Molecular Mechanisms of Therapy and Stress Responses in Cancer Cells and Normal Tissues
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Biochemistry, Molecular and Cellular Biology".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 186
Editor
Interests: DNA damage response and repair; replication stress; transcription-coupled nucleotide excision repair (TC-NER); radiation biology; cancer therapeutics; molecular mechanisms of genome stability; normal tissue toxicity
Special Issue Information
Dear Colleagues,
Cancer treatments, including radiation, chemotherapy, targeted agents, and their combinations, exert their effects by inducing diverse forms of cellular stress and DNA damage. The molecular mechanisms governing how cancer and normal tissues respond to these treatments are critical determinants of therapeutic efficacy, resistance, and toxicity. Understanding these responses is essential for improving treatment outcomes and minimizing adverse effects.
This Special Issue aims to highlight recent advances in the molecular and cellular mechanisms underlying therapy- and stress-induced responses in cancer and normal tissues. We welcome studies exploring DNA damage response and repair pathways, replication stress, transcriptional regulation, redox signaling, cell death mechanisms, and adaptive survival pathways. Emphasis is placed on how these processes influence cancer progression, therapeutic sensitivity, and resistance.
We seek studies that bridge basic and translational research, including the use of advanced model systems, identification of predictive biomarkers, and analysis of tumor–microenvironment interactions and normal tissue toxicity.
By integrating insights from diverse therapeutic modalities and stress conditions, this Special Issue seeks to provide a comprehensive understanding of the molecular basis of therapy response, ultimately contributing to the development of more effective and personalized cancer treatments.
Dr. Ratan Sadhukhan
Guest Editor
Manuscript Submission Information
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Keywords
- cancer therapeutics
- radiotherapy
- DNA damage
- cellular stress response
- genome integrity
- DNA repair
- tumor cells
- normal tissue toxicity
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