG, and 20 normal subjects. All participants underwent [...] Read more.
Background/Objectives: This study investigates adaptive changes in long-lasting pattern electroretinogram (PERG) responses in ocular hypertension (OHT) and open-angle glaucoma (OAG) patients, and in healthy subjects. Methods: Sixty consecutive individuals were recruited, including 20 OHT, 20 OAG, and 20 normal subjects. All participants underwent comprehensive ophthalmologic examination, 30–2 perimetry, and retinal nerve fiber layer imaging. Steady-state (7.5 Hz) PERGs were recorded over approximately 2 min, in response to 90% contrast alternating gratings within a large field size. The recordings were acquired into a sequence of 10 averages (packets), lasting 10 s each, following a standardized adaptation paradigm (Next Generation PERG, PERGx). Key outcome measures included PERGx parameters reflecting response amplitude and phase changes over time. Results: The PERGx grand average scalar amplitude, a surrogate of ordinary PERG, was significantly reduced in both OHT and OAG groups compared to normal subjects (p < 0.01). In contrast, minimal adaptation changes were noted in PERGx amplitude among all groups. The PERGx phase exhibited a progressive decline over time, with consistent delays of approximately 20 degrees across all groups. Angular dispersion of the PERGx phase increased significantly in OHT patients compared to normal subjects (p < 0.05). An inverse relationship was observed between PERGx angular dispersion and treated intraocular pressure, specifically in OHT patients. Conclusions: The findings suggest that both OHT and OAG eyes may exhibit temporal abnormalities in PERG adaptation, potentially indicating early dysfunction in retinal ganglion cell activity. Translational Relevance: PERGx phase changes may have significant implications for glaucoma early detection and management. Full article
(This article belongs to the Special Issue Innovative Diagnostic Approaches in Retinal Diseases)
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