Applications of Optical Coherence Tomography and Optical Coherence Tomography Angiography in Ophthalmology

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Biomedical Optics".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 818

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Special Issue Information

Dear Colleagues,

This Special Issue entitle “Applications of Optical Coherence Tomography and Optical Coherence Tomography Angiography in Ophthalmology” delves into the revolutionary advancements of Optical Coherence Tomography (OCT) and Optical Coherence Tomography Angiography (OCTA) in ophthalmic diagnostics. It highlights how these technologies have transformed our ability to non-invasively image and assess ocular structures with unprecedented precision. From detecting early signs of glaucoma and age-related macular degeneration to mapping microvasculature in retinal diseases, OCT/OCTA offers clinicians a powerful tool for accurate diagnosis, enabling timely interventions and improved patient outcomes. This collection of articles explores the latest research, clinical applications, and future directions in this exciting field.

Dr. Daniela Bacherini
Guest Editor

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Keywords

  • OCT
  • OCTA
  • ophthalmology
  • diagnostics
  • clinical applications

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Published Papers (1 paper)

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Research

11 pages, 1402 KiB  
Article
Comparison of Retinal Microvascular Changes in Axial Spondyloarthritis Using Optical Coherence Tomography Angiography: Anti-TNF vs. NSAID Therapy
by Özlem Karataş, Çisil Erkan Pota, Bülent Akyüz, Yusuf Samet Atlıhan, Kaan Pota, Aslı Çetinkaya Yaprak, Merve Sarı and Serpil Tuna
Diagnostics 2025, 15(5), 597; https://doi.org/10.3390/diagnostics15050597 - 1 Mar 2025
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Abstract
Objectives: The aim of this study was to investigate retinal and choroidal microvascular changes in patients with axial spondyloarthritis (axSpA) treated with long-term anti-TNF therapy and NSAIDs and in healthy control subjects using optical coherence tomography angiography (SS-OCT-A). Methods: A total [...] Read more.
Objectives: The aim of this study was to investigate retinal and choroidal microvascular changes in patients with axial spondyloarthritis (axSpA) treated with long-term anti-TNF therapy and NSAIDs and in healthy control subjects using optical coherence tomography angiography (SS-OCT-A). Methods: A total of 162 eyes from 81 participants were included: 52 eyes from 26 axSpA patients treated with anti-TNF therapy (≥5 years), 44 eyes from 22 axSpA patients treated with NSAIDs, and 66 eyes from 33 healthy control subjects. SS-OCT-A imaging was used to assess retinal thickness, ganglion cell layer thickness, retinal nerve fiber layer thickness, and the vessel densities of the superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC). Disease activity was assessed with ASDAS-CRP. Results: Both axSpA subgroups showed a significant expansion of the foveal avascular zone and reduced SCP and DCP densities compared to the controls. The CC vessel density was higher in axSpA patients than in healthy subjects. The anti-TNF group had a lower CC vascular density than the NSAIDs group. The disease duration correlated with a decreased central DCP density and increased paracentral SCP and CC densities. Conclusions: SS-OCT-A revealed subclinical retinal and choroidal changes in axSpA patients, highlighting the impact of chronic inflammation on the retinal vasculature. While anti-TNF therapy effectively controls systemic inflammation, it cannot completely prevent microvascular changes. Further studies are needed to assess the clinical relevance of these results. Full article
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