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Most Cited

  • Review
  • Open Access
69 Citations
26,659 Views
25 Pages

Ultra-Processed Food, Reward System and Childhood Obesity

  • Valeria Calcaterra,
  • Hellas Cena,
  • Virginia Rossi,
  • Sara Santero,
  • Alice Bianchi and
  • Gianvincenzo Zuccotti

29 April 2023

Obesity and overweight are a major public health problem globally. Diet quality is critical for proper child development, and an unhealthy diet is a preventable risk factor for noncommunicable diseases (NCDs), such as obesity. Consumption of sugar-sw...

  • Review
  • Open Access
67 Citations
14,774 Views
14 Pages

D-Lactate: Implications for Gastrointestinal Diseases

  • Barblin Remund,
  • Bahtiyar Yilmaz and
  • Christiane Sokollik

D-lactate is produced in very low amounts in human tissues. However, certain bacteria in the human intestine produce D-lactate. In some gastrointestinal diseases, increased bacterial D-lactate production and uptake from the gut into the bloodstream t...

  • Review
  • Open Access
64 Citations
16,870 Views
17 Pages

Maternal Infection and Preterm Birth: From Molecular Basis to Clinical Implications

  • George Daskalakis,
  • Alexandros Psarris,
  • Antonios Koutras,
  • Zacharias Fasoulakis,
  • Ioannis Prokopakis,
  • Antonia Varthaliti,
  • Christina Karasmani,
  • Thomas Ntounis,
  • Ekaterini Domali and
  • Angeliki Papapanagiotou
  • + 3 authors

As the leading cause of neonatal morbidity and mortality, preterm birth is recognized as a major public health concern around the world. The purpose of this review is to analyze the connection between infections and premature birth. Spontaneous prete...

  • Review
  • Open Access
58 Citations
10,628 Views
23 Pages

15 March 2023

Elexacaftor/Tezacaftor/Ivacaftor (ELX/TEZ/IVA) is a new CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) modulator treatment, used over the last few years, which has shown an improvement in different clinical outcomes in patients with cysti...

  • Review
  • Open Access
51 Citations
37,432 Views
17 Pages

8 October 2023

Nowadays, children and adolescents are exposed to digital media (DM) from an early age. Therefore, specific guidelines have been published by the World Health Organization, whose aim is to limit daily screen time (ST) viewing. However, during the COV...

  • Review
  • Open Access
49 Citations
12,991 Views
15 Pages

Prematurity and Low Birth Weight and Their Impact on Childhood Growth Patterns and the Risk of Long-Term Cardiovascular Sequelae

  • Iwona Jańczewska,
  • Jolanta Wierzba,
  • Alicja Jańczewska,
  • Małgorzata Szczurek-Gierczak and
  • Iwona Domżalska-Popadiuk

25 September 2023

Preterm birth (before 37 completed weeks of gestation) is a global health problem, remaining the main reason for neonatal mortality and morbidity. Improvements in perinatal and neonatal care in recent decades have been associated with a higher surviv...

  • Opinion
  • Open Access
49 Citations
6,056 Views
5 Pages

21 April 2023

Background: In recent months, there has been growing interest in the potential of artificial intelligence (AI) to revolutionize various aspects of medicine, including research, education, and clinical practice. ChatGPT represents a leading AI languag...

  • Review
  • Open Access
48 Citations
24,543 Views
16 Pages

The Transition from Childhood to Adolescence: Between Health and Vulnerability

  • Francesca Mastorci,
  • Maria Francesca Lodovica Lazzeri,
  • Cristina Vassalle and
  • Alessandro Pingitore

14 August 2024

Transitioning from childhood into adolescence is an extraordinary time of life, associated with major physical, emotional, cognitive, and social changes and characterized by dynamic development in which interaction with the environment modulates the...

  • Review
  • Open Access
47 Citations
26,928 Views
15 Pages

Congenital Syphilis—An Illustrative Review

  • Deepika Sankaran,
  • Elizabeth Partridge and
  • Satyan Lakshminrusimha

29 July 2023

Congenital syphilis is caused by the spirochete, Treponema pallidum, which can be transmitted from an infected mother to her fetus during pregnancy or by contact with a maternal lesion at the time of delivery. The incidence of congenital syphilis is...

  • Review
  • Open Access
44 Citations
49,322 Views
27 Pages

Digital Device Usage and Childhood Cognitive Development: Exploring Effects on Cognitive Abilities

  • Vicente Javier Clemente-Suárez,
  • Ana Isabel Beltrán-Velasco,
  • Silvia Herrero-Roldán,
  • Stephanie Rodriguez-Besteiro,
  • Ismael Martínez-Guardado,
  • Alexandra Martín-Rodríguez and
  • Jose Francisco Tornero-Aguilera

27 October 2024

The increasing ubiquity of digital devices in childhood had outpaced the understanding of their effects on cognitive development, creating a significant research gap regarding their long-term impact. Objective: The present narrative overview explored...

  • Review
  • Open Access
43 Citations
13,228 Views
24 Pages

Ovarian Masses in Children and Adolescents: A Review of the Literature with Emphasis on the Diagnostic Approach

  • Effrosyni Birbas,
  • Theofilos Kanavos,
  • Fani Gkrozou,
  • Chara Skentou,
  • Angelos Daniilidis and
  • Anastasia Vatopoulou

27 June 2023

Most abdominal masses in the pediatric population derive from the ovaries. Ovarian masses can occur in all ages, although their incidence, clinical presentation and histological distribution vary among different age groups. Children and adolescents m...

  • Review
  • Open Access
42 Citations
19,296 Views
18 Pages

Food Advertisement and Dietary Choices in Adolescents: An Overview of Recent Studies

  • Anastasia Tsochantaridou,
  • Theodoros N. Sergentanis,
  • Maria G. Grammatikopoulou,
  • Kyriakoula Merakou,
  • Tonia Vassilakou and
  • Eleni Kornarou

24 February 2023

Adolescents are exposed to food marketing through many routes, including television, movies, videos, print media, online games, and social media. The interplay between exposure to unhealthy food advertisements and food choices by adolescents is a fie...

  • Article
  • Open Access
40 Citations
12,939 Views
14 Pages

18 February 2023

In the context of exercise psychology, the mediating relationship between peer support, self-efficacy and self-regulation, and adolescents’ exercise adherence was to be explored. Methods: A questionnaire was distributed among 2200 teenagers fro...

  • Review
  • Open Access
39 Citations
20,171 Views
27 Pages

Respiratory Management of the Preterm Infant: Supporting Evidence-Based Practice at the Bedside

  • Milena Tana,
  • Chiara Tirone,
  • Claudia Aurilia,
  • Alessandra Lio,
  • Angela Paladini,
  • Simona Fattore,
  • Alice Esposito,
  • Davide De Tomaso and
  • Giovanni Vento

10 March 2023

Extremely preterm infants frequently require some form of respiratory assistance to facilitate the cardiopulmonary transition that occurs in the first hours of life. Current resuscitation guidelines identify as a primary determinant of overall newbor...

  • Review
  • Open Access
38 Citations
13,351 Views
22 Pages

Neuropsychological Outcomes of Children Treated for Brain Tumors

  • Alessia Pancaldi,
  • Marisa Pugliese,
  • Camilla Migliozzi,
  • Johanna Blom,
  • Monica Cellini and
  • Lorenzo Iughetti

27 February 2023

Central nervous system (CNS) neoplasms are the most common solid tumors diagnosed in children. CNS tumors represent the leading cause of cancer death and cancer-related morbidity for children less than 20 years of age, although there has been a moder...

  • Systematic Review
  • Open Access
36 Citations
45,701 Views
17 Pages

5 June 2023

Schools offer a unique environment to influence children’s physical activity (PA) levels positively. This study aims to systematically review the evidence surrounding how PA affects academic performance by analysing how the frequency, intensity...

  • Article
  • Open Access
35 Citations
10,678 Views
17 Pages

Neurodevelopmental, Mental Health, and Parenting Issues in Preterm Infants

  • Richard J. Shaw,
  • Soudabeh Givrad,
  • Celeste Poe,
  • Elizabeth C. Loi,
  • Margaret K. Hoge and
  • Melissa Scala

18 September 2023

The World Health Organization in its recommendations for the care of preterm infants has drawn attention to the need to address issues related to family involvement and support, including education, counseling, discharge preparation, and peer support...

  • Review
  • Open Access
34 Citations
13,444 Views
16 Pages

Micronutrient Deficiency in Children and Adolescents with Obesity—A Narrative Review

  • Valeria Calcaterra,
  • Elvira Verduci,
  • Chiara Milanta,
  • Marta Agostinelli,
  • Carolina Federica Todisco,
  • Federica Bona,
  • Jonabel Dolor,
  • Alice La Mendola,
  • Martina Tosi and
  • Gianvincenzo Zuccotti

7 April 2023

Childhood obesity represents a serious public health burden. Despite excessive dietary consumption, children with obesity present high rates of micronutrient deficiencies, such as deficiencies in minerals and specific vitamins; micronutrient deficien...

  • Review
  • Open Access
34 Citations
9,746 Views
15 Pages

Neonatal Care Unit Interventions on Preterm Development

  • Alexia Séassau,
  • Pascale Munos,
  • Catherine Gire,
  • Barthélémy Tosello and
  • Isabelle Carchon

Prematurity is becoming a real public health issue as more and more children are being born prematurely, alongside a higher prevalence of neurodevelopmental disorders. Early intervention programs in Neonatal Intensive Care Units (NICUs) correspond to...

  • Review
  • Open Access
33 Citations
12,200 Views
11 Pages

Pain Evaluation and Treatment in Children: A Practical Approach

  • Lorenzo Sansone,
  • Cristina Gentile,
  • Eleonora Agata Grasso,
  • Armando Di Ludovico,
  • Saverio La Bella,
  • Francesco Chiarelli and
  • Luciana Breda

13 July 2023

Pain is the most common complaint reported by children who access the emergency departments, but despite its frequency and the availability of many international guidelines, it often remains underreported and undertreated. Recently, the American Acad...

  • Review
  • Open Access
33 Citations
10,543 Views
16 Pages

Pediatric Sleep Respiratory Disorders: A Narrative Review of Epidemiology and Risk Factors

  • Marta Piotto,
  • Antonella Gambadauro,
  • Alessia Rocchi,
  • Mara Lelii,
  • Barbara Madini,
  • Lucia Cerrato,
  • Federica Chironi,
  • Youssra Belhaj and
  • Maria Francesca Patria

Sleep is a fundamental biological necessity, the lack of which has severe repercussions on the mental and physical well-being in individuals of all ages. The phrase “sleep-disordered breathing (SDB)” indicates a wide array of conditions c...

  • Brief Report
  • Open Access
31 Citations
3,178 Views
6 Pages

Can ChatGPT Guide Parents on Tympanostomy Tube Insertion?

  • Alexander Moise,
  • Adam Centomo-Bozzo,
  • Ostap Orishchak,
  • Mohammed K Alnoury and
  • Sam J. Daniel

30 September 2023

Background: The emergence of ChatGPT, a state-of-the-art language model developed by OpenAI, has introduced a novel avenue for patients to seek medically related information. This technology holds significant promise in terms of accessibility and con...

  • Commentary
  • Open Access
31 Citations
11,981 Views
11 Pages

Sedentary Behavior and Lack of Physical Activity among Children in Indonesia

  • Laily Hanifah,
  • Nanang Nasrulloh and
  • Dian Luthfiana Sufyan

26 July 2023

Sedentary behavior and lack of physical activity among children in Indonesia is an important issue that needs to be addressed. It is estimated that 57% of children in Indonesia have insufficient physical activity. Studies have shown that children who...

  • Review
  • Open Access
31 Citations
18,448 Views
19 Pages

Risk Factors of Malnutrition among In-School Children and Adolescents in Developing Countries: A Scoping Review

  • Mustapha Amoadu,
  • Susanna Aba Abraham,
  • Abdul Karim Adams,
  • William Akoto-Buabeng,
  • Paul Obeng and
  • John Elvis Hagan

15 April 2024

Malnutrition among in-school children is a complex issue influenced by socio-economic, environmental, and health-related factors, posing significant challenges to their well-being and educational trajectories in developing countries. This review synt...

  • Review
  • Open Access
30 Citations
8,247 Views
17 Pages

Comparison of Different Types of Palatal Expanders: Scoping Review

  • Angelo Michele Inchingolo,
  • Assunta Patano,
  • Matteo De Santis,
  • Gaetano Del Vecchio,
  • Laura Ferrante,
  • Roberta Morolla,
  • Carmela Pezzolla,
  • Roberta Sardano,
  • Leonardo Dongiovanni and
  • Gianna Dipalma
  • + 4 authors

21 July 2023

Maxillary bone contraction is caused by genetics or ambiental factors and is often accompanied by dental crowding, with the possibility of canine inclusion, crossbite, class II and III malocclusion, temporomandibular joint disorder, and obstructive s...

  • Review
  • Open Access
30 Citations
12,950 Views
9 Pages

8 March 2024

Objective: Orofacial clefts are one of the most common abnormalities that occur in the orofacial area. Due to their high prevalence, special attention provided to risk factors and their possible involvement in the occurrence of orofacial clefts is of...

  • Article
  • Open Access
30 Citations
28,623 Views
20 Pages

Exploring Parenting Styles Patterns and Children’s Socio-Emotional Skills

  • Aikaterini Vasiou,
  • Wassilis Kassis,
  • Anastasia Krasanaki,
  • Dilan Aksoy,
  • Céline Anne Favre and
  • Spyridon Tantaros

29 June 2023

In this study, we adopted parenting styles as a multidimensional and latent construct that includes different aspects of parenting, rather than solely focusing on a single parenting style. In a Web-based survey with 1203 Greek parents, we identified...

  • Review
  • Open Access
30 Citations
11,937 Views
11 Pages

Psychological and Clinical Challenges in the Management of Type 1 Diabetes during Adolescence: A Narrative Review

  • Bruno Bombaci,
  • Arianna Torre,
  • Alessandro Longo,
  • Maria Pecoraro,
  • Mattia Papa,
  • Lacrima Sorrenti,
  • Mariarosaria La Rocca,
  • Fortunato Lombardo and
  • Giuseppina Salzano

4 September 2024

Adolescence, a critical period of physical and psychological development, presents unique challenges in type 1 diabetes (T1D) management due to endocrinological changes, reduced therapeutic adherence, and elevated susceptibility to psychological issu...

  • Review
  • Open Access
30 Citations
12,824 Views
16 Pages

20 November 2024

Background/Objectives: Affective touch is crucial in infant development, particularly in regulating emotional, cognitive, and physiological processes. Preterm infants are often deprived of essential tactile stimulation owing to their early exposure t...

  • Article
  • Open Access
29 Citations
6,671 Views
18 Pages

30 September 2023

Preventing stunting is particularly important for healthy development across the life course. In Papua New Guinea (PNG), the prevalence of stunting in children under five years old has consistently not improved. Therefore, the primary objective of th...

  • Article
  • Open Access
29 Citations
12,911 Views
17 Pages

27 October 2023

The coronavirus pandemic has become an unprecedented world crisis in which we have struggled against the most potent threat of the twenty-first century. This pandemic has had a profound impact on individuals and families. Therefore, the study aimed t...

  • Review
  • Open Access
29 Citations
8,831 Views
26 Pages

28 June 2024

The formation of the human gut microbiome initiates in utero, and its maturation is established during the first 2–3 years of life. Numerous factors alter the composition of the gut microbiome and its functions, including mode of delivery, earl...

  • Review
  • Open Access
29 Citations
14,045 Views
19 Pages

Short- and Long-Term Outcomes of Preeclampsia in Offspring: Review of the Literature

  • Sevasti Koulouraki,
  • Vasileios Paschos,
  • Panagiota Pervanidou,
  • Panagiotis Christopoulos,
  • Angeliki Gerede and
  • Makarios Eleftheriades

Preeclampsia is a multisystemic clinical syndrome characterized by the appearance of new-onset hypertension and proteinuria or hypertension and end organ dysfunction even without proteinuria after 20 weeks of pregnancy or postpartum. Residing at the...

  • Review
  • Open Access
28 Citations
9,104 Views
9 Pages

A Clinical Approach of Allergic Rhinitis in Children

  • Ioannis Goniotakis,
  • Evanthia Perikleous,
  • Sotirios Fouzas,
  • Paschalis Steiropoulos and
  • Emmanouil Paraskakis

19 September 2023

Allergic rhinitis is an important disease with a global footprint and a growing prevalence, affecting children and adults. Although it is commonly under-diagnosed and under-treated, it causes important social and economic effects (diminished quality...

  • Systematic Review
  • Open Access
28 Citations
10,399 Views
17 Pages

Motivation toward Physical Activity and Healthy Habits of Adolescents: A Systematic Review

  • Javier Cachón-Zagalaz,
  • Hanrriette Carrasco-Venturelli,
  • María Sánchez-Zafra and
  • María Luisa Zagalaz-Sánchez

30 March 2023

Adolescence is a transformative period in which rapid physical, cognitive and psychosocial growth takes place. Laying the foundation for healthy behaviors is paramount during these formative years. The aim of this review is to determine which countri...

  • Review
  • Open Access
28 Citations
15,192 Views
32 Pages

Mindfulness-based interventions (MBIs) are growing in popularity, with research concerning their efficacy with youth populations. Following a preliminary analysis of the existing literature, and given the positive effects of such programs, we felt it...

  • Article
  • Open Access
27 Citations
16,077 Views
16 Pages

19 August 2023

This study analyzes the previous literature on the online safety of children and youth under “the 4Cs risk framework” concerning contact, content, conduct, and contract risks. It then conducts a comparative study of Australia, Canada, and...

  • Review
  • Open Access
27 Citations
25,557 Views
22 Pages

Diagnosis and Management of Neonatal Hypoglycemia: A Comprehensive Review of Guidelines

  • Sonia Giouleka,
  • Maria Gkiouleka,
  • Ioannis Tsakiridis,
  • Anastasia Daniilidou,
  • Apostolos Mamopoulos,
  • Apostolos Athanasiadis and
  • Themistoklis Dagklis

14 July 2023

Hypoglycemia represents one of the most frequent metabolic disturbances of the neonate, associated with increased morbidity and mortality, especially if left untreated or diagnosed after the establishment of brain damage. The aim of this study was to...

  • Article
  • Open Access
27 Citations
7,436 Views
13 Pages

Impacts of Integrating Family-Centered Care and Developmental Care Principles on Neonatal Neurodevelopmental Outcomes among High-Risk Neonates

  • Nourah Alsadaan,
  • Osama Mohamed Elsayed Ramadan,
  • Mohammed Alqahtani,
  • Mostafa Shaban,
  • Nadia Bassuoni Elsharkawy,
  • Enas Mahrous Abdelaziz and
  • Sayed Ibrahim Ali

28 October 2023

Background: Integrating family-centered care (FCC) and developmental care (DC) principles in neonatal care settings may improve neurodevelopmental outcomes for high-risk neonates. However, the combined impact of FCC and DC has been underexplored. Thi...

  • Article
  • Open Access
27 Citations
6,008 Views
20 Pages

Exploring the Potential of Three-Dimensional Imaging, Printing, and Modeling in Pediatric Surgical Oncology: A New Era of Precision Surgery

  • Arnau Valls-Esteve,
  • Núria Adell-Gómez,
  • Albert Pasten,
  • Ignasi Barber,
  • Josep Munuera and
  • Lucas Krauel

Pediatric surgical oncology is a technically challenging field that relies on CT and MRI as the primary imaging tools for surgical planning. However, recent advances in 3D reconstructions, including Cinematic Rendering, Volume Rendering, 3D modeling,...

  • Article
  • Open Access
26 Citations
2,715 Views
14 Pages

15 January 2024

(1) Background: Family factors play an important role in the management of diabetes, establishing a relationship between conflicts and non-adherence to therapy. High values of HbA1c are involved in specific complications of the disease (retinopathy,...

  • Review
  • Open Access
26 Citations
6,474 Views
13 Pages

30 October 2023

Background: It is common today to encounter anxiety in patients facing dental treatment. Virtual reality (VR) is presented as a high-performing and innovative procedure because it can distract patients undergoing dental procedures or prepare them for...

  • Article
  • Open Access
26 Citations
7,163 Views
12 Pages

Associations between Force-Time Related Single-Leg Counter Movement Jump Variables, Agility, and Linear Sprint in Competitive Youth Male Basketball Players

  • Ömer Pamuk,
  • Yücel Makaracı,
  • Levent Ceylan,
  • Hamza Küçük,
  • Tuba Kızılet,
  • Tülay Ceylan and
  • Erdi Kaya

22 February 2023

Background: Previous research has reported a strong relationship between vertical jumping, sprinting, and agility, as a reflection of lower-limb power. Unilateral analysis of this relationship has not yet been explored. This study primarily investiga...

  • Systematic Review
  • Open Access
26 Citations
17,995 Views
14 Pages

12 March 2024

Purpose: This review systematically summarizes the studies of the relationship between primary-to-secondary school students’ motor skills and academic achievement, and analyzes the relationship between gross and fine motor skills and performanc...

  • Article
  • Open Access
26 Citations
2,622 Views
11 Pages

20 June 2024

Background: Large language models (LLMs) are becoming increasingly important as they are being used more frequently for providing medical information. Our aim is to evaluate the effectiveness of electronic artificial intelligence (AI) large language...

  • Article
  • Open Access
26 Citations
6,423 Views
11 Pages

12 April 2023

Background: Overweight and obese adolescents are often associated with lower Physical Activity (PA) levels and low Cardiorespiratory Fitness (CRF). Recently, the concept of Physical Literacy (PL), has been suggested to be associated with higher level...

  • Article
  • Open Access
25 Citations
11,377 Views
16 Pages

Relations between Positive Parenting Behavior during Play and Child Language Development at Early Ages

  • Magda Rivero,
  • Rosa Vilaseca,
  • María-José Cantero,
  • Clara Valls-Vidal and
  • David Leiva

3 March 2023

Parental behavior in interactions with children has been related to child language development. Our study contributes to the literature about relations between the characteristics of parent–child interactions during play and a child’s lan...

  • Article
  • Open Access
24 Citations
10,223 Views
16 Pages

Teaching Games for Understanding in Game Performance and Psychosocial Variables: Systematic Review and Meta-Analysis of Randomized Control Trial

  • Marcos Ortiz,
  • Lourdes Meroño,
  • María T. Morales-Belando,
  • Raquel Vaquero-Cristóbal and
  • Noelia González-Gálvez

17 March 2023

Different authors have reported on the influence of the Teaching Games for Understanding (TGfU) intervention on game performance and psychosocial variables. This review aimed: (a) to explore the TGfU experimental studies; (b) to compare the effects o...

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Children - ISSN 2227-9067