Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Dual Role of EpCAM in Tumorigenesis and Therapy
edited by Narendra V. Sankpal
submission deadline 31 Aug 2026 | Viewed by 163 | Submission Open
Keywords: EpCAM; tumor antigen; tumorigenesis; tumor aggressiveness; targeted therapy
Modulation of Senescence and Differentiation in Human Mesenchymal Stem Cells submission deadline 1 Sep 2026 | 3 articles | Viewed by 6526 | Submission Open
Keywords: tissue-specific mesenchymal stem cells; cell senescence; cell differentiation; natural and synthetic molecules; tissue engineering; regenerative medicine
(This special issue belongs to the Section Stem Cells)
Building the Neurons: Cytoskeleton Dynamics and Organelle Interaction in Health and Disease
edited by Xing Liang and
submission deadline 1 Sep 2026 | 1 articles | Viewed by 2548 | Submission Open
Keywords: development and health of neurons; cytoskeleton dynamic; organelle interactions
(This special issue belongs to the Section Cellular Neuroscience)
Cellular Metabolism and Hormonal Signaling in Colorectal Cancer: Biomarkers and Therapeutic Opportunities
edited by Jibran Sualeh Muhammad
submission deadline 7 Sep 2026 | 4 articles | Viewed by 6281 | Submission Open
Keywords: colorectal cancer; metabolic reprogramming; gut microbiome–metabolite interactions; therapy resistance; hormonal signaling
Targeting Immune Dysfunction in Aging and Age-Related Diseases
edited by and
submission deadline 10 Sep 2026 | 4 articles | Viewed by 10016 | Submission Open
Keywords: immunosenescence; inflammaging; immune dysfunction; aging; age-related diseases (ARDs); immune–metabolic interactions; immunomodulators; immunoceuticals; senotherapeutics; lifestyle interventions
Targeting Tumor Suppressor Genes for Cancer Therapy
edited by Jogendra Pawar, Smita Kumari and Naseem Akhter
submission deadline 10 Sep 2026 | 1 articles | Viewed by 1317 | Submission Open
Keywords: tumor suppressor genes; cancer therapy; gene editing; CRISPR-Cas9; DNA damage repair; oncogenic signaling; immunotherapy; tumor microenvironment; artificial intelligence; personalized medicine
Examining the Cellular Biology of Adenovirus
edited by Susan J. Morris, Adam C. T. Gillman and Erwan Sallard
submission deadline 10 Sep 2026 | 1 articles | Viewed by 1116 | Submission Open
Keywords: adenovirus; replication; maturation; transduction; tropism; intracellular trafficking; targeting; virus–host interactions; transcriptome
Myokines in Health and Diseases submission deadline 10 Sep 2026 | 1 articles | Viewed by 1085 | Submission Open
Keywords: myokines; skeletal muscle; metabolic regulation; chronic diseases; muscle–organ crosstalk
Next-Generation CAR-T Cell Therapy: From Bench to Bedside
edited by and
submission deadline 10 Sep 2026 | Viewed by 527 | Submission Open
Keywords: chimeric antigen receptor T cells; cytokine release syndrome; immune effector cell-associated neurotoxicity syndrome (ICANS); immunotoxicity; T cell exhaustion; antigen discovery; CAR engineering; mouse models
(This special issue belongs to the Section Cellular Immunology)
Extracellular Vesicles, Extracellular Particles, and Membrane Biology
edited by Veronika Kralj-Iglič
submission deadline 10 Sep 2026 | Viewed by 301 | Submission Open
Keywords: extracellular vesicles; membrane trafficking; cellular membranes; biological membranes; ev biogenesis; membrane-associated signaling; intercellular communication; exosomes
(This special issue belongs to the Section Intracellular and Plasma Membranes)
Neuroinflammation in Brain Health and Diseases—Second Edition
edited by Debashis Dutta and Nemil Bhatt
submission deadline 10 Sep 2026 | Viewed by 285 | Submission Open
Keywords: neuroinflammation; gliosis; inflammasome; neurodegeneration; neurotherapeutics
(This special issue belongs to the Section Cellular Neuroscience)
Research on Extracellular Vesicles in Health and Disease submission deadline 15 Sep 2026 | 4 articles | Viewed by 5018 | Submission Open
Keywords: extracellular vesicles; molecular mechanism; biomarker discovery; therapeutics; translational medicine; proteins; DNA and RNA
Molecular Mechanisms of Treatment Resistance in Prostate Cancer
edited by
submission deadline 15 Sep 2026 | 1 articles | Viewed by 2447 | Submission Open
Keywords: metastatic castration-resistant prostate cancer (mCRPC); molecular mechanisms; novel treatment strategies; systemic precision treatments; epigenetics; cellular plasticity; tumor microenvironment signaling; therapeutic resistance
Molecular Mechanisms and Therapeutic Strategies of Macular Degeneration
edited by
submission deadline 15 Sep 2026 | 1 articles | Viewed by 1541 | Submission Open
Keywords: macular degeneration; RPE; sirtuin; HDAC; oxidative stress; antioxidant; drusen; lipofuscin
Cellular and Molecular Mechanisms of Placental Development and Function
edited by and
submission deadline 15 Sep 2026 | 1 articles | Viewed by 845 | Submission Open
Keywords: placenta; trophoblast; maternal-fetal interface; pregnancy complications; obstetric; inflammation; immune; fetal programming; developmental origins of health and disease (DOHaD); environmental exposure
(This special issue belongs to the Section Reproductive Cells and Development)
Targeting Breast Cancer: Mechanisms of Resistance and Innovative Therapeutic Strategies
edited by Stefania Belli, and
submission deadline 15 Sep 2026 | 1 articles | Viewed by 844 | Submission Open
Keywords: breast cancer; targeted therapies; novel therapeutic targets; mechanisms of drug resistance; innovative therapeutic strategies; targeting tumor microenvironment; immunotherapy in breast cancer
(This special issue belongs to the Section Cell Microenvironment)
Cellular Mechanisms and Therapies of Hematologic Malignancies
edited by Sayantani Sinha and Stanley Chun-Wei Lee
submission deadline 15 Sep 2026 | Viewed by 332 | Submission Open
Keywords: AML, ALL and CLL; targeted therapy; combination therapy; small molecule inhibitors; immunotherapy; RNA in hematopoiesis; overcoming resistance
(This special issue belongs to the Section Cellular Pathology)
Lipid Homeostasis: Mechanisms, Regulation, and Implications for Health and Disease
edited by and Museer Ahmad Lone
submission deadline 20 Sep 2026 | 5 articles | Viewed by 12713 | Submission Open
Keywords: lipid metabolism; lipid synthesis and degradation; triglyceride storage; fatty acid oxidation; cholesterol homeostasis; adipogenesis; lipid droplets; lipid signaling pathways; lipid transport proteins; phospholipid balance; sphingolipid metabolism; sterol regulatory element-binding proteins (SREBPs); AMP-activated protein kinase (AMPK); peroxisome proliferator-activated receptors (PPARs); insulin signaling and lipid storage; endoplasmic reticulum stress and lipids; lipoprotein metabolism; non-alcoholic fatty liver disease (NAFLD); lipidomics; autophagy and lipid recycling; lysosomal lipid degradation; lipid-binding proteins; oxidized lipids; lipid imbalance and disease; energy homeostasis and lipid storage; lipid transport vesicles; membrane lipid composition; lipid peroxidation; lipid-related genetic disorders, nutrient sensing and lipid regulation
(This special issue belongs to the Section Cellular Biophysics)
Ovarian Cancer and Endometriosis
edited by and
submission deadline 20 Sep 2026 | 2 articles | Viewed by 6910 | Submission Open
Keywords: ovarian cancer; endometriosis; microenvironment; cell-cell interaction; drug resistance; natural product
(This special issue belongs to the Section Cellular Pathology)
Lipid Homeostasis in Health and Disease
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 2117 | Submission Open
Keywords: lipids; metabolism; homeostasis; disease mechanisms; biomarkers; therapeutic targets; nutrition; cellular signaling; systems biology
Single-Molecule Tracking for Live Cells
edited by
submission deadline 20 Sep 2026 | 1 articles | Viewed by 1691 | Submission Open
Keywords: single-molecule level; many-molecule level; biological cell; diluted liquids; single-molecule localization microscopy; nanoscopy; modeling; diffusion; theory
Cellular and Molecular Mechanisms in Sepsis: Pathogenesis, Immune Response, and Therapeutic Strategies
edited by and
submission deadline 20 Sep 2026 | 1 articles | Viewed by 1638 | Submission Open
Keywords: sepsis; cytokine signaling; immune cell dynamics; epigenetic regulation; metabolic reprogramming; non-coding RNAs; redox signaling; receptor polymorphisms; systems immunology; single-cell omics
(This special issue belongs to the Section Cellular Pathology)
Role of Transposons in Regulating the Neural Genome and the Mechanisms of Neuropsychiatric Diseases
edited by Fabio M. Macciardi
submission deadline 20 Sep 2026 | 1 articles | Viewed by 1590 | Submission Open
Keywords: transposable elements; genome evolution; central nervous system development; neural genome; neural gene regulation; neuropsychiatric disorders
(This special issue belongs to the Section Cellular Neuroscience)
Cancer-Associated Fibroblasts: Challenges and Directions—Second Edition submission deadline 20 Sep 2026 | 1 articles | Viewed by 835 | Submission Open
Keywords: cancer-associated fibroblast (CAFs); tumor microenvironment (TME); fibroblast activation protein alpha (FAPα); immunotherapy; cytokines; angiogenesis; metastasis; FAP inhibitors; radioligands; imaging agents
(This special issue belongs to the Section Cell Microenvironment)
Mechanisms of miRNA Metabolism and Extracellular Transport submission deadline 20 Sep 2026 | Viewed by 429 | Submission Open
Keywords: miRNA metabolism; miRNA transport; miRNA exchange; miRNA storage; mRNA biogenesis; extracellular vesicles and miRNA; non-EV miRNA export; miRNA binding proteins; miRNA sponge and inhibitors; miRNA biomarkers
New Insights in Translational Pain Research
edited by
submission deadline 20 Sep 2026 | Viewed by 271 | Submission Open
Keywords: translational pain research; chronic pain; neuroinflammation; pain mechanisms; therapeutic targets
The Role of Glial Cells in Neurodegenerative Disorders
edited by Osama Al Dalahmah and Sebastian Quintremil
submission deadline 20 Sep 2026 | Viewed by 219 | Submission Open
Keywords: astrocytes; oligodendrocytes; microglia; neuropathology
(This special issue belongs to the Section Cellular Neuroscience)
Advances in DNA Damage Responses in Viral Infection
edited by Roger J. Grand
submission deadline 20 Sep 2026 | Viewed by 197 | Submission Open
Keywords: DNA damage response; DNA viruses; RNA viruses; viral replication; DNA repair pathways
(This special issue belongs to the Section Cellular Pathology)
The Silent Regulators: Non-Coding RNAs in Cell Function and Disease submission deadline 25 Sep 2026 | 5 articles | Viewed by 8323 | Submission Open
Keywords: non-coding RNAs; microRNAs; long non-coding RNAs (lncRNAs); regulatory RNAs; RNA interference; epigenetic regulation; RNA editing; cellular signaling; disease biomarkers; RNA therapeutics
(This special issue belongs to the Section Cell and Gene Therapy)
Breaking the Balance: Cellular Stress, Proteostasis, Aggregates and Neurodegeneration
edited by
submission deadline 25 Sep 2026 | 2 articles | Viewed by 1693 | Submission Open
Keywords: proteostasis; cellular stress; protein aggregation; neurodegeneration; autophagy; unfolded protein response; oxidative stress; aging; molecular chaperones; protein quality control
Atherosclerosis and Thrombosis: Molecular and Pathological Research Advance submission deadline 25 Sep 2026 | 1 articles | Viewed by 1175 | Submission Open
Keywords: atherosclerosis; thrombosis; molecular mechanisms; translational research; precision medicine
(This special issue belongs to the Section Cellular Pathology)
Stem Cells and Metabolism in Acute Myeloid Leukemia: Mechanisms, Models, and Therapeutic Opportunities
edited by , Aditi Chatterjee and Maria Baer
submission deadline 25 Sep 2026 | Viewed by 701 | Submission Open
Keywords: AML; leukemic stem cells; hypoxia; metabolism; fatty-acid oxidation; one-carbon metabolism; proteostasis; bone-marrow niche; multi-omics; metabolic inhibitors
Dysregulated Synaptic Plasticity in Chronic Pain: Molecular Mechanisms, Circuit Dysfunction, and Translational Approaches
edited by
submission deadline 25 Sep 2026 | Viewed by 378 | Submission Open
Keywords: chronic pain; synaptic plasticity; circuit dysfunction
(This special issue belongs to the Section Cellular Pathology)
New Molecular Perspectives in Pelvic Floor and Genitourinary Disorders
edited by Mahadevan Rajasekaran
submission deadline 25 Sep 2026 | Viewed by 233 | Submission Open
Keywords: pelvic floor disorders; genitourinary diseases; molecular mechanisms; biomarkers; biomaterials; regenerative medicine; precision medicine
(This special issue belongs to the Section Cellular Pathology)
Natural Products and Their Derivatives Against Human Disease—2nd Edition
edited by
submission deadline 25 Sep 2026 | Viewed by 211 | Submission Open
Keywords: microbiome-mediated modulation; biomarker; therapeutic strategies; drug delivery
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Targeting Metabolic Vulnerabilities to Selectively Eliminate Cancer Cells
edited by Nina Semenova and
submission deadline 29 Sep 2026 | Viewed by 405 | Submission Open
Keywords: cancer cell metabolism; cancer cell signaling pathways; cancer epigenetic regulation; nutrient deprivation; tumor microenvironment; chemotherapy; chemoresistance; radiotherapy; cell death
Role of Extracellular Matrix in Cancer and Disease submission deadline 30 Sep 2026 | 7 articles | Viewed by 25128 | Submission Open
Keywords: extracellular matrix; cancer; disease; ECM targeting; ECM turn-over and remodeling
(This special issue belongs to the Section Cell Microenvironment)
Mechanisms of Immune Responses and Therapy submission deadline 30 Sep 2026 | 3 articles | Viewed by 12781 | Submission Open
Keywords: immunity; immune signaling; immune regulation; cellular immunology; molecular immunology; autoimmunity; immune checkpoint; immunotherapy
(This special issue belongs to the Section Cellular Immunology)
Antioxidants in Redox Homeostasis of Plant Development submission deadline 30 Sep 2026 | 3 articles | Viewed by 10762 | Submission Open
Keywords: reactive oxygen species; radical scavenging; oxidative stress; plant growth and development; primary and secondary metabolites
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
The Potential of Induced Pluripotent Stem Cells
edited by Yun Chang
submission deadline 30 Sep 2026 | 2 articles | Viewed by 10014 | Submission Open
Keywords: pluripotent stem cells; reprogramming; engineering; regenerative medicine; differentiation; therapeutic applications; biomaterials
(This special issue belongs to the Section Stem Cells)
Targeting Tumor Microenvironments for Enhanced Cancer Immunotherapy
edited by
submission deadline 30 Sep 2026 | 2 articles | Viewed by 9668 | Submission Open
Keywords: tumor microenvironment; cancer immunotherapy; immune modulation; immunosuppressive mechanisms; combination therapies
(This special issue belongs to the Section Cell Microenvironment)
The Cell Biology of Heart Disease
edited by Rajeshwary Ghosh and
submission deadline 30 Sep 2026 | 7 articles | Viewed by 8002 | Submission Open
Keywords: cardiomyopathy; endothelial dysfunction; cellular senescence; fibrosis; myocardial infarction; inflammation; mitochondrial dysfunction; CAD; arrhythmia; heart failure
(This special issue belongs to the Section Cells of the Cardiovascular System)
Novel Insights into Cancer Immune Responsiveness submission deadline 30 Sep 2026 | 3 articles | Viewed by 6856 | Submission Open
Keywords: cancers; tumors; immune cells; tumor immunology; cancer immunology; onco-immunology; immunotherapies; resistance; immunotherapy resistance; immune checkpoint; CAR; antibody; cancer vaccines
Biomarkers in Human Diseases and Emerging Diagnostic Technologies for Their Identification and Application
edited by and
submission deadline 30 Sep 2026 | 3 articles | Viewed by 6445 | Submission Open
Keywords: biomarkers; human diseases; disease mechanisms; biomarker validation; early detection; accurate diagnosis; prognosis evaluation; treatment monitoring; diagnostic technologies; biosensors; microfluidics
Epigenetic Regulation in Neuronal Development, Neurodegeneration and Regeneration
edited by
submission deadline 30 Sep 2026 | 2 articles | Viewed by 6310 | Submission Open
Keywords: epigenetic regulation; neuronal development; neuronal regeneration; chromatin remodeling
(This special issue belongs to the Section Cellular Neuroscience)
Cellular and Molecular Mechanisms in Gynecological Disorders—Second Edition
edited by
submission deadline 30 Sep 2026 | 3 articles | Viewed by 6055 | Submission Open
Keywords: uterus; ovary; fallopian tubes; cervix; vagina; endometriosis; polycystic ovary syndrome; primary ovarian insufficiency; ovarian cysts; adenomyosis; endometriosis; leiomyoma (uterine fibroids); endometrial cancer; leiomyosarcoma; female infertility; breast cancer; cell atlas; biomarkers; stem cells; pathways; transcriptome; proteomics; epigenome
(This special issue belongs to the Section Cellular Pathology)
Role of RNA as Regulator, Therapeutic Target and Probe for Early Disease Diagnosis
edited by
submission deadline 30 Sep 2026 | 6 articles | Viewed by 5806 | Submission Open
Keywords: coding RNAs; non-coding RNAs (ncRNAs); regulatory RNAs; RNA-based diagnostics; disease biomarkers; RNA monitoring techniques; molecular probes; RNA interference (RNAi)
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
The Blueprint of Female Reproductive Longevity: From Ovarian Biology to Modifiable Risks and Protective Strategies submission deadline 30 Sep 2026 | 2 articles | Viewed by 5466 | Submission Open
Keywords: ovarian aging; folliculogenesis; oocyte quality; hormonal regulation; epigenetics of reproduction; reproductive lifespan; stem cells in ovarian function; oxidative stress and fertility; metabolic influences on reproduction; cellular signaling in ovarian decline
(This special issue belongs to the Section Reproductive Cells and Development)
Cell Therapeutics for Corneal Diseases submission deadline 30 Sep 2026 | 2 articles | Viewed by 5273 | Submission Open
Keywords: cell therapies; corneal diseases; drug development; tissue engineering; stem cells; regeneration; tissue repair
(This special issue belongs to the Section Tissues and Organs)
Parkinson's Disease: Advances in Molecular Understanding and Emerging Therapies
edited by and Sara Elfarrash
submission deadline 30 Sep 2026 | 1 articles | Viewed by 5219 | Submission Open
Keywords: Parkinson’s disease; atypical Parkinsonism; neurodegeneration; neuroinflammation; alpha-synuclein; disease models; brain organoids; human induced pluripotent stem cells (iPSCs); transcriptomics; proteomics; multi-omics; spatial biology; multiplex imaging; PD genetics
(This special issue belongs to the Section Cellular Aging)
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