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Mechanistic Insights into the Antioxidant Activity of Bioorganic Molecules: A Chemical Perspective

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Bioorganic Chemistry and Medicinal Chemistry".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 129

Special Issue Editor


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Guest Editor
Institute of Pathophysiology “Ljubodrag Buba Mihailović”, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia
Interests: metabolic-dysfunction steatotic liver disease (MASLD); metabolic-dysfunction steatohepatitis (MASH); alcoholic liver disease (ALD); hepatic fibrosis; cirrhosis; hepatocellular carcinoma (HCC); obesity; metabolic syndrome; endocannabinoid system; oxidative stress; redox signaling; neuroendocrino-inflammatory axis; pathophysiology; experimental hepatology

Special Issue Information

Dear Colleagues,

Understanding the molecular mechanisms underlying antioxidant activity is crucial in developing novel therapeutic strategies and functional materials. Bioorganic molecules, including natural products, synthetic compounds, and biomimetic analogs, possess diverse structural features that contribute to their ability to neutralize reactive oxygen and nitrogen species. From electron donation to radical scavenging and metal chelation, these antioxidant actions are governed by intricate chemical principles that merit in-depth exploration. This Special Issue will highlight recent advances in elucidating the antioxidant mechanisms of bioorganic compounds, with a particular emphasis on structure–activity relationships, chemical kinetics, and mechanistic insights derived through both experimental and computational approaches. We invite contributions that explore how chemical modifications, molecular geometry, and reaction environments influence antioxidant behavior. We welcome oresearch and comprehensive review articles that will enhance our understanding of antioxidant mechanisms from a chemical standpoint.

We look forward to receiving your valuable contributions to this Special Issue.

Prof. Dr. Tatjana S. Radosavljević
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidant mechanisms
  • bioorganic molecules
  • redox -active compounds
  • molecular reactivity
  • oxidative stress modulation

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Published Papers (1 paper)

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Research

14 pages, 3075 KB  
Article
Macrophage Inhibitory Factor in Myocardial Oxidative Stress and Inflammation During Thioacetamide-Induced Liver Fibrosis: Modulation by Betaine
by Jasmina Djuretić, Jelena Filipovic, Milica Brankovic, Sanja Stankovic, Janko Samardzic, Danijela Vucevic and Tatjana Radosavljevic
Curr. Issues Mol. Biol. 2025, 47(9), 728; https://doi.org/10.3390/cimb47090728 (registering DOI) - 9 Sep 2025
Abstract
Chronic liver disease is closely associated with impaired cardiovascular function. Cardiac dysfunction is caused in part by oxidative stress and increased levels of proinflammatory and profibrogenic mediators in myocardial tissue. The present study aims to investigate the role of betaine in the modulation [...] Read more.
Chronic liver disease is closely associated with impaired cardiovascular function. Cardiac dysfunction is caused in part by oxidative stress and increased levels of proinflammatory and profibrogenic mediators in myocardial tissue. The present study aims to investigate the role of betaine in the modulation of MIF-mediated oxidative stress, inflammation, and fibrogenesis in heart during TAA-induced liver fibrosis in mice. The experiment is performed on wild-type and knockout MIF−/− C57BL/6 mice (MIF−/− group). They are randomly divided into groups: Control; Bet-group, received betaine (2% wt/v dissolved in drinking water); MIF−/− mice group; MIF−/−+Bet; TAA-group, treated with TAA (200 mg/kg b.w.), intraperitoneally, 3×/week/8 weeks); TAA+Bet; MIF−/−+TAA, and MIF−/−+TAA+Bet group. After eight weeks of treatment, animals are sacrificed and heart samples are taken to determine oxidative stress parameters, proinflammatory cytokines, profibrogenic factors, and histopathology of myocardial tissue. Our results suggest that MIF contributes significantly to lipid peroxidation of cardiomyocytes, as well as oxidative and nitrosative stress in myocardial tissue in mice with TAA-induced liver fibrosis compared to the control group. In addition, MIF was important for myocardial expression of the proinflammatory cytokines IL-6 and TNF as well as the profibrogenic mediators TGF-β1 and PDGF-BB in TAA-treated mice. Notably, betaine attenuated MIF effects in myocardial tissue reducing levels of MDA, AOPP, TNF, TGF-β1, PDGF-BB and increasing SOD and catalase activity in the coexistence of liver fibrosis. These results emphasize the potential of betaine as a therapeutic agent in mitigating MIF effects and demonstrate the need for further research into its optimal dosage and efficacy in preventing or slowing down cardiac dysfunction in patients with liver cirrhosis. Full article
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