Molecular Roles of Neutrophil Extracellular Traps in Immune Responses and Disease
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Biochemistry, Molecular and Cellular Biology".
Deadline for manuscript submissions: 30 October 2025 | Viewed by 442
Special Issue Editor
Special Issue Information
Dear Colleagues,
This Special Issue will explore the multiple roles of neutrophil extracellular traps (NETs) in health and disease, focusing on their molecular mechanisms and immunological consequences. NETs correspond to extracellular structures generated by a neutrophil-exclusive form of cell death known as NETosis, resulting in the secretion of genomic material and proteins with an anti-pathogen function. NETs are produced in response to inflammatory stimuli, including PAMPs and DAMPs, and have emerged as critical players in host defense, inflammation, autoimmunity, thrombosis, and cancer. Despite their protective roles against pathogens, dysregulated NET formation can contribute to chronic inflammation and subsequent tissue damage in various diseases. We invite original research articles and reviews that explore the signaling pathways driving NETosis, identify molecular components of NETs with functional significance, and investigate their interactions with other cell types. Contributions addressing novel therapeutic strategies targeting NETs or their downstream effects are also welcome. This Special Issue aims to advance our understanding of NETs in immunity and pathology by integrating immunology, molecular biology, and clinical research insights.
Dr. Sofía S. Jerez
Guest Editor
Manuscript Submission Information
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Keywords
- neutrophils
- NET
- inflammation
- chronic diseases
- cell death
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