Molecular Mechanisms and Reparative Therapeutic Strategies in Neurodegenerative Diseases
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 31 October 2026 | Viewed by 95
Special Issue Editors
Interests: stem cell therapy; stroke; neonatal hypoxic-ischemic injury; Parkinson's disease; traumatic brain injury; translational research
Special Issues, Collections and Topics in MDPI journals
Interests: neuroplasticity; neurorehabilitation; hyperbaric oxygen therapy; functional neurosurgery; nioinformatics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The brain is arguably the most important part of the human body. As we age and succumb to diseases, the brain degenerates and lacks the ability to repair itself. Neurological disorders are characterized by progressive neurodegeneration, driven by complex molecular signaling pathways that initiate and sustain cascades of cell death. Even conditions traditionally classified as acute central nervous system injuries—such as stroke and traumatic brain injury—are now recognized to exhibit core pathological features reminiscent of chronic neurodegenerative processes. Among the principal pathological hallmarks of neurodegeneration, inflammatory mediators and factors linked to oxidative stress and mitochondrial dysfunction have emerged as critical regulators of cell death propagation. Importantly, these same molecular cell death signaling pathways represent promising therapeutic targets for strategies, such as stem cell therapy and hyperbaric oxygen therapy, aimed at enhancing brain repair. This Special Issue focuses on recent advances in elucidating the molecular mechanisms that regulate both cell death and cell survival in neurodegeneration and its treatment. By harnessing rigorous scientific inquiries into the key role of neurodegeneration in brain disorders, we seek to advance the development of innovative molecule-based therapeutic approaches for neurodegenerative diseases.
You may choose our Joint Special Issue in International Journal of Molecular Sciences.
Prof. Dr. Cesar Borlongan
Dr. Amir Hadanny
Guest Editors
Manuscript Submission Information
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Keywords
- neurodegeneration
- cell death signaling
- oxidative stress
- mitochondrial dysfunction
- brain repair
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