Nutrition and Immune Function in Disease: From Mechanisms to Precision Medicine
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 330
Special Issue Editor
Interests: immunometabolism; musculoskeletal health; bone regeneration; inflammation; precision medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Nutritional status and immune function are deeply intertwined determinants of human health and disease. Growing evidence indicates that nutrients, dietary patterns, and metabolic signals not only provide essential substrates for tissue maintenance and repair, but also actively shape innate and adaptive immune responses, thereby influencing disease susceptibility, progression, and therapeutic outcomes. This concept is particularly relevant in aging-related disorders, metabolic diseases, cancer, chronic inflammatory conditions, and musculoskeletal decline, where dysregulated nutrition–immune crosstalk contributes to pathogenesis and heterogeneity in clinical presentation. Among these conditions, sarcopenia and sarcopenic obesity have emerged as major yet underrecognized health challenges in aging populations, highlighting the need to better understand how nutritional interventions may modulate inflammation, immune homeostasis, muscle regeneration, and anabolic resistance.
In parallel, precision medicine is transforming the management of complex diseases by integrating molecular profiling, biomarkers, clinical phenotyping, and individualized therapeutic strategies. Within this framework, the nutrition–immune axis offers a promising yet insufficiently explored avenue for personalized prevention and treatment. A deeper understanding of how specific nutrients, bioactive compounds, dietary patterns, gut microbiota, and immunometabolic pathways interact across diverse disease contexts may enable the development of targeted nutritional and immune-based interventions tailored to individual risk profiles and biological states.
This Special Issue aims to gather original research, reviews, and translational perspectives that elucidate the mechanistic, clinical, and technological advances at the intersection of nutrition, immunity, and precision medicine. Topics of interest include, but are not limited to, nutritional regulation of immune responses, immunometabolism, inflammation and disease progression, sarcopenia and muscle health, microbiota-mediated diet–immune interactions, biomarker discovery, multi-omics approaches, and personalized nutritional strategies for disease prevention and therapy. By bridging basic science, clinical investigation, and precision health approaches, this Special Issue seeks to advance a more integrated understanding of how nutrition and immunity jointly shape disease trajectories and therapeutic opportunities.
We thank Dr. Xinyue Wan from Chongqing University for his contributions to this Special Issue’s proposal, development, and promotion.
Dr. Liang Chen
Guest Editor
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Keywords
- nutrition–immune interactions
- immunometabolism
- inflammation
- sarcopenia
- precision medicine
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