Exploring Novel Therapeutic Targets for Neuropsychiatric Disorders: Current Research and Future Direction
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 37
Special Issue Editor
Interests: neuroscience; neuropharmacology; behavior; neuroendocrinology; schizophrenia
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The increasing prevalence of mental disorders, resulting from the stress demands of today's society, bad habits that trigger metabolic disorders, and the advent of increased life expectancy, requires not only a better understanding of these conditions, but also the availability of effective and safe therapies. For these reasons, it is crucial to have new therapeutic targets that allow mental dysfunctions to be addressed in a general and modulating manner, whilst minimizing adverse effects.
For example, several studies strongly support the non-reproductive actions of sex hormones and the strong relationship between circulating endogenous concentrations of these hormones and their neuroprotective actions. Similarly, there is abundant evidence supporting the key role of the cerebral angiotensin II system in the pathogenesis of Parkinson's disease and other mental disorders. Vascular alterations and the integrity of the neurovascular unit must also not be overlooked. The role of diabetes and metabolic syndrome as vulnerability factors for mental illness must be taken into consideration when searching for therapeutic targets. Understanding the various inflammatory processes that contribute to the long-term development of mental illness is also important.
Prof. Dr. Claudia Bregonzio
Guest Editor
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Keywords
- microvascular alterations
- Parkinson’s disease
- Alzheimer disease
- schizophrenia
- depression
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