Molecular Research on Metabolic Aberration-Driven Carcinogenesis
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 30 December 2026 | Viewed by 708
Special Issue Editor
Special Issue Information
Dear Colleagues,
This Special Issue aims to bridge the gap between metabolic disorders and the formation and accumulation of carcinogenic mutations. Metabolic syndrome, which includes obesity, insulin resistance, dyslipidemia, and hypertension, is increasingly recognized as a major risk factor for a wide range of mutation-driven epithelial cancers.
Epidemiological and experimental evidence suggests that metabolic interventions—including weight loss, bariatric surgery, metformin, and aspirin—can significantly reduce the incidence of obesity-associated cancers. The economic burden of these cancers, through both healthcare costs and productivity loss, is projected to become a global crisis by 2050.
The hereditary metabolic disorder Perutz–Jaeger Syndrome, which confers a 15-fold increase in cancer risk, highlights the crucial role of AMPK, a central metabolic regulator also impaired in obesity. This underscores the need to understand how energy imbalance affects genomic integrity and promotes oncogenesis.
However, the molecular mechanisms linking metabolic dysfunction to carcinogenesis remain incompletely understood.
We invite submissions of the following:
- Original research articles, reviews, and short communications examining the following:
- Mutation accumulation and expression;
- Cell signaling and energy stress;
- Inflammation, apoptosis, and DNA repair;
- Epigenetic modifications and chromatin dynamics;
- The role of AMPK and related metabolic signaling nodes.
- Studies using the following:
- Molecular biology methods;
- High-throughput omics: genomics, transcriptomics, proteomics, and metabolomics;
- Computational biology, modeling, and systems biology;
- Translational or preclinical cancer models.
We especially encourage the following:
- Interdisciplinary collaborations across metabolism, cancer biology, and genomics;
- Research offering mechanistic insights or novel therapeutic strategies targeting the metabolic–genomic interface.
Best regards,
Prof. Dr. John Joseph Byrnes
Guest Editor
Manuscript Submission Information
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Keywords
- metabolic disorders
- carcinogenic mutations
- carcinogenesis
- obesity-associated cancers
- metabolic signaling
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