Immune Signatures and Biomarkers for Precision Medicine in Inflammatory Bowel Disease
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 31 December 2026 | Viewed by 138
Special Issue Editors
Interests: gastrointestinal pathology; inflammatory bowel disease; histopathology; colorectal cancer; biomarkers; molecular pathology; diagnostic pathology; immunohistochemistry; histologic scoring systems
Interests: inflammatory bowel disease; ulcerative colitis; Crohn’s disease; cytokines; biomarkers; immune profiling; histologic activity; precision medicine; endoscopic–histologic discordance
Special Issue Information
Dear Colleagues,
Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn’s disease, represents a complex and heterogeneous group of chronic inflammatory disorders driven by dysregulated immune responses. Despite significant advances in therapeutic strategies, including biologics and targeted small molecules, substantial variability remains in disease behavior, treatment response and long-term outcomes. This heterogeneity highlights the urgent need for improved tools to enable precision medicine approaches in IBD.
In recent years, increasing attention has been directed toward the identification of biomarkers that can more accurately reflect underlying disease activity and guide clinical decision-making. Traditional markers, such as C-reactive protein and endoscopic assessment, provide valuable but incomplete insights, particularly in capturing subclinical or microscopic inflammation. Emerging evidence suggests that systemic immune signatures, including circulating cytokines and other molecular mediators, may offer a more refined understanding of disease states and immune regulation.
This Special Issue aims to bring together original research articles, reviews and methodological studies focusing on immune profiling, biomarker discovery and personalized disease stratification in IBD. Topics of interest include, but are not limited to, cytokine signaling pathways, the integration of multi-omics approaches, non-invasive biomarkers of histologic activity and novel strategies for monitoring treatment response.
By integrating clinical, molecular and translational perspectives, this Special Issue seeks to advance the field toward more individualized and mechanism-based approaches to disease management, ultimately improving patient outcomes in inflammatory bowel disease.
Dr. Andreas C. Lazaris
Guest Editor
Dr. Nikolaos Martinos
Guest Editor Assistant
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Keywords
- inflammatory bowel disease
- ulcerative colitis
- Crohn’s disease
- cytokines
- IL-10
- IL-23
- biomarkers
- precision medicine
- immune profiling
- histologic remission
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