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Vascular Biology in Health and Diseases

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Biochemistry, Molecular and Cellular Biology".

Deadline for manuscript submissions: 31 May 2026 | Viewed by 470

Special Issue Editor


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Guest Editor
Molecular Cardiology and Angiogenesis Laboratory, Department of Surgery, University of Connecticut School of Medicine, UConn Health, 263 Farmington Avenue, Farmington, CT 06030, USA
Interests: therapeutic angiogenesis; ischemic heart; signal transduction; tissue repair and regeneration; gene expression; apoptosis; diabetic cardiomyopathy; exosome; peripheral artery disease; sepsis
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Special Issue Information

Dear Colleagues,

Vascular biology is important for understanding how blood vessels and cell regeneration are affected by various disease conditions. Vascular disease is a balance between vascular injury and vascular repair. Blood vessels are constantly exposed to various responses and insults. As we know, hypertension is not a disease, but it is a marker for vascular dysfunction. Endothelial and vascular smooth muscle dysfunction precedes the development of various vascular diseases. The endothelium maintains the main vascular health. Therefore, it is essential to investigate the molecular and physiological conditions related to angiogenesis and cellular architecture within vascular tissues. In addition, vascular Biology plays an important role in the initiation of hypertension, cardiovascular disease (CVD), and target organ damage (TOD). Oxidative stress, inflammation, and immunological reactions initiate various pathological pathways to induce CVD and TOD. Various vitamins, antioxidants, minerals, and drugs can prevent these disease conditions through numerous vascular biology mechanisms. Therefore, it is always beneficial to connect basic molecular research with clinical applications, encompassing vascular disease biomarkers, new therapeutics, precision medicine, and preclinical tools.

Prof. Dr. Nilanjana Maulik
Guest Editor

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Keywords

  • vascular biology
  • vascular disease
  • endothelium
  • cardiovascular disease (CVD)
  • pathological mechanisms

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Published Papers (1 paper)

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Research

15 pages, 3837 KB  
Article
Extracellular Adenosine Contributes to the Hydrogen Peroxide-Induced Calcification of Cultured Tendon Cells
by Tomomi Sakuma, Chantida P. N. Mahasarakham, Xin Lin, Hiroyuki Yoshitake, Akira Nifuji, Masaki Noda and Yoichi Ezura
Curr. Issues Mol. Biol. 2026, 48(3), 244; https://doi.org/10.3390/cimb48030244 - 26 Feb 2026
Viewed by 295
Abstract
Background: Well-known risk factors for soft tissue heterotopic ossification (HO) include aging and mechanical stress, which may be linked to oxidative stress and downstream nucleotide metabolites. Thus, we investigated the involvement of extracellular ATP (ex-ATP) and its metabolites in the oxidative stress-induced mineralization [...] Read more.
Background: Well-known risk factors for soft tissue heterotopic ossification (HO) include aging and mechanical stress, which may be linked to oxidative stress and downstream nucleotide metabolites. Thus, we investigated the involvement of extracellular ATP (ex-ATP) and its metabolites in the oxidative stress-induced mineralization of TT-D6 cells and primary mouse tendon cells. Methods: An osteogenic culture with the intermittent addition of hydrogen peroxide was monitored for two weeks using metabolomic and gene expression analyses. Results: Calcium deposition was significantly enhanced by 0.3 mM hydrogen peroxide in the osteogenic media after 2 weeks, with minimal calcification in its absence. Similar results were observed in a medium transfer experiment using 3-day-old hydrogen peroxide-treated conditioned medium, which led to an increased expression of osterix and alkaline phosphatase. Metabolomic analysis revealed a gradual increase in ex-ATP and its metabolites, including ADP, AMP, and adenosine, in the medium. The metabolite increase was enhanced by hydrogen peroxide after 12 h. Moreover, exogenous adenosine (100 μM) increased mineralization in osteogenic media. Additionally, 1 μM dipyridamole, an inhibitor of equilibrative nucleoside transporter 1 (Ent1), also increased it in response to low-dose (0.1 mM) hydrogen peroxide. Conclusions: The enhanced osteogenic calcification of the tendon cell culture by hydrogen peroxide was associated with an increase in extracellular nucleotide metabolites, especially adenosine, with some evidence of causality. Full article
(This article belongs to the Special Issue Vascular Biology in Health and Diseases)
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