Epigenetic Regulation of Cellular Plasticity in Brain Tumors
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell and Gene Therapy".
Deadline for manuscript submissions: 31 October 2026 | Viewed by 111
Editors
Interests: glioblastoma (GBM); epigenetic mediators of phenotypic plasticity; interplay of DNA repair and metabolism in therapeutic resistance; vascular-immune crosstalk in GBM immunosuppression and resistance; novel molecular therapeutics for GBM
Special Issue Information
Dear Colleagues,
Epigenetic regulators play a major role in driving plasticity in brain tumors, enabling tumor cells to dynamically shift between cellular states. This phenotypic plasticity, governed by reversible epigenetic marks, presents both a challenge—by promoting resistance—and an opportunity, as targeting epigenetic modifiers may help reprogram tumor cells into less aggressive states. However, several knowledge gaps remain that limit both mechanistic insight and therapeutic translation. This Special Issue aims to focus on understanding microenvironment–epigenetic interactions in mediating tumor plasticity, spatial and temporal epigenetic heterogeneity, mechanisms of therapy-induced epigenetic reprogramming, modeling plasticity dynamics in vivo in animal models and approaches to selectively target epigenetic modifiers to overcome therapeutic resistance. We welcome original manuscripts, reports on new methodologies and technologies, and reviews on this topic.
Dr. Sree Deepthi Muthukrishnan
Dr. Erina Vlashi
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- brain tumors
- epigenetic modifiers
- tumor plasticity
- epigenetic heterogeneity
- microenvironment-epigenetic interactions
- therapy resistance
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
